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| 1 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 2 | Regional innovation systems: Institutional and organisational dimensions显示文摘 | Philip Cooke Mikel Gomez Uranga Goio Etxebarria | 1997 | Research Policy1997，，4： | 2 |
| 3 | Regional innovation systems:competitive regulation in the new Europe显示文摘 | Philip Cooke | 1992 | Geoforum1992，23，3： | 1 |
| 4 | Modeling Average Current Mode Control 显示文摘 | Philip Cooke | 2000 | IEEE2000:256-2622000，2000，： | 1 |
| 5 | Regional innovation systems, clean technology & ja- cobian cluster-platform policies 显示文摘 | Cooke Philip | 2008 | Regional Science Policy & Practice2008，1，1： | 1 |
| 6 | The use of laparoscopic subtotal cholecystectomy for complicated cholelithiasis 显示文摘 | Philips JA Lawes DA Cook A J | 2008 | Surg Endosc2008，22，7： | 1 |
| 7 | Health effects of natural spring waters:A protocol for systematic reviews with a regional case example显示文摘BACKGROUND: Spring water therapies have been used since at least 1550 BC. Despite the growing body of evidence supporting these therapies for a range of conditions, including musculoskeletal, dermatological, respiratory and cardiovascular conditions, they do not currently form part of mainstream healthcare in many countries. The protocol established in this paper aims to support systematic reviews that examine the health outcomes associated with human exposure to regional spring waters, using the Australia and New Zealand context as a case study. METHODS/DESIGN: The protocol searches for studies in eight health/medical databases, searches three local health/medical journals, and includes forwards and backwards searching. Standard systematic review methods are used including: specifying pre-determined inclusion criteria and data management plans, appraising the studies for bias, and allocation to a hierarchy of evidence. DISCUSSION: The protocol supports a review and comprehensive synthesis of the current evidence regarding the health effects of natural spring water, and can be adapted for reviews in other regions. From this evidence, recommendations regarding practice and future research can be made on the therapeutic role of spring water. | Jessica Stanhope Philip Weinstein Angus Cook | 2015 | Journal of Integrative Medicine2015，13，6： | 1 |
| 8 | Regional innovation system: general find ings and some new evidence from biotechnology clusters 显示文摘 | PHILIP COOKE | 2002 | Journal of Technology Transfer2002，27，： | 1 |
| 9 | The use of laparoscopic subtotal cholecystectomy for complicated cholelithiasis显示文摘 | Philips JA Lawes DA Cook AJ | | 0，，7： | 1 |
| 10 | Regional Innovation Systems:Competitive Regula-tion in the New Europe显示文摘 | Philip Cooke | 1992 | Geoforum1992，23，3： | 1 |
| 11 | The use of laparoscopic subtotal cholecystectomy for complicated cholelithiasis显示文摘 | Philips JA Lawes DA Cook AJ | 2008 | Surg Endosc2008，22，7： | 1 |
| 12 | Regional innovation systems: gener- al findings and some new evidence from biotechnology dusters 显示文摘 | PHILIP COOKE | 2002 | Journal of Technology Transfer2002，，27： | 1 |
| 13 | Regional innovation systems: institutional and organizational dimensions显示文摘 | PHILIP COOK | 1997 | Research Policy1997，，26： | 1 |
| 14 | Novel Mechanism for Endothelial Dysfunction: Dysregulation of Dimethylarginine Dimethylaminohydrolase显示文摘 | Akira Ito Philip S. Tsao Shanthi Adimoolam Masumi Kimoto Tadashi Ogawa John P. Cooke | 1999 | Circulation1999，，： | 1 |
| 15 | The use of laparoscopic subtotal holecystectomy for complicated cholelithiasis 显示文摘 | Philips JAE Lawes DA Cook A J | 2008 | Surg Endosc2008，22，： | 1 |
| 16 | Re- gional innovation systems: Institutional and organizational di- mensions 显示文摘 | Philip Cooke Mikel Gomez Uranga Goio Etxebarria | 1997 | Research Policy1997，26，45： | 1 |
| 17 | Regional Innovation Systems: General Findings and Some New Evidence from Biotechnology Clusters显示文摘 | Philip Cooke | 2002 | The Journal of Technology Transfer2002，，1： | 1 |
| 18 | Small Firms,Social Capital and the Enhancement of Business Performance Through Innovation Programs显示文摘 | Philip Cooke David wills | 1999 | Small Business Economics1999，，13： | 1 |
| 19 | Regional Innovation Systems: Institutional and Organisational Dimen- sions 显示文摘 | Philip Cooke Mikel Gomez Uranga Goio Etxebarria | 1997 | Research Policy1997，26，45： | 1 |
| 20 | Homocysteine Impairs the Nitric Oxide Synthase Pathway: Role of Asymmetric Dimethylarginine显示文摘 | Markus C. Stühlinger Philip S. Tsao Jeng-Horng Her Masumi Kimoto Robert F. Balint John P. Cooke | 2001 | Circulation: Journal of the American Heart Association2001，，： | 1 |
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