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| 1 | Systematic review of surgical resection vs radiofrequency ablation for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) represents one of the most common neoplasms worldwide. Surgical resection and local ablative therapies represent the most frequent first lines therapies adopted when liver transplantation can not be offered or is not immediately accessible. Hepatic resection (HR) is currently considered the most curative strategy, but in the last decade local ablative therapies have started to obtain satisfactory results in term of efficacy and, of them, radiofrequency ablation (RFA) is considered the reference standard. An extensive literature review, from the year 2000, was performed, focusing on results coming from studies that directly compared HR and RFA. Qualities of the studies, characteristics of patients included, and patient survival and recurrence rates were analyzed. Except for three randomized controlled trials (RCT), most studies are affected by uncertain methodological approaches since surgical and ablated patients represent different populations as regards clinical and tumor features that are known to affect prognosis. Unfortunately, even the available RCTs report conflicting results. Until further evidences become available, it seems reasonable to offer RFA to very small HCC (< 2 cm) with no technical contraindications, since in this instance complete necrosis is most likely to be achieved. In larger nodules, namely > 2 cm and especially if > 3 cm, and/or in tumor locations in which ablation is not expected to be effective or safe, surgical removal is to be preferred. | Alessandro Cucchetti Fabio Piscaglia Matteo Cescon Giorgio Ercolani Antonio Daniele Pinna | 2013 | World Journal of Gastroenterology2013，19，26： | 40 |
| 2 | Current concepts in hepatic resection for hepatocellular carcinoma in cirrhotic patients显示文摘Hepatocellular carcinoma(HCC) is one of the most frequent neoplasms worldwide and in most cases it is associated with liver cirrhosis.Liver resection is considered the most potentially curative therapy for HCC patients when liver transplantation is not an option or is not immediately accessible.This review is aimed at investigating the current concepts that drive the surgical choice in the treatment of HCC in cirrhotic patients;Eastern and Western perspectives are highlighted.An extensive literature review of the last two decades was performed,on topics covering various aspects of hepatic resection.Early post-operative and long-term outcome measures adopted were firstly analyzed in an attempt to define an optimal standardization useful for research comparison.The need to avoid the development of post-hepatectomy liver failure represents the 'conditio sine qua non' of surgical choice and the role of the current tools available for the assessment of liver function reserve were investigated.Results of hepatic resection in relationship with tumor burden were compared with those of available competing strategies,namely,radiofrequency ablation for early stages,and trans-arterial chemoembolization for intermediate and advanced stages.Finally,the choice for anatomical versus non-anatomical,as well as the role of laparoscopic approach,was overviewed.The literature review suggests that partial hepatectomy for HCC should be considered in the context of multi-disciplinary evaluation of cirrhotic patients.Scientific research on HCC has moved,in recent years,from surgical therapy toward non-surgical approaches and most of the literature regarding topics debated in the present review is represented by observational studies,whereas very few well-designed randomized controlled trials are currently available;thus,no robust recommendations can be derived. | Alessandro Cucchetti Matteo Cescon Franco Trevisani Antonio Daniele Pinna | 2012 | World Journal of Gastroenterology2012，18，44： | 22 |
| 3 | 'Charge while driving'for electric vehicles:road traffic modeling and energy assessment显示文摘The aim of this research study is to present a method for analyzing the performance of the wireless inductive charge-while-driving(CWD)electric vehicles,from both traffic and energy points of view.To accurately quantify the electric power required from an energy supplier for the proper management of the charging system,a traffic simulation model is implemented.This model is based on a mesoscopic approach,and it is applied to a freight distribution scenario.Lane changing and positioning are managed according to a cooperative system among vehicles and supported by advanced driver assistance systems(ADAS).From the energy point of view,the analyses indicate that the traffic may have the following effects on the energy of the system:in a low traffic level scenario,the maximum power that should be supplied for the entire road is simulated at approximately 9 MW;and in a high level traffic scenario with lower average speeds,the maximum power required by the vehicles in the charging lane increases by more than 50%. | Francesco Paolo DEFLORIO Luca CASTELLO Ivano PINNA Paolo GUGLIELMI | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，2： | 10 |
| 4 | 氯菊酯和溴氰菊酯对大鼠血清及脑甲状腺激素水平的影响显示文摘目的探讨拟除虫菊酯对大鼠甲状腺激素(TH)水平的影响。方法经口连续15d给予大鼠氯菊酯(PM)100、200、400mg·kg-1·d-1和溴氰菊酯(DM)6.25、12.50、25.00mg·kg-1·d-1。用放射免疫分析法检测大鼠血清、脑组织及其亚细胞结构中的TH水平。结果(1)PM:200、400mg·kg-1·d-1组大鼠血清三碘甲腺原氨酸(T3)、四碘甲腺原氨酸(T4)、游离T3(fT3)、游离T4(fT4)均下降,而促甲状腺激素(TSH)上升,且现PM呈现剂量依赖关系(T4:r=0.679,fT4:r=0.511,TSH:r=0.738,均P<0.01);100mg·kg-1·d-1组大鼠T4和fT4下降,T3、fT3、TSH无明显变化。3个处理组大鼠大脑皮层T4分别为(39.9±5.0)、(33.4±9.2)、(32.3±8.2)pg/mgpro,明显低于对照[(44.2±7.1)g/mgpro],且有剂量依赖性(r=0.529,P<0.01);而PM染毒400mg·kg-1·d-1组的T3[(21.2±5.2)pg/mgpro比对照[(30.9±10.0)pg/mgpro]明显降低。200、400mg·kg-1·d-1组大鼠海马T4为(19.1±5.5)、(19.2±6.5)pg/mgpro。 | 王素青 石年 纪之莹 Graziano Pinna | 2002 | 中华劳动卫生职业病杂志2002，20，3： | 9 |
| 5 | Liver transplantation for hepatocellular carcinoma:Role of inflammatory and immunological state on recurrence and prognosis显示文摘Criteria for liver transplantation(LT)for hepatocellular carcinoma(HCC)and post-LT indicators of prognosis are historically based on the measurement of the tumor mass.Recently,high throughput technologies have increased the prediction of recurrence,but these tools are not yet routinely available.The interaction between HCC and the immune system has revealed an imbalance of lymphocyte phenotypes in the peritumoral tissue,and the increase of regulatory T cells with respect to cytotoxic lymphocytes has been linked to a higher rate of post-LT HCC recurrence.Moreover,some inflammatory markers have shown good reliability in predicting cancer reappearance after surgery,as a result of either a systemic inflammatory response or a decreased capacity of the organism to control the tumor growth.Among these markers,the neutrophil-tolymphocyte ratio appears to be the most promising and easily available serum parameter able to predict HCC recurrence after LT and following other types of treatment,although the exact mechanisms determining its elevation have not been clarified.Post-LT immunosuppression may impact on cancer control,and the exposure to high levels of calcineurin inhibitors or other immunusuppressants has recently emerged as a negative prognostic factor for HCC recurrence and patient survival.Despite the absence of prospective randomized trials,inhibitors of the mammalian target of rapamycin have been shown to be associated with lower rates of tumor recurrence compared to other immunosuppressors,suggesting their use especially in patients with HCC exceeding the conventional indication criteria for LT. | Matteo Cescon Valentina Rosa Bertuzzo Giorgio Ercolani Matteo Ravaioli Federica Odaldi Antonio Daniele Pinna | 2013 | World Journal of Gastroenterology2013，19，48： | 8 |
| 6 | Liver transplantation for hepatic tumors:a systematic review显示文摘Improvements in the medical and pharmacological management of liver transplantation(LT)recipients have led to a better long-term outcome and extension of the indications for this procedure.Liver tumors are relevant to LT;however,the use of LT to treat malignancies remains a debated issue because the high risk of recurrence.In this review we considered LT for hepatocellular carcinoma(HCC),cholangiocarcinoma(CCA),liver metastases(LM)and other rare tumors.We reviewed the literature,focusing on the past 10 years.The highly selected Milan criteria of LT for HCC(single nodule<5 cm or up to 3 nodules<3cm)have been recently extended by a group from the University of S.Francisco(1 lesion<6.5 cm or up to3 lesions<4.5 cm)with satisfying results in terms of recurrence-free survival and the'up-to-seven criteria'.Moreover,using these criteria,other transplant groups have recently developed downstaging protocols,including surgical or loco-regional treatments of HCC,which have increased the post-operative survival of recipients.CCA may be treated by LT in patients who cannot undergo liver resection because of underlying liver disease or for anatomical technical challenges.A well-defined protocol of chemoirradiation and staging laparotomy before LT has been developed by the Mayo Clinic,which has resulted in long term diseasefree survival comparable to other indications.LT for LM has also been investigated by multicenter studies.It offers a real benefit for metastases from neuroendocrine tumors that are well differentiated and when a major extrahepatic resection is not required.If LT is an option in these selected cases,liver metastases from colorectal cancer is still a borderline indication because data concerning the disease-free survival are still lacking.Hepatoblastoma and hemangioendothelioma represent rare primary tumors for which LT is often the only possible and effective cure because of the frequent multifocal,intrahepatic nature of the disease.LT is a very promising procedure for both primary and secondary liver malignancies;however,it needs an accurate evaluation of the costs and benefits for each indication to balance the chances of cure with actual organ availability. | Matteo Ravaioli Giorgio Ercolani Flavia Neri Matteo Cescon Giacomo Stacchini Massimo Del Gaudio Alessandro Cucchetti Antonio Daniele Pinna | 2014 | World Journal of Gastroenterology2014，20，18： | 8 |
| 7 | Esophagogastric junction gastrointestinal stromal tumor:Resection vs enucleation显示文摘Esophageal gastrointestinal stromal tumors(GISTs) are extremely uncommon,representing approximately 5% of GISTs with the majority of esophageal GISTs occurring at the esophagogastric junction(EGJ).The treatment options available for these GISTs are fairly controversial.Many different options are nowadays at our disposal.From surgery to the target therapies we have the possibility to treat the majority of GISTs,including those which are defined as unresectable.The EGJ GISTs represent a stimulating challenge for the surgeon.The anatomical location increases the possibility of postoperative complications.As the role of negative margins in GIST surgery is still controversial and the eff icacy of target therapy has been demonstrated,why not treat EGJ GISTs with enucleation and,where indicated,adjuvant target therapy? | Federico Coccolini Fausto Catena Luca Ansaloni Daniel Lazzareschi Antonio Daniele Pinna | 2010 | World Journal of Gastroenterology2010，16，35： | 7 |
| 8 | Antimicrobial management of intra-abdominal infections:Literature's guidelines显示文摘Antimicrobial management of severe intra-abdominal infections (IAIs) involves a delicate balance of optimizing empirical therapy,which has been shown to improve clinical outcomes,while simultaneously reducing unnecessary antimicrobial use.Two sets of guidelines for the management of intra-abdominal infections were recently published.In 2010,the Surgical Infection Society and the Infectious Diseases Society of America (SIS-IDSA) created guidelines for the diagnosis and management of complicated IAIs.The new SIS-IDSA guidelines replace those previously published in 2002 and 2003.The World Society of Emergency Surgery (WSES) guidelines represent additional contributions,made by specialists worldwide,to the debate regarding proper antimicrobial drug methodology.These guidelines represent the conclusions of the consensus conference held in Bologna,Italy,in July 2010 during the first congress of the WSES. | Massimo Sartelli Fausto Catena Federico Coccolini Antonio Daniele Pinna | 2012 | World Journal of Gastroenterology2012，18，9： | 7 |
| 9 | Prophylaxis for venous thromboembolism after resection of hepatocellular carcinoma on cirrhosis: Is it necessary?显示文摘AIM: To assess the safety and effectiveness of prophylaxis for venous thromboembolism (VTE) in a large population of patients with hepatocellular carcinoma (HCC) on cirrhosis.METHODS: Two hundred and twenty nine consecutive cirrhotic patients with HCC who underwent hepatic resection were retrospectively evaluated to assess whether there was any difference in the incidence of thrombotic or hemorrhagic complications between those who received and those who did not receive prophylaxis with low-molecular weight heparin.Differences and possible effects of the following parameters were investigated: age,sex,Child-Pugh and model for end-stage liver disease (MELD) score,platelet count,presence of esophageal varices,type of hepatic resection,duration of surgery,intraoperative transfusion of blood and fresh frozen plasma (FFP),body mass index,diabetes and previous cardiovascular disease.RESULTS: One hundred and fifty seven of 229 (68.5%) patients received antithromboembolic prophylaxis (group A) while the remaining 72 (31.5%) patients did not (group B).Patients in group B had higher Child-Pugh and MELD scores,lower platelet counts,a higher prevalence of esophageal varices and higher requirements for intraoperative transfusion of FFP.The incidence of VTE and postoperative hemorrhage was 0.63% and 3.18% in group A and 1.38% and 1.38% in group B,respectively;these differences were not significant.None of the variables analyzed including prophylaxis proved to be risk factors for VTE,and only the presence of esophageal varices was associated with an increased risk of bleeding.CONCLUSION: Prophylaxis is safe in cirrhotic patients without esophageal varices;the real need for prophylaxis should be better assessed. | Marco Vivarelli Matteo Zanello Chiara Zanfi Alessandro Cucchetti Matteo Ravaioli Massimo Del Gaudio Matteo Cescon Augusto Lauro Eva Montanari Gian Luca Grazi Antonio Daniele Pinna | 2010 | World Journal of Gastroenterology2010，16，17： | 6 |
| 10 | Peritoneal seeding from appendiceal carcinoma:A case report and review of the literature显示文摘Non-carcinoid appendiceal malignancies are rare entities,representing less than 0.5% of all gastrointestinal malignancies.Because of their rarity and particular biological behavior,a substantial number of patients affected by these neoplasms do not receive appropriate surgical resection.In this report,we describe a rare case of primary signetring cell carcinoma of the appendix with peritoneal seeding which occurred in a 40-year old man admitted at the Emergency Surgery Department with the clinical suspicion of acute appendicitis.After a surgical debulking and right hemicolectomy,the patient had systemic chemotherapy according to FOLFOX protocol.After completion of the latter,the patient underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy.This report offers a brief review of the literature and suggests an algorithm for the management of non-carci-noid appendiceal tumors with peritoneal dissemination. | Valentina R Bertuzzo Federico Coccolini Antonio D Pinna | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 6 |
| 11 | Liver function impairment in liver transplantation and after extended hepatectomy显示文摘Extended hepatectomy,or liver transplantation of reduced-size graft,can lead to a pattern of clinical manifestations,namely'post-hepatectomy liver failure'and'small-for-size syndrome'respectively,that can range from mild cholestasis to irreversible organ non-function and death of the patient.Many mechanisms are involved in their occurrence but in the recent past,high portal blood flow through a relatively small liver vascular bed has taken a central role.Therefore,several techniques of inflow modulation have been attempted in cases of portal hyperperfusion first in liver transplantation,such as portocaval shunt,mesocaval shunt,splenorenal shunt,splenectomy or ligation of the splenic artery.However,high portal flow is not the only factor responsible,and before major liver resections,preoperative assessment of the residual liver function is necessary.Techniques such as portal vein embolization or portal vein ligation can be adopted to increase the future liver volume,preventing posthepatectomy liver failure.More recently,a new surgical procedure,that combines in situ splitting of the liver and portal vein ligation,has gradually come to light,inducing remarkable hypertrophy of the healthy liver in just a few days.Further studies are needed to confirm this hypothesis and overcome one of the biggest issues in the field of liver surgery. | Matteo Serenari Matteo Cescon Alessandro Cucchetti Antonio Daniele Pinna | 2013 | World Journal of Gastroenterology2013，19，44： | 6 |
| 12 | Liver grafts from hepatitis B surface antigen-positive donors: A review of the literature显示文摘The scarcity of available organs and the gap between supply and demand continue to be the main limitations of liver transplantation. To relieve the organ shortage, current transplant strategies have implemented extended criteria, which include the use of liver from patients with signs of past or present hepatitis B virus(HBV) infection. While the use of liver grafts from donors with evidence of past HBV infection is quite limited, some data have been collected regarding the feasibility of transplanting a liver graft from a hepatitis B surface antigen(HBs Ag) positive donor. The aim of the present work was to review the literature regarding liver transplants from HBs Ag-positive donors. A total of 17 studies were identified by a search in Medline. To date, HBs Ag positive grafts have preferentially been allocated to HBs Ag positive recipients. The large majority of these patients continue to be HBs Ag positive despite the use of immunoglobulin, and infection prevention can only be guaranteed by using antiviral prophylaxis. Although serological persistence is evident, no significant HBV-related disease has been observed, except in patients coinfected with delta virus. Consistently less data are available for HBs Ag negative recipients, although they are mostly promising. HBs Agpositive grafts could be an additional organ source for liver transplantation, provided that the risk of reinfection/reactivation is properly prevented. | Elisabetta Loggi Fabio Conti Alessandro Cucchetti Giorgio Ercolani Antonio Daniele Pinna Pietro Andreone | 2016 | World Journal of Gastroenterology2016，22，35： | 5 |
| 13 | Is Portal Hypertension a Contraindication to Hepatic Resection?显示文摘 | Alessandro Cucchetti Giorgio Ercolani Marco Vivarelli Matteo Cescon Matteo Ravaioli Giovanni Ramacciato Gian Luca Grazi Antonio Daniele Pinna | 2009 | Annals of Surgery2009，，6： | 5 |
| 14 | Enteric neuropathology of congenital intestinal obstruction:A case report显示文摘试验性的证据显示肠的长期的机械亚吸藏可以损坏伤寒神经系统(ENS ) ,尽管在人的数据正在缺乏。我们这里描述伤寒的第一诉讼与内脏的先天的阻塞有关的退化神经病。3 年的 A 和老女孩开始抱怨了呕吐的 9 瞬间,腹的扩张,有空气液体的便秘在飞机铺平腹的辐射学。她的随后的病历被 3 操作描绘:首先显示出的扩大 duodeno-jejunal 当闭塞的损害不在时循环;第二(2 年以后) 被执行获得扩大的肠的环的完整厚度的活体检视并且在组织病理学说揭示了 hyperganglionosis;第三(在 hyperganglionosis 以后的 9 年被识别) 揭示了 Ladd 被移开的乐队,联系内脏旋转不良被改正。完整厚度的活体检视显示出的重复 intraoperative 与 Cajal 的减少的空隙的房间一起的退化神经病在 Ladd 的乐队下面在阻塞和正常的神经与肌的层上面在扩大的环联网的伤寒。病人容忍了的在最近的外科以后的一年口头的喂并且很好,建议那先天(部分) 在人的小肠的机械阻塞能唤起类似于在肠的机械吸藏的动物模型发现的那些的 ENS 的进步适应变化。如此的 ENS 变化模仿在肠的伪阻塞观察的神经元畸形。 | Giovanni Di Nardo Vincenzo Stanghellini Salvatore Cucchiara Giovanni Barbara Gianandrea Pasquinelli Donatella Santini Cristina Felicani Gianluca Grazi Antonio D Pinna Rosanna Cogliandro Cesare Cremon Alessandra Gori Roberto Corinaldesi Kenton M Sanders Roberto De Giorgio | 2006 | World Journal of Gastroenterology2006，12，32： | 4 |
| 15 | Long term follow-up and outcome of liver transplantation from hepatitis B surface antigen positive donors显示文摘Liver transplant for hepatitis B virus(HBV) currently yields excellent outcomes: it allows to rescue patients with an HBV-related advanced liver disease, resulting in a demographical modification of the waiting list for liver transplant. In an age of patient-tailored treatments, in liver transplantation as well the aim is to offer the best suitable graft to the patient who can benefit from it, also expanding the criteria for organ acceptance and allocation. With the intent of developing strategies to increase the donor pool, we set-up a multicenter study involving 3 Liver Transplant Centers in Italy: patients undergoing liver transplantation between March 03, 2004, and May 21, 2010, were retrospectively evaluated. 1408 patients underwent liver transplantation during the study period, 28(2%) received the graft from hepatitis B surface antigen positive(HBs Ag)-positive deceased donors. The average follow-up after liver transplantation was 63.7 mo [range: 0.1-119.4; SD ± 35.8]. None Primary nonfunction, re-liver transplantation, early or late hepatic artery thrombosis occurred. The 1-, 3-and 5-year graft and patient survival resulted of 85.7%, 82.1%, 78.4%. Our results suggest that the use of HBs Agpositive donors liver grafts is feasible, since HBV can be controlled without affecting graft stability. However, the selection of grafts and the postoperative antiviral therapy should be managed appropriately. | Roberto Ballarin Alessandro Cucchetti Francesco Paolo Russo Paolo Magistri Matteo Cescon Umberto Cillo Patrizia Burra Antonio Daniele Pinna Fabrizio Di Benedetto | 2017 | World Journal of Gastroenterology2017，23，12： | 4 |
| 16 | Successful outcome after combined chemotherapeutic and surgical management in a case of esophageal cancer with breast and brain relapse显示文摘Esophageal cancer (EC) is a highly lethal disease. Approximately 50% of patients present with metastatic EC and most patients with localized EC will have local recurrence or develop metastases, despite potentially curative local therapy. The most common sites of distant recurrence are represented by lung, liver and bone while brain and breast metastases are rare. Usually patients with advanced disease are not treated aggressively and their median survival is six months. We report a woman patient who developed breast and brain metastases after curative surgery. We treated her with a highly aggressive chemotherapeutic and surgical combination resulting in a complete remission of the disease even after 11-year follow-up. We think that in super selected patients with more than one metastasis, when functional status is good and metastases are technically resectable, a surgical excision may be considered as a salvage option and chemotherapy should be delivered to allow a systemic control. | Davide Adriano Santeufemia Gianfranca Piredda Giovanni Maria Fadda Paolo Cossu Rocca Salvatore Costantino Giovanni Sanna Maria Giuseppa Sarobba Maria Antonietta Pinna Carlo Putzu Antonio Farris | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 17 | A Comprehensive Meta-regression Analysis on Outcome of Anatomic Resection Versus Nonanatomic Resection for Hepatocellular Carcinoma显示文摘 | Alessandro Cucchetti Matteo Cescon Giorgio Ercolani Eleonora Bigonzi Guido Torzilli Antonio D. Pinna | 2012 | Annals of Surgical Oncology2012，，12： | 3 |
| 18 | The meaning of tissue and serum HCV RNA quantitation in hepatitis C recurrence after liver transplantation: A retrospective study显示文摘 | Francesco Vasuri Maria Cristina Morelli Elisa Gruppioni Michelangelo Fiorentino Giorgio Ercolani Matteo Cescon Antonio Daniele Pinna Walter Franco Grigioni Antonia D’Errico-Grigioni | 2013 | Digestive and Liver Disease2013，，6： | 3 |
| 19 | 合成氨工业催化剂的一种新型前躯体—维氏体显示文摘关于合成氨铁系催化剂最佳氧化态前躯体相矛盾的实验结果推动了当前以维氏体和磁铁矿为母体的催化剂的比较研究。测定了两种催化剂的许多物理性质(密度、孔结构、晶相、还原速率、金属表面、磨耗量)和催化性能(动力学常数、耐热性)。证明了以维氏体为母体的催化剂具有更高的活性,尤其是在低温下,除了在高转化率情况下之外,可以达到Ru/C催化剂的性能。本文讨论了以维氏体为母体的催化剂具有这种特性的可能原因,并且建议有必要对合成氨铁系催化剂现有统一的理论知识进行重新考虑。 | N. Pernicone F. Ferrero I. Rossetti L. Forni P. Canton P. Riello G. Fagherazzi M. Signoretto F. Pinna | 2004 | 浙江工业大学学报2004，32，2： | 3 |
| 20 | Cost-effectiveness of hepatic resection versus percutaneous radiofrequency ablation for early hepatocellular carcinoma<!-- Doctopic: CAN -->显示文摘 | Alessandro Cucchetti Fabio Piscaglia Matteo Cescon Antonio Colecchia Giorgio Ercolani Luigi Bolondi Antonio D. Pinna | 2013 | Journal of Hepatology2013，，2： | 3 |
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