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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A role for glutamate decarboxylase during tomato ripening:the eharaeterisation of a cDNA encoding a putative glutamate decarboxylase with a calmodulin binding site 显示文摘 | PEDRO P G LEE W STEVE P DON G JULIE E G | 1995 | Plant Molecular Biology1995，27，6： | 1 |
| 3 | Blast resistance capacity of reinforced concrete slabs 显示文摘 | Pedro F Silva P E Lu B G | 2009 | Journal of Structural Engineering2009，135，6： | 1 |
| 4 | Fatigue striation spacing and equivalent initial flaw size in Al 2024-T3 riveted specimens显示文摘 | PEDRO M G P PAULO F P PAULO M S T | 2005 | Theoretical and Applied Fracture Mechanics2005，43，1： | 1 |
| 5 | Synthesis of black ceramic pig- ments from secondary raw materials 显示文摘 | Costa G Della V P Ribeiro M J De Oliverira Antonio Pedro Novaes Monros Tomas Guillermo Labrineha Batista Joao Antonio | 2008 | Dyes and Pig- ments2008，，77： | 1 |
| 6 | Metazihemerythin models feature a bis-benzimidazole tripped ligand structure and spectroscopy of (μ-oxo)bis(μ-benzoate)bis (bis (2-benzimidazoly methyl) amine) diiron( Ⅲ )显示文摘 | Pedro G R Nieves C P Ahmed B H | 1988 | J Am Chem Soc1988，110，： | 1 |
| 7 | Design,synthesis and application of fluorescent 2,1,3-benzothiadiazole-triazole-linked biologically active lapachone derivatives显示文摘 | DA CRUZ EDUARDO H G CARVALHO PEDRO H P R CORRêA JOSéR | 2014 | New J Chem2014，38，： | 1 |
| 8 | Self-organizing maps application in a remote water quality monitoring system显示文摘 | Octavian A P Pedro M B Silva G J | 2005 | IEEE Transaction on Instrumentation and Measurement2005，54，1： | 1 |
| 9 | Evaluation of im- mediate endoscopic realignment as a treatment modality for traumatic urethral inj uries显示文摘 | Hadjizacharia P Inaba K Pedro G | 2008 | J Trauma2008，64，6： | 1 |
| 10 | Clinical evidence for enteral nutri-tional support with glutamine:A systematic review显示文摘 | Abelarda G L Pedro P G | 2003 | Nutri2003，19，： | 1 |
| 11 | Predictive accuracy of original and recalibrated Framingham risk score in the Swiss population显示文摘 | Pedro Marques-Vidal Nicolas Rodondi Murielle Bochud Arnaud Chiolero Alain Pécoud Daniel Hayoz Fred Paccaud Vincent Mooser Mathieu Firmann Gérard Waeber Peter Vollenweider | 2008 | International Journal of Cardiology2008，，3： | 1 |
| 12 | Metazihemerythin models feature a bis-benzimidazole tripped ligand, structure and spectroscopy of (μ-oxo) bis (μ-benzoate) bis (his (2-benzimidazoly methyl) amine) diiron (Ⅲ)显示文摘 | Pedro G R Nieves C P Ahmed B H | 1988 | Chem Soc1988，110，： | 1 |
| 13 | Self-organizing maps application in a remote water quality monitoring system 显示文摘 | Octavian A P Pedro M B Silva G J | 2005 | IEEE Transactions on Instrumentation and Measurement2005，54，1： | 1 |
| 14 | Sleep stage classification using fuzzy sets and machine learning techniques 显示文摘 | Pedro P Pavel G Leticia A | 2004 | Neurocomputing2004，，58： | 1 |
| 15 | Spectral-Spatial PixelCharacterization Using Gabor Filters for Hyperspectral ImageClassification显示文摘 | OLGA R PEDRO G S FILIBERTO P | 2013 | IEEE Geoscience and Remote Sensing Let-ters2013，10，4： | 1 |
| 16 | Integrating Geomorphological Mapping, Trenching, InSAR and GPR for the Identification and Characterization of Sinkholes:A Review and Application in the Mantled Evaporate Karst of the Ebro Valley 显示文摘 | FRANCISCO G JORGE P G PEDRO L | 2011 | Geomorphology2011，132，4： | 1 |
| 17 | A technique for the evaluation of instantaneous heat fluxes for the horizontal Strip casting of aluminum alloys 显示文摘 | Pedro G Netto Q Tavares P | 2001 | ISIJ International2001，41，1： | 1 |
| 18 | Associao de marcadores moleeulares SNP corn o contetado de tcido linolnico em sementes de soja显示文摘 | de Oliveira P M Pedro Ivo V G Maurflio A M et at | 2013 | Pesquisa Agropecuria Brasil- eira2013，48，3： | 1 |
| 19 | cDNA-AFLP reveals striking overlap in race-specific resistance and wound response gene expression profiles显示文摘 | WENDY E D OWEN R PEDRO P KIM E HAMMOND K JONATHAN D G J | 2000 | The Plant Cell2000，12，6： | 1 |
| 20 | Intrapulmonary pharmacokinetics of azithromycin in healthy volunteers given five oral doses 显示文摘 | OLSEN K M SAN PEDRO G GANN L P | 1996 | Antimicrob Agents Chemother1996，40，11： | 1 |
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