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| 1 | Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition. | Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar | 2015 | World Journal of Gastroenterology2015，21，43： | 36 |
| 2 | Biochar increases soil microbial biomass with changes in extra-and intracellular enzyme activities:a global meta-analysis显示文摘Biochar application to soil has been proposed as a potential management strategy to enhance soil carbon(C)sequestration,reduce greenhouse gas emission,improve soil quality,and increase crop productivity.The effects of biochar on soil microbial and enzyme activities are integrally linked to the potential of biochar in achieving these benefits.We conducted a global meta-analysis to assess the effects of biochar on soil microbial biomass C and nitrogen(N)and the activities of 12 enzymes,and identify key factors affecting those soil microbial properties using 964 data points from 72 papers.We found that biochar effects on enzyme activities vary widely with soil type,biochar property and the type of enzyme studied.Biochar significantly increased microbial biomass C(MBC)and urease,alkaline phosphatase and dehydrogenase activities by 21.7%,23.1%,25.4%and 19.8%,respectively,with no significant negative effects on any of the enzymes analyzed in this study.Biochar application was more effective in increasing MBC and enzyme activities in soils with low pH(<6.5),TC(<20 g kg^(−1)),TN(<2 g kg^(−1)),and a fine texture(including clay,clay loam and silt clay).Biochars produced at pyrolysis temperature of 350-550℃ with a high pH(>10)and low C/N ratio(<50)increased MBC and urease and dehydrogenase activities.Biochar increased MBC and N-acquisition enzyme activities in the field but not in lab incubation experiments.Urease was increased in short-term studies(within 100 days of biochar application)while alkaline phosphatase was increased in long-term studies that span more than 1 year.The increase in MBC and activities of some soil enzymes in response to biochar application with no negative effects on any hydrolytic and oxidative enzymes illustrate its potential to enhance soil quality particularly in the degraded soils with low nutrient availability and fertility due to limited soil microbial and enzymatic activities.This study also shows that biochars can be designed to achieve specific properties for enhancing microbial and enzymatic activities for specific soils. | Prem Pokharel Zilong Ma Scott X.Chang | 2020 | Biochar2020，2，1： | 18 |
| 3 | 内窥镜胸交感神经链切断术治疗多汗症显示文摘目的 评价内镜下胸交感神经链切断术治疗多汗症的临床效果。 方法 回顾性分析内镜下胸交感神经链切断术治疗 5 8例多汗症的结果。 结果 5 8例均治愈 ;出现气胸 4例、代偿性多汗 2例、肋间神经痛 1例。 结论 内镜下胸交感神经链切断术比较安全。 | 胡泽勇 Churnpon Chan Prem Pillay Alvin Hong | 2001 | 中国微创外科杂志2001，1，6： | 13 |
| 4 | Efficacy of small-volume simethicone given at least 30 min before gastroscopy显示文摘AIM To evaluate the efficacy of 5 m L simethicone solution in decreasing gastric foam if given at least 30 min before gastroscopy.METHODS This was a randomized, placebo controlled, endoscopist blinded study performed at Changi General Hospital. Patients were at least 21 years old, had no prior sur-gical resection of the upper gastrointestinal tract, and scheduled for elective diagnostic gastroscopies. The primary outcome was the total mucosal visibility score(TMVS) which was evaluated using Mc Nally score. The sample size was calculated to be 24 per group(SD 2.4, 80% power, P < 0.05, 2-sample t test). RESULTS Fifty-four patients were randomised to receive either simethicone [1 m L liquid simethicone(100 mg) in 5 m L of water] or placebo(5 m L of water) at least 30 min before their gastroscopy. Six accredited consultants conductedthe gastroscopy, and the interobserver agreement of scoring TMVS was good with a Kappa statistic of 0.73. The simethicone group had significantly better mean TMVS compared to placebo(5.78 ± SD 1.65 vs 8.89 ± SD 1.97, P < 0.001). The improvement was statistically significant for the duodenum and the gastric antrum, angularis, body, and fundus. Percent 51.9 of patients in the simethicone group had a TMVS of 4(no bubbles at all) to 5(only 1 area with minimal bubbles), while in the placebo group 3.7% of patients had TMVS of 4 or 5. The number needed to treat was 2.1 to avoid a TMVS of 6 and more. The simethicone group also had a significantly shorter procedure time with less volume of additional flushes required during gastroscopy to clear away obscuring gastric foam.CONCLUSION With a premedication time of at least 30 min, 5 m L simethicone can significantly decrease gastric foam, decrease the volume of additional flushes, and shorten gastroscopy time. | Mingjun Song Andrew Boon Eu Kwek Ngai Moh Law Jeannie Peng Lan Ong Jessica Yi-Lyn Tan Prem Harichander Thurairajah Daphne Shih Wen Ang Tiing Leong Ang | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 10 |
| 5 | Proximate Composition,Mineral Content and Fatty Acids Analyses of Aromatic and Non-Aromatic Indian Rice显示文摘Awareness on nutritive value and health benefits of rice is of vital importance in order to increase the consumption of rice in daily diet of the human beings. In this study, a total of six aromatic and two non-aromatic rice accessions grown in India were analysed for their nutritional quality attributes including proximate composition, mineral contents and fatty acids. Data with three replications were used to measure Pearson's simple correlation co-efficient in order to establish the relationship among various nutritional quality attributes. The result on proximate composition showed that Govind Bhog had the highest moisture(13.57%) and fat(0.92%) content, which signifies its tasty attribute. Badshah Bhog exhibited the highest fibre content(0.85%), carbohydrate content(82.70%) and food energy(365.23 k Cal per 100 g). Among the minerals, the higher Ca(98.75 mg/kg), Zn(17.00 mg/kg) and Fe(31.50 mg/kg) were in Gopal Bhog, whereas the highest Na(68.85 mg/kg) was in Badshah Bhog, the highest K(500.00 mg/kg) was in Swetganga, Khushboo and Sarbati. The highest contents of unsaturated fatty acids viz. oleic acid(49.14%), linoleic acid(46.99%) and linolenic acid(1.27%) were found in Sarbati, whereas the highest content of saturated fatty acids viz. myristic acid(4.60%) and palmitic acid(31.91%) were found in Govind Bhog and stearic acid(6.47%) in Todal. The identified aromatic rice accessions Gopal Bhog, Govind Bhog and Badshah Bhog and non-aromatic rice accession Sarbati were found nutritionally superior among all eight tested accessions. The nutritional quality oriented attributes in this study were competent with recognized prominent aromatic and non-aromatic rice accessions as an index of their nutritional worth and recommend to farmers and consumers which may be graded as export quality rice with good unique nutritional values in international market. | Deepak Kumar VERMA Prem Prakash SRIVASTAV | 2017 | Rice science2017，24，1： | 8 |
| 6 | 亚洲群众参与流域管理的政策问题显示文摘群众参与流域管理相关的重大政策问题的提出,旨为1999年7月19~24日在泰国清迈由亚洲群众参与流域管理培训项目(世界粮农组织/荷兰)和泰国皇家林业局流域管理处联合主办的“亚洲群众参与流域管理政策问题地区研讨会”上作进一步的讨论和研究。自1992年联合国环发大会上大多数国家在《21世纪议程》上签字以来,人们增强了对雨养山区发展问题的重新思考。群众参与流域管理就是人们重新思考后的一种直接构想。它明确了需要大量投资,并切实到位,才能保证群众参与流域管理项目的顺利实施,而过去10多年内亚洲国家从来都没有如此迫切的需求。因此,制定有效的政策,以保证群众参与流域管理方案顺利实施是最重要的。在审查和分析了参与国的相关政策之后,虽然解决了一些政策问题,但一些关键性的政策仍需引起进一步重视,包括派生于或建立在人们固有的(或内在的)制度、文化、知识和风俗以及不同的性别、阶级、种族之间的平等观念。而人们在群众参与流域管理开发项目中的所有权、受益者的直接投资、项目的设备和技术援助以及人力资源开发也同等重要。 | 周金星 王礼先 Prem N. Sharma | 2000 | 水土保持科技情报2000，18，2： | 8 |
| 7 | Recent advances in catalytic combustion of AP-based composite solid propellants显示文摘Composite solid propellants(CSPs) have widely been used as main energy source for propelling the rockets in both space and military applications. Internal ballistic parameters of rockets like characteristic exhaust velocity, specific impulse, thrust, burning rate etc., are measured to assess and control the performance of rocket motors. The burn rate of solid propellants has been considered as most vital parameter for design of solid rocket motors to meet specific mission requirements. The burning rate of solid propellants can be tailored by using different constituents, extent of oxidizer loading and its particle size and more commonly by incorporating suitable combustion catalysts. Various metal oxides(MOs),complexes, metal powders and metal alloys have shown positive catalytic behaviour during the combustion of CSPs. These are usually solid-state catalysts that play multiple roles in combustion of CSPs such as reduction in activation energy, enhancement of rate of reaction, modification of sequences in reaction-phase, influence on condensed-phase combustion and participation in combustion process in gas-phase reactions. The application of nanoscale catalysts in CSPs has increased considerably in recent past due to their superior catalytic properties as compared to their bulk-sized counterparts. A large surface-to-volume ratio and quantum size effect of nanocatalysts are considered to be plausible reasons for improving the combustion characteristics of propellants. Several efforts have been made to produce nanoscale combustion catalysts for advanced propellant formulations to improve their energetics. The work done so far is largely scattered. In this review, an effort has been made to introduce various combustion catalysts having at least a metallic entity. Recent developments of nanoscale combustion catalysts with their specific merits are discussed. The combustion chemistry of a typical CSP is briefly discussed for providing a better understanding on role of combustion catalysts in burning rate enhancement. Available information on different types of combustion nanocatalysts is also presented with critical comments. | Narendra Yadav Prem Kumar Srivastava Mohan Varma | 2021 | Defence Technology(防务技术)2021，17，3： | 8 |
| 8 | Tuning the particle size and morphology of high energetic material nanocrystals显示文摘Morphology controlled synthesis of nanoparticles of powerful high energetic compounds(HECs) such as l,3,5-trinitro-l,3,5-triazinane(RDX) and 1,3,5,7-tetranitro-l,3,5,7-tetrazocane(HMX) were achieved by a simple solvent—antisolvent interaction(SAI) method at 70 ℃.The effects of different solvents on particle size and morphology of the prepared nano-HECs were studied systematically.Particle size and morphology of the nano-HECs was characterized using field emission scanning electron microscopy(FE-SEM) imaging.X-ray diffraction(XRD) and Fourier transform infrared(FTIR) spectroscopy studies revealed that RDX and HMX were precipitated in their most stable polymorphic forms,i.e.a and P,respectively.Thermogravimetric analysis coupled with differential scanning calorimetry(TGA-DSC) studies showed that the thermal response of the nanoparticles was similar to the respective raw-HECs.HEC nanoparticles with spherical and rod shaped morphology were observed under different solvent conditions.The mean particle size also varied considerably with the use of different solvents. | Raj KUMAR Prem Felix SIRIL Pramod SONI | 2015 | Defence Technology(防务技术)2015，11，4： | 7 |
| 9 | A Comparative Study on the Role of Cytokinins in Caryopsis Development in the Maize miniature1 Seed Mutant and Its Wild Type显示文摘We report here on a comparative developmental profile of plant hormone cytokinins in relation to cell size,cell number and endoreduplication in developing maize caryopsis of a cell wall invertase-deficient miniature1(mn1) seed mutant and its wild type,Mn1,genotype.Both genotypes showed extremely high levels of total cytokinins during the very early stages of development,followed by a marked and genotype specific reduction.While the decrease of cytokinins in Mn1 was associated with their deactivation by 9-glucosylation,the absolute and the relative part of active cytokinin forms was higher in the mutant.During the exponential growth phase of endosperm between 6 d after pollination and 9 d after pollination,the mean cell doubling time,the absolute growth rate and the level of endoreduplication were similar in the two genotypes.However,the entire duration of growth was longer in Mn1 compared with mn1,resulting in a significantly higher cell number in the Mn1 endosperm.These data correlate with the previously reported peak levels of the Mn1-encoded cell wall invertase-2(INCW2) at 12 d after pollination in the Mn1 endosperm.A model showing possible crosstalk among cytokinins,cell cycle and cell wall invertase as causal to increased cell number and sink strength of the Mn1 developing endosperm is discussed. | Tomaz Rijavec Maja Kova Ale Kladnik Prem S.Chourey Marina Dermastia | 2009 | Journal of Integrative Plant Biology2009，51，9： | 7 |
| 10 | A review on assessment and treatment of the trunk in stroke A need or luxury显示文摘Trunk function has been identified as an important early predictor of functional outcome after stroke and the same deteriorates on both contralateral and ipsilateral sides of the body following stroke.The primary contribution of the trunk muscles is to allow the body to remain upright,adjust weight shifts,and control movements against constant pull of gravity and is considered central key point of the body.Proximal stability of the trunk is a pre-requisite for distal limb mobility,balance,gait and functional activities and its positive correlation in hemiplegia has been demonstrated in a cross-sectional study.Both isokinetic and handheld dynamometer muscle strength testing demonstrated the weakness of bilateral trunk flexors,extensors and rotator muscles in both acute and chronic hemiplegic patients.This was confirmed by electromyography analysis which identified poor bilateral trunk muscles activity in patients with stroke.Trunk impairment scale is sensitive to evaluate the selective muscle control of upper and lower trunk,and it has been reported that lateral flexion of the trunk is easier than rotation of the trunk and the clinical observation concurs to the difficulty in lower trunk rotation of stroke patients.However,trunk exercises given early after stroke could produce enhanced balance performance post-stroke.This review attempts to report the evidence supporting the involvement of the trunk and its influence on balance and functional performance in post-stroke hemiplegia. | Suruliraj Karthikbabu Mahabala Chakrapani Sailakshmi Ganeshan Kedambadi C Rakshith Syed Nafeez Venkatesan Prem | 2012 | Neural Regeneration Research2012，7，25： | 5 |
| 11 | Assessment of tumor markers CA 19-9,CEA,CA 125,and CA 242 for the early diagnosis and prognosis prediction of gallbladder cancer显示文摘BACKGROUND Gallbladder cancer(GBC)is one of the leading and aggressive cancers in this region of India.It is very difficult to diagnose in the early stage,as it lacks typical early signs and symptoms;thus,the diagnosis is often in the advanced stage,which ultimately leads to a poor 5-year survival outcome.Tumor markers including carbohydrate antigen 19-9(CA 19-9),carcinoembryonic antigen(CEA),CA 125,CA 242,and alpha fetoprotein are used as indicators in the diagnosis and prognosis of GBC.AIM To compare tumor marker levels between GBC and benign GB diseases(GBDs)and to assess the combined use of tumor markers to increase the diagnostic accuracy for GBC.METHODS Patients of either sex aged≥18 years,with suspected GBC(GB polyp,irregular thick GB wall,GB mass,porcelain GB)on the basis of radiological imaging were included in this study.GB wall thickness using ultrasonography and tumor markers CEA,CA 125,CA 19-9,and CA 242 in all patients were recorded.All cases after surgical intervention were divided into two groups,GBC and benign GBD,according to histopathological examination findings.The cases were followed up and clinical findings,radiological findings,and levels of tumor markers were assessed.RESULTS A total of 200 patients were included in this study,of whom 80 patients had GBC and 120 patients had benign GBD.The median(interquartile range)age was 52.0(41.0-60.0)years and the majority of patients(132,66.0%)were women.Tumor markers including CA 19-9,CA 125,CEA,and CA 242 were significantly elevated in patients with GBC(P<0.001).There was a significant reduction in tumor markers at 3 and 6 mo from baseline(P<0.001).The mean survival of patients with normal and elevated levels of tumor markers CA 125,CA 19-9,and CEA was comparable;however lymph node metastasis and CA 242 expression level were independent prognostic factors.CONCLUSION Serum levels of tumor markers including CA 19-9,CA 125,CEA,and CA 242 were significantly associated with GBC.However,no significant association was observed between the presence of elevated levels of any tumor marker with respect to survival.Tumor marker assessment during follow-up may represent a treatment response. | Seema Rani Sinha Prem Prakash Rakesh Kumar Singh Dinesh Kumar Sinha | 2022 | World Journal of Gastrointestinal Surgery2022，14，11： | 5 |
| 12 | Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers显示文摘OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to cisplatin.METHODS The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse model.RESULTS We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by cisplatin.Both the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and garcinol.The pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,respectively.CONCLUSION Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers. | Feng Li Muthu K. Shanmugam Kodappully Sivaraman Siveen Fan Wang Tina H. Ong Ser Yue Loo Mahadeva M.M. Swamy Somnath Mandal Alan Prem Kumar Boon Cher Goh Tapas Kundu Kwang Seok Ahn Ling Zhi Wang Kam Man Hui Gautam Sethi | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 4 |
| 13 | Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease显示文摘AIM: To determine if hyperpolarisation-activated nucleotide-gated(HCN) channels exist in human colon, and to investigate the expression of HCN channels in Hirschsprung's disease.METHODS:We investigated HCN1,HCN2,HCN3 and HCN4 protein expression in pull-through specimens from patients with Hirschsprung’s disease(HSCR,n=10)using the proximal-most ganglionic segment and distalmost aganglionic segment,as well as in healthy control specimens obtained at the time of sigmoid colostomy closure in children who had undergone anorectoplasty for imperforate anus(n=10).Fluorescent immunohistochemistry was performed to assess protein distribution,which was then visualized using confocal microscopy.RESULTS:No HCN1 channel expression was observed in any of the tissues studied.Both HCN2 and HCN4proteins were found to be equally expressed in the aganglionic and ganglionic bowel in HSCR and controls.HCN3 channel expression was found to be markedly decreased in the aganglionic colon vs ganglionic colon and controls.HCN2-4 channels were seen to be expressed within neurons of the myenteric and submucosal plexus of the ganglionic bowel and normal controls,and also co-localised to interstitial cells of Cajal in all tissues studied.CONCLUSION:We demonstrate HCN channel expression in human colon for the first time.Reduced HCN3expression in aganglionic bowel suggests its potential role in HSCR pathophysiology. | Anne Marie O’Donnell David Coyle Prem Puri | 2015 | World Journal of Gastroenterology2015，21，18： | 4 |
| 14 | Sugar-Hormone Cross-Talk in Seed Development: Two Redundant Pathways of IAA Biosynthesis Are Regulated Differentially in the Invertase- Deficient miniature 1 (mn 1) Seed Mutant in Maize显示文摘 | Prem S. Chourey Qin-Bao Li Dibyendu Kumar | 2010 | Molecular Plant2010，3，6： | 3 |
| 15 | Transcriptome-Based Examination of Putative Pollen Allergens of Rice (Oryza sativa ssp. japonica)显示文摘花粉变应原在富有地植物的生活历史上抄录并且翻译产品的大多数之中,并且特别地草。在米饭识别不同花粉变应原,通常认为的变应原在用 Affymetrix 57K 米饭 GeneChip microarray 描绘的米饭染色体和他们的表示被识别。在最丰富的花粉特定的候选人抄本之中是 Ory s 1 beta-expansin, Ory s 2, Ory s 7 EF 手, Ory s 11, Ory s 12 profilin A, Ory s 23, glycosyl hydrolase 家庭 28 (polygalacturonase ) ,并且一度时髦的风尚有约束力的蛋白质。高度表示的花粉蛋白质经常是在多重拷贝数字的现在,有时与位于相反的 DNA 海滨的附近的区域的镜像。这些中的许多是 intronless 并且作为保留他们的规章的元素的将近准确的拷贝的拷贝插入。23 反映的 Ory s 低可变性和高拷贝数,建议最近的基因扩大。一些拷贝包含 pseudogenes,它可以通过 retrotransposition 的活动反映他们的起源;一些通常认为的引起过敏症的序列与 transposable 元素(LTR ) 的重复序列忍受熔化产品。附近的许多重复序列, transposable 元素的激活,和 mRNA 抄本的高生产看起来在花粉与一致并且可以贡献高度抄录的蛋白质可以为翻译与优化特征在被拷贝并且插入的症候群,包括组织和 introns 的移动。 | Scott D. Russell Prem L. Bhalla Mohan B. Singh | 2008 | Molecular Plant2008，1，5： | 3 |
| 16 | Making More Food Available:Promoting Sustainable Agricultural Production显示文摘INTRODUCTION During the 20th century food availability worldwide has increased considerably. The increase in population was outnumbered by the productivity increase in agriculture mainly by higher yields per ha. Globally there is more food available per person than ever before. In the coming decades the world population will further | Rudy Rabbinge Prem S Bindraban | 2012 | Journal of Integrative Agriculture2012，11，1： | 3 |
| 17 | Emerging targets in cancer drug resistance显示文摘Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer treatment.Malignant cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and pathways.Understanding the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic outcomes.This review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance. | Shashank Kumar Prem Prakash Kushwaha Sanjay Gupta | 2019 | Cancer Drug Resistance2019，2，2： | 3 |
| 18 | Influence of A-site cation disorder on structural and magnetocaloric properties of Nd_(0.7–x)La_xSr_(0.3)MnO_3(x=0.0, 0.1, 0.2 & 0.3)显示文摘In the present research, the influence of A-site ionic size disorder on structural, magnetic and magnetocaloric properties of Nd0.7–xLaxSr0.3MnO3(for x=0.0, 0.1, 0.2 & 0.3) compounds were investigated. These compounds were synthesized by solid state reaction route and crystallized in orthorhombic structure with Pnma space group. An average ionic radius increased with La-substitution which influenced the physical properties such as the magnetic entropy varying from 4.78 J/kg·K(for x=0.0) to 3.55 J/kg·K(for x=0.3) and the maximum magnetization at 5 K changing from 3.92 μB(for x=0.0) to 3.59 μB(for x=0.3). The change in maximum magnetic entropy decreased with increase of A-site average ionic radius. The decrease in magnetic entropy indicated the suppression of lattice disorder that influenced the spin-lattice coupling. The ferromagnetic transition temperature shifted toward room temperature with La substitution. As increased, the phase transition changed from first order(for x=0.0) to second order(for x≥ 0.1) and the refrigeration capacity increased to a significant level. The modest change in magnetic entropy over a wide range of transition temperature might be useful for future active magnetic refrigeration technology. | Sudharshan Vadnala Prem Pal Saket Asthana | 2015 | Journal of Rare Earths2015，33，10： | 3 |
| 19 | Thymoquinone: Potential cure for inflammatory disorders and cancer显示文摘 | Chern Chiuh Woo Alan Prem Kumar Gautam Sethi Kwong Huat Benny Tan | 2011 | Biochemical Pharmacology2011，，4： | 2 |
| 20 | Modeling Spatial–Temporal Dynamics of Urban Residential Fire Risk Using a Markov Chain Technique显示文摘This article applies a Markov chain method to compute the probability of residential fire occurrence based on past fire history. Fitted with the fire incidence data gathered over a period of 10 years in Melbourne, Australia,the spatially-integrated fire risk model predicts the likely occurrence of fire incidents using space and time as key model parameters. The mapped probabilities of fire occurrence across Melbourne show a city-centric spatial pattern where inner-city areas are relatively more vulnerable to a fire than outer suburbia. Fire risk reduces in a neighborhood when there is at least one fire in the last1 month. The results show that the time threshold of reduced fire risk after the fire occurrence is about 2 months.Fire risk increases when there is no fire in the last 1 month within the third-order neighborhood(within 5 km). A fire that occurs within this distance range, however, has no significant effect on reducing fire risk level within the neighborhood. The spatial–temporal dependencies of fire risk provide new empirical evidence useful for fire agencies to effectively plan and implement geo-targeted fire risk interventions and education programs to mitigate potential fire risk in areas where and when they are most needed. | Rifan Ardianto Prem Chhetri | 2019 | International Journal of Disaster Risk Science2019，10，1： | 2 |
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