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| 1 | Pancreatico-biliary endoscopic ultrasound:A systematic review of the levels of evidence,performance and outcomes显示文摘Our aim was to record pancreaticobiliary endoscopic ultrasound(EUS) literature of the past 3 decades and evaluate its role based on a critical appraisal of published studies according to levels of evidence(LE).Original research articles(randomized controlled trials,prospective and retrospective studies),meta-analyses,reviews and surveys pertinent to gastrointestinal EUS were included.All articles published until September 2011 were retrieved from PubMed and classified according to specific disease entities,anatomical subdivisions and therapeutic applications of EUS.The North of England evidencebased guidelines were used to determine LE.A total of 1089 pertinent articles were reviewed.Published research focused primarily on solid pancreatic neoplasms,followed by disorders of the extrahepatic biliary tree,pancreatic cystic lesions,therapeutic-interventional EUS,chronic and acute pancreatitis.A uniform observation in all six categories of articles was the predominance of LE Ⅲ studies followed by LE Ⅳ,Ⅱb,Ⅱa,Ⅰb and Ⅰ a,in descending order.EUS remains the most accurate method for detecting small(< 3 cm) pancreatic tumors,ampullary neoplasms and small(< 4 mm) bile duct stones,and the best test to define vascular invasion in pancreatic and peri-ampullary neoplasms.Detailed EUS imaging,along with biochemical and molecular cyst fluid analysis,improve the differentiation of pancreatic cysts and help predict their malignant potential.Early diagnosis of chronic pancreatitis appears feasible and reliable.Novel imaging techniques(contrast-enhanced EUS,elastography) seem promising for the evaluation of pancreatic cancer and autoimmune pancreatitis.Therapeutic applications currently involve pancreaticobiliary drainage and targeted fine needle injection-guided antitumor therapy.Despite the ongoing development of extra-corporeal imaging modalities,such as computed tomography,magnetic resonance imaging,and positron emission tomography,EUS still holds a leading role in the investigation of the pancreaticobiliary area.The major challenge of EUS evolution is its expanding therapeutic potential towards an effective and minimally invasive management of complex pancreaticobiliary disorders. | Pietro Fusaroli Dimitrios Kypraios Giancarlo Caletti Mohamad A Eloubeidi | 2012 | World Journal of Gastroenterology2012，18，32： | 17 |
| 2 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 3 | 【原创论文】德国东西部睾丸癌后发生第二原发癌的风险关注对侧睾丸癌显示文摘上世纪70年代起以顺铂为基础的化疗使睾丸癌的存活率显著提高。然而,化疗和放疗具有潜在的致癌性。本研究的目的是评估德国睾丸癌存活者患第二原发癌(包括原发组织学类型精原细胞瘤和非精原细胞瘤)的风险。我们确认了德国东部地区(1961-1989年和1996-2008年)癌症登记的16990例睾丸癌和德国西部地区萨尔州(1970.2008年)癌症登记的1401例睾丸癌。我们用标准化发病率(SIRs)和95%N信区间(95%CI)估计第二原发癌的风险。我们将估计的年标准化发病率绘制成图以显示趋势。德国东部1961.1989年观察到301例第二原发癌(SIR:1.9;95%CI:1.7-2.1),1996—2008年观察到159例第二原发癌(SIR:1.7:95%CI:1.4~2.0)。两地癌症登记的对侧睾丸癌增加(SIR:萨尔6.0,德国东部13.9)。与其它地区相比,德国东部精原细胞瘤的SIR增加更为显著。数据分析显示对侧睾丸癌的SIR有稳定的趋势。大多数其它癌症(包括组织学特异性肿瘤)的SIRs的估计精度低,可能与样本量较小有关。睾丸癌患者患第二原发癌尤其是对侧睾丸癌的风险增加,因此应进行严密随访。 | Carsten Rusner Brigitte Streller Christa Stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn Britton Traberts Andreas Stang | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 4 | Structural and biochemical characterization of the lungfish (Lepidosiren paradoxa) liver basic fatty acid binding protein显示文摘 | Di Pietro S M Santome J A | 2001 | Archives of Biochemistry and Biophysics2001，388，： | 1 |
| 5 | Molecular characterization of an endopolygalacturonase from Fusarium oxysporum expressed during early stages of infection显示文摘 | Garcia-Maceira F I DI Pietro A Huertas-Gonztles M D | 2001 | Applied and Environmental Microbiology2001，67，： | 1 |
| 6 | Fu- sarium oxysporum: exploring the molecular arsenal of a vascular wilt fungus 显示文摘 | DI PIETRO A MADRID M P CARACUEL Z | 2003 | Mol plant pathol2003，4，5： | 1 |
| 7 | Pro-and anti-apoptotic effects of p53 in cisplatin-treated humantesticular cancer are cell context-dependent显示文摘 | di Pietro A Koster R Boersma-van Eck W | 2012 | Cell Cy-cle2012，11，24： | 1 |
| 8 | Lentiviral effector pathways of TRIM proteins显示文摘 | Turrini F Di Pietro A Vicenzi E | 2014 | DNA Cell Bid2014，33，4： | 1 |
| 9 | Metronomic ad- ministration of pegylated liposomal-doxorubicin in extensively pre- treated metastatic breast cancer patients: a mono-institutional case-series report显示文摘 | Munzone E Di Pietro A Goldhirsch A | 2010 | Breast2010，19，1： | 1 |
| 10 | Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells显示文摘 | Pellegrino A Ria R Di Pietro G | | 0，，： | 1 |
| 11 | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study显示文摘 | Sheila A Bingham Nicholas E Day Robert Luben Pietro Ferrari Nadia Slimani Teresa Norat Fran?oise Clavel-Chapelon Emmanuelle Kesse Alexandra Nieters Heiner Boeing Anne Tj?nneland Kim Overvad Carmen Martinez Miren Dorronsoro Carlos A Gonzalez Timothy J Key | 2003 | The Lancet2003，，9368： | 1 |
| 12 | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) regulates en dothelial nitric oxide synthase (eNOS) activity and its localization within the human vein endothelial cells (HUVEC) in culture 显示文摘 | Di Pietro R Mariggio M A Guarnieri S | 2006 | J Cell Biochem2006，97，78： | 1 |
| 13 | Role in pathogenesis of two endo-β-l,4-xylanase genes from the vascular wilt fungus Fusariurn oxysporum显示文摘 | Gomez-G6mez E Ruiz-Rold/m M C DI Pietro A | 2002 | Fungal Genetics and Biology2002，35，： | 1 |
| 14 | Assessment of the health status of 2499 dermatological outpatients using the 12-item Medical Out- comes Study Short Form (SF-12) questionnaire 显示文摘 | Tabolli S Spagnoli A Di Pietro C | 2011 | British Asso- ciation of Dermatologists2011，16，5： | 1 |
| 15 | Endochitinase from Guocladium virens:isolation,characterization,and synergistic antifungal activity in combination with cliotoxin显示文摘 | Di Pietro A Lorito M Hayes C K | | 0，，： | 1 |
| 16 | Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells显示文摘 | Pellegrino A Ria R Di Pietro G | 2005 | Br J Haematol2005，129，2： | 1 |
| 17 | The membrane mucin Msb2 regu- lates invasive growth and plant infection in Fusarium oxysporum显示文摘 | Perez - Nadales E Di Pietro A | 2011 | Plant CeU2011，23，3： | 1 |
| 18 | Cyto- plasmic p21 expression levels determine cisplatin resist- ance in human testicularcancer显示文摘 | Koster R di Pietro A Timmer-Bosscha H | 2010 | J Cliu Invest2010，120，10： | 1 |
| 19 | Situation awareness in applicationsof ambient assisted living for cognitive impaired people显示文摘 | Coronato A Pietro G | 2013 | Mobile Networks and Applications2013，18，3： | 1 |
| 20 | Cloning,expression,androle in pathogenicity of pg1encoding the major extra-cellular endopolygalacturonase of the vascular wiltpathogen Fusarium oxysporum显示文摘 | Pietro D A Roncero M I G | 1998 | Molecular Plant-Microbe Interactions1998，11，2： | 1 |
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