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| 1 | Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats显示文摘AIM: To investigate the role of oxidative injury and the effect of exogenous melatonin administration on liver damage induced by bile duct ligation (BDL), and second,to evaluate the role of nitric oxide (NO), a free oxygen radical, in oxidative injury.METHODS: Thirty-two Sprague-Dawley rats were assigned to four groups: sham operation (SO), BDL, BDL+melatonin,and BDL+vehicle. Cholestasis was achieved by double ligature of the common bile duct. Melatonin was injected intraperitoneally 500 μg/(kg.d) for 8 d. Hepatic oxidative stress markers were evaluated by changes in the amount of lipid peroxides, measured as malondialdehyde (MDA),and reduced GSH. Total nitrite (NOx) concentrations were determined in hepatic homogenates. Histopathological examination was performed using a histological scoring system.RESULTS: The histopathological changes including portal inflammation, necrosis, apoptosis, focal inflammation and fibrosis were severe in the BDL and BDL+vehicle groups. There were numerous large areas of coagulation necrosis. Histological Activity Index scores of these groups were significantly higher than that of the SO group. Treatment with melatonin reduced these alterations significantly. The degree of necro-infiammation and fibrosis showed significant difference between the BDL and BDL+melatonin groups. BDL was accompanied by a significant increase in MDA and NOx, and a significant decrease in GSH levels. Mean±SE values of MDA, GSH and NOx levels of SO group were 147.47±6.69, 0.88±0.33 μmol/g and 180.70±6.58 nm/g, respectively. The values of BDL group were 200.14±21.30, 0.65±0.02 μmol/g, and 400.46±48.89 nm/g, respectively, whereas the values of BDL+melatonin group were 115.93±6.8, 0.74±0.02 μmol/g,and 290.38±32.32 nm/g, respectively. Melatonin treatment was associated with a significant recovery of MDA, GSH and NOx levels.CONCLUSION: We have concluded that oxidative stress is associated with the pathogenesis of cholestatic liver damage and NO contributes to oxidative damage. Melatonin,even at low dose, is an efficient agent in reducing negative parameters of cholestasis. | Mukaddes Esrefoglu Mehmet Gül Memet Hanifi Emre Alaattin Polat Mukadder Ayse Selimoglu | 2005 | World Journal of Gastroenterology2005，11，13： | 6 |
| 2 | Precontoured buttress plate vs reconstruction plate for acetabulum posterior wall fractures: A biomechanical study显示文摘BACKGROUND The purpose of open reduction and internal fixation of acetabulum posterior wall fractures is to restore anatomical structure and stability of the hip joint, in order to start weight bearing as soon as possible and prevent hip arthrosis; restoration of the anatomy should preserve function of the joint as well. Although 'special shaped precontoured plates' have been developed in recent years for surgical treatment of this region, studies comparing the traditional plates with the newly designed precontoured plates are lacking.AIM To evaluate the biomechanical properties of precontoured anatomic buttress and conventional curved reconstruction plates(CCRPs) for posterior wall acetabulum fracture treatment.METHODS Twelve pelvis models were created for testing plate treatment of fracture in the posterior wall of the acetabulum. These 12 pelvis models were used to create 24 hemipelvis models(experimental) by cutting from the sagittal plane and passing over the center of gravity, after which the posterior wall acetabular fractures(of similar type and size) were created. In these experimental models, the right acetabulum was fixed with a 5-hole CCRP, while the left was fixed with a precontoured anatomic buttress plate(PABP). Samples were placed through thetest device and were subjected to static load testing, with a constant testing velocity of 2 mm/min until the load reached 2.3 kN or the acetabular fixation failed. Dynamic tests were also performed with sinusoidal wave load, with a maximal load of 2.3 kN and a load ratio of 0.1.RESULTS The average stiffness values were 460.83 ± 95.47 N/mm for the PABP and 291.99± 118.58 N/mm for the 5-hole CCRP. The precontoured anatomic acetabulum buttress plates had significantly higher rigidity than the CCRPs(P = 0.022). There was a statistically significant difference between the unloaded and 2.3 kN-loaded values of AL(posterosuperior fracture line vertical to the ground surface) and CL(posteroinferior fracture line vertical to the ground surface) parameters for both the PABPs and the 5-hole CCRPs(P = 0.036 and P = 0.045, respectively).According to the static tests, the amount of total displacement was significantly less in the PABPs than in the CCRPs. Comparative analysis of the displacement in the BL(posterior wall fracture line horizontal to the ground) parameter yielded no statistically significant differences between the PABP and the 5-hole CCRPs(P= 0.261).CONCLUSION PABP provides more stable fixation in acetabulum posterior wall fractures than5-hole CCRP, allowing for proximal or distal fracture line screw application without reshaping. | Güray Altun Gürsel Saka Teyfik Demir Fatma Kübra Erbay Elibol Mehmet Or?un Polat | 2019 | World Journal of Orthopedics2019，10，5： | 3 |
| 3 | Thermal and microstructural characterization of a novel ductile cast iron modified by aluminum addition显示文摘In high-temperature applications,like exhaust manifolds,cast irons with a ferritic matrix are mostly used.However,the increasing demand for higher-temperature applications has led manufacturers to use additional expensive materials such as stainless steels and Ni-resist austenitic ductile cast irons.Thus,in order to meet the demand while using low-cost materials,new alloys with improved high-temperature strength and oxidation resistance must be developed.In this study,thermodynamic calculations with Thermo-Calc software were applied to study a novel ductile cast iron with a composition of 3.5wt%C,4wt%Si,1wt%Nb,0‒4wt%Al.The designed compositions were cast,and thermal analysis and microstructural characterization were performed to validate the calculations.The lowest critical temperature of austenite to pearlite eutectoid transformation,i.e.,A1,was calculated,and the solidification sequence was determined.Both calculations and experimental data revealed the importance of aluminum addition,as the A1 increased by increasing the aluminum content in the alloys,indicating the possibility of utilizing the alloys at higher temperature.The experimental data validated the transformation temperature during solidification and at the solid state and confirmed the equilibrium phases at room temperature as ferrite,graphite,and MC-type carbides. | Gülsah Aktas Celik Maria-Ioanna TTzini Seyda Polat SHakan Atapek Gregory NHaidemenopoulos | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，2： | 2 |
| 4 | Efficacy of a Modified Sequential Therapy Including Bismuth Subcitrate as First‐Line Therapy to Eradicate H elicobacter pylori in a Turkish Population显示文摘 | Ahmet Uygun A. Melih OZEL Bulent Sivri Zulfikar Polat Halil Gen? Yusuf Serdar Sakin Gürkan ?elebi Oya Uygur‐Bayrami?li Cemal Nuri Er?in Abdurrahman Kadayif?i Ozdes Emer Armagan Gunal Sait Bagci | 2012 | Helicobacter2012，，6： | 2 |
| 5 | Synthesis and characterization of Dy-Eu-Tm co-doped cubic phase stabilized bismuth oxide based electrolytes in terms of intermediate temperature-solid oxide fuel cells(IT-SOFCs)显示文摘In this study,a new Dy-Eu-Tm co-doped cubic phase stabilized bismuth oxide solid electrolyte system was synthesized by using solid-state reaction method in atmospheric conditions.Before conductivity measurements,X-ray diffraction(XRD)pro files of the annealed samples show that created mixtures have heterogeneous phase,but after conductivity measurements,the face-centered cubic(FCC)crystal structure is stabilized for all samples.Also,the increase in total dopant rate causes an increase in full width half maxima(FWHM)of main peak(111)on the XRD pattern while average crystal size decreases with it.On the other hand,the highest conductivity value was obtained for the sample having 15%total dopant rate with 0.62 S/cm at 750℃,whose dopants are evenly distributed in mole percent.Differential thermal analysis(DTA)results of the samples having 1:1:1 and 1:2:1 dopant content ratios show that endothermic peak occurs on their DTA curve,indicating crystal structure transformation such as phase transition or order-disorder transition.Also,thermo-gravimetric analysis(TGA)depending on temperature was evaluated in terms of mass loss.According to TGA curves,mass loss for both heating and cooling process can be negligible due to the small fluctuations(2%)on their TGA curves. | Ayhan Güldeste Mustafa Aldoori Murat Balci Mehmet Ari Yasin Polat | 2023 | Journal of Rare Earths2023，41，3： | 2 |
| 6 | Elevated plasma endothelin-l levels in coronary sinus during rapid right atrial pacing in pa-tients with slow coronary flow显示文摘 | Pekdemir H Polat G Cin VG | 2004 | Int J Cardiol2004，，97： | 1 |
| 7 | The prognostic value of D-dimer in lung cancer 显示文摘 | INAL T ANAR C POLAT G | 2015 | Clin Respir J2015，9，3： | 1 |
| 8 | Admission levels of C-ctireprotein and plasminogen activator inhibitor-1in patients with acute myocardial infarction with and without eardiogenie shock or heart failure on admission显示文摘 | Akkus MN Polat G Yurtdas M et a1 | 2009 | Int Heart J2009，50，1： | 1 |
| 9 | Ganglioneuroma mimicking ovarian tumor: a report of a case and review of the ganglioneuromas显示文摘 | Murat Gültekin Polat Dursun Coskun Salman ?zgür ?zyüncü Arzu Saglam Türkan Kü?ükali Ali Ayhan | 2005 | Archives of Gynecology and Obstetrics2005，，1： | 1 |
| 10 | Removing intranasal splints after septal surgery显示文摘 | AKSOY E SERIN G M POLAT S | 2011 | J Craniofac Surg2011，22，： | 1 |
| 11 | Admission levels of C- reactive protein and plasminogen activator inhibitor-1 in pa- tients with acute myocardial infarction with and without car- diogenic shock or heart failure on admission 显示文摘 | Akkus M N Polat G Yurtdas M | 2009 | Int Heart J2009，50，1： | 1 |
| 12 | CT in Differential Diagnosis of Benign and Malignant Pleural Disease显示文摘 | Yilmaz U Polat G Sahin N | 2005 | Monaldi Arch Chest Dis2005，63，1： | 1 |
| 13 | Elevated plasma endothelin levels in coronary sinus during rapidright atrialpacing in patients with slow coronary flow显示文摘 | Pekdenir H Polat G Cin VG | 2004 | Int J Cardio2004，97，3： | 1 |
| 14 | Dexamethasone dowmregulates endothelial expression of intercellular adhesion molecule and impairs the healing of bowel anastomoses显示文摘 | Polat A Nayci A Polat G | 2002 | Eur J Surg2002，168，： | 1 |
| 15 | The relation ofbruxism and dermatoglyphics显示文摘 | Polat M H Azak A Evlioglu G | 2000 | J Clin Pediatr Dent2000，24，3： | 1 |
| 16 | Study of axial bone mineral density in postmenopausal women with diffuse idiopathic skeletal hyperostosis related to type 2 diabetes mellitus显示文摘 | Sahin G Polat G Bagis S | 2002 | J Womens Health (Larchmt)2002，11，9： | 1 |
| 17 | Posterior fossa epidural bematomas observation on a series of 73 cases显示文摘 | Bozbuga M Jzgi N Polat G | 1999 | Neurosurg ReV1999，22，7： | 1 |
| 18 | Admission levels of C-reactive protein and plasminogen activator inhibitor-1 in patients with acute myocardial infarction with and without cardiogenic shock or heart failure on admission显示文摘 | Akkus MN Polat G Yurtdas M | 2009 | Int Heart J2009，50，： | 1 |
| 19 | Elevated plasma endothelin-1 levels in coronary sinus during rapid right atrial pacing in patients with slowcoronary flow显示文摘 | Pekdemir H Polat G Cin VG | 2004 | Int J Cardiol2004，97，1： | 1 |
| 20 | Removing intranasal splints after septal surgery显示文摘 | AKSOY E SERIN G M POLAT S | 2011 | J Craniofacial Surg2011，22，： | 1 |
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