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| 1 | 英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。 | Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) | 2020 | 中华胃肠内镜电子杂志2020，7，2： | 10 |
| 2 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 3 | Optoelectronic properties and Seebeck coefficient in SnSe thin films显示文摘SnSe thin films of thickness 180 nm have been deposited on glass substrates by reactive evaporation at an optimized substrate temperature of 523 ± 5 K and pressure of 10^(-5) mbar.The as-prepared SnSe thin films are characterized for their structural,optical and electrical properties by various experimental techniques.The p-type conductivity,near-optimum direct band gap,high absorption coefficient and good photosensitivity of the SnSe thin film indicate its suitability for photovoltaic applications.The optical constants,loss factor,quality factor and optical conductivity of the films are evaluated.The results of Hall and thermoelectric power measurements are correlated to determine the density of states,Fermi energy and effective mass of carriers and are obtained as 2.8×10^(17)cm^(-3),0.03 eV and 0.05m_0 respectively.The high Seebeck coefficient ≈ 7863 μV/K,reasonably good power factor ≈7.2×10^(-4) W/(m·K^2) and thermoelectric figure of merit ≈1.2 observed at 42 K suggests that,on further work,the prepared SnSe thin films can also be considered as a possible candidate for cryogenic thermoelectric applications. | K S Urmila T A Namitha J Rajani R R Philip B Pradeep | 2016 | Journal of Semiconductors2016，37，9： | 2 |
| 4 | Dose--related effect of propofol on pancreatic enzymes and triglyceride levels in patients undergoing non-- abdominal surgery显示文摘 | Pradeep K Wig J Panda N B | 2009 | Anaesth Intensive Care2009，37，1： | 1 |
| 5 | The promoting effect of MgO layer in sensitized photodegradation of colorants on TiO2/MgO composite oxide显示文摘 | Bandara J Kuruppu S S Pradeep U W | 2006 | Colloids and Surfaces A:Physicochem Eng Aspects2006，276，： | 1 |
| 6 | Dual polarized microstrip patch antennas for ultra-wideband applications 显示文摘 | PRADEEP K MASA-CAMPOS J L | 2014 | Microwave Opt Technol Lett2014，56，9： | 1 |
| 7 | Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling显示文摘 | Pradeep C R Kstler W J Lauriola M | 2012 | Oncogene2012，31，7： | 1 |
| 8 | Development of dimethylsiloxane based tetraglycidyl epoxy nanocomposites for high performance, aerospace and advanced engineering applications 显示文摘 | Shree Meenakshi K Pradeep Jaya Sudhan E Ananda Kumar S Umapathy M J | 2012 | Progress in Organic Coatings2012，74，1： | 1 |
| 9 | Chemical Composition and Antibacterial Activity of the Leaf, Bark and Fruit Oils of Neolitsea fischeri Gamble显示文摘 | John A J George V Pradeep N S | 2008 | Journal of Essential Oil Research2008，20，3： | 1 |
| 10 | Assessment of organochlorine pesticide residue levels in dairy milk and buffalo mild from Jaipur City, Rajasthan, India 显示文摘 | John P J Neela B Pradeep B | 2001 | Environmental International2001，26，4： | 1 |
| 11 | An efficient primary-segmented backup scheme for dependable real-time communication in multihop networks显示文摘 | GUMMADI K P PRADEEP M J MURTHY C S R | 2003 | IEEE/ACM Transactions on Networking2003，11，1： | 1 |
| 12 | Caryophyllene-rich rhizome oil of Zingiber nimmonii from South India: Chemical characterization and antimicrobial activity显示文摘 | Baby Sabulal Mathew Dan Anil John J Rajani Kurup Nediyamparambu Sukumaran Pradeep Renju Krishna Valsamma Varughese George | 2006 | Phytochemistry2006，，22： | 1 |
| 13 | Runoff quality analysis of urban catchments with analytical proba-bilistic model 显示文摘 | Pradeep K Behera Barry J A dams James Y Li | 2006 | Journal of Water Resources Planning and Management2006，132，1： | 1 |
| 14 | Ion/Surface Reactions at Monolayers in Solution:A Combined Surface Enhanced Raman-X-Ray Photoelectron Spectroscopic Investigation of the Chemical Modification of a 2-Mercaptobenzothiazole Monolayer on Polycrystalline Au Films显示文摘 | Pradeep T J | 1999 | Colloid Interface Sci1999，218，： | 1 |
| 15 | Determination of thickness, re-fractive index, and spectral scattering of an inhomoge-neous thin film with rough interfaces 显示文摘 | Pradeep J A Agarwal P | 2010 | Journal of Ap-plied Physics2010，108，43： | 1 |
| 16 | Modeling and Simulation Methods for Design of Engineering Systems 显示文摘 | Rajarishi Sinha Christiaan J J Parodis Vei-Chung Liang Pradeep K Khosla | 2001 | Journal of Computing and Information Science in Engineering (S1530-9827)2001，1，1： | 1 |
| 17 | 显示文摘 | Bandara J Kuruppu S S Pradeep U W | 2006 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2006，276，： | 1 |
| 18 | Effects of triploidy induction on growth and masculinization of red tilapia 显示文摘 | PRADEEP P J SRIJAYA T C PAPINI A | 2012 | Aquaculture2012，，： | 1 |
| 19 | Synthesis and CNS depressant activity of some novel 3- -2-styryl quinazoline-4 (3H) - ones 显示文摘 | Varsha J Pradeep M Sushil K | 2008 | European Journal of Medicinal Chemistry2008，43，： | 1 |
| 20 | Evaluation of single-stage adjustable strabismus surgery under conscious sedation显示文摘 | PRADEEP S ANURAG J RITU G | | 0，，02： | 1 |
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