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| 1 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 2 | The eco-physiological complexity of plant responses to insect herbivores显示文摘 | BALDWIN I T PRESTON C A | 1999 | Planta1999，208，： | 2 |
| 3 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 4 | Pneumocystis murina infection and cigarette smoke exposure interact to cause increased organism burden,development of airspace enlargement,and pulmonary Inflammation in mice显示文摘 | Christensen P J Preston A M Ling T | 2008 | Infect Immun2008，76，8： | 1 |
| 5 | Molecular analysis of bacterial pathogens in otitis media with effusion显示文摘 | POST J C PRESTON R A JEROME J A | 1995 | JAMA1995，273，： | 1 |
| 6 | Miti- gating methane production from ruminants; effect of calcium nitrate as modifier of the fermentation in an in vitro incubation using cassava root as the energy source and leaves of cassava or Mimosa pigra as source of protein 显示文摘 | INTHAPANYA S PRESTON T R LENG R A | 2011 | Livestock Research for Rural Development2011，23，2： | 1 |
| 7 | A brief review of the past,present and future of wood preservation显示文摘 | SCHULTA T Nicholas D Preston A | 2007 | Pest Management Science2007，63，8： | 1 |
| 8 | Ultrastructural analysis of priman epithelial cell cultures infected with Neisseria gonorrhoeae显示文摘 | Ketterer MR Preston A | 1997 | Infect Immun1997，65，6： | 1 |
| 9 | A Spectroscopic Analysis of 33 of the Most Metal-poor Stars I显示文摘 | MCWILLIAM A PRESTON G W SNEDEN C | 1995 | AJ1995，109，： | 1 |
| 10 | Separation of Nickel and Calci- um by Solvent Extraction Using Mixtures of Carboxylic Acids and Alkylpyridines显示文摘 | Preston J S Du Preez A C | 2000 | Hydrometallurgy2000，58，3： | 1 |
| 11 | Origin of the fastphotoresponse of epitaxial YBa2Cu3O7-8 thin film显示文摘 | Hegmann F A Preston J S | 1993 | Physical Review B1993，48，21： | 1 |
| 12 | Effect of diet form and enzyme supplementation on growth, efficiency and energy utilization of wheat - based diets for broilers 显示文摘 | Preston C M Mccracken K J McaUister A | 2000 | British Poultry Science2000，41，： | 1 |
| 13 | Vertical distribution and phylogenetic characterilation of marine Planktonic Archaea in the Janta Barbara channel显示文摘 | MASSANA R MURRAY A F PRESTON C M | 1997 | E M1997，63，1： | 1 |
| 14 | Vertical distribution and phylogenetic characterization of marine planktonic archaea in the santa barbara channel显示文摘 | MASSANA R MURRAY A E PRESTON C M | 1997 | Applied and Environmental Microbiology1997，63，1： | 1 |
| 15 | A numerical investigation of unsteady bubbly cavitating nozzle flows 显示文摘 | Preston A Colonius T Brennen C E | 2002 | Physics of Fluids2002，14，1： | 1 |
| 16 | Herbicide resistance: impact and management 显示文摘 | Jutsum A R Preston C Bryan I B | 1997 | Advances in Agronomy1997，58，： | 1 |
| 17 | Mandibular prognathism 显示文摘 | Jacobson A Evans WG Preston CB | 1974 | Am J Orthod1974，66，2： | 1 |
| 18 | Development of a high-throughput enzyme-linked immunosorbent assay for the routine detection of the carcinogen acrylamide in food, via rapid derivatisation pre-analysis显示文摘 | PRESTON A FODEY T ELLIOTT C | 2008 | Analytica Chimica Acta2008，608，2： | 1 |
| 19 | Glyphosate Resistance in Four Different Populations of Lolium rigidum is Associated with Reduced Translocation of Glyphosate to Meristematic Zones 显示文摘 | WAKELIN A M LORRAINE-COLWILL D F PRESTON C | 2004 | Weed Res2004，44，： | 1 |
| 20 | Endothel in receptor antagonism in pulmonary arterial hypertension-a role for selective ETA inhibition? 显示文摘 | Jacobs A Preston IR Gomberg-Maitland M | 2006 | Curr Med Res Opin2006，22，12： | 1 |
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