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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Role of DL-lactic acid as an intermediate in rumen metabolism of dairy cows显示文摘 | COUNOTTE G H M LANKHORST A PRINS R A | 1983 | Journal of Animal Science1983，56，： | 1 |
| 3 | Ni EXAFS studies of the Ni-Mo S structure in carbon-supported and alumina-supported Ni-Mo catalysts显示文摘 | Louwers S P A Prins R | 1992 | J Catal1992，133，1： | 1 |
| 4 | Carbohydrate fermentation by the tu- reen ciliate isotrichaprostoma显示文摘 | Prins R A Hoven W | 1977 | Protistologica1977，13，3： | 1 |
| 5 | A 300-kyr record of aridity and wind strength in southwestern African : inference from grain-size distributions of sediments on Walvis Ridge, Southeast Atlantic 显示文摘 | Stuut J B Prins M A Schneider P R | 2002 | Marine Geology2002，180，： | 1 |
| 6 | An EXAFS study on the Ni and W environment in carbon-supported,sulfided W and Ni-W cata lysts显示文摘 | Louwers S P A Prins R | 1993 | J Catal1993，139，2： | 1 |
| 7 | Mechanisms of hydrodesulfurization and hydrodenitrogenation显示文摘 | PRINS R EGOROVA M R(O)THLISBERGER A ZHAO Y SIVASANKAR N KUKULA P | | 0，，1： | 1 |
| 8 | Principles of a novel multistage circulating fluidized bed reactor for biomass gasification显示文摘 | Sascha R A K Wolter Prins Bram van der Drift | 2003 | Chemical Engineering Science2003，58，36： | 1 |
| 9 | Modelling of flash pyrolysis of a single particle显示文摘 | Janse A M C Westerhout R W J Prins W | 2000 | Chemical Engineering and Processing2000，39，3： | 1 |
| 10 | Structure and function of the catalyst and the promoter in Co-Mo hydrodesul- furization catalysts 显示文摘 | PRINS R DE BEER V H J SOMORJAI G A | 1989 | Catalysis Reviews--Science and Engi- neering1989，31，12： | 1 |
| 11 | Intermediates in the hydrodesulfurization of 4,6-dimethyl-dibenzothiophene over Pd/gamma-Al2O3显示文摘 | Rothlisberger A Prins R | | 0，，01： | 1 |
| 12 | Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs显示文摘 | Briejer M R Prins N H Schuurkes J A | 2001 | Neurogastroenterol Motil2001，13，： | 1 |
| 13 | The Late Quaternary sedimentary record on Reykjanes Ridge (North Atlantic)显示文摘 | PRINS M A TROELSTRA S R KRUK R W | 2001 | Radiocarbon2001，43，2： | 1 |
| 14 | Regulation of lactate metabolism in the rumen显示文摘 | COUNOTFE G H M PRINS R A | 1981 | Veterinary Research Communi- cation1981，5，1： | 1 |
| 15 | Late Quaternary sedimentary processes and ocean circulation changes at the Southeast Greenland Margin显示文摘 | KUIJPERS A TROELSTRA S R PRINS M A | 2003 | Marine Geology2003，195，： | 1 |
| 16 | A Review of the Feedback Between Bivalve Grazing and Ecosystem Processes显示文摘 | PRINS T C SMALL A C DAME R F | 1998 | Aquatic Ecology1998，31，： | 1 |
| 17 | Regulation of lactate metabolism in the rumen显示文摘 | Countte G H M Prins R A | 1981 | Veterinary Research Communications1981，5，1： | 1 |
| 18 | Regulation of lactate metabolism in the rumen显示文摘 | COUNOTTE G H M PRINS R A | 1981 | Veterinarijair Research Communication1981，，5： | 1 |
| 19 | QTL mapping of stripe leaf and stem rust resistance genes in a Kariega x Av- ocet S doubled haploid wheat population 显示文摘 | Prins R Pretorius Z A Bender C M | 2011 | Mol Breeding2011，27，： | 1 |
| 20 | Biomass gasification in near- and super-critical water: Status and prospects显示文摘 | MASTUMURA Y MINOWA T POTIC B KERSTEN S R A PRINS W | 2005 | Biomass Bioenergy2005，29，10： | 1 |
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