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| 1 | Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?显示文摘AIM: To determine the association between the neutrophil to lymphocyte(N/L) ratio and the degree of liver fibrosis in patients with chronic hepatitis B(CHB) infection. METHODS: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver fibrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the 'no/minimal liver fibrosis' group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the 'advanced liver fibrosis' group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically significant.RESULTS: Three experienced and blinded pathologists evaluated the fibrotic status and inflammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the 'no/minimal fibrosis' group included 79 individuals, while the 'advanced fibrosis' group included 50 individuals. Mean(N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal fibrosis.CONCLUSION: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB. | Murat Kekilli Alpaslan Tanoglu Yusuf Serdar Sakin Mevlut Kurt Serkan Ocal Sait Bagci | 2015 | World Journal of Gastroenterology2015，21，18： | 15 |
| 2 | Association of a genetic variant in AKT1 gene with features of the metabolic syndrome显示文摘Metabolic syndrome(MetS)is a clustering of metabolic abnormalities that is associated with increased risk of developing cardiovascular disease and type 2 diabetes.There is growing body of data showing the associations of genetic variants of the genes involved in the PI3K/AKT/mTOR pathway with diabetes and obesity.We aimed to investigate the association between MetS and its components with the genetic polymorphism in AKT1,rs1130233(T>C).Total of 618 participants,recruited from Mashhad stroke and heart atherosclerosis disorder cohort(MASHAD study).Patients with MetS were defined by using international diabetes federation(IDF)criteria(n Z 326)and those without MetS(n Z 261)were recruited.Anthropometric and biochemical parameters were measured in all subjects.Genetic analysis for the rs1130233 polymorphism was performed,using the ABI-StepOne instruments with SDS version-2.0 software.Individuals with MetS had a significantly higher levels of BMI,waistcircumference,total cholesterol,triglyceride,high sensitivity-c reactive protein(hs-CRP)and blood-pressure,and lower concentrations of high density lipoprotein(HDL-C),compared to non-MetS individuals(P<0.05).The association between the rs1130233 and MetS was not significant.Subjects with a CC or CT genotypes had a significantly higher serum hs-CRP-level(OR:1.5;95%CI(1.05e2.1),P Z 0.02).Additionally,subjects who carried the TC genotype had a higher BMI compared to the CC genotype(p value Z 0.045).Our findings demonstrated that AKT1,rs1130233(T>C)polymorphism was associated with major components of MetS such as hs-CRP,and BMI,indicating further investigation in a multi-center setting to explore its value as an emerging biomarker of risk stratification marker. | Fateme Sadat Eshaghi Hamideh Ghazizadeh Sakine Kazami-Nooreini Ameneh Timar Habibollah Esmaeily Mehrane Mehramiz Amir Avan Majid Ghayour-Mobarhan | 2019 | Genes & Diseases2019，6，3： | 6 |
| 3 | Analysis of the high-temperature dry sliding behavior of CoCrFeNiTi0.5Alx high-entropy alloys显示文摘In this study,CoCrFeNiTi0.5Alx high‐entropy alloys were produced by induction melting and their dry sliding wear behavior was examined at different temperatures.In addition to face‐centered cubic(FCC)phases,low amounts of a tetragonal phase were detected in the microstructures of alloys without Al and microscratches were formed by wear particles on the worn surfaces of the alloy specimens.Two body‐centered cubic(BCC)phases were detected in the alloy with 0.5Al and a fatigue‐related extrusion wear mechanism was detected on the worn surface.The alloy specimen with a high Al content exhibited the best wear characteristics.No wear tracks were formed in single‐phase BCC intermetallic alloys at room temperature and they exhibited a higher wear strength at high temperatures when compared to other samples. | Azmi ERDOGAN Mustafa Sabri GOK Sakin ZEYTIN | 2020 | Friction2020，8，1： | 5 |
| 4 | Efficacy of a Modified Sequential Therapy Including Bismuth Subcitrate as First‐Line Therapy to Eradicate H elicobacter pylori in a Turkish Population显示文摘 | Ahmet Uygun A. Melih OZEL Bulent Sivri Zulfikar Polat Halil Gen? Yusuf Serdar Sakin Gürkan ?elebi Oya Uygur‐Bayrami?li Cemal Nuri Er?in Abdurrahman Kadayif?i Ozdes Emer Armagan Gunal Sait Bagci | 2012 | Helicobacter2012，，6： | 2 |
| 5 | Combined orthodontic and surgical therapy for a deeply impacted third molar related with a dentigerous cyst显示文摘 | Celebi N Canakci GY Sakin C | 2015 | J Maxillofac Oral Surg2015，14，1： | 1 |
| 6 | Antiperoxidative and anti-apoptotic effects of lycopene and ellagic acid on cyclophosphamide-induced testicular lipid peroxidation and apoptosis显示文摘 | Türk G Ceriba(s)i AO Sakin F | 2010 | Reprod Fertil Dev2010，22，4： | 1 |
| 7 | An investigation of bending fatigue behavior for glass-fiber reinforced polyester composite materials显示文摘 | SAKIN R AY I YAMAN R | 2008 | Materials & Design2008，29，1： | 1 |
| 8 | Angiotensin converting enzymeI/D, angiotensinogen M235T and AT1-R A/Cl 166 genepolymorphisms in patients with acromegly显示文摘 | Turgut SAkin F Akcilar R | 2011 | Mol Biol Rep2011，38，1： | 1 |
| 9 | Chemiluminescence in soybean root tissue: effect of various substrates and inhibitors显示文摘 | SAKIN M L BRIDGES S M | 1983 | Photobiochem and Photobioph ys1983，6，： | 1 |
| 10 | Prognostic significance of primary tumor localization in stage Ⅱ and Ⅲ colon cancer显示文摘IM To investigate the effects of tumor localization on disease free survival(DFS) and overall survival(OS) in patients with stage Ⅱ-Ⅲ colon cancer.METHODS This retrospective study included 942 patients with stage Ⅱ and Ⅲ colon cancer, which were followed up in our clinics between 1995 and 2017. The tumors from the caecum to splenic flexure were defined as right colon cancer(RCC) and those from splenic flexure to the sigmoid colon as left colon cancer(LCC).RESULTS The median age of the patients was 58 years(range: 19-94 years). Male patients constituted 54.2%. The rates of RCC and LCC were 48.4%(n = 456) and 51.6%(n = 486), respectively. During the median follow-up of 90 mo(range: 6-252 mo), 14.6% of patients developed recurrence and 9.1% of patients died. In patients with stage Ⅱ and Ⅲ disease with or without adjuvant therapy, DFS was similar in terms of primary tumor localization(stage Ⅱ; P = 0.547 and P = 0.481, respectively; stage Ⅲ; P = 0.976 and P = 0.978, respectively). In patients with stage Ⅱ and Ⅲ disease with or without adjuvant therapy, OS was not statistically significant with respect to primary tumor localization(stage Ⅱ; P = 0.381 and P = 0.947, respectively; stage Ⅲ; P = 0.378 and P = 0.904, respectively). The difference between median OS of recurrent RCC(26 ± 6.2 mo) and LCC(34 ± 4.9 mo) cases was eight months(P = 0.092).CONCLUSION Our study showed no association of tumor localization with either DFS or OS in patients with stage Ⅱ or Ⅲ colon cancer managed with or without adjuvant therapy. However, post-recurrence OS appeared to be worse in RCC patients. | Abdullah Sakin Serdar Arici Saban Secmeler Orcun Can Caglayan Geredeli Nurgul Yasar Cumhur Demir Osman Gokhan Demir Sener Cihan | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 1 |
| 11 | Determination of lead, cadmium and arsenic in infusion tea cultivated in north of Iran显示文摘 | Sakine S Mahboobeh G Azita M | 2012 | Iranian Journal of Environmental Health Sciences & Engineering2012，9，： | 1 |
| 12 | An investigation of bending fatigue behavior for glass-fiber reinforced polyester composite materials 显示文摘 | Raif Sakin Irfan Ay Ramazan Yaman | 2008 | Materials and design2008，29，1： | 1 |
| 13 | Purification of a manganese containing superoxide dismutase from Halo bacterium halobium显示文摘 | Sakin M L Oesterhelt D | 1998 | Archives of Biochemistry and Biophysics1998，260，2： | 1 |
| 14 | Mutant pS3 (R175H) upregulates Twistl expression and promotes epithelial -mesenchymaltransition in immortalized prostate cells显示文摘 | Kogan -Sakin I Tmch Y Buganim Y | 2011 | Cell Death Differ2011，18，2： | 1 |
| 15 | Robust control with rejection of harmonic disturbances 显示文摘 | Sakin A V Petrsen I R | 1995 | IEEE Transactions on Automatic Control1995，40，： | 1 |
| 16 | Effect of different tillage systems on the quality and crop productivity of a clay-loam soil in semi-arid northwestern Turkey显示文摘 | Sakine Ozpinar Anil Cay | 2006 | Soil and Tillge Research2006，，88： | 1 |
| 17 | Transfer of stripe resistance gene Yr26 to Turkish wheats using microsatellite markers显示文摘 | YILDIRIM A KARADAG Y SAKIN M A | 2004 | Cereal Research Communication2004，31，1： | 1 |
| 18 | Robust Control with Rejection of Harmonic Disturbances 显示文摘 | Sakin A V Petrsen I R | 1995 | IEEE Trans on Automatic Control1995，40，11： | 1 |
| 19 | Growth Morphology and Phase Analysis of Titanium Based Coating Produced hy Thermo Chemical Method显示文摘 | USTEL Fatih ZEYTIN Sakin | 2006 | Vacuum2006，81，3： | 1 |
| 20 | Statistical analysis of bending fatigue life data using Weibull distribution in glass-fiber reinforced polyester composites显示文摘 | Sakin Raif Ay Irfan | 2008 | Mater Des2008，29，6： | 1 |
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