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| 1 | Targeting the insulin-like growth factor pathway in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the third leading cause of cancer-related deaths worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments, which include surgical resection as the first option, liver transplantation and percutaneous ablation. Unfortunately, there is a high frequency of tumor recurrence after surgical resection and most HCC seem resistant to conventional chemotherapy and radiotherapy. Sorafenib, a multi-tyrosine kinase inhibitor, is the only chemotherapeutic option for patients with advanced hepatocellular carcinoma. Patients treated with Sorafenib have a significant increase in overall survival of about three months. Therefore, there is an urgent need to develop alternative treatments. Due to its role in cell growth and development, the insulin-like growth factor system is commonly deregulated in many cancers. Indeed, the insulin-like growth factor(IGF) axis has recently emerged as a potential target for hepatocellular carcinoma treatment. To this aim, several inhibitors of the pathway have been developed suchas monoclonal antibodies, small molecules, antisense oligonucleotides or small interfering RNAs. However recent studies suggest that, unlike most tumors, HCC development requires increased signaling through insulin growth factor Ⅱ rather than insulin growth factor Ⅰ. This may have great implications in the future treatment of HCC. This review summarizes the role of the IGF axis in liver carcinogenesis and the current status of the strategies designed to target the IGF-Ⅰ signaling pathway for hepatocellular carcinoma treatment. | Mónica Enguita-Germán Puri Fortes | 2014 | World Journal of Hepatology2014，6，10： | 10 |
| 2 | Endothelial-specific CYP4A2 overexpression leads to renal injury and hy- pertension via increased production of 20-HETE 显示文摘 | Inoue K Sodhi K Puri N | 2009 | Am J Physiol Renal Physiol2009，297，4： | 1 |
| 3 | N-hexane neuropathy in screen printers 显示文摘 | PURI V CHAUDHRY N TATKE M | 2007 | Electromyogr Clin Neurophysiol2007，47，3： | 1 |
| 4 | Aberrant pH of melanosomes in pink-eyed dilution (p) mutant melanocytes 显示文摘 | PURI N GARDNER J M BRILLIANT M H | 2000 | J Invest Dermatol2000，115，4： | 1 |
| 5 | Mannanases: microbial sources, production, properties and potential biotechnological applications显示文摘 | Chauhan P S Puri N Sharma P | 2012 | Applied Microbiology and Biotechnology2012，，93： | 1 |
| 6 | Turnour Angiogenesis and Angiogenic Inhibitors: A Review 显示文摘 | Yadav L Puri N Rastogi V | 2015 | J Clin Diagn Res2015，9，6： | 1 |
| 7 | What insights can we gain from studying early-onset schizophrenia? The neuro develop- mental pathway and beyond 显示文摘 | VYAS N KUMRA S PURI B | 2010 | Expert Rev Neurother2010，10，： | 1 |
| 8 | Vitamin B12 deficiency:a clinical and electrophysiological profile 显示文摘 | Puri V Chaudhry N Goel S | 2005 | Electromyogr Clin Neurophysiol2005，45，5： | 1 |
| 9 | Novel anticancer therapeutics targeting telomer-ase显示文摘 | Ruden M Puri N | 2013 | Cancer Treat Rev2013，39，5： | 1 |
| 10 | Fuzzy Random variables显示文摘 | Puri M L Ralescu D N | 1986 | Journal of Mathematical Analysis and Applications1986，114，： | 1 |
| 11 | In vitro growth characteristics of melanocytes obtained from adult normal and vitiligo subjects显示文摘 | Puri N Mojamdar M Ramaiah A | 1987 | J Invest Dermatol1987，88，4： | 1 |
| 12 | Apo A1 Mimetic Rescues the Dia- betic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway 显示文摘 | Cao J Puri N Sodhi K | 2012 | Int J Hy- pertens2012，2012，4： | 1 |
| 13 | pH of melanosomes of B16 murine melanoma is acidic: its physiologic importance in the regulation of melanin biosynthesis 显示文摘 | Bhatnagar V Anjaiah S Puri N | 1993 | Arch Biochem Biophys1993，307，： | 1 |
| 14 | Impaction grafting for bone defects in revision total knee arthroplasty 显示文摘 | Lotke PA Carolan GF Puri N | 2006 | Clin Orthop Relat Res2006，446，6： | 1 |
| 15 | The outcome of the treatment of diaphyseal primary bone sarcoma by resection,irradiation and re-implantation of the host bone:extracorporeal irradiation as an option for reconstruction in diaphyseal bone sarcomas显示文摘 | Puri A Gulia A Jambhekar N | | 0，，07： | 1 |
| 16 | Choosing an intensity-modulated radiation therapy technique in the treatment of head-and-neck cancer显示文摘 | Lee N Mechalakos J Puri DR | 2007 | Int J Radiat Oncol Biol Phys2007，68，： | 1 |
| 17 | Demonstration of neuronal networks in the human upper tract using confocal laser scanning microscopy显示文摘 | Laszlo N O' Briain D S Puri P | 2001 | J Urol2001，166，： | 1 |
| 18 | The ins and outs of RNAi in mammalian cells 显示文摘 | Banan M Puri N | 2004 | Curr Pharm Biotechnol2004，5，5： | 1 |
| 19 | Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides显示文摘 | Puri N Pitman RT Mulnix RE | | 0，，01： | 1 |
| 20 | Mannanases: microbial sources, production, properties and potential biotechnological applications显示文摘 | Chauhan P S Puri N Sharma P Gupta N | 2012 | Applied Microbiology Biotechnology2012，，： | 1 |
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