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| 1 | Impact of endoscopic ultrasound-guided fine needle biopsy for diagnosis of pancreatic masses显示文摘AIM: To evaluate the diagnostic accuracy of histologi- cal evaluation of pancreatic tissue samples obtained by a modified method for recovering and processing the endoscopic ultrasound (EUS)-guided fine needle aspira- tion (FNA) material in the differential diagnosis of pan- creatic solid masses. METHODS: Sixty-two consecutive patients with pan- creatic masses were prospectively studied. EUS was performed by the linear scanning Pentax FG-38UX ech- oendoscope. Three FNAs (22G needle) were carried out during each procedure. The materials obtained with first and second punctures were processed for cytological study. Materials of the third puncture were recovered into 10% formol solution by careful injection of saline so- lution through the needle, and processed for histological study. RESULTS: Length of the core specimen obtained for his- tological analysis was 6.5 ± 5.3 mm (range 1-22 mm). Cytological and histological samples were considered as adequate in 51 (82.3%) and 52 cases (83.9%), respec- tively. Overall sensitivity of both pancreatic cytology and histology for diagnosis of malignancy was 68.4%. Con- trary to cytology, histology was able to diagnose tumours other than adenocarcinomas, and all cases of inflamma- tory masses. Combination of cytology and histology al- lowed obtaining an adequate sample in 56 cases (90.3%), with a global sensitivity of 84.21%, specificity of 100% and an overall accuracy of 90.32%. The complication rate was 1.6%.CONCLUSION: Adequate pancreatic core specimens forhistological examination can be obtained by EUS-guided FNA. This technique is mainly useful for the diagnosis of different types of pancreatic tumours and evaluation of benign diseases. | Julio Iglesias-Garcia Enrique Dominguez-Munoz Antonio Lozano-Leon Ihab Abdulkader Jose Larino-Noia Jose Antunez Jeronimo Forteza | 2007 | World Journal of Gastroenterology2007，13，2： | 17 |
| 2 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 3 | Quantitative Endoscopic Ultrasound Elastography: An Accurate Method for the Differentiation of Solid Pancreatic Masses显示文摘 | Julio Iglesias–Garcia Jose Larino–Noia Ihab Abdulkader Jeronimo Forteza J. Enrique Dominguez–Munoz | 2010 | Gastroenterology2010，，4： | 3 |
| 4 | EUS elastography for the characterization of solid pancreatic masses显示文摘 | Julio Iglesias-Garcia Jose Larino-Noia Ihab Abdulkader Jeronimo Forteza J. Enrique Dominguez-Munoz | 2009 | Gastrointestinal Endoscopy2009，，6： | 3 |
| 5 | Human papillomavirus and cervical cancer显示文摘 | Mark Schiffman Philip E Castle Jose Jeronimo Ana C Rodriguez Sholom Wacholder | 2007 | 2007 (9590)2007，，9590： | 2 |
| 6 | Human papillomavirus and cervical cancer显示文摘 | Mark Schiffman Philip E Castle Jose Jeronimo Ana C Rodriguez Sholom Wacholder | 2007 | The Lancet . 2007 (9590)2007，，9590： | 2 |
| 7 | 牙周炎和院内获得性肺炎之间的关联:观察性研究的系统评价和荟萃分析显示文摘目的:评估重症监护病房(ICU)患者的牙周炎与院内获得性肺炎之间的关联。材料和方法:本研究依据系统评价和荟萃分析的首选报告项目(PRISMA)的指南进行,并已在PROSPERO(国际前瞻性系统评价注册,英国约克大学)注册,注册号为CRD42018105124。本研究在五个数据库中进行了搜索,没有语言或出版日期的限制。在检索的560项研究中,对10篇进行了全文分析,其中五项病例对照研究符合条件,纳入荟萃分析。荟萃分析结果通过敏感性分析和异质性检验进行评价。通过比值比(OR)和95%置信区间计算简要效果量度。结果:在苔萃分析中.牙周炎与院内获得性肺炎之间存在显著相关性(OR 2.55,95%CI:1.68-3.86)。在此荟萃分析中,12=0%。结论:证据表明牙周炎与院内获得性肺炎之间呈正相关。与没有牙周炎的患者相比,入住ICU的牙周炎患者更容易出现院内获得性肺炎。 | Laura Silva Jeronimo Lucas Guimaraes Abreu Fabiano Araujo Cunha Rafael Paschoal Esteves Lima 程梦琳(译) 张珊珊(审) 郑树国(审) | 2020 | 中国口腔医学继续教育杂志2020，23，5： | 2 |
| 8 | Human papillomavirus and cervical cancer显示文摘 | Schiffman M Castle PE Jeronimo J | 2007 | The Lancet2007，370，9590： | 1 |
| 9 | Nucleosomes in the pathogenesis of systemic lupus erythematosus显示文摘 | Koutouzov S Jeronimo AL Campos H | 2004 | Rheum Dis Clin North Am2004，30，3： | 1 |
| 10 | Positive correla tion of tissue inhibitor of metalloproteinase 3 and death associated protein kinase hypermethylation in head and neck squamous cell carcinoma显示文摘 | Nayak C S Carvalho A L Jeronimo C | 2007 | Laryngoscope2007，117，8： | 1 |
| 11 | Optimal positive cutoff points for care HPV testing of clinician-and self-collected specimens in primary cervical cancer screening:an analysis from rural China显示文摘 | Kang LN Jeronimo J Qiao YL | 2014 | J Clin Microbiol2014，52，6： | 1 |
| 12 | Positive correlation of tissue inhibitor of metalloproteinase-3 and deathassociated protein kinase hypermethylation in head and neck squamous cell carcinoma 显示文摘 | Nayak CS Carvalho AL Jeronimo C | 2007 | Laryngoscope2007，117，8： | 1 |
| 13 | A quantitative promoter methylation profile of prostate cancer 显示文摘 | Jeronimo C Henrique R Hoque MO | 2004 | Clin Cancer Res2004，10，24： | 1 |
| 14 | A quantitative promoter methylation profile of prostate cancer 显示文摘 | Jeronimo C Henrique R Hoque MO | 2004 | Clin Cancer Res2004，10，24： | 1 |
| 15 | multicountry evaluation of care HPV testing,visual inspection with acetic acid,and papanicolaou testing for the detection of cervical cancer显示文摘 | Jeronimo J Bansil P Lim J | 2014 | Int J Gynecol Cancer2014，24，3： | 1 |
| 16 | Influence of environmental and nutritional factors in the production of astaxanthin from Haematococcus pluvialis显示文摘 | Dominguez-Bocanegra A R Legarreta I G Jeronimo F M | 2004 | Biores Technol2004，92，2： | 1 |
| 17 | Human papillomavirns and cervical cancer显示文摘 | Schiffman M Castle PE Jeronimo J | 2007 | Lancet2007，370，9590： | 1 |
| 18 | Quantitative methylation profiling of renal tumors and the discovery of a new generation of molecular markers显示文摘 | JERONIMO C | 2005 | Future Oncol2005，1，2： | 1 |
| 19 | The accuracy of colposcopic grading for detection of high-grade cervical intraepithelial neoplasia 显示文摘 | Massad LS Jeronimo J Katki HA | 2009 | J Low Genit Tract Dis2009，13，3： | 1 |
| 20 | Assessment of the cervix after acetic acid wash:Interrater agreement using photographs 显示文摘 | SELLDRS JW JERONIMO J SANKARANARAYANANR | 2002 | Obstetrics & Gynecology2002，99，4： | 1 |
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