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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | A role for glutamate decarboxylase during tomato ripening:the eharaeterisation of a cDNA encoding a putative glutamate decarboxylase with a calmodulin binding site 显示文摘 | PEDRO P G LEE W STEVE P DON G JULIE E G | 1995 | Plant Molecular Biology1995，27，6： | 1 |
| 3 | Heterosis and correlation analysis of the vegetative components and ajmalicine content in the roots of the medicinal plant-Catharanthus roseus 显示文摘 | Don G Levy A Milo J | 1983 | Euphytica1983，32，2： | 1 |
| 4 | Characterization of DegU, a response regulator in Listeria monocytogenes, involved in regulation of motility and contributes to virulence显示文摘 | Knudsen G M Olsen J E Dons L | 2004 | FEMS Microbiol Lett2004，240，2： | 1 |
| 5 | Serum albumin:relationship to Inflammation and nutrition显示文摘 | Don BR Kaysen G | 2004 | Semin Dial2004，17，6： | 1 |
| 6 | Continuous detoxification,transformation and degradation of nitrophenol in upflow anaerobic sludge blanket(UASB)reactors显示文摘 | Don]on B A Bazo-Flares E Lettiga G | 1996 | Biotechnology and Bioengineeting1996，51，： | 1 |
| 7 | Children' s lnternet searching on complex problems : Performance and process analysis 显示文摘 | Schaehter J Chung G K Don' A | 1998 | Journal of the American Society for Information Science1998，49，9： | 1 |
| 8 | Insectresistant chrysanthemum calluses by introduction of a Bacillus thuringiensis crystal protein gene 显示文摘 | Wordragen M F Honee G Dons H J M | 1993 | Transgenic Research1993，2，3： | 1 |
| 9 | Effects of Atrazine on Cytoehrome P450 Enzymes of Zebrafish (Dartio rero ) 显示文摘 | DON G Xiao-li ZHU Lu-sheng WANG Jin-hua | 2009 | Chemosphere2009，77，3： | 1 |
| 10 | Serum albumin:relationship to inflammationand nutrition显示文摘 | Don BR Kaysen G | 2004 | Semin Dial2004，17，43： | 1 |
| 11 | Ethanol vaponr treat- ment alleviates postharvest decay and maintains fruit quality in Chinese bayberry显示文摘 | ZHANG W S LI X WANG X X WANG G Y ZHENG J T ABERSINGHE Don C FERGUSON Ian B | 2007 | Postharvest Biology and Technology2007，46，2： | 1 |
| 12 | CT imaging of wormhole growth undersolution-gasdrive显示文摘 | Tremblay B Sedgwick G Vu Don | 1999 | SPE Reservoir Evaluation & Engineering1999，2，1： | 1 |
| 13 | Atcel:a novel mouse cyclic adenosine 3',5' monophos-phate-responsive element-binding protein-like gene exclusively expressed in postmeiotic spermatids显示文摘 | Stelzer G Don J | 2002 | Endocrinology2002，143，5： | 1 |
| 14 | A Field Guide to the Geology of Sudbury,Ontario显示文摘 | Don H Rousell G Heather Brown | 2009 | Ontario Geological Survey Open File Re- port 6243 Queen'' s Printer for Ontario2009，3136，： | 1 |
| 15 | Inhibition of p38 MAP kinase as a therapeutic strategy显示文摘 | JOHN L C SANJAY K DON E G | 2000 | Immunopharmacology2000，47，23： | 1 |
| 16 | On the p&thogenesis of the Kttner tumor of the submandibular gland &nalysis of 549 c&ses with chronic sia]adenitis of the submandibular (author's transl)显示文摘 | Seifert G Don&th K | 1977 | HNO1977，25，5： | 1 |
| 17 | Sonograplaic pitfalls in the diagnosis of enteric duplication cysts 显示文摘 | Chen G Don S Alan D | 2005 | AJR Am J Roentgenol2005，184，2： | 1 |
| 18 | Conditional economic incentives for reducing HIV risk behaviors:integration of psychology and behavioral economics显示文摘 | Don Operario Caroline Kuo Sandra G | 2013 | Health Psychology2013，32，： | 1 |
| 19 | Cutaneous reactions to vitamin K1 injections 显示文摘 | Lemlich G Green M Phelps R Lebwohl M Don P Gordon M | 1993 | J Am acad Dermatol1993，28，22： | 1 |
| 20 | Treatment of non-small- cell lung cancer with erlotinib or gefitinib 显示文摘 | Vince D C Don L G Roman P S | 2011 | N Engl J Med2011，364，10： | 1 |
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