|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 2 | Fourth C hinese National Consensus Report on the management of H elicobacter pylori infection显示文摘 | Wen Zhong Liu Yong Xie Hong Cheng Nong Hua Lu Fu Lian Hu Wan Dai Zhang Li Ya Zhou Ye Chen Zhi Rong Zeng Chong Wen Wang Shu Dong Xiao Guo Zong Pan Pin Jin Hu | 2013 | Journal of Digestive Diseases2013，，5： | 9 |
| 3 | Telomere shortening activates TGF-β/Smads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis显示文摘弄短的 Telomere 与自发的肺的纤维变性(IPF ) 被联系,未知病原学的高病态、高死亡的肺疾病。然而,内在的机制仍然保持大部分不清楚。在这研究,野类型(WT ) 有正常 telomeres 和产生的老鼠 3 (G3 ) 或 G2 telomerase RNA 部件(TERC ) 大美人有短 telomeres 的 Terc / 老鼠被 intratracheal 有或没有 lipopolysaccharide (LPS ) 或 bleomycin 对待注射。我们证明在 LPS 正式就职下面, G3 Terc / 老鼠开发由我和 hydroxyproline 满足的显著地增加的 -SMA, 骨胶原显示了的加重的肺的纤维变性。有趣地,发信号的 TGF-/Smads 显著地与那些相比在 G3 Terc / 老鼠的肺被激活,由 phosphorylated Smad3 和 TGF-1 的显著地提高的层次显示了 WT 老鼠。表明激活的这 TGF-/Smads 显著地对待 LPS 的 WT 或未经治疗的 G3 Terc / 老鼠与那些相比在对待 LPS 的 G3 Terc / 老鼠的肺被增加。表明激活和在肺的纤维变性弄短的 telomere 的提高的角色的 TGF-/Smads 的一个类似的模式也在导致 bleomycin 的模型被证实。而且, LPS 挑战生产了天生的有免疫力的房间的更现在的细胞的老朽, apoptosis 和渗入包括在 G3 Terc / 老鼠的肺的巨噬细胞和 neutrophils,与 WT 老鼠相比。到我们的知识,这是第一次报导弄短的 telomere 激活在肺发信号的 TGF-/Smads。我们的数据建议弄短的 telomere 与损害加速的导致环境的肺合作了肺的纤维变性的开发,和弄短的 telomere 通过 TGF-/Smads 发信号的激活授与一个固有的提高因素到 IPF 的开始。 | Ying-ying Liu Yao Shi Ya Liu Xing-hua Pan Ke-xiong Zhang | 2018 | Acta Pharmacologica Sinica2018，39，11： | 9 |
| 4 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 5 | Three-dimensional Culture of Human Airway Epithelium in Matrigel for Evaluation of Human Rhinovirus C and Bocavirus Infections显示文摘Objective Newly identified human rhinovirus C(HRV-C) and human bocavirus(HBoV) cannot propagate in vitro in traditional cell culture models; thus obtaining knowledge about these viruses and developing related vaccines are difficult. Therefore, it is necessary to develop a novel platform for the propagation of these types of viruses. Methods A platform for culturing human airway epithelia in a three-dimensional(3 D) pattern using Matrigel as scaffold was developed. The features of 3 D culture were identified by immunochemical staining and transmission electron microscopy. Nucleic acid levels of HRV-C and HBoV in 3 D cells at designated time points were quantitated by real-time polymerase chain reaction(PCR). Levels of cytokines, whose secretion was induced by the viruses, were measured by ELISA. Results Properties of bronchial-like tissues, such as the expression of biomarkers CK5, ZO-1, and PCK, and the development of cilium-like protuberances indicative of the human respiration tract, were observed in 3 D-cultured human airway epithelial(HAE) cultures, but not in monolayer-cultured cells. Nucleic acid levels of HRV-C and HBoV and levels of virus-induced cytokines were also measured using the 3 D culture system. Conclusion Our data provide a preliminary indication that the 3 D culture model of primary epithelia using a Matrigel scaffold in vitro can be used to propagate HRV-C and HBoV. | CHEN Ya Xiong XIE Guang Cheng PAN Dong DU Ya Rong PANG Li Li SONG Jing Dong DUAN Zhao Jun HU Bu Rong | 2018 | Biomedical and Environmental Sciences2018，31，2： | 6 |
| 6 | Taxonomy notes on Vandeae(Orchidaceae)from China:Five new species and two new records显示文摘Five new species(Gastrochilus yei,Gastrochilus minimus,Luisia simaoensis,Taeniophyllum xizangense,Tuberolabium subulatum)and two newly recorded species(Cleisostoma tricornutum,Luisia inconspicua)of Vandeae(Orchidaceae)from China are described and illustrated.Gastrochilus yei is similar to G.affinis and G.nepalensis,but differs from them by having an epichile not lobed,the apex of the hypochile not bilobed,and a tine on the apex of the leaf.Gastrochilus minimus is similar to G.acinacifolius,but can be distinguished from the latter by having a flabellate epichile that is densely hirsute on the adaxial surface and an inconspicuous central cushion;in addition,the hypochile of G.minimus has a keel that extends to the apex of the epichile.Taeniophyllum xizangense is similar to T.stella and T.radiatum,but it is distinguished from them by having much bigger flowers,inflorescences densely covered with short-bristly hairs,papillae on the external surface of sepals,and bigger triangular-ovate viscidium.Luisia simaoensis is similar to L magniflora and L ramosii,but can be easily distinguished from them by having lateral sepals longer than dorsal sepals and petals,lip with irregular and waved margins,and lip with bilobed apex.Luisia inconspicua is moved from Gastrochilus to Luisia based on phylogenetic analyses of plastid matK sequence data.Tuberolabium subulatum is similar to T.camosum,but it can be easily distinguished from the latter by having an inflorescence much shorter than the leaves,yellow sepals and petals,and many small papillae outside the lip lobes. | Jian-Wu Li Ji-Dong Ya De-Ping Ye Cheng Liu Qiang Liu Rui Pan Zai-Xing He Bo Pan Jie Cai Dong-Liang Lin Xiao-Hua Jin | 2021 | Plant Diversity2021，43，5： | 5 |
| 7 | Thioredoxin-Interacting Protein(TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson’s Disease and Diabetes显示文摘Patients with diabetes mellitus have a higher risk of developing Parkinson’s disease(PD). However, the molecular links between PD and diabetes remain unclear.In this study, we investigated the roles of thioredoxininteracting protein(TXNIP) in Parkin/PINK1-mediated mitophagy in dopaminergic(DA) cells under high-glucose(HG) conditions. In streptozotocin-induced diabetic mice,TXNIP was upregulated and autophagy was inhibited in the midbrain, while the loss of DA neurons was accelerated by hyperglycemia. In cultured PC12 cells under HG, TXNIP expression was upregulated and the intracellular reactive oxygen species(ROS) levels increased, leading to cell death. Autophagic flux was further blocked and PINK1 expression was decreased under HG conditions. Parkin expression in the mitochondrial fraction and carbonyl cyanide 3-chlorophenylhydrazone(CCCP)-induced co-localization of COX IV(marker for mitochondria) and LAMP1(marker for lysosomes) were also significantly decreased by HG. Overexpression of TXNIP was sufficient to decrease the expression of both PINK1 and Parkin in PC12 cells, while knockdown of the expression of TXNIP by si RNA decreased intracellular ROS and attenuated cellular injury under HG. Moreover, inhibition of TXNIP improved the CCCP-induced co-localization of COX IV and LAMP1 in PC12 cells under HG. Together, these results suggest that TXNIP regulates Parkin/PINK1-mediated mitophagy under HG conditions, and targeting TXNIP may be a promising therapeutic strategy for reducing the risk of PD under hyperglycemic conditions. | Cun-Jin Su Zhu Shen Ru-Xiao Cui Ya Huang De-Lai Xu Feng-Lun Zhao Jie Pan Ai-Ming Shi Tong Liu Yun-Li Yu | 2020 | Neuroscience Bulletin2020，36，4： | 5 |
| 8 | Electrochemical reactions at the electrode/solution interface:Theory and applications to water electrolysis and oxygen reduction显示文摘Theoretical simulations on complex electrochemical processes have been developed on the basis of the understanding in electrochemistry,which has benefited from quantum mechanics calculations.This article reviews the recent progress on the theory and applications in electrocatalysis.Two representative reactions,namely water electrolysis and oxygen reduction,are selected to illustrate how the theoretical methods are applied to electrocatalytic reactions.The microscopic nature of these electrochemical reactions under the applied potentials is described and the understanding of the reactions is summarized.The thermodynamics and kinetics of the electrochemical reactions affected by the interplay of the electrochemical potential,the bonding strength and the local surface structure are addressed at the atomic level. | Fang, Ya Hui Liu, Zhi Pan | 2010 | Science China Chemistry2010，53，3： | 5 |
| 9 | An Efficient Synthetic Method of Nordihydroguaiaretic Acid (NDGA)显示文摘Nordihydroguaiaretic acid (NDGA) has been synthesized in nine steps from piperonal using Stobbe condensation as the key step with high yield. By this approach, five relative natural products were obtained. | Ya Mu XIA, Xiao Ping CAO, Kun PENG, Xin Feng REN, Xin Fu PAN* Department of Chemistry and National Laboratory of Applied Organic Chemistry Lanzhou University, Lanzhou 730000 | 2003 | Chinese Chemical Letters2003，14，4： | 5 |
| 10 | Radix Achyranthis Bidentatae improves learning and memory capabilities in ovariectomized rats显示文摘Kidney-tonifying recipe can reduce the accumulation of advanced glycation end products, prevent neuronal degeneration and improve cognitive functions in ovariectomized rats. Radix Achyranthis Bidentatae alcohol extracts may dose-dependently inhibit non-enzymatic saccharification in vitro. This study aimed to examine the effect of Radix Achyranthis Bidentatae on advanced glycation end products and on learning and memory capabilities in ovariectomized rats. Ovariectomized rats were treated with Radix Achyranthis Bidentatae alcohol extracts (containing 1.5 g/kg crude drug) or 0.1% aminoguanidine for 12 weeks and behavioral testing was performed with the Y-electrical maze. This test revealed that Radix Achyranthis Bidentatae and aminoguanidine could improve the learning and memory capabilities of ovariectomized rats. Results of competitive enzyme-linked immunosorbent assay showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine reduced the accumulation of advanced glycation end products in the frontal cortex of ovariectomized rats, while increasing content in the blood and urine. Biochemical tests showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine decreased superoxide dismutase activity in the serum and frontal cortex, and increased serum levels of glutathione peroxidase in ovariectomized rats. In addition, there was no apparent effect on malondialdehyde levels. These experimental findings indicate that Radix Achyranthis Bidentatae inhibits production of advanced glycation end products and its accumulation in brain tissue, and improves learning and memory capabilities in ovariectomized rats. These effects may be associated with an anti-oxidative action of the extract. | Yuefen Wang Ya Xu Yanshu Pan Weihong Li Wei Zhang Yang Liu Jing Jia Pengtao Li | 2013 | Neural Regeneration Research2013，8，18： | 4 |
| 11 | Non-dormant Axillary Bud 1 regulates axillary bud outgrowth in sorghum显示文摘Tillering contributes to grain yield and plant architecture and therefore is an agronomically important trait in sorghum(Sorghum bicolor).Here,we identified and functionally characterized a mutant of the Nondormant Axillary Bud 1(NAB1)gene from an ethyl methanesulfonate-mutagenized sorghum population.The nab1 mutants have increased tillering and reduced plant height.Map-based cloning revealed that NAB1encodes a carotenoid-cleavage dioxygenase 7(CCD7)orthologous to rice(Oryza sativa)HIGH-TILLERING DWARF1/DWARF17 and Arabidopsis thaliana MORE AXILLARY BRANCHING 3.NAB1 is primarily expressed in axillary nodes and tiller bases and NAB1 localizes to chloroplasts.The nab1 mutation causes outgrowth of basal axillary buds;removing these non-dormant basal axillary buds restored the wild-type phenotype.The tillering of nab1 plants was completely suppressed by exogenous application of the synthetic strigolactone analog GR24.Moreover,the nab1plants had no detectable strigolactones and displayed stronger polar auxin transport than wild-type plants.Finally,RNA-seq showed that the expression of genes involved in multiple processes,including auxin-related genes,was significantly altered in nab1.These results suggest that NAB1 functions in strigolactone biosynthesis and the regulation of shoot branching via an interaction with auxin transport. | Jun Chen Limin Zhang Mengjiao Zhu Lijie Han Ya Lv Yishan Liu Pan Li Haichun Jing Hongwei Cai | 2018 | Journal of Integrative Plant Biology2018，60，10： | 3 |
| 12 | The Philadelphia chromosome in leukemogenesis显示文摘The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Phila?delphia chromosome(Ph) and is a hallmark of chronic myeloid leukemia(CML).In leukemia cells,Ph not only impairs the physiological signaling pathways but also disrupts genomic stability.This aberrant fusion gene encodes the breakpoint cluster region?proto?oncogene tyrosine?protein kinase(BCR?ABL1) oncogenic protein with persistently enhanced tyrosine kinase activity.The kinase activity is responsible for maintaining proliferation,inhibiting differentia?tion,and conferring resistance to cell death.During the progression of CML from the chronic phase to the accelerated phase and then to the blast phase,the expression patterns of different BCR?ABL1 transcripts vary.Each BCR?ABL1 transcript is present in a distinct leukemia phenotype,which predicts both response to therapy and clinical outcome.Besides CML,the Ph is found in acute lymphoblastic leukemia,acute myeloid leukemia,and mixed?phenotype acute leukemia.Here,we provide an overview of the clinical presentation and cellular biology of different phenotypes of Ph?positive leukemia and highlight key findings regarding leukemogenesis. | Zhi-Jie Kang Yu-Fei Liu Ling-Zhi Xu Zi-Jie Long Dan Huang Ya Yang Bing Liu Jiu-Xing Feng Yu-Jia Pan Jin-Song Yan Quentin Liu | 2016 | Chinese Journal of Cancer2016，35，6： | 3 |
| 13 | A new gain-of-function OsGS2/GRF4 allele generated by CRISPR/Cas9 genome editing increases rice grain size and yield显示文摘Grain size is one of the most important factors affecting rice grain quality and yield,and attracts great attention from molecular biologists and breeders.In this study,we engineered a CRISPR/Cas9 system targeting the miR396 recognition site of the rice GS2 gene,which encodes growth-regulating factor 4(OsGRF4)and regulates multiple agronomic traits including grain size,grain quality,nitrogen use efficiency,abiotic stress response,and seed shattering.In contrast to most previous genome editing efforts in which indel mutations were chosen to obtain null mutants,a mutant named GS2^(E) carrying an in-frame 6-bp deletion and 1-bp substitution within the miR396-targeted sequence was identified.GS2^(E) plants showed increased expression of GS2 in consistent with impaired repression by miR396.As expected,the gain-of-function GS2^(E) mutant exhibited multiple beneficial traits including increased grain size and yield and bigger grain length/width ratio.Thousand grain weight and grain yield per plant of GS2^(E) plants were increased by 23.5%and 10.4%,respectively.These improved traits were passed to hybrids in a semidominant way,suggesting that the new GS2^(E) allele has great potential in rice improvement.Taken together,we report new GS2 germplasm and describe a novel gene-editing strategy that can be widely employed to improve grain size and yield in rice.This trait-improvement strategy could be applied to other genes containing miRNA target sites,in particular the conserved miR396-GRF/GIF module that governs plant growth,development and environmental response. | Wenshu Wang Weipeng Wang Yanlin Pan Chao Tan Hongjing Li Ya Chen Xingdan Liu Jing Wei Nian Xu Yu Han Han Gu Rongjian Ye Qi Ding Chonglie Ma | 2022 | The Crop Journal2022，10，4： | 3 |
| 14 | Inducible overexpression of RUNX1b/c in human embryonic stem cells blocks early hematopoiesis from mesoderm显示文摘RUNX1 绝对为 RUNX1b/c 的权威的造血作用,而是功能被要求,人的 RUNX1 的二 isoforms,是不清楚的。我们建立了可诱导的 RUNX1b/c-overexpressing 人的胚胎的干细胞(hESC ) 线,在 RUNX1b/c, overexpression 阻止了 CD34+ 房间的出现早舞台,急速地从而减少造血的干细胞的生产。同时,造血作用相关的因素的表示是 downregulated。然而,如此的阻塞效果从在 hESC/AGM-S3 房间合作文化的白天 6 消失了,证明阻塞发生在 hemogenic endothelial 房间的产生前。这阻塞被 RepSox 部分救,转变生长因素(TGF ) 的一个禁止者 - 发信号的小径,显示在 RUNX1b/c 和 TGF- 小径之间的一种靠近的关系。我们的结果在早造血作用的开发建议 RUNX1b/c 的一个唯一的禁止的函数并且可以在正常和 diseased 模型帮助它的生物函数的进一步的理解。 | Bo Chen Jiawen Teng Hongwei Liu Xu Pan Ya Zhou Shu Huang Mowen Lai Guohui Bian Bin Mao Wencui Sun Qiongxiu Zhou Shengyong Yang Tatsutoshi Nakahata Feng Ma | 2017 | Journal of Molecular Cell Biology2017，9，4： | 3 |
| 15 | A novel mutation in proprotein convertase subtilisin/kexin type 9 gene leads to familial hypercholesterolemia in a Chinese family显示文摘背景家庭血胆脂醇过多(FH ) 是与低密度脂蛋白(LDL ) 铺平导致早熟的冠的心疾病(CHD ) 的提高的血浆联系的正染色体的混乱。由于长期的 hyperlipemia, FH 病人将介绍 endarterium 变厚和动脉粥样硬化。在现在的学习,我们为可能的变化扫描了一个临床上诊断的正染色体的基因血胆脂醇过多家庭的相关基因并且建立了 proprotein convertase subtilisin/kexin 类型 9 的变化( PCSK9 )的真核细胞的表示向量有基因再结合的基因在低密度脂蛋白受体上调查变化的贡献的技术( LDL-R )新陈代谢和功能 alternation.Methods 变化察觉为 LDL-R 被进行, apolipoprotein B100 ( apoB10 野类型 PCSK9 基因(WT-PCSK9 ) 的全身的 cDNA 从 Bel-7402 被获得。地点 mutagenesis 被用来真核细胞的表示向量带建立 recombinant PCSK9 基因和插入的碎片的病原的类型被定序。与是的空白的向量控制, liposome transfection 方法习惯于 transfect 有 recombinant plasmid 的 Bel-7402 房间。LDL-R mRNA 的表示被 RT-PCR 检验。PCSK9 和 LDL-R 蛋白质的表示被西方的弄污决定。结果在 PCSK9 基因的 918 核苷酸的 GT 变化在 codon 由丝氨酸导致了精氨酸的替换 306 exon 6。在定序以后,确定的表示向量的插入的碎片有正确尺寸和顺序,异种高度在 Bel-7402 房间被表示,这被证实。在 LDL-R mRNA 的层次没有重要变化。在房间是由 WT-PCSK9 plasmid 的 transfected 以后, LDL-R 成熟蛋白质被 57% 减少。在房间是由变异的 R306S 的 transfected 以后,成熟 LDL-R 是由灰色的规模扫描证实了被12%显著地减少,建议新变异的 R306S 罐头显著地减少成熟 LDL-R protein.Conclusions 的表示 PCSK9 基因的一个新奇错误感觉变化, R306S ,被发现并且真核细胞的表示向量 PCSK9 变异、野类型基因被建立。在 LDL-R mRNA 的层次没有重要变化。R306S 变化能显著地导致 LDL-R 成熟蛋白质表示的减少,它可能是 FH 家庭的病原的基因。 | LIN Jie WANG Lu-ya LIU Shu WANG Xu-min YONG Qiang YANG Ya DU Lan-ping PAN Xiao-dong WANG Xu JIANG Zhi-sheng | 2010 | Chinese Medical Journal2010，，9： | 2 |
| 16 | GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis显示文摘Intestinal epithelium serves as the first barrier against the infections and injuries that mediate colonic inflammation.Colorectal cancer is often accompanied with chronic inflammation.Differed from its well-known oncogenic role in many malignancies,we present here that Golgi membrane protein 1(G0LM1,also referred to as GP73)suppresses colorectal tumorigenesis via maintenance of intestinal epithelial barrier.G0LM1 deficiency in mice conferred susceptibility to mucosal inflammation and colitis-induced epithelial damage,which consequently promoted colon cancer.Mechanistically,depletion of G0LM1 in intestinal epithelial cells(lECs)led to aberrant Notch activation that interfered with IEC differentiation,maturation,and lineage commitment in mice.Pharmacological inhibition of Notch pathway alleviated epithelial lesions and restrained pro-tumorigenic inflammation in G0LM1-deficient mice.Therefore,G0LM1 maintains IEC homeostasis and protects against colitis and colon tumorigenesis by modulating the equilibrium of Notch signaling pathway. | Yang Pu Ya Song Mengdi Zhang Caifeng Long Jie Li Yanan Wang Yinzhe Xu Fei Pan Na Zhao Xinyu Zhang Yanan Xu Jianxin Cui Hongying Wang Yan Li Yong Zhao Di Jin Hongbing Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 2 |
| 17 | Association of Catalase Genotype with Oxidative Stress in the Predication of Colorectal Cancer:Modification by Epidemiological Factors显示文摘Objective This paper aims to assess the interaction between common variations in catalase(CAT) polymorphic gene and environmental factors for antioxidant defense enzyme in modulating individual susceptibility to colorectal cancer(CRC).Methods A case-control study with 880 colorectal cancer cases and 848 controls was conducted to investigate whether variations in the catalase(CAT) gene,one of the genes involved in scavenging oxidative stress,influenced susceptibility to CRC.Results The interaction between life style and genotypes as well as with their effects on colorectal cancer was deduced from the present study.Significant difference(P=0.01) was identified in the distribution of CAT genotype between the colorectal cancer cases and the controls.The CRC cases had significantly lower mean activity than the controls(P<0.01).Correlation analyses revealed statistically significant correlations between CAT activity and CAT genotype(P<0.01).Conclusion The risk of CRC was associated with smoking,low vegetable consumption,high pork and poultry consumptions,and low or high BMI.This is the first study reporting an association of polymorphism CAT-21A>T with colorectal cancer.Low CAT activity was associated with an increased risk of CRC;however,no evidence was found to support an association between CAT-21A>T polymorphism and CRC risk. | CHANG Dong HU Zhang Liang ZHANG Lin ZHAO Ya Shuang MENG Qing Hui GUAN Qing Bai ZHOU Jin PAN Hong Zhi | 2012 | Biomedical and Environmental Sciences2012，25，2： | 2 |
| 18 | Influencing factors and mechanism of high-temperature oxidation of high-entropy alloys: A review显示文摘High-temperature oxidation is a common failure in high-temperature environments,which widely occur in aircraft engines and aerospace thrusters;as a result,the development of anti-high-temperature oxidation materials has been pursued.Ni-based alloys are a common high-temperature material;however,they are too expensive.High-entropy alloys are alternatives for the anti-oxidation property at high temperatures because of their special structure and properties.The recent achievements of high-temperature oxidation are reviewed in this paper.The high-temperature oxidation environment,temperature,phase structure,alloy elements,and preparation methods of high-entropy alloys are summarized.The reason why high-entropy alloys have anti-oxidation ability at high temperatures is illuminated.Current research,material selection,and application prospects of high-temperature oxidation are introduced. | Ya Wei Yu Fu Zhi-min Pan Yi-chong Ma Hong-xu Cheng Qian-cheng Zhao Hong Luo Xiao-gang Li | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，6： | 2 |
| 19 | Metal-organic frameworks as functional materials for implantable flexible biochemical sensors显示文摘Metal-organic frameworks(MOFs)exhibit attractive properties such as highly accessible surface area,large porosity,tunable pore size,and built-in redox-active metal sites.They may serve as excellent candidates to construct implantable flexible devices for biochemical sensing due to their high thermal and solution stability.However,MOFs-based sensors have only been mostly reported for in-vitro chemical sensing,their use in implantable chemical sensing and combination with flexible electronics to achieve excellent mechanical compatibility with tissues and organs has rarely been summarized.This paper systematically reviews the biochemical sensors based on MOFs and discusses the feasibility to achieve implantable biochemical sensing through MOFs-based flexible electronics.The properties of MOFs and underlying mechanisms have been intrcxluced,followed by a summarization of different biochemical sensing applications.Strategies to integrate MOFs with flexible devices have been supplied from the standpoints of matching mechanics and compatible fabrication processes.Issues that should be addressed in developing flexible MOFs sensors and potential solutions have also been provided,followed by the perspective for future applications of flexible MOFs sensors.This paper may serve as a reference to offer potential guidelines for the development of flexible MOFs-based biochemical sensors that may benefit future applications in personal healthcare,disease diagnosis and treatment,and fundamental study of various biological processes. | Ya Li Wei Ling Xinyu Liu Xue Shang Pan Zhou Zhaorun Chen Hang Xu Xian Huang | 2021 | Nano Research2021，14，9： | 2 |
| 20 | Lowering serum lipids via PCSK9-targeting drugs: current advances and future perspectives显示文摘Proprotein convertase subtilisin/kexin 类型 9 (PCSK9 ) ,也已知的同样神经的 apoptosis 调整了 convertase (NARC1 ) ,是胆固醇新陈代谢的一个关键调节的人。PCSK9 由从肝的房间的膜陪同低密度的脂蛋白受体(LDLR ) 进 lysosomes 增加低密度的脂蛋白胆固醇的浆液集中,在 LDLR 被降级的地方。由于在类脂化合物新陈代谢的 PCSK9 的重要性,可观的努力在开发指向 PCSK9 降低浆液类脂化合物层次的药在过去的十年被作了。不过,一些问题和挑战留下。在这评论我们首先描述 PCSK9 和它的基因多型性的结构和功能。我们然后讨论 PCSK9 的药理学目标的各种各样的图案,包括堵住到肝的 LDLR (模仿的肽, adnectins ,和 monoclonal 抗体)的 PCSK9 的绑定的那些,禁止 PCSK9 表示(定期聚类 interspaced 短 palindromic repeats/Cas9 站台,小分子, antisense oligonucleotides ,并且小介入 RNA ),并且防碍 PCSK9 分泌物。最后,这评论在这块地里加亮未来挑战,包括与 PCSK9 monoclonal 抗体,在中央神经系统的 PCSK9 禁止者的有限用途,和 PCSK9 禁止者的划算联系的安全担心。 | Ni-ya HE Qing LI Chun-yan WU Zhong REN Ya GAO Li-hong PAN Mei-mei WANG Hong-yan WEN Zhi-shengJIANG Zhi-han TANG Lu-shan LIU | 2017 | Acta Pharmacologica Sinica2017，38，3： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员