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| 1 | Human papillomavirus does not have a causal role in colorectal carcinogenesis显示文摘AIM: To investigate the presence of human papillomavirus(HPV) DNA along with the integration,the quantification and the expression of the HPV16 in colorectal cancers.METHODS: A prospective series of colorectal tumors were genotyped for HPV DNA.The clinical and pathological variables of the HPV-positive tumors were compared to those of HPV-negative samples.The integration status of HPV16 was evaluated by calculating E2/E6 ng ratios.HPV16-positive tumors were also evaluated for(1) E2,E4,E5,E6 and E7 viral gene ng quantification;(2) relative quantification compared to W12 cells; and(3) viral E2,E4,E5,E6 and E7 mR NA transcripts by real-time polymerase chain reaction.RESULTS: HPV infection was detected in 16.9% of all tumors examined,and HPV16 was the most frequent type detected(63.6% of positive tissues).Notably,the clinical and pathological features of HPV-positive colorectal cancers were not significantly different than those of HPV-negative cancers(χ2 and t-test for all clinical and pathological features of HPV-positive vs HPV-negative colorectal cancers: p ns).HPV16 DNA was present exclusively in episomal form,and the HPV16 E2,E4,E5,E6 and E7 genes were detected in tracenanogram quantities.Furthermore,the HPV16 genes ranged from 10-3 to 10-9 compared to W12 cells at an episomal stage.Although the extractions were validated by housekeeping gene expression,all the HPV16 positive tissues were transcriptionally inactive for the E2,E4,E5,E6 and E7 mR NAs.CONCLUSION: Based on our results,HPV is unlikely involved in colorectal carcinogenesis. | Laura Lorenzon Francesca Mazzetta Emanuela Pilozzi Giordana Uggeri Maria Rosaria Torrisi Mario Ferri Vincenzo Ziparo Deborah French | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 2 | 感染毛滴虫女性的人乳头瘤病毒感染情况分析显示文摘目的分析感染毛滴虫女性的人乳头瘤病毒(HPV)感染率及基因型分布情况。方法 2010年1月至2014年12月该院收治的滴虫感染,且同时做了HPV检查的女性患者673例,分析HPV感染率及基因型分布。结果 HPV总感染率为42.20%(284/673),40~<50岁年龄段感染率最高,达46.36%(121/261),其次为大于或等于50岁年龄段感染率,达40.78%(84/206),但是不同年龄段的感染率差异无统计学意义(χ2=3.450、P=0.329)。在284例同时感染滴虫、HPV女性中,高危型感染以16型为主,其次是52、58、18型等。低危型感染以11型为主。结论感染毛滴虫女性的HPV感染率高于一般人群,但是感染的HPV基因型分布与一般人群相似。 | 孟少志 | 2015 | 国际检验医学杂志2015，36，22： | 0 |
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