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| 1 | YKL40 expression in CD14^+ liver cells in acute and chronic injury显示文摘AIM:To demonstrate that CD14 + cells are an important source of the growth factor YKL40 in acute and chronic liver damage.METHODS:Rats were inoculated with one dose of CCl4 to induce acute damage.Liver biopsies were obtained at 0,6,12,24,48 and 72 h.For chronic damage,CCl4 was administered three days per week for 6 or 8 wk.Tissue samples were collected,and cellular populations were isolated by liver digestion and purified by cell sorting.YKL40 mRNA and protein expression were evaluated by realtime polymerase chain reaction and western blot.RESULTS:Acute liver damage induced a rapid increase of YKL40 mRNA beginning at 12 h.Expression peaked at 24 h,with a 26fold increase over basal levels.By 72 h however,YKL40 expression levels had nearly returned to control levels.On the other hand,chronic damage induced a sustained increase in YKL40 expression,with 7and 9fold higher levels at 6 and 8 wk,respectively.The pattern of YKL40 expression in different subpopulations showed that CD14+cells,which include Kupffer cells,are a source of YKL40 after acute damage at 72 h[0.09 relative expression units(REU)]as well as after chronic injury at 6 wk(0.11 REU).Hepatocytes,in turn,accounted for 0.06 and 0.01 REU after 72 h(acute)or 6 wk(chronic),respectively.The rest of the CD14cells(including T lymphocytes,B lymphocytes,natural killer and natural killer T cells) yielded 0.07 and 0.15 REU at 72 h and 6 wk,respectively.YKL40 protein expression in liver was detected at 72 h as well as 6 and 8 wk,with the highest expression relative to controls(11fold;P≤0.05)seen at 6 wk.Macrophages were stimulated by lipopolysaccharide.We demonstrate that under these conditions,these cells showed maximum expression of YKL40 at 12 h,with P<0.05 compared with controls.CONCLUSION:Hepatic CD14 + cells are an YKL40 mRNA and protein source in acute and chronic liver injury,with expression patterns similar to growth factors implicated in inflammationfibrogenesis. | Oscar Pizano-Martínez Irinea Yaez-Sánchez Pilar Alatorre-Carranza Alejandra Miranda-Díaz Pablo C Ortiz-Lazareno Trinidad García-Iglesias Adrian Daneri-Navarro Mónica Vázquez-Del Mercado Mary Fafutis-Morris Vidal Delgado-Rizo | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 2 | Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘 | Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa | 2002 | 2002 (9325)2002，，9325： | 3 |
| 3 | 在与心肌的梗塞介绍的就医的病人的心率的预示的意义显示文摘 AIM: To investigate the prognostic significance of resting heart rate in patients with acute coronary syndrome (ACS), independent of other known factors. METHODS: Patients 40 years of age or older who had been admitted with acute coronary syndrome (ACS) to one of the 94 hospitals participating in the Prevalence of Peripheral Arterial Disease in Patients with Acute Coronary Syndrome (PAMISCA) study were included. Patients were divided into two groups based on their resting heart rate (HR ≥ or < 70 bpm). Complications were recording during a follow-up period of 1 year. RESULTS: There were 1054 ACS patients analyzed (43.5% with ST segment elevation and 56.5% without elevation). Mean age was 66.6 ± 11.7 years, 70.6% were male and 29.4% of subjects were female. During follow-up, more patients in the HR ≥ 70 bpm group were hospitalized for heart failure and they also had a higher mortality rate. In the multivariate analysis, a heart rate of ≥ 70 bpm was independently related to overall mortality during the follow-up period (hazard ratio 2.5; 95% confidence interval, 1.26-4.97, P = 0.009). CONCLUSION: A resting heart rate ≥ 70 bpm in patients who survive an ACS is an indicator of a high risk of suffering cardiovascular events during follow-up. | Lorenzo Fácila Pedro Morillas Juan Quiles Federico Soria Alberto Cordero Pilar Mazón Manuel Anguita Cándido Martín-Luengo Jose Ramón Gonzalez-Juanatey Vicente Bertomeu | 2012 | World Journal of Cardiology2012，4，1： | 3 |
| 4 | Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘 | Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa | 2002 | The Lancet2002，，9325： | 2 |
| 5 | Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘 | Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa | 2002 | The Lancet2002，，9325： | 2 |
| 6 | Evidence of thermaldecomposition of fatty acid methyl esters during the synthesis of biodiesel with supercritical methanol 显示文摘 | JOAQUIN Q M PILAR O C | 2011 | The Journal of Supercritical Fluids2011，56，1： | 1 |
| 7 | Chitosan and Chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as noval carriers for proteins and vaccines显示文摘 | PILAR C CARMEN R L JOSE LUIS V J | 1997 | Pharm Res1997，14，10： | 1 |
| 8 | Biochemical and genetic characterization of enterocin p,a novel sec-dependent bacteriocin from Enterococcus faecium P13 with a broad antimicrobial spectrum显示文摘 | Luis MC Pilar C Leiv SH | | 0，，11： | 1 |
| 9 | Association between nailfold capillaroscopy findings and pulmonary function tests in patients with systemic sclerosis 显示文摘 | Ivan C Carmen Pilar SA Menica S etal | 2015 | J Rheumatol2015，42，2： | 1 |
| 10 | Epoxides,cyclic sulfites,and sulfate from natural pentacyclic triterpenoids:theoretical calculations and chemical transformation显示文摘 | Pilar E L Enrique M | 2003 | Journal of Organic Chemistry2003，68，： | 1 |
| 11 | High-sensitivity C-reactive protein in high-grade carotid stenosis: risk marker for unstable carotid plaque 显示文摘 | BeatrizAG Carmen R Pilar C | 2003 | J Varscular Surgery2003，38，5： | 1 |
| 12 | Pyrrolidine dithiocarbamate protects mice from Lethal shock induced by LPS or TNF-α显示文摘 | PILAR L SARA M M PABBO C D et al | 1999 | Eur J Immunol1999，29，6： | 1 |
| 13 | MRI of focal splenic le- sions without and with dynamic gadolinium enhancement显示文摘 | Antonio L Ramon R Pilar C | 2006 | AJR2006，186，： | 1 |
| 14 | Inflammation,obesity and comorbidities:the role of diet显示文摘 | MONICA B PATRICIA C A PILAR A | | 0，，10： | 1 |
| 15 | Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease显示文摘 | Isabel González‐Aramburu Pascual Sánchez‐Juan Silvia Jesús Ana Gorostidi Eduardo Fernández‐Juan Fátima Carrillo María Sierra Pilar Gómez‐Garre María T. Cáceres‐Redondo José Berciano Javier Ruiz‐Martínez Onofre Combarros Pablo Mir Jon Infante | 2013 | Mov Disord2013，，： | 1 |
| 16 | Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘 | Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa | 2002 | The Lancet . 2002 (9325)2002，，： | 1 |
| 17 | Dietary polyunsatured fatty acids (PUFA) differentially modulate melamineinduced preneoplastic urothelial proliferation and apoptosis in mice显示文摘 | CREMONEZZI D C SILVA R A DEL PILAR D M | 2001 | Prostaglandins Leukot Essent Fatty Acids2001，64，3： | 1 |
| 18 | Molecular analysisin hemophilia B families:identification of six new muta-tions in factorⅨgene显示文摘 | Garmen E Pilar C Satumino H | 2003 | Haematologiea2003，88，101： | 1 |
| 19 | Regulation of nonsymbiotic and truncated hemoglobin genes of Lotus japonicus in plant organs and in response to nitric oxide and hormones 显示文摘 | Pilar B S Alejandro T M Martin C | 2011 | New Phytologist2011，189，： | 1 |
| 20 | Preparation of pure hectorite using microwaves显示文摘 | ISABEL V PILAR S YOLANDA C | 2010 | Physics Procedia2010，8，： | 1 |
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