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| 1 | Adipose tissue and vascular inflammation in coronary artery disease显示文摘Obesity has become an important public health issue in Western and developing countries,with well known metabolic and cardiovascular complications.In the last decades,evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences.As a consequence of the expansion of fat depots,in obese subjects,adipose tissue cells develope a phenotypic modification,which turns into a change of the secretory output.Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling,vascular biology and,moreover,participate to the systemic inflammatory response,which characterizes obesity and metabolic syndrome.This might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events.A great number of adipocytokines have been described recently,linking inflammatory mileu and vascular pathology.The understanding of these pathways is crucial not only from a pathophysiological point of view,but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic targets.The aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease. | Enrica Golia Giuseppe Limongelli Francesco Natale Fabio Fimiani Valeria Maddaloni Pina Elvira Russo Lucia Riegler Renatomaria Bianchi Mario Crisci Gaetano Di Palma Paolo Golino Maria Giovanna Russo Raffaele Calabrò Paolo Calabrò | 2014 | World Journal of Cardiology2014，6，7： | 8 |
| 2 | Intranasal delivery of nanostructured lipid carriers,solid lipid nanoparticles and nanoemulsions:A current overview of in vivo studies显示文摘The management of the central nervous system(CNS)disorders is challenging,due to the need of drugs to cross the blood-brain barrier(BBB)and reach the brain.Among the various strategies that have been studied to circumvent this challenge,the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising results.In addition,the encapsulation of the drugs in lipid-based nanocarriers,such as solid lipid nanoparticles(SLNs),nanostructured lipid carriers(NLCs)or nanoemulsions(NEs),can improve nose-to-brain transport by increasing the bioavailability and site-specifc delivery.This review provides the state-of-the-art of in vivo studies with lipid-based nanocarriers(SLNs,NLCs and NEs)for nose-to-brain delivery.Based on the literature available from the past two years,we present an insight into the different mechanisms that drugs can follow to reach the brain after intranasal administration.The results of pharmacokinetic and pharmacodynamics studies are reported and a critical analysis of the differences between the anatomy of the nasal cavity of the different animal species used in in vivo studies is carried out.Although the exact mechanism of drug transport from the nose to the brain is not fully understood and its effectiveness in humans is unclear,it appears that the intranasal route together with the use of NLCs,SLNs or NEs is advantageous for targeting drugs to the brain.These systems have been shown to be more effective for nose-to-brain delivery than other routes or formulations with non-encapsulated drugs,so they are expected to be approved by regulatory authorities in the coming years. | Cláudia Pina Costa Joao Nuno Moreira JoséManuel Sousa Lobo Ana Catarina Silva | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 3 | Prevalence and dietetic management of mild gastrointestinal disorders in milk-fed infants显示文摘AIM: To assess the prevalence of mild gastrointestinal disorders in milk-fed infants in paediatric practice, and to evaluate the effectiveness and satisfaction with dietetic treatment.METHODS: A cross-sectional epidemiological study was first carried out. A total of 285 paediatricians included 3487 children seen during a period of one week. In a second phase an observational, prospective and multicentre study was conducted and 2069 milk-fed infants with mild gastrointestinal disorders (colic, constipation, regurgitation and diarrhoea) were included. There was a baseline visit (start of treatment) and a final visit four weeks later. The effectiveness of the various Novalac formulas, as well as the satisfaction of the parents/tutors and paediatricians with the dietetic treatment were assessed at the final visit.RESULTS: The prevalence of mild gastrointestinal disorders was 27.8% of all paediatrician consultations (9.2%, 7.8%, 6.1% and 4.6% in relation to colic, constipation, regurgitation and diarrhoea, respectively). The several Novalac adapted milk formulas resolved 88.4% of the mild gastrointestinal disorders. Depending on the type of disorder, differences in response rate were observed. The highest effectiveness was recorded with respect to diarrhoea (92.6%), followed by constipation (91.6%), colic (87.6%) and regurgitation (81%). Overall, 91% of the paediatricians and 88.8% of the parents/tutors were satisfied or very satisfied with the Novalac adapted milk formulas.CONCLUSION: Mild gastrointestinal disorders show a high prevalence in paediatric practice. The Novalac adapted milk formulas have been shown to be effective in treating mild gastrointestinal disorders in milk-fed infants in the context of routine clinical practice. | D Infante Pina X Badia Llach B Ario-Armengol V Villegas Iglesias | 2008 | World Journal of Gastroenterology2008，14，2： | 5 |
| 4 | Liver Involvement in Obese Children (Ultrasonography and Liver Enzyme Levels at Diagnosis and During Follow-up in an Italian Population)显示文摘 | Maria Carmela Saviano Francesco Brunetti Armido Rubino Adriana Franzese Pietro Vajro Alessandro Argenziano Alessandro Puzziello Maria Pina Iannucci | 1997 | Digestive Diseases and Sciences1997，，7： | 3 |
| 5 | Inventory and action plan for PFOS and related substances in Suriname as basis for Stockholm Convention implementation显示文摘Within the framework of the Stockholm Convention implementation in Suriname,the first inventory of perfluorooctane sulfonic acid(PFOS)has been developed.The major stocks of PFOS are firefighting foams with minor stocks in pesticides(ant baits)and possibly carpets.The inventory of firefighting foams assessed the import,current stocks and major use sites and recent releases.Considerable amount of PFOS and potentially PFOS containing firefighting foams are stored at the military base,the oil company and small firefighting departments throughout the country.The total amount of stored PFAS firefighting foam in Suriname is estimated to be at least 275.6 tonnes,where the major stockpile of 206 tonnes is at the oil storage facilities.For some of these foams PFOS content is confirmed and for others it is not clear if the foam contains PFOS or other per-or polyfluorinated alkylated substances(PFAS).The upper estimate of PFOS content is 4133 kg in these foams.Additionally,PFOS or other PFAS has also been discovered in fire extinguishers in institutions.The total amount of PFOS related substance EtFOSA imported with the pesticide sulfluramid was 75 kg.The imports were banned in 2014 and is controlled.A considerable amount of synthetic carpets are in stores even produced before 2003 where main use of PFOS from 3 M took place possibly containing PFOS related substances.A compilation of potentially PFOS contaminated sites has been made.Potentially contaminated sites result from firefighting foam use,dumpsites and sulfluramid use.The airport where firefighting foam was applied is above a major drinking water reservoir,where an urgent assessment is needed.Due to the lack of analytical capacity for PFOS and precursors,drinking water,firefighting foam or impacted carpets,could not been analysed.An action plan for the control of PFOS and other PFAS has been developed considering the synergy of the Stockholm Convention and the Strategic Approach to International Chemicals Management(SAICM)addressing this emerging pollution issue for developing countries. | Victorine Pinas Carmen Van Dijk Roland Weber | 2020 | Emerging Contaminants2020，6，1： | 3 |
| 6 | Effect of Pretreatment Antibiotic Resistance to Metronidazole and Clarithromycin on Outcome of Helicobacter pylori Therapy显示文摘 | Maria Pina Dore Gioacchino Leandro Giuseppe Realdi Antonia Rogado Sepulveda David Yates Graham | 2000 | Digestive Diseases and Sciences2000，，1： | 2 |
| 7 | Platelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease显示文摘Background:Platelets and P-selectin(CD62P)play an unequivocal role in the pathology of hepatic ischemia/reperfusion(I/R)injury.Inhibition or knock-out of P-selectin or immunodepletion of platelets results in amelioration of post-ischemic inflammation,reduced hepatocellular damage,and improved survival.However,P-selectin expression on platelets and endothelial cells,which concurs with platelet activation,has never been clearly demonstrated in I/R-subjected livers.Aims:To determine whether platelets become activated and degranulate in the acute phase of liver I/R and whether the platelets interact with neutrophils.Methods:Hepatic I/R was induced in male C57BL/6J mice(N=12)using 37.5-min ischemia time.Platelets,endothelial cells,and neutrophils were fluorescently labeled by systemic administration of non-blocking antibodies.Cell kinetics were monitored by intravital spinning disk confocal microscopy during 90 min of reperfusion.Image analysis and quantification was performed with dedicated software.Results:Platelets adhered to sinusoids more extensively in post-ischemic livers compared to livers not subjected to I/R and formed aggregates,which occurred directly after ischemia.Platelets and endothelial cells did not express P-selectin in post-ischemic livers.There was no interaction between platelets and neutrophils.Conclusions:Platelets aggregate but do not become activated and do not degranulate in post-ischemic livers.There is no platelet-neutrophil interplay during the early reperfusion phase in a moderate model of hepatic I/R injury.The mechanisms underlying the biological effects of platelets and P-selectin in this setting warrant further investigation.Relevance for patients:I/R in surgical liver patients may compromise outcome due to post-ischemic oxidative stress and sterile inflammation.Both processes are mediated in part by platelets.Understanding platelet function during I/R is key to developing effective interventions for I/R injury and improving clinical outcomes. | Rowan F.van Golen Katarzyna M.Stevens Pina Colarusso Hartmut Jaeschke Michal Heger | 2015 | Journal of Clinical & Translational Research2015，1，2： | 2 |
| 8 | 3,5-diiodo- l -thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet显示文摘 | Maria Pina Mollica Lillà Lionetti Maria Moreno Assunta Lombardi Pieter De Lange Alessandro Antonelli Antonia Lanni Gina Cavaliere Antonio Barletta Fernando Goglia | 2009 | Journal of Hepatology2009，，2： | 2 |
| 9 | Effective bowel cleansing before colonoscopy: a randomized study of split-dosage versus non-split dosage regimens of high-volume versus low-volume polyethylene glycol solutions显示文摘 | Riccardo Marmo Gianluca Rotondano Giovanni Riccio Armando Marone Maria Antonia Bianco Italo Stroppa Anna Caruso Nicola Pandolfo Stefano Sansone Elena Gregorio Giuseppe D’Alvano Nicoletta Procaccio Pina Capo Clelia Marmo Livio Cipolletta | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 10 | Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering显示文摘The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered sca ffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TCP) bottom layer were developed. Furthermore, a comparative analysis between two types of sca ffolds pro- duced using di fferent SF concentrations, i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was performed. In terms of architecture and morphology, the produced sca ffolds presented homogeneous porosity in both layers and no di fferences were observed when comparing both sca ffolds. A decrease in terms of mechanical performance of the sca ffolds was observed when SF concentration decreased from 16 to 8% (w/v). Hi16 revealed a static compressive modulus of 0.66 ± 0.05 MPa and dynamical mechanical properties ranging from 2.17 ± 0.25 to 3.19 ± 0.38 MPa. By its turn, Hi8 presented a compressive modulus of 0.27 ± 0.08 MPa and dynamical mechanical properties ranging from 1.03 ± 0.08 MPa to 1.56 ± 0.13 MPa. In vitro bioactivity studies showed formation of apatite crystals onto the surface of Hi8 and Hi16 bottom layers. Human meniscus cells (hMCs) and human primary osteoblasts were cultured separately onto the top layer (SF8 and SF16) and bottom layer (SF8/TCP and SF16/TCP) of the hierarchical sca ffolds Hi8 and Hi16, respectively. Both cell types showed good adhesion and proliferation as denoted by the live/dead staining, Alamar Blue assay and DNA quanti fication analysis. Subcutaneous implantation in mice revealed weak in flammation and sca ffold’s integrity. The hierarchical indirect printed SF sca ffolds can be promising candidate for meniscus TE sca ffolding applications due their suitable mechanical properties, good biological performance and possibility of being applied in a patient-speci fic approach. | Joao BCosta Joana Silva-Correia Sandra Pina Alain da Silva Morais Sílvia Vieira Hélder Pereira Joao Espregueira-Mendes Rui LReis Joaquim M.Oliveira | 2019 | Bio-Design and Manufacturing2019，2，4： | 2 |
| 11 | Efficacy and Safety of Combination Therapy With Everolimus and Sorafenib for Recurrence of Hepatocellular Carcinoma After Liver Transplantation显示文摘 | P. De Simone L. Crocetti D. Pezzati I. Bargellini D. Ghinolfi P. Carrai G. Leonardi C. Della Pina D. Cioni L. Pollina D. Campani C. Bartolozzi R. Lencioni F. Filipponi | 2014 | Transplantation Proceedings2014，，1： | 2 |
| 12 | Evaluating the Efficiency of Nonprofit Organizations:An Application of Data Envelopment Analysis to the Public Health Service显示文摘 | Vicente Pina Lourdes Torres | 1992 | Financial Accountability& Management1992，8，3： | 1 |
| 13 | Overexpression of a novel Arabidopsis gene related to putative zinc-transporter genes from animals can lead to enhanced zinc resistance and accumulation显示文摘 | VAN DER ZAAL B J NEUTEBOOM L W PINAS J E | 1999 | Plant Physiology1999，119，： | 1 |
| 14 | Classification and identification of enterococci: a comparative phenotypic, genotypic, and vibrational spectroscopic study 显示文摘 | Kirschner C Maquelin K Pina P | 2001 | J Clin Microbiol2001，5，： | 1 |
| 15 | Trimeric autotransporters of Haemo philus parasuis , generation of an extensive passenger domain repertoire specific for pathogenic strains显示文摘 | Pina S Olvera A BarcelO A | 2009 | BacteriolJ2009，191，： | 1 |
| 16 | Genetic analysis of hepatitis A virus strains recovered from the environment and from patients with acute hepatitis 显示文摘 | Pina S Buti M Jardf R | 2001 | J Gen Virol2001，82，12： | 1 |
| 17 | Analysis of the efficiency of local government services delivery:an application to urban public transport显示文摘 | PINA V TORRES L | 2001 | Trans- portation Research Part A: Policy and Practice2001，35，10： | 1 |
| 18 | Improving heart failure disease management in skilled nursing facilities: lessons learned显示文摘 | Dolansky MA Hitch JA Pina IL | 2013 | Clin Nurs Res2013，22，4： | 1 |
| 19 | ParasightR- F rapid manual diagnositic test of Plasmodium falciparum infection显示文摘 | Rabodonirina M De Pina JJ | 1995 | Bull WHO1995，73，5： | 1 |
| 20 | Brucellar spinal epidural abscess of cervical location : report of four cases 显示文摘 | Pina MA Modreqo PJ Uroz JJ | 2001 | Eur Neurol2001，45，4： | 1 |
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