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| 1 | Ferroptosis is an autophagic cell death process显示文摘Ferroptosis 是调整坏死的一种铁依赖者形式。它在各种各样的人的疾病被含有,包括 ischemic 机关损坏和癌症。这里,我们报导 autophagy 的关键角色,特别地细胞的铁存储蛋白质(作为 ferritinophagy 知道的一个过程) 的 autophagic 降级,在 ferroptosis。用 RNAi,屏蔽结合了随后的基因分析,我们作为 ferroptosis 的积极管理者识别了多重 autophagy 相关的基因。Ferroptosis 正式就职导致了 autophagy 激活和 ferritin 和 ferritinophagy 货物受体 NCOA4 的作为结果的降级。一致地,由 autophagy 的阻塞的 ferritinophagy 的抑制或废除的 NCOA4 击倒联系 ferroptosis 的细胞的易变的铁的累积和反应的氧种类,以及最终的 ferroptotic 细胞死亡。因此, ferroptosis 是一个 autophagic 房间死亡过程,并且调停 NCOA4 的 ferritinophagy 由控制细胞的铁动态平衡支持 ferroptosis。 | Minghui Gao Prashant Monian Qiuhui Pan Wei Zhang Jenny Xiang Xuejun Jiang | 2016 | Cell Research2016，26，9： | 138 |
| 2 | Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures显示文摘 | Bin-Kuan Chou Prashant Mali Xiaosong Huang Zhaohui Ye Sarah N Dowey Linda MS Resar Chunlin Zou Alex Zhang Jay Tong Linzhao Cheng | 2011 | Cell Research2011，21，3： | 38 |
| 3 | Dynamic hip screw with locking side plate: a viable treatment option for intertrochanteric fracture显示文摘ObjectiveDynamic 新潮的螺丝钉(DHS ) 为稳定的 intertrochanteric 破裂的固定被推荐。它的手术后的开口率从 1% ~ 6%。在 osteoporotic 骨头,在 DHS 片的正常螺丝钉与锁螺丝钉相比提供更少的抛锚。这研究试图把 DHS 与锁方面板和常规方面 plate.MethodsFifty 作比较有 intertrochanteric 破裂的连续病人随机与标准 DHS (组 A ) 和锁住的 DHS 为固定被分配(Combi 板,组 B ) 。我们在 intertrochanteric 破裂为常规 DHS 和锁住的 DHS 比较了临床、放射学的结果。功能的结果用 score.ResultsCoxa valga 比在组 B 在组 A 更经常被发现的帕克活动性被评估(12% 对 0% , P = 0.42 ) 。臀部 vara 显示出一样的趋势(12% 对 8% , P = 0.81 ) 。在健全方面的 20 °
以内的手术后的颈柄角度的恢复的率比在组 A 在组 B (8% 盒子) 是更高的(4% 盒子, P = 0.98 ) 。在健全方面的 10 °
以内的子宫前倾角度恢复的率在组 B 也是更高的(100% 对 88% , s = 0.85 ) 。一般水准落后在组 A 和组 B 的螺丝钉滑动是 3.2 公里和 4.2 公里,平均破裂联合持续时间是 17.1 个星期, 16.4 个星期,和吝啬的帕克得分分别地是 5.6 和 5.8。螺丝钉开口在组 A 在一个病人被看见。没有开口在组 B 在任何病人被看见。没有耐心的发达深感染, avascular 坏死,深静脉血栓或任何东西学习表明了的在场的另外的重要 complications.ConclusionThe 有锁住的 DHS 的那对待的 intertrochanteric 破裂允许健全骨头愈合并且是没与任何主要复杂并发症联系。尽管这份报告是有希望的,因为仅仅有一种大样品尺寸的未来的研究将允许权威的结论,它应该小心地被解释。 | Nilesh Barwar Sanjay Meena Shashi Kant Aggarwal Prashant Garhwal | 2014 | Chinese Journal of Traumatology2014，17，2： | 23 |
| 4 | Delphi methodology in healthcare research:How to decide its appropriateness显示文摘The Delphi technique is a systematic process of forecasting using the collective opinion of panel members.The structured method of developing consensus among panel members using Delphi methodology has gained acceptance in diverse fields of medicine.The Delphi methods assumed a pivotal role in the last few decades to develop best practice guidance using collective intelligence where research is limited,ethically/logistically difficult or evidence is conflicting.However,the attempts to assess the quality standard of Delphi studies have reported significant variance,and details of the process followed are usually unclear.We recommend systematic quality tools for evaluation of Delphi methodology;identification of problem area of research,selection of panel,anonymity of panelists,controlled feedback,iterative Delphi rounds,consensus criteria,analysis of consensus,closing criteria,and stability of the results.Based on these nine qualitative evaluation points,we assessed the quality of Delphi studies in the medical field related to coronavirus disease 2019.There was inconsistency in reporting vital elements of Delphi methods such as identification of panel members,defining consensus,closing criteria for rounds,and presenting the results.We propose our evaluation points for researchers,medical journal editorial boards,and reviewers to evaluate the quality of the Delphi methods in healthcare research. | Prashant Nasa Ravi Jain Deven Juneja | 2021 | World Journal of Methodology2021，11，4： | 21 |
| 5 | 集合系统CT三维重建精准指导经皮肾镜手术目标肾盏选择和穿刺的临床研究显示文摘目的探讨集合系统CT三维重建帮助经皮肾镜手术(PCNL)精准进行目标肾盏选择和目标肾盏穿刺的可行性和安全性。方法肾结石PCNL患者196例,均行术前腹部泌尿系平片(KUB)、静脉肾盂造影(IVU)、CT平扫和增强扫描,分别获取肾结石、集合系统及肾脏周围器官的CT三维影像,在集合系统三维重建后面观影像上确定最佳PCNL目标肾盏,将确定的目标肾盏通过影像转化技术标识在IVU影像上,C臂机引导下穿刺该目标肾盏建立手术通道。结果所有PCNL手术均按术前的规划实现了精准穿刺目标肾盏建立手术通道,196例患者术中、术后无严重出血、邻近器官损伤等并发症,均未输血。鹿角形肾结石手术无石率为88%,肾盂肾盏结石94.1%。结论通过对影像的技术转化,将CT集合系统三维重建确定的目标肾盏准确标识在IVU影像上,指导PCNL术中对目标肾盏进行精准选择和精准穿刺,建立更加安全的手术通道,最大程度降低PCNL出血和器官损伤等并发症。 | 李炯明 王光 刘建和 姜永明 张劲松 方克伟 石鑫 Prashant Mishra | 2017 | 临床外科杂志2017，25，2： | 12 |
| 6 | Euglycemic diabetic ketoacidosis:A missed diagnosis显示文摘Euglycemic diabetic ketoacidosis(DKA)is an acute life-threatening metabolic emergency characterized by ketoacidosis and relatively lower blood glucose(less than 11 mmol/L).The absence of hyperglycemia is a conundrum for physicians in the emergency department and intensive care units;it may delay diagnosis and treatment causing worse outcomes.Euglycemic DKA is an uncommon diagnosis but can occur in patients with type 1 or type 2 diabetes mellitus.With the addition of sodium/glucose cotransporter-2 inhibitors in diabetes mellitus management,euglycemic DKA incidence has increased.The other causes of euglycemic DKA include pregnancy,fasting,bariatric surgery,gastroparesis,insulin pump failure,cocaine intoxication,chronic liver disease and glycogen storage disease.The pathophysiology of euglycemic DKA involves a relative or absolute carbohydrate deficit,milder degree of insulin deficiency or resistance and increased glucagon/insulin ratio.Euglycemic DKA is a diagnosis of exclusion and should be considered in the differential diagnosis of a sick patient with a history of diabetes mellitus despite lower blood glucose or absent urine ketones.The diagnostic workup includes arterial blood gas for metabolic acidosis,serum ketones and exclusion of other causes of high anion gap metabolic acidosis.Euglycemic DKA treatment is on the same principles as for DKA with correction of dehydration,electrolytes deficit and insulin replacement.The dextrosecontaining fluids should accompany intravenous insulin to correct metabolic acidosis,ketonemia and to avoid hypoglycemia. | Prashant Nasa Sandeep Chaudhary Pavan Kumar Shrivastava Aanchal Singh | 2021 | World Journal of Diabetes2021，12，5： | 11 |
| 7 | Role of Moringa oleifera in regulation of diabetes-induced oxidative stress显示文摘Objective:To evaluate the antioxidant activity of aqueous extract of Atoringa oleifeta M.oleifera) young leaves by in vivo as well as in vitro assays.Methods:In vitro study included estimation of total phenolic,total ilavonol,total flavonoid and total antioxidant power(FRAP assay).Tn addition, in vivo study was done with the identified most effective dose of 200 nig/kg of its lyophilized powder on normal and diabetic rats.Its effect on different oxidative free radical scavenging enzymes,viz,superoxide dismutase(SOD),catalase(CAT),glutathione-S-transferase(GST),lipid peroxide(LPO) contents were measured.Results:Significant increase in activities of SOD.CAT, GST while,a decrease in LPO content was observed.Whereas,total phenolic,flavonoid and ilavonol contents in the extract were found to be 120 mg/g of CAK,40.5 mg/g of QEK and 12.12 mg/g of QE,respectively.On the other hand.FRAP assay results of M.oleifera leaves was(85.00±5.00)μM of Fe^+/g of extract powder.Conclusions:The significant antioxidant activities of M.oleifera leaves from both in vivo as well as in vitro studies suggests that the regular intake of its leaves through diet can protect normal as well as diabetic patients against oxidative damage. | Dolly Jaiswal Prashant Kumar Rai Shikha Mehta Sanjukta Chatterji Surekha Shukla Devendra Kumar Rai Gaurav Sharma Bechan Sharma Shahidul khair Geeta Watal | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，6： | 11 |
| 8 | Nonunion of coronal shear fracture of femoral condyle显示文摘大腿骨的髁的孤立的花冠破裂在成年人是稀罕的并且 Hoffa 骨折不属于工会被报导仅仅在文学的一些时间。我们分析了六个案例在三年的一个时期上的 Hoffa 破裂不属于工会。三个病人保存地被对待,三个病人有固定失败。表示的延期是到一年的 2 个月。治疗协议与膝 arthrolysis 一起由开的减小, pseudoarthrosis 的切除,骨头 grafting 和内部固定组成了。联合在平均数 16 星期在所有病人被完成。治疗 Hoffa 破裂不属于工会要求小心的外科手术前的计划和过细的外科的技术。关于在破裂管理和外科的技术的争吵的文学被考察。 | Ajay Pal Singh Ish Kumar Dhammi Raju Vaishya Anil Kumar Jain Arun Pal Singh Prashant Modi | 2011 | Chinese Journal of Traumatology2011，14，3： | 11 |
| 9 | Severe sepsis and septic shock in the elderly:An overview显示文摘The incidence of severe sepsis and septic shock is increasing in the older population leading to increased admissions to the intensive care units(ICUs). The elderly are predisposed to sepsis due to co-existing comorbidities, repeated and prolonged hospitalizations, reduced immunity, functional limitations and above all due to the effects of aging itself. A lower threshold and a higher index of suspicion is required to diagnose sepsis in this patient population because the initial clinical picture may be ambiguous, and aging increases the risk of a sudden deterioration in sepsis to severe sepsis and septic shock. Management is largely based on standard international guidelines with a few modifications. Age itself is an independent risk factor for death in patients with severe sepsis, however, many patients respond well to timely and appropriate interventions. The treatment should not be limited or deferred in elderly patients with severe sepsis only on the grounds of physician prejudice, but patient and family preferences should also be taken into account as the outcomes are not dismal. Future investigations in the management of sepsis should not only target good functional recovery but also ensure social independence and quality of life after ICU discharge. | Prashant Nasa Deven Juneja Omender Singh | 2012 | World Journal of Critical Care Medicine2012，1，1： | 9 |
| 10 | Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation显示文摘AIM: To determine effect of irritable bowel syndrome(IBS) subtype on IBS-specific quality of life(QOL) questionnaire and its subscales.METHODS: We studied IBS patients visiting our functional gastroenterology disorder clinic at a tertiary care center of Unites States.IBS and IBS subtype were diagnosed using Rome-Ⅲ questionnaire.QOL was assessed using IBS-QOL questionnaire.IBSQOL assesses quality of life along eight subscales: dysphoria,interference with activities,body image,health worry,food avoidance,social reactions,sexual health,and effect on relationships.IBS-QOL and its subscales were both scored on a range of 0-100 with higher scores suggestive of better QOL.Results of overall IBS-QOL scores and subscale scores are expressed as means with 95%CI.We compared mean IBS-QOL score and its subscales among various IBSsubtypes.Analysis of variance(ANOVA) was used to compare the mean difference between more than two groups after controlling for age and gender.A posthoc analysis using Bonferroni correction was used only when P value for ANOVA was less than 0.05.RESULTS: Of 542 patients screened,243 had IBS as per Rome-Ⅲ criteria.IBS-mixed(IBS-M) was the most common IBS subtype(121 patients,49.8%) followed by IBS- diarrhea(IBS-D)(56 patients,23.1%),IBSconstipation(IBS-C)(54 patients,22.2%) and IBSunspecified(IBS-U)(12 patients,4.9%).Overall IBSQOL scores were significantly different among various IBS-subtypes(P = 0.01).IBS-QOL of patients with IBS-D(61.6,95%CI: 54.0-69.1) and IBS-M(63.0,95%CI: 58.1-68.0) was significantly lower than patients with IBS-C(74.5,95%CI: 66.9-82.1)(P = 0.03 and 0.02 respectively).IBS-D patients scored significantly lower than IBS-C on food avoidance(45.0,95%CI: 34.8-55.2 vs 61.1,95%CI: 50.8-71.3,P = 0.04) and interference with activity(59.6,95%CI: 51.4-67.7 vs 82.3,95%CI: 74.1-90.6,P < 0.001).IBS-M patients had more interference in their activities(61.6,95%CI: 56.3-66.9 vs 82.3,95%CI: 74.1-90.6,P = 0.001) and greater impact on their relationships(73.3,95%CI: 68.4-78.2 vs 84.7,95%CI: 77.2-92.2,P = 0.02) than IBS-C patients.Patients with IBS-M also scored significantly lower than IBS-C on food avoidance(47.2,95%CI: 40.7-53.7 vs 61.1,95%CI: 50.8-71.3,P = 0.04) and social reaction(66.1,95%CI: 61.1-71.1 vs 80.0,95%CI: 72.1-87.7,P = 0.005).CONCLUSION: IBS-D and IBS-M patients have lower IBS-QOL than IBS-C patients.Clinicians should recognize food avoidance,effects on daily activities and relationship problems in these patients. | Prashant Singh Kyle Staller Kenneth Barshop Elaine Dai Jennifer Newman Sonia Yoon Shahar Castel Braden Kuo | 2015 | World Journal of Gastroenterology2015，21，26： | 9 |
| 11 | 国际糖尿病足工作组:促进糖尿病足溃疡创面愈合干预指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘推荐1.考虑到疼痛或严重缺血等相对禁忌证,采用锐性清创术去除糖尿病足溃疡的腐肉、坏死组织和周围的胼胝优于其他方法。(GRADE推荐强度:强;证据质量:低)2.选择敷料主要是考虑渗出物控制、舒适性和成本。(强;低)3.不要使用含表面抗菌药物的敷料以加速溃疡的愈合。(强;低)4.针对曾用最佳标准治疗难以愈合的未感染的神经性缺血性糖尿病足溃疡,可以考虑使用蔗糖八硫酸盐敷料(脂质水胶寡糖敷料—校者注)。 | Gerry Rayman Prashant Vas Ketan Dhatariya Vicki Driver Agnes Hartemann Magnus Londahl Alberto Piaggesi Jan Apelqvist Chris Attinger Fran Game 无 杨彩哲(译) 许樟荣(审校) | 2019 | 感染.炎症.修复2019，20，4： | 8 |
| 12 | Current Status of Conventional and Molecular Interventions for Blast Resistance in Rice显示文摘Pyricularia oryzae anamorph of Magnaporthe oryzae is one of the most notorious fungal pathogens causing severe economic loss in rice production worldwide. Various methods, viz. cultural, biological and molecular approaches, are utilized to counteract this pathogen. Moreover, some tolerant or resistant rice varieties have been developed with the help of breeding programmes. Isolation and molecular characterization of different blast resistance genes now open the gate for new possibilities to elucidate the actual allelic variants of these genes via various molecular breeding and transgenic approaches. However, the behavioral pattern of this fungus breakups the resistance barriers in the resistant or tolerant rice varieties. This host-pathogen barrier will be possibly countered in future research by comparative genomics data from available genome sequence data of rice and M. oryzae for durable resistance. Present review emphasized fascinating recent updates, new molecular breeding approaches, transgenic and genomics approaches(i.e. mi RNA and genome editing) for the management of blast disease in rice. The updated information will be helpful for the durable, resistance breeding programme in rice against blast pathogen. | Deepti SRIVASTAVA Md SHAMIM Mahesh KUMAR Anurag MISHRA Pramila PANDEY Deepak KUMAR Prashant YADAV Mohammed Harrish SIDDIQUI Kapildeo Narayan SINGH | 2017 | Rice science2017，24，6： | 8 |
| 13 | TiO2 coated urchin-like SnO2 microspheres for efficient dye-sensitized solar cells显示文摘 | Amit Thapa Jiantao Zai Hytham Elbohy Prashant Poudel Nirmal Adhikari Xuefeng Qian Qiquan Qiao | 2014 | Nano Research2014，7，8： | 7 |
| 14 | Spectroscopic analysis on the binding interaction of biologically active pyrimidine derivative with bovine serum albumin显示文摘A biologically active antibacterial reagent, 2–amino-6-hydroxy–4–(4-N, N-dimethylaminophenyl)-pyrimidine-5-carbonitrile(AHDMAPPC), was synthesized. It was employed to investigate the binding interaction with the bovine serum albumin(BSA) in detail using different spectroscopic methods. It exhibited antibacterial activity against Escherichia coli and Staphylococcus aureus which are common food poisoning bacteria. The experimental results showed that the fluorescence quenching of model carrier protein BSA by AHDMAPPC was due to static quenching. The site binding constants and number of binding sites(n E 1) were determined at three different temperatures based on fluorescence quenching results. The thermodynamic parameters, enthalpy change(ΔH), free energy(ΔG) and entropy change(ΔS) for the reaction were calculated to be 15.15 k J/mol, –36.11 k J/mol and 51.26 J/mol K according to van't Hoff equation, respectively. The results indicated that the reaction was an endothermic and spontaneous process, and hydrophobic interactions played a major role in the binding between drug and BSA. The distance between donor and acceptor is 2.79 nm according to F?rster's theory. The alterations of the BSA secondary structure in the presence of AHDMAPPC were confirmed by UV–visible, synchronous fluorescence, circular dichroism(CD) and three-dimensional fluorescence spectra. All these results indicated that AHDMAPPC can bind to BSA and be effectively transported and eliminated in the body. It can be a useful guideline for further drug design. | Vishwas D. Suryawansht Laxman S. Walekar Anil H. Gore Prashant V. Anbhule Govind B. Kolekar | 2016 | Journal of Pharmaceutical Analysis2016，6，1： | 7 |
| 15 | Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions显示文摘我们以前证明 Wnt3a 能刺激人的胚胎的茎(hES ) 细胞增殖并且影响房间命运决心。当 feeder cell-derivedfactors 不在时,在一个喂入器饲料分送器免费的条件下面有教养的 hES 房间糟糕幸存并且增殖。当 feeder 房间不在时的 Addingrecombinant Wnt3a 导出因素的刺激 hES 细胞增殖而且区别。在现在的学习,我们进一步扩大了我们的分析到象 Wnt1 和 Wnt5a 那样的另外的 Wntligands。当 Wnt1 作为 Wnt3a 在 hES 房间上显示了类似的效果时,在这个系统的 Wnt5ahad 小效果。当喂入器饲料分送器导出自强因素和 bFGF 也是现在时, Wnt3a 和 Wnt1 提高了无差别的 hES 房间的增长。探索可能性由激活 Wnt 发信号支持无差别的 hES 细胞的增长,在使不朽的人的成年成纤维细胞(HAFi ) 的 weoverexpressed Wnt3a 或 Wnt1 基因在比主要老鼠支持无差别的 hES 细胞的长期的生长是优异的细胞胚胎的成纤维细胞。HAFi 房间与或没有 Wnt transgene 能被宣传 Wnt3a 基因的 indefinitely.Over 表示显著地提高了 HAFi 喂入器饲料分送器房间的能力支持我们测试了的 3 根不同 hES 房间线的无差别的生长。在 Wnt3a-overpressing HAFi 房间的 threecommonly-used 药选择基因的合作表示进一步使我们能在稳定的 transfection 或转导以后选择稀罕 hES 克隆。这些使不朽的设计喂入器饲料分送器房间(W3R ) 那列合作快车象 Wnt3a 那样的支持生长的基因和三药选择基因应该授权我们高效地为基本、翻译的研究使修改 hES 房间线基因。 | Liuhong Cai Zhaohui Ye Betty Ying Zhou Prashant Mali Canquan Zhou Linzhao Cheng | 2007 | Cell Research2007，17，1： | 7 |
| 16 | 640层CT动态评估压力性尿失禁及盆腔脏器脱垂的研究显示文摘目的:女性压力性尿失禁(FSUI)和盆腔脏器脱垂(POP)是中老年女性常见的问题,本研究为了探讨640层螺旋CT(640-MSCT)诊断FSUI和POP的可能性。方法:本研究招募了62例FSUI患者(SUI组)、96例POP患者(POP组)和50例健康女性志愿者(对照组)进行640-MSCT骨盆扫描。所有志愿者和患者在排尿前、排尿时和排尿后进行扫描,然后用640-MSCT扫描图像重建3D和4D图像,由2名放射科医师进行复查。通过观察这些图像,我们测量并比较了每个时期的耻骨尾骨线(PCL)、H线、M线、PCL到膀胱颈(PCL-BN)、PCL到宫颈(PCL-c)、尿道倾斜角(UIA)和膀胱尿道后角(PUVA)。结果:本研究比较了志愿者和患者(SUI患者和POP患者)的结果。实验组和对照组中的生育状况和BMI比较差异无统计学意义(P>0.05)。结果表明,各组H线、M线排尿前、排尿及排尿后比较差异均有统计学(P<0.01,P<0.05)。各组排尿时PCL-BN和PCL-C均降低。SUI组和POP组中部分受试者排尿前PCL-BN在PCL线以下,排尿时更加明显。排尿时,POP组中PCL-C明显下降。对照组的UIA和PUVA对比SUI组和POP组在排尿时差异有统计学意义(P<0.05)。结论:采用640-MSCT的3D和4DCT图像进行SUI和POP诊断是一种敏感且具体可行的方法。 | 赵永先 杨博伟 苏云杉 Prashant Mishra 陈韬 毛崇文 刘建和 张海燕 郭海翔 王家平 刘攀 方克伟 | 2020 | 临床泌尿外科杂志2020，，5： | 7 |
| 17 | 含氨燃料预混火焰的层流火焰速度及NO排放特性显示文摘将甲烷或氢气与氨气共燃可以克服NH_(3)火焰的点火能量高、燃烧速度慢的缺点。为了解NH_(3)作为燃料的燃烧特性,对含NH_(3)燃料进行一维层流预混火焰数值模拟,研究其层流火焰速度及NO排放特性。采用文献中5个简化反应机理进行数值计算,发现Okafor机理模拟NH_(3)/CH_(4)/air火焰精度更高;Xiao机理模拟NH_(3)/H_(2)/air、NH_(3)/air精度适中,计算时间较短。此外,开展了当量比、燃料混合物组分比例、压力等参数对含NH_(3)燃料燃烧时烟气中NO浓度影响的研究。研究发现:含NH_(3)燃料燃烧时NO主要通过OH、H、O自由基和O_(2)分子的消耗而生成,主要通过与NH_(i)(i=0,1,2)自由基反应消耗;含NH_(3)燃料在富燃状态下燃烧可有效减少NO排放,但富燃燃烧效率低,可采用富燃-贫燃分级燃烧技术来提高燃烧效率,同时保持NO的低排放;掺有较多NH_(3)的含NH_(3)燃料在中高压下燃烧时可有效减少NO排放。 | 毛晨林 王平 Prashant Shrotriya 何宏凯 Antonio Ferrante | 2021 | 化工学报2021，72，10： | 6 |
| 18 | 基于强化学习的自主式水下潜器障碍规避技术(英文)显示文摘Obstacle avoidance becomes a very challenging task for an autonomous underwater vehicle(AUV)in an unknown underwater environment during exploration process.Successful control in such case may be achieved using the model-based classical control techniques like PID and MPC but it required an accurate mathematical model of AUV and may fail due to parametric uncertainties,disturbance,or plant model mismatch.On the other hand,model-free reinforcement learning(RL)algorithm can be designed using actual behavior of AUV plant in an unknown environment and the learned control may not get affected by model uncertainties like a classical control approach.Unlike model-based control model-free RL based controller does not require to manually tune controller with the changing environment.A standard RL based one-step Q-learning based control can be utilized for obstacle avoidance but it has tendency to explore all possible actions at given state which may increase number of collision.Hence a modified Q-learning based control approach is proposed to deal with these problems in unknown environment.Furthermore,function approximation is utilized using neural network(NN)to overcome the continuous states and large statespace problems which arise in RL-based controller design.The proposed modified Q-learning algorithm is validated using MATLAB simulations by comparing it with standard Q-learning algorithm for single obstacle avoidance.Also,the same algorithm is utilized to deal with multiple obstacle avoidance problems. | Prashant Bhopale Faruk Kazi Navdeep Singh | 2019 | Journal of Marine Science and Application2019，18，2： | 5 |
| 19 | 插层FeSe高温超导体的高压研究进展显示文摘通过对FeSe进行化学插层可以将其超导转变温度(T_c)从约8 K提高到40 K以上,实现高温超导电性.最近,我们对两种插层FeSe高温超导材料(Li_(0.84)Fe_(0.16))OHFe_(0.98)Se和Li_(0.36)(NH_3)_yFe_2Se_2开展了高压调控研究,发现压力会首先抑制高温超导相(称为SC-I相),然后在临界压力P_c以上诱导出第二个高温超导相(称为SC-Ⅱ相),呈现出双拱形T-P超导相图.这两个体系的P_c分别约为5和2 GPa,两个体系SC-Ⅱ相的最高T_c分别可以达到约52和55 K,比相应SC-I相的初始T_c提高了10 K.对(Li_(0.84)Fe_(0.16))OHFe_(0.98)Se的正常态电输运性质分析表明,SC-Ⅰ和SC-Ⅱ相的正常态分别具有费米液体和非费米液体行为,意味着这两个超导相可能存在显著差异.此外,还发现这两个体系的SC-Ⅱ相的T_c与霍尔系数倒数1/R_H (∝载流子浓度n_e)具有很好的线性依赖关系.对(Li_(0.84)Fe_(0.16))OHFe_(0.98)Se的高压X射线衍射测量排除了其在10 GPa以内发生结构相变的可能,因此P_c以上SC-Ⅱ相的出现和载流子浓度的增加很可能起源于压力导致的费米面重构. | 孙建平 Prashant Shahi 周花雪 倪顺利 王少华 雷和畅 王铂森 董晓莉 赵忠贤 程金光 | 2018 | 物理学报2018，67，20： | 4 |
| 20 | COVID-19 and the liver: What do we know so far?显示文摘The coronavirus disease 2019(COVID-19)pandemic has caused unprecedented pressure on public health and healthcare.The pandemic surge and resultant lockdown have affected the standard-of-care of many medical conditions and diseases.The initial uncertainty and fear of cross transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have changed the routine management of patients with pre-existing liver diseases,hepatocellular carcinoma,and patients either listed for or received a liver transplant.COVID-19 is best described as a multisystem disease caused by SARS-CoV-2,and it can cause acute liver injury or decompensation of the pre-existing liver disease.There has been considerable research on the pathophysiology,infection transmission,and treatment of COVID-19 in the last few months.The pathogenesis of liver involvement in COVID-19 includes viral cytotoxicity,the secondary effect of immune dysregulation,hypoxia resulting from respiratory failure,ischemic damage caused by vascular endotheliitis,congestion because of right heart failure,or drug-induced liver injury.Patients with chronic liver diseases,cirrhosis,and hepatocellular carcinoma are at high risk for severe COVID-19 and mortality.The phase Ⅲ trials of recently approved vaccines for SARS-CoV-2 did not include enough patients with pre-existing liver diseases and excluded immunocompromised patients or those on immunomodulators.This article reviews the currently published research on the effect of COVID-19 on the liver and the management of patients with pre-existing liver disease,including SARS-CoV-2 vaccines. | Prashant Nasa George Alexander | 2021 | World Journal of Hepatology2021，13，5： | 4 |
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