|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immune checkpoint inhibitor-induced colitis:A comprehensive review显示文摘Immune checkpoint inhibitors(ICIs) are monoclonal antibodies that target downregulators of the anti-cancer immune response: Cytotoxic T-lymphocyte antigen-4, programmed cell death protein-1, and its ligand programmed death-ligand 1.ICIs have revolutionized the treatment of a variety of malignancies. However,many immune-related adverse events have also been described which mainly occurs as the immune system becomes less suppressed, affecting various organs including the gastrointestinal tract and causing diarrhea and colitis. The incidence of immune-mediated colitis(IMC) ranges from 1%-25% depending on the type of ICI and if used in combination. Endoscopically and histologically there is a significant overlap between IMC and inflammatory bowel disease,however more neutrophilic inflammation without chronic inflammation is usually present in IMC. Corticosteroids are recommended for grade 2 or more severe colitis while holding the immunotherapy. About one third to two thirds of patients are steroid refractory and benefit from infliximab. Recently vedolizumab has been found to be efficacious in steroid and infliximab refractory cases. While in grade 4 colitis, the immunotherapy is permanently discontinued, the decision is controversial in grade 3 colitis. | Aniruddh Som Rohan Mandaliya Dana Alsaadi Maham Farshidpour Aline Charabaty Nidhi Malhotra Mark C Mattar | 2019 | World Journal of Clinical Cases2019，7，4： | 14 |
| 2 | Seismites resulting from high-frequency, high-magnitude earthquakes in Latvia caused by Late Glacial glacio-isostatic uplift显示文摘Geologically extremely rapid changes in altitude by glacial rebound of the Earth crust after retreat of the Scandinavian Ice Sheet at the end of the last Weichselian glaciation influenced the palaeogeography of northern Europe.The uplift of the Earth crust apparently was not gradual,but shock-wise,as the uplift was accompanied by frequent,high-magnitude earthquakes.This can be deduced from strongly deformed layers which are interpreted as seismites.Such seismites have been described from several countries around the Baltic Sea,including Sweden,Germany and Poland.Now similarly deformed layers that must also be interpreted as seismites,have been discovered also in Latvia,a Baltic country that was covered by an ice sheet during the last glaciation.The seismites were found at two sites:Near Valmiera in the NE part and near Rakuti in the SE part of the country.The seismites were found in sections of about 7 m and 4.5 m high,respectively,that consist mainly of glaciofluvial and glaciolacustrine sands and silts.At the Valmiera site,7 seismites were found,and at the Rakuti site these were even 12 seismites.The two sections have not been dated precisely up till now,but lithological correlations and geomorphological characteristics suggest that the sediments at the Valmiera site cannot be older than 14.5 ka.Because the accumulation of the section did not take more than about 1000 years,the average recurrence time of the high-magnitude(M≥4.5-5.0) earthquakes must have been maximally only 100-150 years,possibly only 6-7years.The sediments at Rakuti must also have formed within approx.1000 years(17-16 ka),implying a recurrence time of high-magnitude earthquakes of maximally once per 100-200 years. | A.J. (Tom) van Loon Matgorzata Pisarska-Jamrozy Maris Nartiss Maris Krievans Juris Soms | 2016 | Journal of Palaeogeography2016，5，4： | 13 |
| 3 | Core Shell Au Ag Nanoparticles in Dielectric Nanocomposites with Plasmon-Enhanced Fluorescence: A New Paradigm in Antimony Glasses显示文摘The nano era demands the synthesis of new nanostructured materials,if possible by simplified techniques,with remarkable properties and versatile applications.Here,we demonstrate a new single-step reproducible melt-quench methodology to fabricate core-shell bimetallic(Au0 Ag0)nanoparticles(2889 nm)embedded glasses(dielectrics)by the use of a new reducing glass matrix,K_(2)O B_(2)O_(3) Sb_(2)O_(3)(KBS)without applying any external reducing agent or multiple processing steps.The surface plasmon resonance(SPR)band of these nanocomposites embedded in KBS glass is tunable in the range 554-681 nm.More remarkably,taking advantage of the selective reduction capability of Sb_(2)O_(3),this single-step methodology is used to fabricate inter-metallic:rare-earth ions co-embedded(AuAg:Sm^(3+))dielectric(glass)-based-dnanocomposites and study the effect of enhanced local fi eld on the red upconversion fl uorescence of Sm^(3+)ions at 636 nm.The enhancement is found to be about 2 folds.This single-step in-situ selective reduction approach can be used to fabricate a variety of hybrid-nanocomposite devices for laser based applications(see supplementary information). | Tirtha Som Basudeb Karmakar | 2009 | Nano Research2009，2，8： | 7 |
| 4 | Role of Joshi's external stabilization system with percutaneous screw fixation in high-energy tibial condylar fractures associated with severe soft tissue injuries显示文摘Purpose: The treatment of high-energy tibial condylar fractures which are associated with severe soft tissue injuries remains contentious and challenging. In this study, we assessed the results of Joshi's external stabilization system (JESS) by using the principle of ligamentotaxis and percutaneous screw fixation for managing high-energy tibial condylar fractures associated with severe soft tissue injuries. Methods: Between June 2008 and June 2010, 25 consecutive patients who were 17-71 years (mean, 39.7), underwent the JESS fixation for high-energy tibial condylar fractures associated with severe soft tissue injuries. Out of 25 patients, 2 were lost during follow-up and in 1 case early removal of frame was done, leaving 22 cases for final follow-up. Among them, 11 had poor skin condition with abrasions and blisters and 2 were open injuries (Gustilo-Anderson grade I & 11). The injury mechanisms were motor vehicle accidents (n - 19), fall from a height (n = 2) and assault (n - 1). The fractures were classified according to Schatzker classification system. Results: There were 7 type-V, 14 type-Vl and 1 type-IV Schatzker's tibial plateau fractures. The average interval between the injury and surgery was 6.8 days (range 2-13). The average hospital stay was 13 days (range, 7-22). The average interval between the surgery and full weight bearing was 13.6 weeks (range 11-20). The average range of knee flexion was 121° (range 105°-135°). The normal extension of the knee was observed in 20 patients, and an extensor lag of 5°-8° was noted in 2 patients. The complications included superficial pin tract infections (n 4) with no knee stiffness. Conclusion: JESS with lag screw fixation combines the benefit of traction, external fixation, and limited internal fixation, at the same time as allowing the ease of access to the soft tissue for wound checks, pin care, dressing changes, measurement of compartment pressure, and the monitoring of the neurovascular status. In a nutshell, JESS along with screw fixation offers a promising alternative treatment for high- energy tibial condylar fractures associated with severe soft tissue injuries. | Ashish Kumar Gupta Rahul Sapra Rakesh Kumar Som Prakash Gupta Devwart Kaushik Sahil Gaba Mahesh Chand Bansal Ratan Lal Dayma | 2015 | Chinese Journal of Traumatology2015，18，6： | 4 |
| 5 | Hemodynamic effects of propranolol with spironolactone in patients with variceal bleeds: A randomized controlled trial显示文摘AIM: To study the hemodynamic effects of spironolactone with propranolol vs propranolol alone in the secondary prophylaxis of variceal bleeding. METHODS: Thirty-five cirrhotics with variceal bleeding randomly received propranolol (n = 17: Group A) or spironolactone plus propranolol (n = 18: Group B). Hemodynamic assessment was performed at baseline and on the eighth day. RESULTS: Spironolactone with propranolol caused a greater reduction in the hepatic venous pressure gradient than propranolol alone (26.94% vs 10.2%; P < 0.01). Fourteen out of eighteen patients on the combination treatment had a reduction in hepatic venous pressure gradient to ≤ 12 mmHg or a 20% reduction from baseline in contrast to only six out of seventeen (6/17) on propranolol alone (P < 0.05). CONCLUSION: Spironolactone with propranolol results in a better response with a greater reduction in hepatic venous pressure gradient in the secondary prophylaxis of variceal bleeding. A greater number of patients may be protected by this combination therapy than by propranolol alone. Hence, this combination may be recommended for secondary prophylaxis in patients with variceal bleeding. | Binay K De Deep Dutta Rimi Som Pranab K Biswas Subrata K Pal Anirban Biswas | 2008 | World Journal of Gastroenterology2008，14，12： | 3 |
| 6 | Effects of primary breakup modeling on spray and combustion characteristics of compression ignition engines显示文摘 | S. Som S.K. Aggarwal | 2010 | Combustion and Flame2010，，6： | 2 |
| 7 | SOM描绘天津未来蓝图 智能可持续地区规划显示文摘近年来,中国政府和业界领导已对智能性和可持续性兼备的未来城市发展作出意义深远的承诺。而承诺的核心是以科学为基础的城市功能布局所造就的'近距离(尺度)'城市,它们既能互为补充,又能同时推动经济、社会和生态发展。中国在天津滨海新区的努力,已朝这一承诺大步迈进。2007年春,SOM建筑事务所芝加哥办公室接受委托,为一片27km^2的区域编制总体规划,旨在将这一昔日的工业用地转型为繁荣新城。通过活跃的中心商务区、完善的公共交通网络、综合功能的社区邻里以及壮丽的滨河公园,SOM的规划将滨海新区中心商务区定位为全球精英城市网络中的一员——将其发展为经济成功的象征、绿色开发的模范以及容纳健康和可持续生活的载体。 | SOM Chicago and Shanghai Team | 2010 | 时代建筑2010，53，5： | 2 |
| 8 | The basic and applied aspects of superoxide dismutase显示文摘 | Amit Bafana Som Dutt Arun Kumar Sanjay Kumar Paramvir S. Ahuja | 2010 | B, Enzymatic2010，，2： | 2 |
| 9 | Exploring the concept of strategic corporate social responsibility for an integrated perspective显示文摘 | Som Sekhar Bhattacharyya | 2010 | European Business Review2010，，1： | 2 |
| 10 | Recurrence of a deep neck infection: a clinical indication of an underlying congenital lesion显示文摘 | NUSBAUM A O SOM P M ROTHSCHILD M A | 1999 | Arch Otolaryngol Head Neck Surg1999，125，： | 1 |
| 11 | Parametric Study of a Braced Cut by Finite Element Method 显示文摘 | Bose S K and Som K K | 1998 | Computer and Geotechnics1998，，2： | 1 |
| 12 | Regional myocardial substrate uptake in hypertensive rats:a quantitative autoradiographic measurement显示文摘 | Yonekura Y Brill AB Som P | | Science0，，： | 1 |
| 13 | Effect of nozzle orifice geometry on spray, combustion, and emission characteristics under diesel engine conditions显示文摘 | Som S Ramirez A I Longman D E | 2011 | Fuel2011，90，3： | 1 |
| 14 | benign metastasizing meningiomas显示文摘 | Som PM Sacher M Strenger SW | 1987 | AJNR1987，8，1： | 1 |
| 15 | An imaging -based classification for the cervical nodes designed as an adjunct to recent clinically based nodal classifications 显示文摘 | Som PM Curtin HD Mancuso AA | 1999 | Arch Otolaryngol Head Neck Surg1999，125，4： | 1 |
| 16 | Compressive Imaging Using Approximate Message Passing and a Markov-tree Prior显示文摘 | Som S Schniter P | 2012 | IEEE Transactions on Signal Processing2012，60，7： | 1 |
| 17 | Improved large MIMO detection based on damped belief propagation显示文摘 | SOM P DATTA T CHOCKALINGAM A | 2010 | IEEE Information Theory Workshop(ITW)2010，，： | 1 |
| 18 | Effects of primary breakup mod- eling on spray and combustion characteristics of com- pression ignition engines显示文摘 | Som S Aggarwal S K | 2010 | Combustion and Flame2010，157，6： | 1 |
| 19 | In vito hatched oncospheres of Asian Taenia from Koreanand Taiwan develop into cysticerci in the peritoneal cavity of femals scid(severe combinedimmunodeficiency)mice 显示文摘 | ITO A ITO M Som K S | 1993 | Journal of Helminthology1993，73，： | 1 |
| 20 | Benign and malignant pleomorphic adenomas; CT and MR study显示文摘 | Som P M Shugar J M Sacher M | 1988 | J Comput Assist Tomogr1988，12，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员