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| 1 | Characterization of modified mesoporous silica nanoparticles as vectors for siRNA delivery显示文摘Gene therapy using siRNA molecules is nowadays considered as a promising approach. For successful therapy, development of a stable and reliable vector for siRNA is crucial. Non-viral and non-organic vectors like mesoporous silica nanoparticles(MSN) are associated with lack of most viral vector drawbacks, such as toxicity, immunogenicity, but also generally a low nucleic acid carrying capacity. To overcome this hurdle, we here modified the pore walls of MSNs with surface-hyperbranching polymerized poly(ethyleneimine)(hbPEI), which provides an abundance of amino-groups for loading of a larger amount of siRNA molecules via electrostatic adsorption. After loading, the particles were covered with a second layer of pre-polymerized PEI to provide better protection of siRNA inside the pores, more effective cellular uptake and endosomal escape. To test the transfection efficiency of PEI covered si RNA/MSNs, MDA-MB 231 breast cancer cells stably expressing GFP were used. We demonstrate that PEI-coated si RNA/MSN complexes provide more effective delivery of si RNAs compared to unmodified MSNs. Thus, it can be concluded that appropriately surface-modified MSNs can be considered as prospective vectors for therapeutic siRNA delivery. | Anna Slita Anna Egorova Eudald Casals Anton Kiselev Jessica M.Rosenholm | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 2 |
| 2 | The efficiency of growing suckling piglets when adding the prepa- ration Frodo to the mixed food 显示文摘 | Egorova O G Moshkutelo I I Gorodetskaya A A | 1998 | Russian Agricultural Sci- ences1998，，4： | 1 |
| 3 | Functional MRI with variable echo time acquisition 显示文摘 | Chen NK Egorova S Guttmann CR | 2003 | Neuroimage2003，20，4： | 1 |
| 4 | Quantum-chemical investigation of the formation of Lewis acid centers of high-siliceous zeolites显示文摘 | LAMBEROV A A KUZNETSOV A M SHAPNIK M S MASLIY A N BORISEVICH S V ROMANOVA R G EGOROVA S R | 2000 | J Mol Catal A: Chem2000，158，1： | 1 |
| 5 | Mechanisms of hydrodesulfurization and hydrodenitrogenation显示文摘 | PRINS R EGOROVA M R(O)THLISBERGER A ZHAO Y SIVASANKAR N KUKULA P | | 0，，1： | 1 |
| 6 | Mutual influence of the HDS of dibenzo- thiophene and HDN of 2-methylpyridine显示文摘 | Egorova M Prins R | 2004 | J Catal2004，221，1： | 1 |
| 7 | Lessons teamed from the analysis of gender effect on risK factm and procedural outcomes of tower extremity anw'ial dtse4se显示文摘 | Vouyouka AG Egorova NN SaBoum A | 2010 | Journal of Vascular Surgery2010，52，5： | 1 |
| 8 | Trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide in the treatment of chronic heart failure 显示文摘 | Egorova EN Kuz'mina MI Mazur VV | 2011 | Kalinkin MN Mazur ES Ter Arkh2011，83，1： | 1 |
| 9 | Synthesis of metallic nanoparticles in reverse micelles in the presence of quercetin显示文摘 | Egorova E M | 2000 | Colloids Surf A: Physieochem Eng Aspects2000，168，1： | 1 |
| 10 | Mutual influence of the HDS of dibenzothiophene and HDN of 2-methylpyridine显示文摘 | EGOROVA M PRINS R | 2004 | J Catal2004，221，1： | 1 |
| 11 | National trends in rotator cuff repair显示文摘 | Colvin AC Egorova N Harrison AK | | 0，，03： | 1 |
| 12 | Hydredesulfurization of dibenzo- tliiophene and 4, 6-dimethyl-dibenzothiopheneover stdfided NiMo/r-Al 03 catalysts 显示文摘 | Marina Egorova Roel Prim | 2004 | Journal of Catalysis2004，225，： | 1 |
| 13 | Schedule execution for two-machine flow-shop with interval processing times显示文摘 | Matsveichuk N M Sotskov Y N Egorova N G | 2009 | Mathematical and Computer Modelling2009，49，56： | 1 |
| 14 | Azimuthal Modulation of the Event Rate of Cosmic-Ray Extensive Air Showers by the Geomagnetic Field 显示文摘 | IVANOV A A EGOROVA V P KOLOSOV V A | 1999 | JETP Letters1999，69，4： | 1 |
| 15 | Hydrodesulfurization of dibenzothiophene and 4,6-dimethyldibenzothiophene over sulfided NiMo/gamma-Al2O3,CoMo/gamma-Al2O3,and Mo/gamma-Al2O3catalysts显示文摘 | Egorova M Prins R | | 0，，02： | 1 |
| 16 | Trends,complications,and mortality in peripheral vascular surgery显示文摘 | Nowygrod R Egorova N Greco G | 2006 | J Vasc Surg2006，43，2： | 1 |
| 17 | Survival and outcomes following bioprosthetic vs mechanical mitral valve replacement in patients aged 50 to 69 years显示文摘 | Chikwe J Chiang YP Egorova NN | 2015 | JAMA2015，313，14： | 1 |
| 18 | Preservative microflora in stored pollen显示文摘 | Egorova A I | 1971 | Veterinariya1971，，8： | 1 |
| 19 | Effect of the structure on the cutability of titanium alloys显示文摘 | Egorova Y B Il'in A A Kolachev B A | 2003 | Metal Science and Heat Treatment2003，45，2： | 1 |
| 20 | The role of Ni and Co promoters in the simultaneous HDS of dibenzothiophene and HDN of amines over Mo/γ-Al2O3 catalysts显示文摘 | Prins R Egorova M | 2006 | Journal of Catalysis2006，241，1： | 1 |
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