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| 1 | Targeting the insulin-like growth factor pathway in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the third leading cause of cancer-related deaths worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments, which include surgical resection as the first option, liver transplantation and percutaneous ablation. Unfortunately, there is a high frequency of tumor recurrence after surgical resection and most HCC seem resistant to conventional chemotherapy and radiotherapy. Sorafenib, a multi-tyrosine kinase inhibitor, is the only chemotherapeutic option for patients with advanced hepatocellular carcinoma. Patients treated with Sorafenib have a significant increase in overall survival of about three months. Therefore, there is an urgent need to develop alternative treatments. Due to its role in cell growth and development, the insulin-like growth factor system is commonly deregulated in many cancers. Indeed, the insulin-like growth factor(IGF) axis has recently emerged as a potential target for hepatocellular carcinoma treatment. To this aim, several inhibitors of the pathway have been developed suchas monoclonal antibodies, small molecules, antisense oligonucleotides or small interfering RNAs. However recent studies suggest that, unlike most tumors, HCC development requires increased signaling through insulin growth factor Ⅱ rather than insulin growth factor Ⅰ. This may have great implications in the future treatment of HCC. This review summarizes the role of the IGF axis in liver carcinogenesis and the current status of the strategies designed to target the IGF-Ⅰ signaling pathway for hepatocellular carcinoma treatment. | Mónica Enguita-Germán Puri Fortes | 2014 | World Journal of Hepatology2014，6，10： | 10 |
| 2 | The Surgical Treatment and Outcome of Nonmetastatic Extremity Osteosarcoma with Pathological Fractures显示文摘 | Zhi-Ping Deng Yi Ding Ajay Puri Edward H M Wang Ashish Gulia Claire Durban Xiao-Hui Niu | 2015 | Chinese Medical Journal2015，，19： | 2 |
| 3 | Channel estimation techniques based on pilot arrangement in OFDM systems显示文摘 | COLERI S ERGEN M PURI A | 2002 | IEEE Trans on Broadcasting2002，48，3： | 1 |
| 4 | Leaf nitrogen, photosynthesis, conductance and transpiration: scaling from leaves to canopies显示文摘 | Leuning R Kclliher F M De Pury D G G | 1995 | Plant Cell and Environment1995，18，10： | 1 |
| 5 | Specifieally targeted killing of interleukin 13 receptor-expressing breast cancer by IL-13 fusion evtotoxin in animal model of human diease显示文摘 | Kawakami K Kawakami M Puri RK | | 0，，02： | 1 |
| 6 | Channel estimation techniques based on pilot arrangement in OFDM systems显示文摘 | Coleri S Ergen M Puri A | 2002 | IEEE Transactions on Broadcasting2002，48，9： | 1 |
| 7 | Sexual behavior and perceived risk of HIV/AIDS among young migrant factory workers in Nepal显示文摘 | Puri M Cleland J | 2006 | J Adolesc Health2006，38，： | 1 |
| 8 | Long - term outcome of patients with en- terocolitis complicating Hirschsprung's disease 显示文摘 | MESIEZES M PURI P | 2006 | Pediatr Surg Int2006，22，4： | 1 |
| 9 | Optimism and economic choice显示文摘 | Puri M Robinson D.T | | 0，，01： | 1 |
| 10 | Use of bovine pericardium as a wrapping material for hydroxyapatite orbital implants显示文摘 | Gupta M Puri P Rennie IG | 2002 | Br J Ophthalmol2002，86，： | 1 |
| 11 | Studies on the applicability of alginate-entrapped naringinase for the debittering of kinnow juice 显示文摘 | Puri M Marwaha S S Kothari R M | 1996 | Enzyme & Microbial Technology1996，18，4： | 1 |
| 12 | Outcome of surgical resection of pel- vic osteosarcoma 显示文摘 | Puri A Gulia A Pruthi M | 2014 | Indian J Orthop2014，48，3： | 1 |
| 13 | N-hexane neuropathy in screen printers 显示文摘 | PURI V CHAUDHRY N TATKE M | 2007 | Electromyogr Clin Neurophysiol2007，47，3： | 1 |
| 14 | Heat transfer and power capabilities of EHF helix TWTs显示文摘 | R Harper M P Puri | 1986 | IEDM1986，，： | 1 |
| 15 | Fuzzy random variables显示文摘 | Puri M L Raleseu D A | 1986 | Journal of Mathematical Analysis and Applications1986，114，2： | 1 |
| 16 | Aberrant pH of melanosomes in pink-eyed dilution (p) mutant melanocytes 显示文摘 | PURI N GARDNER J M BRILLIANT M H | 2000 | J Invest Dermatol2000，115，4： | 1 |
| 17 | Channel estimation techniques based on pilot arrangement in OFDM Systems显示文摘 | Coleri S Ergen M Puri A | 2002 | IEEE Trans Broadcast2002，48，3： | 1 |
| 18 | Relationship between soil microbial biomass and gross N mineralization显示文摘 | PURI G ASHMAN M | 1992 | Soil Biol Biochem1992，30，： | 1 |
| 19 | Anion-exchange in lithium aluminate hydrox-ides显示文摘 | DUTTA P K PURI M | 1989 | J Phys Chem1989，93，37： | 1 |
| 20 | Credit ratings,collateral,and loan characteristics:Implications for yield显示文摘 | KOSE J LYNCH A W PURI M | | 0，，3： | 1 |
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