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| 1 | Phytochemical analysis,hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats显示文摘Objective:To investigate the hepatoprotective and antioxidant activities of Alchornea cordifolia (A.cordifolia) leaf extract.Methods:Various solvent fractions of the methanol extract of the leaf of the plant.4.cordifolia Mull.Arg(Fam:Euphorbiaceae) were evaluated for hepatoprotective activity by carbon tetrachloride-induced liver damage in rats.The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase(SGOT/ AST),serum glutamate pyruvate transaminase(SCPT/ALT),alkaline phosphatase(ALP) and total bilirubin.The in vitro antioxidant activity of the extract was also evaluated by the I,I-diphenyl 2-picrylhydrazyl(DPPH) free radical scavenging assay.The extract was subjected to preliminary phytoehemical screening.Results:The ethyl acetate and chloroform fractions,at a dose of 300 mg/kg,produced significant(P<0.05) hepatoprolection by decreasing the activities of the serum enzymes and bilirubin while there were marked scavenging of the DPPH free radicals by the fractions.The effects were comparable to those of the standard drugs used for the respective experiments,silymarin and ascorbic acid.Alkaloids,flavonoids,saponins and tannins were delected in the phylochemical screening.Conclusion:From this study,it was concluded that the plant of A.cordifolia possesses hepatoprotective as well as antioxidant activities and these activities reside mainly in the ethyl acetate and acetone fractions of methanol leaf extract. | Patience O Osadebe Festus BC Okoye Philip F Uzor Nneka R Nnamani Ijeoma E Adiele Nkemakonam C Obiano | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 2 |
| 2 | Human papillomavirus and cervical cancer显示文摘 | Mark Schiffman Philip E Castle Jose Jeronimo Ana C Rodriguez Sholom Wacholder | 2007 | 2007 (9590)2007，，9590： | 2 |
| 3 | Human papillomavirus and cervical cancer显示文摘 | Mark Schiffman Philip E Castle Jose Jeronimo Ana C Rodriguez Sholom Wacholder | 2007 | The Lancet . 2007 (9590)2007，，9590： | 2 |
| 4 | Causes cortical brain slices during hypoxia and ischemic: role of ion channels and membrane damage显示文摘 | PHILIP E BICKER M BONN of calcium accumulation in rat C M | 1994 | Brain Res1994，665，2： | 1 |
| 5 | BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy显示文摘 | Cerchietti Leandro C Hatzi Katerina Caldas-Lopes Eloisi Yang Shao Ning Figueroa Maria E Morin Ryan D Hirst Martin Mendez Lourdes Shaknovich Rita Cole Philip A Bhalla Kapil Gascoyne Randy D Marra Marco Chiosis Gabriela Melnick Ari | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 6 | Local Heat Transfer and Pressure Drop for Finned-Tube Heat Exchangers Using Oval Tubes and Vortex Generatots 显示文摘 | O'Brien James E Sohal Manohar S Wallstedt Philip C | 2004 | Journal of Heat Transfer2004，126，82： | 1 |
| 7 | Surface modification for aluminium pigment inhibition 显示文摘 | Philip K Anders E Palmqvist C | 2006 | Advances in Colloid and Interface Science2006，，118120： | 1 |
| 8 | Distance to nearest neighbor as a measure of spatial relationships in populations ecology显示文摘 | Philip J C Francis C E | 1954 | The Ecological Society of America1954，35，： | 1 |
| 9 | Generalized vector explicit guidance显示文摘 | Ohlmeyer E J Philips C A | 2006 | Journal of Guidance Control and Dynamics2006，29，2： | 1 |
| 10 | Reversible middle cerebral artery occlusion craniectomy in rats显示文摘 | Zea long E Philip RW Saca C | 1989 | Stroke1989，20，： | 1 |
| 11 | Separation of functionalities in pyrolytic tar by gel permeation chromatography-gas chromatography显示文摘 | SHEU Y-H E PHILIP C V ANTHONY R G | 1984 | J Chromatogr Sci1984，22，1： | 1 |
| 12 | The cellular immune response in the tracheal mueosa to Myco- plasma gallisepticum in vaccinated and unvaccinated chick- ens in the acute and chronic stages of disease 显示文摘 | GAUNSON J E PHILIP C J WHITHEAR K G | 2006 | Vac- cine2006，24，14： | 1 |
| 13 | Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes显示文摘 | PHILIP E C | 2012 | Endocrinology2012，153，2： | 1 |
| 14 | Extending synthesis access to proteins with a removable acyl transfer auxiliary显示文摘 | JOHN OFFER C N C BODDY PHILIP E DAWSON | 2002 | J Am Chem Soc2002，124，： | 1 |
| 15 | The cellular immune response in the tracheal mucosa to Myco- plasma gaUisepticum in vaccinated and unvaccinated chick- ens in the acute and chronic stages of disease 显示文摘 | GAUNSON J E PHILIP C J WHITHEAR K G | 2006 | Vac- cine2006，24，14： | 1 |
| 16 | The Relationship Between Competitive Anxiety and Self-Presentational Concerns显示文摘 | PHILIP W ROBERT C E | 1998 | J Sport Exe Psychol1998，20，： | 1 |
| 17 | Multi-site evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | Serge Andréfou?t Philip Kramer Damaris Torres-Pulliza Karen E Joyce Eric J Hochberg Rodrigo Garza-Pérez Peter J Mumby Bernhard Riegl Hiroya Yamano William H White Mayalen Zubia John C Brock Stuart R Phinn Abdulla Naseer Bruce G Hatcher Frank E Muller-Karg | 2003 | Remote Sensing of Environment2003，，1： | 1 |
| 18 | Plant regeneration from tissue culture of maize显示文摘 | Green C E Philips R L | 1975 | Crop Sci1975，15，： | 1 |
| 19 | Separating population structure from population history: A cladistic analysis the geographical distribution of mitochondrial DNA haplotypes in the tiger salamander, Ambystoma tigrinum显示文摘 | Templeton A R Routman E Philips C A | 1995 | Genetics1995，140，： | 1 |
| 20 | Chromosomal DNA restriction endonuclease digestion patterns of b-lactamase- producing Enterococcus faecalis isolates collectedfrom a single hospital over a 7-year period显示文摘 | Prema S S John F T Philip E C | 1996 | J Clin Microbiol1996，，8： | 1 |
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