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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Structural and biochemical characterization of the lungfish (Lepidosiren paradoxa) liver basic fatty acid binding protein显示文摘 | Di Pietro S M Santome J A | 2001 | Archives of Biochemistry and Biophysics2001，388，： | 1 |
| 3 | Molecular characterization of an endopolygalacturonase from Fusarium oxysporum expressed during early stages of infection显示文摘 | Garcia-Maceira F I DI Pietro A Huertas-Gonztles M D | 2001 | Applied and Environmental Microbiology2001，67，： | 1 |
| 4 | Fu- sarium oxysporum: exploring the molecular arsenal of a vascular wilt fungus 显示文摘 | DI PIETRO A MADRID M P CARACUEL Z | 2003 | Mol plant pathol2003，4，5： | 1 |
| 5 | Pro-and anti-apoptotic effects of p53 in cisplatin-treated humantesticular cancer are cell context-dependent显示文摘 | di Pietro A Koster R Boersma-van Eck W | 2012 | Cell Cy-cle2012，11，24： | 1 |
| 6 | Lentiviral effector pathways of TRIM proteins显示文摘 | Turrini F Di Pietro A Vicenzi E | 2014 | DNA Cell Bid2014，33，4： | 1 |
| 7 | Metronomic ad- ministration of pegylated liposomal-doxorubicin in extensively pre- treated metastatic breast cancer patients: a mono-institutional case-series report显示文摘 | Munzone E Di Pietro A Goldhirsch A | 2010 | Breast2010，19，1： | 1 |
| 8 | Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells显示文摘 | Pellegrino A Ria R Di Pietro G | | 0，，： | 1 |
| 9 | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) regulates en dothelial nitric oxide synthase (eNOS) activity and its localization within the human vein endothelial cells (HUVEC) in culture 显示文摘 | Di Pietro R Mariggio M A Guarnieri S | 2006 | J Cell Biochem2006，97，78： | 1 |
| 10 | Role in pathogenesis of two endo-β-l,4-xylanase genes from the vascular wilt fungus Fusariurn oxysporum显示文摘 | Gomez-G6mez E Ruiz-Rold/m M C DI Pietro A | 2002 | Fungal Genetics and Biology2002，35，： | 1 |
| 11 | Assessment of the health status of 2499 dermatological outpatients using the 12-item Medical Out- comes Study Short Form (SF-12) questionnaire 显示文摘 | Tabolli S Spagnoli A Di Pietro C | 2011 | British Asso- ciation of Dermatologists2011，16，5： | 1 |
| 12 | Endochitinase from Guocladium virens:isolation,characterization,and synergistic antifungal activity in combination with cliotoxin显示文摘 | Di Pietro A Lorito M Hayes C K | | 0，，： | 1 |
| 13 | Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells显示文摘 | Pellegrino A Ria R Di Pietro G | 2005 | Br J Haematol2005，129，2： | 1 |
| 14 | The membrane mucin Msb2 regu- lates invasive growth and plant infection in Fusarium oxysporum显示文摘 | Perez - Nadales E Di Pietro A | 2011 | Plant CeU2011，23，3： | 1 |
| 15 | Cyto- plasmic p21 expression levels determine cisplatin resist- ance in human testicularcancer显示文摘 | Koster R di Pietro A Timmer-Bosscha H | 2010 | J Cliu Invest2010，120，10： | 1 |
| 16 | Endochitinase from Gliocladium virens:Isolation characterization synergistic anti-fungal activity in combination with gliotoxin显示文摘 | DI PIETRO A LORITO M HAYES C K | 1993 | Phyto Pathology1993，83，： | 1 |
| 17 | High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes显示文摘 | Buzzetti R Di Pietro S Giaccari A | 2007 | Diabetes Care2007，30，4： | 1 |
| 18 | Blockmon: a High-performance Composable Network Traffic Measurement System显示文摘 | Huiei F Di Pietro A Trammell B | 2012 | Computer Communication Review2012，42，4： | 1 |
| 19 | Squamous cell carcinoma of the prostate显示文摘 | Di Pietro C Celia A De Stefani S | 2006 | Arch Ital Urol Androl2006，78，2： | 1 |
| 20 | Endochitinase from glioeladium virens: isolation, characterization, and synergistic antifungal activity in combination with glio- toxin显示文摘 | Di Pietro A Lorito M Hayes C K | 1993 | Phytopathology1993，83，： | 1 |
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