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| 1 | Puerarin protects brain tissue against cerebral ischemia/reperfusion injury by inhibiting the inflammatory response显示文摘Puerarin, a traditional Chinese medicine, exerts a powerful neuroprotective effect in cerebral ischemia/reperfusion injury, but its mechanism is unknown. Here, we established rat models of middle cerebral artery ischemia/reperfusion injury using the suture method. Puerarin(100 mg/kg) was administered intraperitoneally 30 minutes before middle cerebral artery occlusion and 8 hours after reperfusion. Twenty-four hours after reperfusion, we found that puerarin significantly improved neurological deficit, reduced infarct size and brain water content, and notably diminished the expression of Toll-like receptor-4, myeloid differentiation factor 88, nuclear factor kappa B and tumor necrosis factor-α in the ischemic region. These data indicate that puerarin exerts an anti-inflammatory protective effect on brain tissue with ischemia/reperfusion damage by downregulating the expression of multiple inflammatory factors. | Feng Zhou Liang Wang Panpan Liu Weiwei Hu Xiangdong Zhu Hong Shen Yuanyuan Yao | 2014 | Neural Regeneration Research2014，9，23： | 27 |
| 2 | Purification and Characterization of a New Thermostable κ-CarrageenasefromtheMarineBacterium Pseudoalteromonas sp. QY203显示文摘A new extracellular κ-carrageenase, namely CgkP, 34.0 kDa in molecular weight, was purified from Pseudoalteromonas sp. QY203. CgkP showed relatively high activity at acidities ranging from pH6.0 to pH9.0 and temperatures ranging from 30℃ to 50℃ with the highest activity at 45℃ and pH7.2. Sodium chloride increased its activity markedly, and KCl increased its activity slightly. The divalent and trivalent metal ions including Cu2+ , Ni2+ , Zn2+ , Mn2+ , Al3+ and Fe3+ significantly inhibited its activity, while Mg2+ did not. CgkP remained 70% of original activity after being incubated at 40℃ for 48 h, and remained 80% of the activity after being incubated at 45℃ for 1 h. It exhibited endo-κ-carrageenase activity, mainly depolymerizing the κ-carrageenan into disaccharide and tetrasaccharide. CgkP was more thermostable than most of previously reported κ-carrageenases with a potential of being used in industry. | LI Shangyong JIA Panpan WANG Linna YU Wengong HAN Feng | 2013 | Journal of Ocean University of China2013，12，1： | 10 |
| 3 | Concurrent chemoradiotherapy comparison of taxanes and platinum versus 5-fluorouracil and platinum in nasopharyngeal carcinoma treatment显示文摘 | Chen Xichuang Hong Yuan Feng Jinhua Ye Jianlin Zheng Panpan Guan Xiyin You Xiaohong Song Huizhu | 2014 | Chinese Medical Journal2014，，1： | 8 |
| 4 | G protein-coupled receptor 183 facilitates endothelial-to- hematopoietic transition via Notch1 inhibition显示文摘 | Panpan Zhang Qiuping He Dongbo Chen Weixiao Liu Lu Wang Chunxia Zhang Dongyuan Ma Wei Li Bing Liu Feng Liu | 2015 | Cell Research2015，25，10： | 7 |
| 5 | Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy显示文摘The development of effective nanoplatforms is extremely necessary for cancer therapy.Herein,we prepared polydopamine(PDA)andammonium bicarbonate(NH4HCO3)coated and doxorubicin(Dox)loaded hollow cerium oxide(CeO2)NPs(PDAC NPs),which showedexcellent synergistic effect for photothermal therapy,chemotherapy and chemodynamic therapy.Under near infrared laser irradiation,PDA shell could absorb the incident light and convert it into heat,which could not only kill tumor cells with hyperthermia,but also trigger thedecomposition of NH4HCO3 into gaseous carbon dioxide and ammonia,leading to the destroy of PDA shell.The leakage of PDA furtheraccelerated Dox release and exposed CeO2 surface,in which Dox could enter into cell nucleus to induce chemotherapy,and CeO2 couldcatalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy.In fact,PDAC NPs showed an excellenttherapeutic efficacy both in vitro and in vivo.This design provides a new strategy for synergistic tumor therapy. | Keqiang Xu Yan Cheng Jiao Yan Yanlin Feng Runxiao Zheng Xiaqhig Wu Yanjing Wang Panpan Song Haiyuan Zhang | 2019 | Nano Research2019，12，12： | 4 |
| 6 | Ultralow-weight loading Ni catalyst supported on two-dimensional vermiculite for carbon monoxide methanation显示文摘Nickel-based catalysts represent the most commonly used systems for CO methanation.We have successfully prepared a Ni catalyst system supported on two-dimensional plasma-treated vermiculite(2D-PVMT)with a very low Ni loading(0.5 wt%).The catalyst precursor was subjected to heat treatment via either conventional heat treatment(CHT)or the plasma irradiation method(PIM).The as-obtained CHT-Ni/PVMT and PIM-Ni/PVMT catalysts were characterized with scanning electron microscopy(SEM),energy dispersive X-ray(EDX),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),inductively coupled plasma-atomic emission spectroscopy(ICP-AES)and high-angle annular dark field scanning transmission electron microscopy(HAADF-STEM).Additionally,CHT-NiO/PVMT and PIM-NiO/PVMT catalysts were characterized with hydrogen temperature programmed reduction(H_2-TPR).Compared with CHT-Ni/PVMT,PIM-Ni/PVMT exhibited superior catalytic performance.The plasma treated catalyst PIM-Ni/PVMT achieved a CO conversion of93.5%and a turnover frequency(TOF)of 0.8537 s^(-1),at a temperature of 450°C,a gas hourly space velocity of 6000 ml·g^(-1)·h^(-1),a synthesis gas flow rate of 65 ml·min^(-1),and a pressure of 1.5 MPa.Plasma irradiation may provide a successful strategy for the preparation of catalysts with very low metal loadings which exhibit excellent properties. | Mengjuan Zhang Panpan Li Mingyuan Zhu Zhiqun Tian Jianming Dan Jiangbing Li Bin Dai Feng Yu | 2018 | Chinese Journal of Chemical Engineering2018，26，9： | 3 |
| 7 | Inhibitor of DNA binding 2 accelerates nerve regeneration after sciatic nerve injury in mice显示文摘Inhibitor of DNA binding 2(Id2)can promote axonal regeneration after injury of the central nervous system.However,whether Id2 can promote axonal regeneration and functional recovery after peripheral nerve injury is currently unknown.In this study,we established a mouse model of bilateral sciatic nerve crush injury.Two weeks before injury,AAV9-Id2-3×Flag-GFP was injected stereotaxically into the bilateral ventral horn of lumbar spinal cord.Our results showed that Id2 was successfully delivered into spinal cord motor neurons projecting to the sciatic nerve,and the number of regenerated motor axons in the sciatic nerve distal to the crush site was increased at 2 weeks after injury,arriving at the tibial nerve and reinnervating a few endplates in the gastrocnemius muscle.By 1 month after injury,extensive neuromuscular reinnervation occurred.In addition,the amplitude of compound muscle action potentials of the gastrocnemius muscle was markedly recovered,and their latency was shortened.These findings suggest that Id2 can accelerate axonal regeneration,promote neuromuscular reinnervation,and enhance functional improvement following sciatic nerve injury.Therefore,elevating the level of Id2 in adult neurons may present a promising strategy for peripheral nerve repair following injury.The study was approved by the Experimental Animal Ethics Committee of Jinan University(approval No.20160302003)on March 2,2016. | Zhong-Hai Huang Ai-Ying Feng Jing Liu Libing Zhou Bing Zhou Panpan Yu | 2021 | Neural Regeneration Research2021，16，12： | 2 |
| 8 | Design of Intelligent Irrigation Monitoring System Based on GPRS and Zigbee显示文摘In order to solve the present dual contradiction of the low utilization of water resources in China's agricultural sector and the low land management efficiency,using Zigbee wireless sensor network and GPRS technology,this paper designs an intelligent monitoring system based on the GPRS and Zigbee wireless network technology. The Zigbee wireless sensor network is established based on the IEEE 802. 15. 4 / Zigbee protocol,consisting of terminal node for capturing and transmitting soil and environmental information to the coordinator node( gateway node)or acting the control command from the GPRS network. The irrigation remote monitoring network layer consists of coordinator node connected by the TCP / IP protocol,which can implement the precision irrigation of crops and the information management of arable land to the monitor center or user. And the monitor center using Java to write the system is safe and effective. | Fuping WANG Panpan FENG | 2015 | Asian Agricultural Research2015，7，6： | 2 |
| 9 | Local Precise Large Deviations for Independent Sums in Multi-Risk Model显示文摘In this paper, we study the case of independent sums in multi-risk model. Assume that there exist k types of variables. The ith are denoted by {Xij, j ≥ 1}, which are i.i.d.with common density function fi(x) ∈ OR and finite mean, i = 1,..., k. We investigate local large deviations for partial sums k i=1Sni= k i=1 nij=1Xij. | Jinghai FENG Panpan ZHAO Libin JIAO | 2014 | Journal of Mathematical Research with Applications2014，34，2： | 2 |
| 10 | Influence mechanism of boron segregation on the microstructure evolution and hot ductility of super austenitic stainless steel S32654显示文摘Influence mechanism of B segregation on the microstructure evolution and hot ductility of S32654 at850-1250℃was systematically investigated through experimental research and theoretical calculation.The results demonstrated that the segregation of B at grain boundary(GB)played different roles in the microstructure evolution and hot ductility at various temperatures.At 850℃,B segregation inhibited Mo segregation at the GB and enhanced the GB cohesion.At 900-950℃,B segregation restricted the diffusion and segregation of Mo to the GB,inhibiting the precipitation ofσphase.At 1000-1050℃,B segregation accelerated the dislocation accumulation and limited the GB migration,promoting the nucleation and inhibiting the growth of DRX grains.At 1100-1150℃,B has little effect on the DRX due to sufficient energy supply by higher temperature.Under the above beneficial effects of B,the hot ductility of S32654 was improved to varying degrees at 850-1150℃.However,as the temperature increased to1200-1250℃,B segregation decreased the solidus temperature and enhanced the liquefaction cracking tendency,resulting in a deterioration of the hot ductility. | Jiangtao Yu Shucai Zhang Huabing Li Zhouhua Jiang Hao Feng Panpan Xu Peide Han | 2022 | Journal of Materials Science & Technology2022，，17： | 2 |
| 11 | Tunable Dynamic Black Phosphorus/Insulator/Si Heterojunction Direct-Current Generator Based on the Hot Electron Transport显示文摘Static heterojunction-based electronic devices have been widely applied because carrier dynamic processes between semiconductors can be designed through band gap engineering.Herein,we demonstrate a tunable direct-current generator based on the dynamic heterojunction,whose mechanism is based on breaking the symmetry of drift and diffusion currents and rebounding hot carrier transport in dynamic heterojunctions.Furthermore,the output voltage can be delicately adjusted and enhanced with the interface energy level engineering of inserting dielectric layers.Under the ultrahigh interface electric field,hot electrons will still transfer across the interface through the tunneling and hopping effect.In particular,the intrinsic anisotropy of black phosphorus arising from the lattice structure produces extraordinary electronic,transport,and mechanical properties exploited in our dynamic heterojunction generator.Herein,the voltage of 6.1 V,current density of 124.0 A/m^(2),power density of 201.0 W/m^(2),and energy-conversion efficiency of 31.4%have been achieved based on the dynamic black phosphorus/AlN/Si heterojunction,which can be used to directly and synchronously light up light-emitting diodes.This direct-current generator has the potential to convert ubiquitous mechanical energy into electric energy and is a promising candidate for novel portable and miniaturized power sources in the in situ energy acquisition field. | Yanghua Lu Sirui Feng Runjiang Shen Yujun Xu Zhenzhen Hao Yanfei Yan Haonan Zheng Xutao Yu Qiuyue Gao Panpan Zhang Shisheng Lin | 2019 | Research2019，，1： | 2 |
| 12 | A meta-analysis of the effects of statins on serum C-reactive protein in Chinese population with coronary heart disease or hyperlipidemia显示文摘There is little doubt that statins reduce cardiovascular events more than what the lipid lowering effect can account for. Additional mechanisms have been postulated including the anti-inflammatory effects manifested by reduced C-reactive protein (CRP). It is not known, however, whether statins can decrease CRP in Chinese population. The aim of this study is to investigate the effects of statins on serum CRP in Chinese patients with coronary heart disease (CHD) or hyperlipidemia. Trials were retrieved through Medline (1980 to May, 2009), bibliographies, and the author’s reference files limited to English-language articles. Data were extracted and meta-analysis was performed. Analysis showed statistically significant reduction in CRP after statin treatment (weighted mean difference [WMD] = -0.73, 95% confidence interval [CI] = [-0.80, -0.66], P < 0.00001) and lower CRP after statin treatment than non-statin routine treatment ([WMD] = -0.52, 95% CI [-0.86, -0.18], P = 0.002). In conclusion, statins significantly reduce serum CRP in Chinese population, which may contribute to statin-induced reduction in the cardiovascular risk in addition to the lipid lowering effect. | HAO PanPan CHEN YuGuo WANG XingLi XU Feng WANG JiaLi ZHANG Yun | 2009 | Chinese Science Bulletin2009，54，23： | 1 |
| 13 | A computational model of topological and geometric recovery for visual curve completion显示文摘Visual curve completion is a fundamental problem in understanding the principles of the human visual system. This problem is usually divided into two problems: a grouping problem and a shape problem.On one hand, though perception of the visually completed curve is clearly a global task(for example,a human perceives the Kanizsa triangle only when seeing all three black objects), conventional methods for solving the grouping problem are generally based on local Gestalt laws. On the other hand, the shape of the visually completed curve is usually recovered by minimizing shape energy in existing methods.However, not only do these methods lack mechanisms to adjust the shape of the recovered visual curve using perceptual, psychophysical, and neurophysiological knowledge, but it is also difficult to calculate an explicit representation of the visually completed curve. In this paper, we present a systematic computational model for generating a visually completed curve. Firstly, based on recent studies of perception, psychophysics, and neurophysiology, we formulate a grouping procedure based on the human visual system by seeking a minimum Hamiltonian cycle in a graph, solving the grouping problem in a global manner. Secondly, we employ a B′ezier curve-based model to represent the visually completed curve. Not only is an explicit representation deduced, but we also present a means to integrate knowledge from related areas, such as perception, psychophysics, and neurophysiology, and so on. The proposed computational model has been validated using many modal and amodal completion examples, and desirable results were obtained. | Hongwei Lin Zihao Wang Panpan Feng Xingjiang Lu Jinhui Yu | 2016 | Computational Visual Media2016，2，4： | 1 |
| 14 | Ameliorative effect of scutellarin on acute alcohol brain injury in mice显示文摘Drinking culture has high significance in both China and the world,whether in the entertainment sector or in social occasions;according to the World Health Organization's 2018 Global Alcohol and Health Report,about 3 million people died from excessive drinking in 2016,accounting for 5.3%of the total global deaths that year.Oxidative stress and inflammation are the most common pathological phenomena caused by alcohol abuse(Snyder et al.,2017). | Tianmeng ZHANG Kun WANG Hui FAN Qiankun YANG Xiao ZHANG Feixue LIU Xin FENG Yi CHEN Daoyang TENG Panpan ZHAO Jingquan DONG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，3： | 1 |
| 15 | In vivo imaging of hematopoietic stem cell development in the zebrafish显示文摘In vivo imaging is crucial for developmental biology and can further help to follow cell development/differentiation in normal and pathological conditions.Recent advances in optical imaging techniques has facilitated tracing of the developmental dynamics of a specific organ,tissue,or even a single cell.The zebrafish is an excellent model for imaging of hematopoiesis due to its transparent embryo at early stage;moreover,different zebrafish hematopoietic stem cells(HSCs)transgenic lines have been demonstrated as very useful tools for illustrating the details of the HSC developmental process.In this review,we summarize recent studies related to the non-invasive in vivo imaging of HSC transgenics,to show that zebrafish transgenic lines are powerful tools for developmental biology and disease.At the end of the review,the perspective and some open questions in this field will be discussed. | Panpan Zhang Feng Liu | 2011 | Frontiers of Medicine2011，5，3： | 0 |
| 16 | A Novel Fluorescence Tool for Monitoring Agricultural Industry Chain Based on AIEgens显示文摘With the development of the global economy,the safety of agricultural production has attracted intense attention.To minimize the risk of harmful ingredients in the whole industry chain,it is very necessary to cover the entire process of safety inspections from planting to production to environmental management.Fluorescence sensing as a promising and powerful screening tool is widely used for the detection of ions,toxic gases,biological molecules and so on.However,traditional fluorescent probes often suffer from aggregation-induced quenching(ACQ)effects,which limits their practical applications.In this regard,aggregation-induced emission luminogens(AIEgens)can perfectly address this notorious issue and have shown great potential in agricultural safety analysis.In this review,we briefly summarize their applications in agricultural safety monitoring,including the fabrication of agricultural film,agricultural sewage treatment and selective detection of harmful residues in agricultural products.The challenge and future development of AIEgens in this field are also discussed and highlighted.Hopefully,this review can inspire more researchers to participate in this fascinating area. | CHEN Mingyu XIANG Song LV Panpan Ql Chunxuan FENG Hai-Tao TANG Ben Zhong | 2021 | Chemical Research in Chinese Universities2021，37，1： | 0 |
| 17 | Interfacial synthesis of crystalline quasi-two-dimensional polyaniline thin films for high-performance flexible on-chip micro-supercapacitors显示文摘Quasi-two-dimensional(q2 D)conducting polymer thin film synergizes the advantageous features of longrange molecular ordering and high intrinsic conductivity,which are promising for flexible thin film-based micro-supercapacitors(MSCs).Herein,we present the high-performance flexible MSCs based on highly ordered quasi-two-dimensional polyaniline(q2 D-PANI)thin film using surfactant monolayer assisted interfacial synthesis(SMAIS).Owing to high electrical conductivity,rich redox chemistry,and thin-film morphology,the q2 D-PANI MSCs show high volumetric specific capacitance(ca.360 F/cm^(3))and energy density(17.9 m Wh/cm^(3)),which outperform the state-of-art PANI thin-film based MSCs and promise for future flexible electronics. | Tao Zhang Panpan Zhang Zhongquan Liao Faxing Wang Jinhui Wang Mingchao Wang Ehrenfried Zschech Xiaodong Zhuang Oliver G.Schmidt Xinliang Feng | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 18 | Unique fluorophilic pores engineering within porous aromatic frameworks for trace perfluorooctanoic acid removal显示文摘Perfluorooctanoic acid(PFOA),a representative of per/polyfluorinated alkyl substances,has become a persistent water pollutant of widespread concern due to its biological toxicity and refractory property.In this work,we design and synthesize two porous aromatic frameworks(PAF)of PAF-CF3 and PAF-C2F5 using fluorine-containing alkyl based monomers in tetrahedral geometry.Both PAFs exhibit nanosized pores(~1.0 nm)of high surface areas(over 800 m2 g-1)and good fluorophilicity.Remarkable adsorption capacity(>740 mg g-1)and superior efficiency(>24 g mg-1 h-1)are achieved toward the removal of PFOA with 1μg L-1 concentration owing to unique C-F…F-C interactions.In particular,PAF-CF3 and PAF-C2F5 are able to reduce the PFOA concentration in water to 37.9 ng L-1 and 43.3 ng L-1,below EPA regulations(70 ng L-1).The reusability and high efficiency give both PAFs a great potential for sewage treatment. | Chi Zhang Junchao Dong Panpan Zhang Lei Sun Liu Yang Wenjian Wang Xiaoqin Zou Yunning Chen Qingkun Shang Danyang Feng Guangshan Zhu | 2023 | National Science Review2023，10，10： | 0 |
| 19 | Interactive effects of warming and eutrophication on zooplankton could reverse the stoichiometric mismatch with phytoplankton显示文摘The core ecosystem functioning(e.g.trophic transfer efficiency)is at risk of being disrupted by the growing mismatch between nutrient content of primary producers and nutrient demand of grazing consumers.Ecological stoichiometry provides a conceptual framework that explains this trophic interaction using C,N and P elemental composition across trophic levels.In light of ongoing climate change and eutrophication,previous studies have raised concerns regarding the growing stoichiometric mismatch between phytoplankton and zooplankton,given the stoichiometric plasticity of phytoplankton.However,there is currently little conclusive evidence on the stoichiometric mismatch from a dual perspective of phytoplankton and zooplankton.To address this,we conducted a mesocosm experiment to investigate the separate and combined effects of climate warming(a constant increase of t3.5C plus heat waves)and eutrophication(nutrient addition)on stoichiometric mismatch between phytoplankton and zooplankton by examining stoichiometric changes in both communities.We observed a growing trend in stoichiometric mismatches when warming or nutrient addition acted individually,which was mediated by the increase in nutrient demand(N,P elements)of zooplankton growth.However,when these stressors acted jointly,the mismatches were reversed.This could be because climate warming and eutrophication combined would lead to changes in species composition,which accordingly reshaped the stoichiometric composition at the community level.These results illustrate the need of stoichiometric mismatches for understanding the implication of global change on trophic interactions and ecosystem functioning,requiring consideration not only of cross-trophic levels but also of compositional changes within communities. | Konghao Zhu Huan Zhang Peiyu Zhang Panpan Wang Hailu Li Mingjun Feng Huan Wang Hongxia Wang Min Zhang Jun Xu | 2023 | Water Biology and Security2023，2，4： | 0 |
| 20 | Fabrication of ZnO with tunable morphology through a facile treatment of Zn-based coordination polymers显示文摘The morphology and structure of zinc oxide(ZnO), one of the important semiconductors, are relevant to its properties and applications. The preparation of ZnO with tunable morphology and desired structure is an attractive topic in the field of material synthesis. This work reports a facile method for the synthesis of Zn O with controllable morphology and crystal orientation using Zn-based coordination polymer particles(Zn-CPP) as precursors. Using hydrothermal method, Zn-CPP with morphologies of microrod, nanoplate, flower-like, arrow-tipped microsheet, and square cylinder were successfully synthesized via the coordination between metal ions Zn2+ and organic ligand 1,4,5,8-naphthalenetetracarboxylic dianhydride in aqueous solution. Subsequent thermal treatment of the Zn-CPP successfully resulted in the formation of porous Zn O with similar morphology to Zn-CPP. It is also found that the Zn O with enhanced(002) orientation could be obtained from Zn-CPP with preferred(002) orientation. This strategy could be extended for the preparation of other metal oxides with desired shape and structure. | Panpan Su Jiao Zhao Feng Rong Can Li Qihua Yang | 2015 | Science China Chemistry2015，58，3： | 0 |
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