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| 1 | Purification and Characterization of a New Thermostable κ-CarrageenasefromtheMarineBacterium Pseudoalteromonas sp. QY203显示文摘A new extracellular κ-carrageenase, namely CgkP, 34.0 kDa in molecular weight, was purified from Pseudoalteromonas sp. QY203. CgkP showed relatively high activity at acidities ranging from pH6.0 to pH9.0 and temperatures ranging from 30℃ to 50℃ with the highest activity at 45℃ and pH7.2. Sodium chloride increased its activity markedly, and KCl increased its activity slightly. The divalent and trivalent metal ions including Cu2+ , Ni2+ , Zn2+ , Mn2+ , Al3+ and Fe3+ significantly inhibited its activity, while Mg2+ did not. CgkP remained 70% of original activity after being incubated at 40℃ for 48 h, and remained 80% of the activity after being incubated at 45℃ for 1 h. It exhibited endo-κ-carrageenase activity, mainly depolymerizing the κ-carrageenan into disaccharide and tetrasaccharide. CgkP was more thermostable than most of previously reported κ-carrageenases with a potential of being used in industry. | LI Shangyong JIA Panpan WANG Linna YU Wengong HAN Feng | 2013 | Journal of Ocean University of China2013，12，1： | 10 |
| 2 | Increased leptin by hypoxic-preconditioning promotes autophagy of mesenchymal stem cells and protects them from apoptosis显示文摘Autophagy is the basic catabolic progress involved in cell degradation of unnecessary or dysfunctional cellular components.It has been proven that autophagy could be utilized for cell survival under stresses.Hypoxic-preconditioning(HPC)could reduce apoptosis induced by ischemia and hypoxia/serum deprivation(H/SD)in bone marrow-derived mesenchymal stem cells(BMSCs).Previous studies have shown that both leptin signaling and autophagy activation were involved in the protection against apoptosis induced by various stress,including ischemia-reperfusion.However,it has never been fully understood how leptin was involved in the protective effects conferred by autophagy.In the present study,we demonstrated that HPC can induce autophagy in BMSCs by increased LC3-II/LC3-I ratio and autophagosome formation.Interestingly,similar effects were also observed when BMSCs were pretreated with rapamycin.The beneficial effects offered by HPC were absent when BMSCs were incubated with autophagy inhibitor,3-methyladenine(3-MA).In addition,down-regulated leptin expression by leptin-shRNA also attenuated HPC-induced autophagy in BMSCs,which in turn was associated with increased apoptosis after exposed to sustained H/SD.Furthermore,increased AMP-activated protein kinase phosphorylation and decreased mammalian target of rapamycin phosphorylation that were observed in HPC-treated BMSCs can also be attenuated by down-regulation of leptin expression.Our data suggests that leptin has impact on HPC-induced autophagy in BMSCs which confers protection against apoptosis under H/SD,possibly through modulating both AMPK and mTOR pathway. | WANG LiHan HU XinYang ZHU Wei JIANG Zhi ZHOU Yu CHEN PanPan WANG JianAn | 2014 | Science China(Life Sciences)2014，57，2： | 8 |
| 3 | Preferential adsorption behaviour of CH_4 and CO_2 on high-rank coal from Qinshui Basin,China显示文摘In order to better understand the prevailing mechanism of CO2 storage in coal and estimate CO2 sequestration capacity of a coal seam and enhanced coalbed methane recovery(ECBM) with CO2 injection into coal, we investigated the preferential adsorption of CH4 and CO2on coals. Adsorption of pure CO2,CH4 and their binary mixtures on high-rank coals from Qinshui Basin in China were employed to study the preferential adsorption behaviour. Multiple regression equations were presented to predict CH4 equilibrium concentration from equilibrium pressure and its initial-composition in feed gas. The results show that preferential adsorption of CO2 on coals over the entire pressure range under competitive sorption conditions was observed, however, preferential adsorption of CH4 over CO2on low-volatile bituminous coal from higher CH4-compostion in source gas was found at up to 10 MPa pressure. Preferential adsorption of CO2 increases with increase of CH4 concentration in source gas, and decreases with increasing pressure. Although there was no systematic investigation of the effect of coal rank on preferential adsorption, there are obvious differences in preferential adsorption of gas between low-volatile bituminous coal and anthracite. The obtained preferential adsorption gives rise to the assumption that CO2 sequestration in coal beds with subsequent CO2-ECBM might be an option in Qinshui Basins, China. | Yu Hongguan Jing Renxia Wang Panpan Chen Lihui Yang Yongjie | 2014 | International Journal of Mining Science and Technology2014，24，4： | 4 |
| 4 | Purification of starch and phosphorus wastewater using core-shell magnetic seeds prepared by sulfated roasting显示文摘Core-shell magnetic seeds with certain adsorption capacity that were prepared by sulfated roasting, served as the core of a magnetic separation technology for purification of starch wastewater. XRD and SEM results indicate that magnetite's surface transformed to be porous α-Fe_2O_3 structure. Compared with magnetite particles, the specific surface area was significantly improved to be 8.361 from 2.591 m^2/g, with little decrease in specific susceptibility. Zeta potential, FT-IR and XPS experiments indicate that both phosphate and starch adsorbed on the surface of the core-shell magnetic seeds by chemical adsorption, which fits well with the Langmuir adsorption model. The porous surface structure of magnetic seeds significantly contributes to the adsorption of phosphate and starch species, which can be efficiently removed to be 1.51 mg/L(phosphate) and 9.51 mg/L(starch) using magnetic separation. | Chunjie Du Jinsheng Yu Wei Sun Haisheng Han Yuehua Hu Pan Chen Panpan Hou Runqing Liu Li Wang Yue Yang Ruohua Liu Lei Sun | 2019 | Journal of Environmental Sciences2019，31，7： | 4 |
| 5 | Ultralow-weight loading Ni catalyst supported on two-dimensional vermiculite for carbon monoxide methanation显示文摘Nickel-based catalysts represent the most commonly used systems for CO methanation.We have successfully prepared a Ni catalyst system supported on two-dimensional plasma-treated vermiculite(2D-PVMT)with a very low Ni loading(0.5 wt%).The catalyst precursor was subjected to heat treatment via either conventional heat treatment(CHT)or the plasma irradiation method(PIM).The as-obtained CHT-Ni/PVMT and PIM-Ni/PVMT catalysts were characterized with scanning electron microscopy(SEM),energy dispersive X-ray(EDX),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),inductively coupled plasma-atomic emission spectroscopy(ICP-AES)and high-angle annular dark field scanning transmission electron microscopy(HAADF-STEM).Additionally,CHT-NiO/PVMT and PIM-NiO/PVMT catalysts were characterized with hydrogen temperature programmed reduction(H_2-TPR).Compared with CHT-Ni/PVMT,PIM-Ni/PVMT exhibited superior catalytic performance.The plasma treated catalyst PIM-Ni/PVMT achieved a CO conversion of93.5%and a turnover frequency(TOF)of 0.8537 s^(-1),at a temperature of 450°C,a gas hourly space velocity of 6000 ml·g^(-1)·h^(-1),a synthesis gas flow rate of 65 ml·min^(-1),and a pressure of 1.5 MPa.Plasma irradiation may provide a successful strategy for the preparation of catalysts with very low metal loadings which exhibit excellent properties. | Mengjuan Zhang Panpan Li Mingyuan Zhu Zhiqun Tian Jianming Dan Jiangbing Li Bin Dai Feng Yu | 2018 | Chinese Journal of Chemical Engineering2018，26，9： | 3 |
| 6 | Long noncoding RNA(lncRNA)HOTAIR:Pathogenic roles and therapeutic opportunities in gastric cancer显示文摘Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease.Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer.HOTAIR is an effective epigenetic agent known as long noncoding RNA(lncRNA).HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors,leading to genomic stability,proliferation,survival,invasion,migration,metastasis,and drug resistance.In the present article,we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer,whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes,leading to the development of potential therapeutic strategies. | Wencheng Kong Guang Yin Sixin Zheng Xinchun Liu Akao Zhu Panpan Yu Jian Zhang Yuqiang Shan Rongchao Ying Huicheng Jin | 2022 | Genes & Diseases2022，9，5： | 3 |
| 7 | Inhibitor of DNA binding 2 accelerates nerve regeneration after sciatic nerve injury in mice显示文摘Inhibitor of DNA binding 2(Id2)can promote axonal regeneration after injury of the central nervous system.However,whether Id2 can promote axonal regeneration and functional recovery after peripheral nerve injury is currently unknown.In this study,we established a mouse model of bilateral sciatic nerve crush injury.Two weeks before injury,AAV9-Id2-3×Flag-GFP was injected stereotaxically into the bilateral ventral horn of lumbar spinal cord.Our results showed that Id2 was successfully delivered into spinal cord motor neurons projecting to the sciatic nerve,and the number of regenerated motor axons in the sciatic nerve distal to the crush site was increased at 2 weeks after injury,arriving at the tibial nerve and reinnervating a few endplates in the gastrocnemius muscle.By 1 month after injury,extensive neuromuscular reinnervation occurred.In addition,the amplitude of compound muscle action potentials of the gastrocnemius muscle was markedly recovered,and their latency was shortened.These findings suggest that Id2 can accelerate axonal regeneration,promote neuromuscular reinnervation,and enhance functional improvement following sciatic nerve injury.Therefore,elevating the level of Id2 in adult neurons may present a promising strategy for peripheral nerve repair following injury.The study was approved by the Experimental Animal Ethics Committee of Jinan University(approval No.20160302003)on March 2,2016. | Zhong-Hai Huang Ai-Ying Feng Jing Liu Libing Zhou Bing Zhou Panpan Yu | 2021 | Neural Regeneration Research2021，16，12： | 2 |
| 8 | Influence mechanism of boron segregation on the microstructure evolution and hot ductility of super austenitic stainless steel S32654显示文摘Influence mechanism of B segregation on the microstructure evolution and hot ductility of S32654 at850-1250℃was systematically investigated through experimental research and theoretical calculation.The results demonstrated that the segregation of B at grain boundary(GB)played different roles in the microstructure evolution and hot ductility at various temperatures.At 850℃,B segregation inhibited Mo segregation at the GB and enhanced the GB cohesion.At 900-950℃,B segregation restricted the diffusion and segregation of Mo to the GB,inhibiting the precipitation ofσphase.At 1000-1050℃,B segregation accelerated the dislocation accumulation and limited the GB migration,promoting the nucleation and inhibiting the growth of DRX grains.At 1100-1150℃,B has little effect on the DRX due to sufficient energy supply by higher temperature.Under the above beneficial effects of B,the hot ductility of S32654 was improved to varying degrees at 850-1150℃.However,as the temperature increased to1200-1250℃,B segregation decreased the solidus temperature and enhanced the liquefaction cracking tendency,resulting in a deterioration of the hot ductility. | Jiangtao Yu Shucai Zhang Huabing Li Zhouhua Jiang Hao Feng Panpan Xu Peide Han | 2022 | Journal of Materials Science & Technology2022，，17： | 2 |
| 9 | Tunable Dynamic Black Phosphorus/Insulator/Si Heterojunction Direct-Current Generator Based on the Hot Electron Transport显示文摘Static heterojunction-based electronic devices have been widely applied because carrier dynamic processes between semiconductors can be designed through band gap engineering.Herein,we demonstrate a tunable direct-current generator based on the dynamic heterojunction,whose mechanism is based on breaking the symmetry of drift and diffusion currents and rebounding hot carrier transport in dynamic heterojunctions.Furthermore,the output voltage can be delicately adjusted and enhanced with the interface energy level engineering of inserting dielectric layers.Under the ultrahigh interface electric field,hot electrons will still transfer across the interface through the tunneling and hopping effect.In particular,the intrinsic anisotropy of black phosphorus arising from the lattice structure produces extraordinary electronic,transport,and mechanical properties exploited in our dynamic heterojunction generator.Herein,the voltage of 6.1 V,current density of 124.0 A/m^(2),power density of 201.0 W/m^(2),and energy-conversion efficiency of 31.4%have been achieved based on the dynamic black phosphorus/AlN/Si heterojunction,which can be used to directly and synchronously light up light-emitting diodes.This direct-current generator has the potential to convert ubiquitous mechanical energy into electric energy and is a promising candidate for novel portable and miniaturized power sources in the in situ energy acquisition field. | Yanghua Lu Sirui Feng Runjiang Shen Yujun Xu Zhenzhen Hao Yanfei Yan Haonan Zheng Xutao Yu Qiuyue Gao Panpan Zhang Shisheng Lin | 2019 | Research2019，，1： | 2 |
| 10 | A rapid real-time recombinase polymerase amplification assay for diagnosis of acute hepatopancreatic necrosis disease in shrimp显示文摘Acute hepatopancreatic necrosis disease(AHPND)is an emerging disease in the shrimp farming industry with a high mortality rate that causes serious economic losses in Asia,Africa,and America[1].AHPND is also known as early mortality syndrome because of its early onset of the disease at 5-30 days of shrimp postlarvae stocking and a high mortality rate up to 100%.Symptoms of AHPND include lighter hepatopancreas,atrophy,jejunal empty stomach,softened carapace,and loss of vitality.AHPND is caused by infection of special strains of Vibrio parahaemolyticus(referred to VPAHPND in this study)containing the 69-kb pVA1 plasmid with the binary toxic Photorhabdus insect-related genes PirA and PirB(referred to PirAB in this study)[2].In January 2016,the World Organization for Animal Health(OIE)added AHPND to the OIE List of Aquatic Animal Diseases.Rapid,sensitive,and reliable diagnosis assays for AHPND are demanded by the shrimp farming industry to prevent the disease and reduce economic loss. | Haiyi Yu Xiaohan Yang Juan Zhang Haitao Yang Panpan Zhao Hui Shen Ge Jiang Jing Ji Jingquan Dong Song Gao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 2 |
| 11 | Effect of chondroitin sulfate proteoglycans on neuronal cell adhesion, spreading and neurite growth in culture显示文摘As one major component of extracellular matrix(ECM) in the central nervous system, chondroitin sulfate proteoglycans(CSPGs) have long been known as inhibitors enriched in the glial scar that prevent axon regeneration after injury. Although many studies have shown that CSPGs inhibited neurite outgrowth in vitro using different types of neurons, the mechanism by which CSPGs inhibit axonal growth remains poorly understood. Using cerebellar granule neuron(CGN) culture, in this study, we evaluated the effects of different concentrations of both immobilized and soluble CSPGs on neuronal growth, including cell adhesion, spreading and neurite growth. Neurite length decreased while CSPGs concentration arised, meanwhile, a decrease in cell density accompanied by an increase in cell aggregates formation was observed. Soluble CSPGs also showed an inhibition on neurite outgrowth, but it required a higher concentration to induce cell aggregates formation than coated CSPGs. We also found that growth cone size was significantly reduced on CSPGs and neuronal cell spreading was restrained by CSPGs, attributing to an inhibition on lamellipodial extension. The effect of CSPGs on neuron adhesion was further evidenced by interference reflection microscopy(IRM) which directly demonstrated that both CGNs and cerebral cortical neurons were more loosely adherent to a CSPG substrate. These data demonstrate that CSPGs have an effect on cell adhesion and spreading in addition to neurite outgrowth. | Jingyu Jin Sharada Tilve Zhonghai Huang Libing Zhou Herbert M.Geller Panpan Yu | 2018 | Neural Regeneration Research2018，13，2： | 2 |
| 12 | Interfacial Built-In Electric Field-Driven Direct Current Generator Based on Dynamic Silicon Homojunction显示文摘Searching for light and miniaturized functional device structures for sustainable energy gathering from the environment is the focus of energy society with the development of the internet of things.The proposal of a dynamic heterojunction-based direct current generator builds up new platforms for developing in situ energy.However,the requirement of different semiconductors in dynamic heterojunction is too complex to wide applications,generating energy loss for crystal structure mismatch.Herein,dynamic homojunction generators are explored,with the same semiconductor and majority carrier type.Systematic experiments reveal that the majority of carrier directional separation originates from the breaking symmetry between carrier distribution,leading to the rebounding effect of carriers by the interfacial electric field.Strikingly,NN Si homojunction with different Fermi levels can also output the electricity with higher current density than PP/PN homojunction,attributing to higher carrier mobility.The current density is as high as 214.0 A/m^(2),and internal impedance is as low as 3.6 kΩ,matching well with the impedance of electron components.Furthermore,the N-i-N structure is explored,whose output voltage can be further improved to 1.3V in the case of the N-Si/Al2O3/N-Si structure,attributing to the enhanced interfacial barrier.This approach provides a simple and feasible way of converting low-frequency disordered mechanical motion into electricity. | Yanghua Lu Qiuyue Gao Xutao Yu Haonan Zheng Runjiang Shen Zhenzhen Hao Yanfei Yan Panpan Zhang Yu Wen Guiting Yang Shisheng Lin | 2020 | Research2020，，1： | 2 |
| 13 | Preparation and Characterization of regenerated cellulose fibers from a novel solvent system 显示文摘 | Zhenguo Li Panpan Hu Junrong Yu Zuming Hu and Zhaofeng Liu | 2008 | Jourmal Macromolecular Science Part B: Physics2008，47，2： | 1 |
| 14 | Multi-objective and multi-scheme research on water and sediment regulation potential of reservoirs in the upper Yellow River显示文摘The problems of the deteriorating relation between water and sediment,and the escalating conflict between water supply and demand in the upper Yellow River(YR),need to be addressed.Reservoirs of Longyangxia,Liujiaxia,and Heishanxia(Long-Liu-Hei)in the upper YR are taken as the research object,and a multi-objective,water-sediment optimal operation model for cascade reservoirs Long-Liu-Hei has been developed.This operation model considers the comprehensive requirements of water supply,power generation,flood control,and especially,water and sediment regulation.The improved Non-dominated Sorting Genetic Algorithms(NSGA-II)method is used to demonstrate the water and sediment regulation potential of three scenario schemes under long-term conditions,and the adjustable water allocation of four schemes under typical year conditions are calculated.It is recommended to use the mode of generating hydropower depending on the available water amount as the best operating mode under the conditions of a long time series and for typical years.This recommended operation mode has verified the rationality and accuracy of the reservoir operations model.At the same time,compared with the calculation results for water and sediment regulation after the construction of the Heishanxia,the current research indicates:(1)Under the recommended model,the potential for water and sediment regulation under the long-term series and typical years is once every four years.(2)Inter-basin water transfer greatly improves the cascade power generation.When the adjustable water volume is converted into the controlled volume for water and sediment regulation,the intensity frequency of water and sediment regulation of cascade reservoirs are improved.(3)With the intensification of the contradiction between the supply of and demand for water resources in the upper YR in the future,the amount of transferable water exhibits a decreasing trend,and the regulation of water and sediment in the upper YR is facing huge challenges.(4)Through joint operation with the Longyangxia and Liujiaxia reservoirs(Long-Liu),Heishanxia will play an important role in the regulation and control of power generation,water supply,flood control,and ice prevention in the upper YR.The current research results can provide a theoretical basis and technical support for water and sediment regulation in the YR basin. | Tao Bai Jia Yu Wenting Jin Jiaquan Wan Shaojie Gou Xu Ma Panpan Ma | 2023 | International Journal of Sediment Research2023，38，2： | 1 |
| 15 | Flue Gas Monitoring System With Empirically-Trained Dictionary显示文摘The monitoring of flue gas of the thermal power plants is of great significance in energy conservation and environmental protection.Spectral technique has been widely used in the gas monitoring system for predicting the concentrations of specific gas components.This paper proposes flue gas monitoring system with empirically-trained dictionary(ETD)to deal with the complexity and biases brought by the uninformative spectral data.Firstly,ETD is extracted from the raw spectral data by an alternative optimization between the sparse coding stage and the dictionary update stage to minimize the error of sparse representation.D1,D2 and D3 are three types of ETD obtained by different methods.Then,the predictive model of component concentration is constructed on the ETD.In the experiments,two real flue gas spectral datasets are collected and the proposed method combined with the partial least squares,the background propagation neural network and the support vector machines are performed.Moreover,the optimal parameters are chosen according to the 10-fold root-mean-square error of cross validation.The experimental results demonstrate that the proposed method can be used for quantitative analysis effectively and ETD can be applied to the gas monitoring systems. | Hui Cao Yajie Yu Panpan Zhang Yanxia Wang | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，2： | 1 |
| 16 | A computational model of topological and geometric recovery for visual curve completion显示文摘Visual curve completion is a fundamental problem in understanding the principles of the human visual system. This problem is usually divided into two problems: a grouping problem and a shape problem.On one hand, though perception of the visually completed curve is clearly a global task(for example,a human perceives the Kanizsa triangle only when seeing all three black objects), conventional methods for solving the grouping problem are generally based on local Gestalt laws. On the other hand, the shape of the visually completed curve is usually recovered by minimizing shape energy in existing methods.However, not only do these methods lack mechanisms to adjust the shape of the recovered visual curve using perceptual, psychophysical, and neurophysiological knowledge, but it is also difficult to calculate an explicit representation of the visually completed curve. In this paper, we present a systematic computational model for generating a visually completed curve. Firstly, based on recent studies of perception, psychophysics, and neurophysiology, we formulate a grouping procedure based on the human visual system by seeking a minimum Hamiltonian cycle in a graph, solving the grouping problem in a global manner. Secondly, we employ a B′ezier curve-based model to represent the visually completed curve. Not only is an explicit representation deduced, but we also present a means to integrate knowledge from related areas, such as perception, psychophysics, and neurophysiology, and so on. The proposed computational model has been validated using many modal and amodal completion examples, and desirable results were obtained. | Hongwei Lin Zihao Wang Panpan Feng Xingjiang Lu Jinhui Yu | 2016 | Computational Visual Media2016，2，4： | 1 |
| 17 | Development of a double antibodies sandwich ELISA for the detection of avian leukosis virus subgroup J based on monoclonal antibodies against gp85显示文摘Avian leukosis virus(ALV)belongs to the genus Alpharetrovirus of the family Retroviridae and can cause various types of neoplastic diseases,even mortality in infected chickens[1].ALV is categorized into seven subgroups,including A,B,C,D,E,J,and K,based on the pathogenicity and antibody neutralization characteristics[2].The subgroup E is endogenous and transmitted by Mendelian inheritance.The subgroups A,B,C,D,J,and K are exogenous and oncogenic,transmitted horizontally and vertically and caused different pathological lesions[3].Among them,subgroups A and B were most common in commercial poultry and subgroup J is the major cause for myeloid leukosis and nephromas in broilers.In 1980,ALV subgroup J(ALV-J)was first isolated and identified from infected broilers in Britain.It caused significant economic losses in the poultry industry because of increased myelocytomas and other tumors[4].In China,ALV-J was first detected in broilers in 1999 and,subsequently,spread to other chicken types.Compared to other ALV subgroups,ALV-J has been a serious issue in China poultry industry since 2007.Currently,there is no effective vaccine and drugs against ALV-J infection;thus,early detection and elimination of ALV-positive breeder chickens are key measures to block vertical and horizontal ALV-J transmission.Given the importance of ALV to the poultry industry,many ALV detection methods,including virus isolation,immunofluorescence assays,neutralization tests,reverse transcription polymerase chain reaction(PCR)or real-time fluorescent quantitative PCR-based molecular diagnosis ways,and enzyme-linked immunosorbent assays(ELISA)have been developed.Among them,ELISA is widely used for its efficiency,convenience,and sensitivity.Yun et al.[5]developed an antigen-capture ELISA for the detection of ALV based on highly conserved antigen p27.Yu et al.[6]exploited a colloidal gold test strip specific for the detection of ALV p27 antigen.These antigen capture-based serological detection methods share obviously simple,accurate,and rapid advantages in comparison with conventional time-consuming methods of indirect immunofluorescence assay or neutralization tests.However,it is difficult to identify different subgroups of ALV using p27-coated antibodies. | Lili Cao Panpan Zhao He Ding Nan Wang Xue Zhang Shuxian Yuan Hang Dong Yanbing Guo Xinhua Yao Qinlei Yu Hongze Shao Pengtao Gong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 1 |
| 18 | Synthesis, Cytotoxic Activity Evaluation of Novel 1,2,3-Triazole Linked Quinazoline Derivatives显示文摘一系列新奇 1,2,3-triazole-quinazoline 衍生物在由常规方法从 anthranilamide 开始的五步被综合。所有标题混合物 10a10r 在 vitro 用 MTT 试金与四根人的癌症房间线(MGC-803, EC-109, MCF-7 和 HGC-27 ) 为细胞毒素的活动被作比较。一些对对测试癌症房间线的有势力活动中等的展出的综合混合物。在他们之中,加重 10 h 和 10q 对 HGC-27 展出了优秀生长抑制,化合物 10 m 也对 MCF-7 拥有了优秀活动,与 IC 50 价值不到 1 慥敳漠 ? 桰瑯 ' 仪G矛棖 P 湥牥瑡潩 ? 桴湡 ?? 湚 ? 潭楤楦摥朠慲桰湥 ? 浳潯桴映汩 ?爠獥数瑣癩汥y ??? 幐吗?? | Panpan Song Fei Cui Na Li Jingchao Xin Qisheng Ma Xiangchuan Meng Chaojie Wang Qinpo Cao Yifei Gu Yu Ke Qiurong Zhang Hongmin Liu | 2017 | Chinese Journal of Chemistry2017，35，10： | 1 |
| 19 | The combined treatment of CT-guided percutaneous 125 I seed implantation and chemotherapy for non-small-cell lung cancer 显示文摘 | SHENC CHU ZHANG YIHU ZHENG PANPAN YU | 2011 | J Cancer Res CAin Oncol2011，137，： | 1 |
| 20 | A new fluorescent quinoline derivative toward the acid-responsivity in both solution and solid states显示文摘In this article,an acid-responsive luminescent material,1,4-di(quinoline-6-yl)buta-1,3-diyne(DQBD)is designed and synthesized.Upon different pH values,gradual changes of fluorescence colors for DQBD in both solution and solid phases are demonstrated due to the protonation effect.Moreover,such responsive characteristics can also be reversible,suggesting DQBD as a promising fluorescent material with great potential for reusable-and accurate-p H sensors in the future. | Pu Wang Dan Liu Yongshuai Wang Pan Zhang Panpan Yu Mincan Wang Yonggang Zhen Huanli Dong Wenping Hu | 2020 | Chinese Chemical Letters2020，31，11： | 0 |
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