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| 1 | Outcome of nonerosive gastro-esophageal reflux disease patients with pathological acid exposure显示文摘AIM: To assess the management and outcome of nonerosive gastro-esophageal reflux disease (NERD) patients who were identified retrospectively, after a 5-year follow-up.METHODS: We included patients with gastro-esophageal reflux disease (GERD) symptoms who had a negative endoscopy result and pathological 24-h esophageal pH-monitoring while off therapy. We interviewed them after an average period of 5 years (range 3.5-7 years) by means of a structured questionnaire to assess presence of GERD symptoms, related therapy, updated en-doscopic data and other features. We assessed predictors of esophagitis development by means of univariate and multivariate statistical analysis.RESULTS: 260 patients (137 women) were included. Predominant GERD symptoms were heartburn andregurgitation in 103/260 (40%). 70% received a maintenance treatment, which was proton pump inhibitor (PPI) in 55% of cases. An average number of 1.5 symptomatic relapses per patient/year of follow-up were observed. A progression to erosive gastro-esophageal reflux disease (ERD) was found in 58/193 (30.0%) of patients undergoing repeat endoscopy; 72% of these were Los Angeles grade A-B. CONCLUSION: This study shows that progression to ERD occurs in about 5% of NERD cases per year, despite therapy. Only two factors consistently and independently influence progression: smoking and absence of PPI therapy. | Fabio Pace Stefano Pallotta Gianpiero Manes Annalisa de Leone Patrizia Zentilin Luigi Russo Vincenzo Savarino Matteo Neri Enzo Grossi Rosario Cuomo | 2009 | World Journal of Gastroenterology2009，15，45： | 8 |
| 2 | Effect of infliximab on small bowel stenoses in patients with Crohn's disease显示文摘AIM: To assess prospectively small bowel stenoses in Crohn's disease (CD) patients treated with infliximab using Small Intestine Contrast Ultrasonography (SICUS). METHODS: Twenty patients (M 12, age, 42.7 ± 11.8 years), 15 of whom showed obstructive symptoms indicating the presence of small bowel stenosis, and 5 without stenosis, were treated with infliximab (5 mg/kg at wk 0, 2, 6 and 5 mg/kg every 8 wk thereafter) for steroid refractoriness, fistulizing disease, or to avoid high-risk surgery. SICUS was performed at the induction phase and at regular time intervals during the follow-up period of 34.7 ± 16.1 mo (range 7-58). Small bowel stenoses were detected by SICUS, endoscopy and MRI. RESULTS: In no case was progression of stenoses or the appearance of new ones seen. Of the 15 patients with stenosis, 5 stopped treatment after the induction phase (2 for no response, 3 for drug intolerance, one of whom showed complete regression of one stenosis). Among the remaining 10 patients, a complete regression of 8 stenoses (1 stenosis in 5 patients and 3 stenoses in one patient) was observed after 6-22 infliximab infusions. CONCLUSION: In patients with CD treated with infliximab we observed: (a) No progression of small bowel stenosis and no appearance of new ones, (b) Complete regression of 1/22 stenosis after the induction phase and of 8/15 (53.3%) stenosis after 6-22 infusionsduring maintenance therapy. | Nadia Pallotta Fausto Barberani Naima Abdulkadir Hassan Danila Guagnozzi Giuseppina Vincoli Enrico Corazziari | 2008 | World Journal of Gastroenterology2008，14，12： | 7 |
| 3 | Relationship between antral distension and postprandial symptoms in functional dyspepsia显示文摘AIM: To investigate in patients with functional dyspepsia (FD) after an every-day meal whether (1) gastrointestinal (GI) and extra-GI symptoms had any relation with the degree of antral volume, (2) the onset of postprandial symptoms was associated with, and may predict, delayed gastric emptying. METHODS: In 94 symptomatic FD patients, antral volume variations and gastric emptying were assessed with ultrasonography after a 1050 kcal meal. Symptoms were evaluated with a standardized questionnaire. The association of GI and extra-GI symptoms with antral volumes and gastric emptying were estimated with logistic regression analysis. RESULTS: Forty percent of patients did not report any symptoms after a meal. Compared to the healthy controls, the antrum was more distended in patients throughout the entire observation period and 37 (39.4%) patients had delayed gastric emptying. Only postprandial drowsiness was associated with antral volume variations (AOR = 1.42; P < 0.001) and with delayed gastric emptying (AOR = 3.59; P < 0.03). CONCLUSION: In FD patients, GI symptoms are neither associated with antral distension nor with gastric emptying. Drowsiness is associated with antral distension and delayed gastric emptying. The onset of drowsiness is preceded by an increment of antral distension and the duration of the symptom appears to be related to the persistence of antral distension. | Nadia Pallotta Patrizio Pezzotti Enrico Corazziari | 2006 | World Journal of Gastroenterology2006，12，43： | 7 |
| 4 | Endoscopic findings in patients with upper gastrointestinal bleeding clinically classified into three risk groups prior to endoscopy显示文摘AIM: To investigate in a prospective study whether a simplifi ed clinical score prior to endoscopy in upper gastrointestinal bleeding (UGIB) patients was able to predict endoscopic findings at urgent endoscopy. METHODS: All consecutive UGIB patients referred to a single endoscopic center during a 16 mo period were enrolled. Before endoscopy patients were strati- fied according to a simple clinical score (T-score), including T1 (high-risk), T2 (intermediate-risk) and T3 (low-risk). Endoscopy was performed in all cases within 2 h, and high-risk stigmata were considered for further analysis. RESULTS: Out of the 436 patients included into the study, 126 (29%) resulted to be T1, 135 (31%) T2, and 175 (40%) T3. Overall, stigmata of recent haem-orrhage (SRH) were detected in 118 cases (27%). SRH occurred more frequently in T1 patients than in T2/T3 cases (85% vs 3.2%; χ2 = 304.5309, P < 0.001). Older age (t=3.311; P < 0.01) and presence of comor-bidities (χ2 = 14.7458; P < 0.01) were more frequently detected in T1 than in T2/T3 patients. CONCLUSION: Our simplifi ed clinical score appeared to be associated with the detection of endoscopic findings which may deserve urgent endoscopy. A further,randomised study is needed to assess its accuracy in safely scheduling endoscopy in UGIB patients. | Leonardo Tammaro Maria Carla Di Paolo Angelo Zullo Cesare Hassan Sergio Morini SebastianoCaliendo Lorella Pallotta | 2008 | World Journal of Gastroenterology2008，14，32： | 6 |
| 5 | Relationship between gastrointestinal and extra-gastrointestinal symptoms and delayed gastric emptying in functional dyspeptic patients显示文摘AIM: Delayed gastric emptying and an enlarged fasting gastric antrum are common findings in functional dyspepsia but their relationship with gastrointestinal (GI), and the frequently associated extra-GI symptoms remains unclear.This study evaluated the relationship between GI and extra-GI symptoms, fasting antral volume and delayed gastric emptying in functional dyspepsia.METHODS: In 108 functional dyspeptic patients antral volume and gastric emptying were assessed with ultrasonography (US). Symptoms were assessed with standardized questionnaire. The association of symptoms and fasting antral volume with delayed gastric emptying was estimated with logistic regression analysis.RESULTS: Delayed gastric emptying was detected in 39.8% of the patients. Postprandial drowsiness (AOR 11.25; 95%CI 2.75-45.93), nausea (AOR 3.51; 95%CI 1.19-10.32), fasting antral volume (AOR 1.93; 95%CI 1.22-3.05), were significantly associated with delayed gastric emptying. Symptoms, mainly the extra-GI ones as postprandial drowsiness and nausea, combined with fasting antral volume predicted the modality of gastric emptying with a sensitivity and specificity of 78%.CONCLUSION: In functional dyspeptic patients, (1) an analysis of fasting antral volume and of symptoms can offer valuable indication on the modality of gastric emptying,and (2) it seems appropriate to inquire on postprandial drowsiness that showed the best correlation with delayed gastric emptying. | N Pallotta P Pezzotti E Calabrese F Baccini E Corazziari | 2005 | World Journal of Gastroenterology2005，11，28： | 4 |
| 6 | Heterogeneity of endoscopy negative heartburn:Epidemiology and natural history显示文摘It has now become clear that only about 40% or less of patients with heartburn and/or regurgitation have esophagitis, and that the majority of them lack visible distal esophageal mucosa breaks. These subjects are referred to as non-erosive gastroesophageal reflux disease (NERD) patients. It has been estimated that in the Western world at least one tenth of the general population has at least weekly heartburn. This proportion seems to be lower in Asia, while prevalence is rapidly increasing. Although it would be extremely useful to have prospective information regarding the fate of such patients, the natural history of NERD is largely unknown, and very few studies in the literature have addressed this issue. These studies are for the greater part old, not well conducted, and suffer from methodological drawbacks including ill-defined entry criteria. However, a review of these studies indicates that a consistent minority of NERD patients may develop erosive disease at an approximate rate of about 10% per year. | Fabio Pace Valentina Casini Stefano Pallotta | 2008 | World Journal of Gastroenterology2008，14，34： | 3 |
| 7 | Small Intestine Contrast Ultrasonography in Pediatric Crohn’s Disease显示文摘 | Nadia Pallotta Fortunata Civitelli Giovanni Di Nardo Giuseppina Vincoli Marina Aloi Franca Viola Paolo Capocaccia Enrico Corazziari Salvatore Cucchiara | 2013 | The Journal of Pediatrics2013，，： | 2 |
| 8 | An uncommon cause of corrosive esophageal injury显示文摘We present an unusual case of corrosive esophageal injury following liquid glue ingestion. The endoscopic f indings were tissue sloughing and blackened appearance of the esophagogastric junction,due to caustic esophageal injuries following ingestion of glue containing toluene. | Fabio Pace Salvatore Greco Stefano Pallotta Daniela Bossi Emilio Trabucchi Gabrielle Bianchi Porro | 2008 | World Journal of Gastroenterology2008，14，4： | 2 |
| 9 | Calcium dependence of open and shut interval distributions from calcium-activated potassium channels in cultured rat muscle显示文摘 | Magleby KL Pallotta BS | 1983 | J Physiol1983，344，1： | 1 |
| 10 | Properties of single calcium-activated potassium channels in cultured rat muscle显示文摘 | Barrett JN Magleby KL Pallotta BS | 1982 | J Physiol1982，331，： | 1 |
| 11 | Rabeprazole: a second-generation proton pump inhibitor in the treatment of acid-related disease显示文摘 | Pallotta S Pace F Marelli S | 2008 | Expert Rev Gastroenterol Hepatol2008，2，4： | 1 |
| 12 | Low molecular weight hyaluronic acid prevents oxygen free radical damage to granulation tissue during wound healing显示文摘 | TRABUCCtII E PALLOTTA S MORINI M | 2002 | Int J Tissue React2002，24，2： | 1 |
| 13 | Covariance Matrix Estimation via Geometric Barycenters and Its Application to Radar Training Data Selection显示文摘 | Aubry A De Maio A Pallotta L | 2013 | IET Radar Sonar & Navigation2013，7，6： | 1 |
| 14 | Calciumdependent of open and shut interval distribution from calcium activated potassium channelsin cultured rat muscle 显示文摘 | Magleby KL Pallotta BS | 1983 | J Physiol1983，344，： | 1 |
| 15 | Use of double-balloon enteroscopy in the management of patients with Crohn’s disease: feasibility and diagnostic yield in a high-volume centre for inflammatory bowel disease显示文摘 | Gianpiero Manes Venerina Imbesi Sandro Ardizzone Andrea Cassinotti Stefano Pallotta Gabriele Bianchi Porro | 2009 | Surgical Endoscopy2009，，12： | 1 |
| 16 | Dichotomous responses to thyroid hormone treatment in a patient with primary hypothyroidism and thyroidhormone resistance显示文摘 | Sabet A Pallotta JA | 2011 | Thyroid2011，21，5： | 1 |
| 17 | Low molecular weight hyaluronic acid prevents oxygen free radical damage to granulation tissue during wound healing显示文摘 | Trabucchi E Pallotta S Morini M | 2002 | Int J Tissue React2002，24，2： | 1 |
| 18 | Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells 显示文摘 | Pallotta MT Orabona C Volpi C | 2011 | Nat Immunol2011，12，9： | 1 |
| 19 | Low molecular weight hyaluronie acid prevents oxygen free radical damage to granulation tissue during wound healing显示文摘 | Trabuechi E Pallotta S Morini M | 2002 | Int J Tissue React2002，24，2： | 1 |
| 20 | Rabeprazole: a second- generation proton pump inhibitor in the treatment of acid- related disease 显示文摘 | Pallotta S Pace F Marelli S | 2008 | Expert Rev Gastroenterol Hepatol2008，2，4： | 1 |
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