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| 1 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 2 | Predictive value of serum uric acid on cardiovascular disease and all-cause mortality in urban Chinese patients显示文摘背景在尿酸(SUA ) 铺平的增加的浆液和心血管的风险之间的协会被辩论十年了。几大研究规定了在心血管的疾病(CVD ) 或脑血管的疾病关于提高的 SUA 层次的临床的意义冲突结果。这研究的目的从 56 ~ 95 年在年龄的 3570 个住院病人是调查在 SUA 和 CVD 和所有原因死亡和他们的潜在的诊断 value.Methods A 之间的关系全部的(平均数(67. | WU Yong-quan LI Jue XU Yuan-xi WANG Yong-liang LUO Ying-yi HU Da-yi LIU Wei-jing YANG Ming PI Lin WANG Ming-sheng WANG Ji-yun ZHAO Shu-mei LI Mei-jing | 2010 | Chinese Medical Journal2010，，11： | 11 |
| 3 | No association between low-dose reserpine use and depression in older hypertensive patient: result of a multicenter, cross-sectional study显示文摘Background Reserpine is currently used by millions of Chinese hypertensive patients, in spite of the continued concern of its depressogenic effect, even when used in low dose. This study aimed to investigate the association between low-dose reserpine use and depression in older Chinese hypertensive patient. Methods In this cross-sectional, case-control study, we recruited patient aged 60 years or over who had regularly taken one or two tables of “compound reserpine and triamterene tablets (CRTTs)” for more than one year (reserpine user) from 26 community health centers located in 10 provinces in China. For each patient who took CRTTs, we selected an age (within five years) and sex matched hypertensive patient who had never taken any drugs containing reserpine (non-reserpine user) as control. Depressive symptoms were evaluated using a Chinese depression scale adapted from the Zung Self-Rating Depression Scale. Demographic, clinical data and laboratory examination results within six months were collected. Results From August 2018 to December 2018, 787 reserpine user and 787 non-reserpine user were recruited. The mean age of all study subjects was 70.3 years, with about equal numbers of males and females. The mean depression score was 40.4 in reserpine users and 40.6 in non-reserpine users (P = 0.7). The majority of study subject had a depression score < 53 (87.6% in reserpine users and 88.2% in non-reserpine users, respectively). There were no significant differences in the prevalence of mild, moderate or severe depression in reserpine users and non-reserpine users. Conclusions There is no association between low-dose reserpine use and depression in older hypertensive patient. The role of reserpine in the treatment and control of hypertension should be reconsidered;and further studies, especially randomized, controlled clinical trials to compare efficacy and safety of reserpine and other widely recommended anti-hypertensive agents are needed. | Guo-Hua ZHU Xi-Peng SUN Jing LI Lin PI Hai-Qin TANG Hai-Qing GAO Hong-Liang CONG Peng QU Xin-Zheng LU Xin-Jun ZHANG Luo-Sha ZHAO Yi-Fang GUO Dong-Xia LIU Liang-Qing ZHANG Hua TANG Yi-Xin HU Li FAN Qi HUA | 2019 | Journal of Geriatric Cardiology2019，16，8： | 8 |
| 4 | Urinary metabonomics study of Wu-tou-tang and its co-decoction with Pinelliae Rhizoma in adjuvant-induced arthritis rats显示文摘Wu-tou-tang was applied to treat rheumatoid arthritis,rheumatic arthritis,and joint pain for thousands of years.Aconiti Radix Cocta is the primary component of Wu-tou-tang,and Aconiti Radix and Pinelliae Rhizoma is one of the famous combination taboos in traditional Chinese medicine.A urinary metabonomics method based on the ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) had been established to quantify the changes of the endogenous metabolites in the urine of adjuvant-induced arthritis rats treated by Wutou-tang and Wu-tou-tang and Pinelliae Rhizoma(WP) co-decoctions.There was a clear separation between Wu-tou-tang and WP co-decoction treated groups in the PCA model.16 potential biomarkers had been identified which correlated with how Pinelliae Rhizoma influenced the therapeutic effect made by Wu-tou-tang.Results showed that it could reduce the therapeutic effects or make some side effects when Pinelliae Rhizoma is added in Wu-tou-tang.This is the first time to use metabonomics to investigate the reason of combination taboo. | Yao Qi Zi-Feng Pi Shu Liu Feng-Rui Song Ying Xu Na Lin Zhi-Qiang Liu | 2015 | Chinese Chemical Letters2015，26，3： | 6 |
| 5 | A Preliminary Study of the Noninvasive Remote Control System for Rat Bio-Robot显示文摘A system is described here that can noninvasively control the navigation of freely behaving rat via ultrasonic,epidermaland LED photic stimulators on the back.The system receives commands from a remote host computer to deliver specifiedelectrical stimulations to the hearing,pain and visual senses of the rat respectively.The results demonstrate that the three stimuliwork in groups for the rat navigation.We can control the rat to proceed and make right and left turns with great efficiency.Thisexperiment verified that the rat was able to reach a setting destination in the way of cable with the help of a person through theappropriate coordination of the three stimulators.The telemetry video camera mounted on the head of the rat also achieveddistant image acquisition and helped to adjust its navigation path over a distance of 300 m.In a word,the non-invasive motioncontrol navigation system is a good,stable and reliable bio-robot. | Xitian Pi~(1,2),Shuangshuang Li~1,Lin Xu~1,Hongying Liu~1,Shenshan Zhou~1,Kang Wei~1,Zhenyu Wang~1,Ziru Jia,Xiaolin Zheng~(1,2),Zhiyu Wen~2 1.Bioengineering College,Chongqing University,Chongqing 400030,P.R.China 2.Key Laboratories for National Defense Science and Technology of Innovative Micro-Nano Devices and System Technology,Chongqing University,Chongqing 400030,P.R.China | 2010 | Journal of Bionic Engineering2010，7，4： | 4 |
| 6 | Mechanism of Incompatible Herb Pairs, Panax ginseng and Veratrum nigrum L,: Material Basis and Metabolic Profiles of Ginsenosides in Rat Intestinal Bacteria显示文摘在繁体中文药理论,人参属人参和 Veratrum nigrum L。是重要不兼容的植物对。在老鼠的新陈代谢上的主要部件和影响的内容变化上的研究肠的细菌是有用的理解这的不兼容的机制植物对。在这研究,人参皂甙和他们的 metaboltic 的内容变化在 P 的摘录介绍。P 的人参和相容性。有 V 的人参。nigrum L。(G-V ) 用 electrospray 电离团 spectrometry (ESIMS ) 和 UPLCMS n , 分别地。大多数人参皂甙的相对内容在 G-V 的摘录被减少。而且,人参皂甙 Rb 1, Rb 2, Rc 和 Rd 能在老鼠被使产生代射变化到 Rd, F2 和 C-K 肠的细菌。在在 10:5, 10:7 和 10:10 和人参皂甙 Rb 1, Rb 2 的新陈代谢的率的比率的 G-V 摘录的 Rb 1, Rb 2 和 Rc 和到 Rd 的 Rc 的新陈代谢的速度,到在所有相容性摘录的 F2 的 Rd 在 P 是比那低的。人参摘录。在结论,这研究说明了机制由相对内容的比较和在 P 的相容性以后的人参皂甙的新陈代谢的侧面减少效果。人参和 V。nigrum L。 | Xiudong Yang Xue Li Ying Xu Zifeng Pi Na Lin Zhiqiang Liu Fengrui Song | 2015 | Chinese Journal of Chemistry2015，33，9： | 3 |
| 7 | Overexpression of UHRF1 is significantly associated with poor prognosis in laryngeal squamous cell carcinoma显示文摘 | Pi JT Lin Quan Q | 2013 | Med Oncol2013，30，4： | 1 |
| 8 | Expression of vascular endothelial growth factor in normal liver and hepatocellular carcinoma:an immuno-histochemical study显示文摘 | Chow NH Hsu PI Lin XZ | 1997 | Hum Pathol1997，28，6： | 1 |
| 9 | Quenched solid density functional theory and pore size analysis of micro- mesoporous carbons显示文摘 | Neimark A Lin Y Ravikovitch PI | 2009 | Carbon2009，47，7： | 1 |
| 10 | Analgesic effect of lidocaine patch 5% in the treatment of acute herpes zoster:doule lind and vehicle controlled study显示文摘 | Lin pi Fan SZ Huang CH | 2008 | Reg Anesth Pain Med2008，33，4： | 1 |
| 11 | Expression of vascular endothelial growth factor in normal liver and hepatocellular carcinoma:an immunohistochemical study显示文摘 | Chow NH Hsu PI Lin XZ | 1997 | Hum Pathol1997，28，6： | 1 |
| 12 | Community based epidemiological study on hy 2 peruricemia and gout in Kin-Hu, Kinmen 1 显示文摘 | Lin KC Lin HY Chou PI | 2000 | J Rheumatol2000，27，4： | 1 |
| 13 | Expression of vascular endothelial growth factor in normal liver and hepatocellular carcinoma: an immunohistochemical study 显示文摘 | Chow NH Hsu PI Lin XZ | 1997 | Hum Pathol1997，28，： | 1 |
| 14 | Expression of vascular endothelial growth factor in normal liver and hepatocellular carcinoma,an immunohistochemical study显示文摘 | Clow NH Hsu PI Lin XZ | 1997 | Hum Pathol1997，28，： | 1 |
| 15 | Expression of vascular endothelial growth factor in normal liver and hepatocellular carcinoma:an immunohistochemical study显示文摘 | Hsu PI Lin XZ | 1997 | Hum Pathol1997，28，6： | 1 |
| 16 | Clinical correlates and familial aggregation of age at onset in bipolar disorder显示文摘 | Lin PI McInnis MG Potash JB | 2006 | Am J Psychiatry2006，163，2： | 1 |
| 17 | Electronic structures of Ga2O3(Gd2O3) gate dielectric on n-Ge(001) as grown and after CF4 plasma treatment:A synchrotron-radiation photoemission study显示文摘 | Pi T W Lee W C Huang M L Chu L K Lin T D Chiang T H Wang Y C Wu Y D Hong M Kwo J | | 0，，： | 1 |
| 18 | Mycoplasma pneumoniae encephalitis in childhood 显示文摘 | Lin WC Lee PI Lu CY | 2010 | J Micorbiol Immunol In- feet2010，35，3： | 1 |
| 19 | Expression of vascular endohelial growth factor in normal and hepa to cellular carcinomas an immunohisto-chemical study显示文摘 | Chow NH Hsu PI Lin Xz | 1997 | Hum Pahol1997，28，： | 1 |
| 20 | The relationship of rs2070744 polymorphismof endothelial nitric oxide synthase gene to essential hypertension 显示文摘 | Li Dongbao Hua Qi Pi Lin | 2006 | J Cap Univ Med Sei2006，27，2： | 1 |
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