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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | The functional role of mussels in the Oosterschelde Estuary显示文摘 | Smaal A C Vonck W Prins T C | 1990 | J Shellfish Res1990，，9： | 1 |
| 3 | Carbohydrate fermentation by the tu- reen ciliate isotrichaprostoma显示文摘 | Prins R A Hoven W | 1977 | Protistologica1977，13，3： | 1 |
| 4 | Numerical calculation of wall-to-bed heat-transfer coefficients in gas-fluidized beds显示文摘 | Kuipers JA M Prins W Swaaij W PM van | 1992 | AIChE Journal1992，38，7： | 1 |
| 5 | MAS NMR, TPR and TEM studies of the interaction of NiMo with alumina and silica-alumina supports显示文摘 | QU L ZHANG W KOOYMAN P J PRINS R | 2003 | J Catal2003，215，1： | 1 |
| 6 | MAS NMR, TPR, and TEM studies of the interaction of NiMo with alumina and silica-alumina supports显示文摘 | QU L ZHANG W KOOYMAN P J PRINS R | 2003 | J Catal2003，215，1： | 1 |
| 7 | Calphad显示文摘 | Prins S N Cornish L A Stumpf W E | 2003 | 27(1):792003，27，1： | 1 |
| 8 | Modelling of flash pyrolysis of a single particle显示文摘 | Janse A M C Westerhout R W J Prins W | 2000 | Chemical Engineering and Processing2000，39，3： | 1 |
| 9 | Competitivememetic algorithms for routing problem 显示文摘 | LACOMME P PRINS C RAMDANE - CHERIF W | 2004 | Annals of OperationsResearch2004，131，1： | 1 |
| 10 | Proposal for a regenerative high-temperature process for coal gas cleanup withcalcined limestone 显示文摘 | vanderHam A G J Heesink A B M Prins W | 1996 | Industrial & Engineering Chemistry Research1996，35，5： | 1 |
| 11 | The kinetics of NH4+ and NO3- uptake by Douglas fir from single N-solutions and from solutions containing both NH4^+ and NO3显示文摘 | KAMMINGA-VAN W C PRINS H B A | 1993 | Plant and Soil1993，151，1： | 1 |
| 12 | Competitive memetic algorithms for arc routing problems 显示文摘 | Lacomme P Prins C Ramdane-Cherif W | 2004 | Annals of Operations Research2004，131，： | 1 |
| 13 | The tomato gene Sw-5 is a member of the coiled coil,nucle- otide binding,leucine-rich repeat class of plant resistance genes and confers resistance to TSWV in tobacco 显示文摘 | Spassova M L Prins T W Folkertsma R T | 2001 | Mol Breed2001，7，2： | 1 |
| 14 | Competitive memetic algorithms for arc routing problems 显示文摘 | Lacomme P Prins C Ramdane - Cherif W | 2004 | Annals of Operations Research2004，131，14： | 1 |
| 15 | The Late Quaternary sedimentary record on Reykjanes Ridge (North Atlantic)显示文摘 | PRINS M A TROELSTRA S R KRUK R W | 2001 | Radiocarbon2001，43，2： | 1 |
| 16 | Development al expo- sure to bisphenol A increases prostate cancer susceptibility in adult rats: epigenetic mode of action is implicated显示文摘 | Prins G S Tang W Y Belmonte J | 2008 | Fertil Steril2008，89，2： | 1 |
| 17 | Competi- tive memetic algorithms for are routing problems显示文摘 | Lacomme P Prins C Ramdane-Cherif W | 2004 | Annals of Operations Research2004，131，1： | 1 |
| 18 | Biomass gasification in near- and super-critical water: Status and prospects显示文摘 | MASTUMURA Y MINOWA T POTIC B KERSTEN S R A PRINS W | 2005 | Biomass Bioenergy2005，29，10： | 1 |
| 19 | A memetic algorithm with population management (MA|PM) for the capacitated location-routing problem显示文摘 | Prins C Prodhon C Calvo R W | 2006 | Lecture Notes in Computer Science2006，3906，： | 1 |
| 20 | Adaptation of microorganisms to extreme environments 显示文摘 | PRINS R VRIJ W GOTTSCHAL J | 1990 | FEMS Mi- crobiology Letters1990，75，23： | 1 |
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