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| 1 | Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction显示文摘Historically,influenza pandemics have arisen from avian influenza viruses.Avian influenza viruses H5N1 and H9N2 are potential pandemic candidates.Infection of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%,which has been attributed to dysregulation of the cytokine system.Human macrophages and epithelial cells infected with some genotypes of H5N1 and H9N2 viruses express markedly elevated cytokine and chemokine levels when compared with seasonal influenza A subtype H1N1 virus.The mechanisms underlying this cytokine and chemokine hyperinduction are not fully elucidated.In the present study,we demonstrate that autophagy,a tightly regulated homeostatic process for self-digestion of unwanted cellular subcomponents,plays a role in cytokine induction.Autophagy is induced to a greater extent by H9N2/G1,in association with cytokine hyperinduction,compared with H1N1 and the novel pandemic swine-origin influenza A/H1N1 viruses.Using 3-methyladenine to inhibit autophagy and small interfering RNA to silence the autophagy gene,Atg5,we further show that autophagic responses play a role in influenza virus-induced CXCL10 and interferon-a expression in primary human blood macrophages.Our results provide new insights into the pathogenic mechanisms of avian influenza viruses. | Anna Hing-Yee Law Davy Chun-Wai Lee Kwok-Yung Yuen Malik Peiris Allan Sik-Yin Lau | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 2 | Avian influenza virus directly infects human natural killer cells and inhibits cell activity显示文摘Natural killer(NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously,we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza,and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity. | Huawei Mao Yinping Liu Sin Fun Sia JS Malik Peiris Yu-Lung Lau Wenwei Tu | 2017 | Virologica Sinica2017，32，2： | 4 |
| 3 | 感染人类的禽流感病毒A(H5N1)研究进展显示文摘 | Abdel-Nasser Abdel-Ghafar Tawee Chotpitayasunondh Zhancheng Gao Frederick G. Hayden Nguyen Duc Hien Menno D. de Jong Azim Naghdaliyev J.S. Malik Peiris Nahoko Shindo Santoso Soeroso Timothy M. Uyeki 钟晓琴(译) 王关嵩(校) | 2009 | 中华肺部疾病杂志(电子版)2009，2，1： | 4 |
| 4 | Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury显示文摘 | Yumiko Imai Keiji Kuba G. Greg Neely Rubina Yaghubian-Malhami Thomas Perkmann Geert van Loo Maria Ermolaeva Ruud Veldhuizen Y.H. Connie Leung Hongliang Wang Haolin Liu Yang Sun Manolis Pasparakis Manfred Kopf Christin Mech Sina Bavari J.S. Malik Peiris Ar | 2008 | Cell2008，，2： | 4 |
| 5 | Value of multi-disciplinary input into laparoscopic management of rectal cancer-An observational study显示文摘AIM To assess the impact of multi-disciplinary teams(MDTs)management in optimising the outcome for rectal cancers.METHODS We undertook a retrospective review of a prospectively maintained database of patients with rectal cancers(defined as tumours≤15 cm from anal verge)discussed at our MDT between Jan 2008 and Jan 2011.The data was validated against the national database to ensure completeness of dataset.The clinical course and follow-up data was validated using the institution’s electronic patient records.The data was analysed in terms of frequencies and percentages.Significance of any differences were analysed usingχ2 test.A Kaplan-Meier analysis was performed for overall survival and disease free survival.RESULTS Following appropriate staging,one hundred and thirtythree patients were suitable for potentially curative resections.Seventy two(54%)were upper rectal cancer(URC)-tumour was>6 cm from the anal verge and 61(46%)were lower rectal cancers(LRC)-lower extent of the tumour was palpable≤6 cm.Circumferential resection margin(CRM)appeared threatened on preoperative MRI in 19/61(31%)patients with LRC requiring neo-adjuvant therapy(NAT).Of the 133 resections,118(89%)were attempted laparoscopically(5%conversion rate).CRM was positive in 9(6.7%)patients;Median lymph node harvest was 12(2-37).Major complications occurred in 8(6%)patients.Median follow-up was 53 mo(0-82).The 90-d mortality was 2(1.5%).Over the followup period,disease related mortality was 11(8.2%)and overall mortality was 39(29.3%).Four(3%)patients had local recurrence and 22(16.5%)patients had distant metastases.CONCLUSION Management of rectal cancers can be optimized with multidisciplinary input to attain acceptable long-term oncological outcomes even when incorporating a laparoscopic approach to rectal cancer resection. | Pawan Kumar Dhruva Rao Sooriyaratchige Pradeep Manjula Peiris Seema Safia Arif Rhodri A Davies Ashraf Gergies Masoud Puthucode Narayanan Haray | 2017 | World Journal of Gastrointestinal Surgery2017，9，6： | 2 |
| 6 | SARS study group:coro-navirus as a possible cause of severe acute respiratory syndrome显示文摘 | Peiris J S Lai S T Poon L L | 2003 | Lancet2003，361，： | 2 |
| 7 | Coronavirus as a possible cause of severe acute respiratory syndrome显示文摘 | Peiris JS Lai ST Poon LL | | 0，，： | 2 |
| 8 | Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis显示文摘 | Lok Yung Chan Hoi Hin Kwok Renee Wan Yi Chan Malik Joseph Sriyal Peiris Nai Ki Mak Ricky Ngok Shun Wong Michael Chi Wai Chan Patrick Ying Kit Yue | 2011 | Journal of Ethnopharmacology2011，，3： | 2 |
| 9 | Human herpesvirus 6 and 7 DNA in peripheral blood leukocytes and plasma in patients with pityriasis rosea by polymerase chain reaction - a prospective case control study显示文摘 | Chiu SSS Peiris JSM | 2001 | Acta Derm Venereol2001，81，： | 1 |
| 10 | Biopolymer production by a Klebsiella oxytoca isolate using whey as fermentation substrate显示文摘 | PEIRIS P S | 1997 | Biotechnology Letters1997，19，2： | 1 |
| 11 | H5N1 influenza viruses isolated from geese in Southeastern China: evidence for genetic reassortment and interspecies transmission to duck 显示文摘 | Guan Y Peiris M Kong K F | 2002 | Virol2002，292，： | 1 |
| 12 | Human infection with influenza H9N2 显示文摘 | Peiris M Yuen KY Leung CW | 1999 | Lancet1999，354，： | 1 |
| 13 | Coronavirus as a possible cause of severe acute respiratory syndrome显示文摘 | Peiris J Lai S Poon L | 2003 | Lancet2003，361，9366： | 1 |
| 14 | Primary human herpes virus infection transmitted from donor to recipient through bone marrow infusion显示文摘 | Lau YL Peiris M Chan GCF | 1998 | Bone Marrow Transplant1998，21，： | 1 |
| 15 | Human infection with influenza H9N2显示文摘 | Peiris M Yuen K Y Leung C W | 1999 | lancet1999，354，： | 1 |
| 16 | Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus 显示文摘 | Yuen KY Chan PK Peiris M | 1998 | Lancet1998，351，9101： | 1 |
| 17 | H5N1 outbreaks and en- zooticinfluenza显示文摘 | Webster RG Peiris M Chen H | 2006 | Emerg Infect Dis2006，，12： | 1 |
| 18 | Optimization of bioprocess conditions for exopolysaccharide production by Klebsiella oxytoca显示文摘 | DLAMINI A M BAVOR H J | 1998 | World Journal of Microbiology & Biotechnology1998，，14： | 1 |
| 19 | Emergence of a novel swine-origin influenza A virus (S-OIV) H1NI virus in humans显示文摘 | Peiris JS Poon LL Guan Y | 2009 | J Clin Virol2009，45，3： | 1 |
| 20 | Coronavirus as a possible cause of severe acute respiratory syndrome显示文摘 | Peiris JS Lai ST Poon LL | 2003 | Lancet2003，361，9366： | 1 |
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