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| 1 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 2 | Spontaneous bacterial peritonitis prevalence in pretransplant patients and its effect on survival and graft loss post-transplant显示文摘AIM To investigate the incidence of spontaneous bacterial peritonitis(SBP) in pre-transplant patients and its effect on post transplant mortality and graft failure. METHODS We conducted a retrospective cohort study of patient records from the organ procurement and transplant network data set. Patients were identified by the presence of SBP pre-transplant. Univariate post-transplant survival models were constructed using the Kaplan-Meier technique and multivariate models were constructed using the Cox proportional hazards model. Variables that affected post-transplant graft survival were identified in the SBP population. RESULTS Forty-seven thousand eight hundred and eighty patient records were included in the analysis for both groups, and 1966(4.11%) patients were identified in the data set as having pre-transplant SBP. Patients that had pre-transplant SBP had higher rates of graft loss from recurrent hepatitis C virus(HCV)(3.6% vs 2.0%, P < 0.0001), infections leading to graft loss(1.9% vs 1.3%, P = 0.02), primary non-function(4.3% vs 3.0%, P < 0.0001) and chronic rejection(1.1% vs 0.7%, P = 0.04). Kaplan-Meier survival analysis showed a statistically significant difference in all-cause survival in patients with a history of SBP vs those without(P < 0.0001). Pretransplant history of SBP was independently predictiveof mortality due to recurrent HCV(HR = 1.11, 95%CI: 1.02-1.21, P < 0.017) after liver transplantation.CONCLUSION HCV patients prior to the advent of directing acting anti-viral agents had a higher incidence of pre-transplant SBP than other patients on the liver transplant wait list. SBP history pre-transplant resulted in a higher rate of graft loss due to recurrent HCV infection and chronic rejection. | Neeral L Shah Nicolas M Intagliata Zachary H Henry Curtis K Argo Patrick G Northup | 2016 | World Journal of Hepatology2016，8，36： | 2 |
| 3 | Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis显示文摘AIM To examine if liver transplant recipients with high-risk non-alcoholic steatohepatitis(NASH) are at increased risk for pre-transplant portal venous thrombosis.METHODS Data on all liver transplants in the United States from February 2002 through September 2014 were analyzed. Recipients were sorted into three distinct groups: High-risk(age > 60, body mass index > 30 kg/m2, hypertension and diabetes), low-risk and non-NASH cirrhosis. Multivariable logistic regression models were constructed.RESULTS Thirty-five thousand and seventy-two candidates underwent liver transplantation and of those organ recipients, 465 were transplanted for high-risk and 2775 for lowrisk NASH. Two thousand six hundred and twentysix(7.5%) recipients had pre-transplant portal vein thrombosis; 66(14.2%) of the high-risk NASH group had portal vein thrombosis vs 328(11.8%) of the lowrisk NASH group. In general, all NASH recipients were less likely to be male or African American and more likely to be obese. In adjusted multivariable regression analyses, high-risk recipients had the greatest risk ofpre-transplant portal vein thrombosis with OR = 2.11(95%CI: 1.60-2.76, P < 0.001) when referenced to the non-NASH group.CONCLUSION Liver transplant candidates with high-risk NASH are at the greatest risk for portal vein thrombosis development prior to transplantation. These candidates may benefit from interventions to decrease their likelihood of clot formation and resultant downstream hepatic decompensating events. Prospective study is needed. | Jonathan G Stine Curtis K Argo Shawn J Pelletier Daniel G Maluf Stephen H Caldwell Patrick G Northup | 2017 | World Journal of Hepatology2017，9，3： | 2 |
| 4 | Hybrid fiber Bragg grating/long period fiber grating sensor for strain/temperature discrimination显示文摘 | Patrick H J Williams G M Kersey A D | 1996 | IEEE Photon Technol Lett1996，8，： | 1 |
| 5 | Lack of Association Between the MEF2A Gene and Myocardial Infarction显示文摘 | Wolfgang Lieb Bj?rn Mayer Inke R. K?nig Iris Borwitzky Anika G?tz Silke Kain Christian Hengstenberg Patrick Linsel-Nitschke Marcus Fischer Angela D?ring H -Erich Wichmann Thomas Meitinger Reinhold Kreutz Andreas Ziegler Heribert Schunkert Jeanette Erdmann | 2008 | Circulation2008，，2： | 1 |
| 6 | Comparison of the Bishop score , ultrasonographically measured cervical length,and fetal fibronectin assay in predicting time until delivery and type of delivery at term显示文摘 | Patrick R Francois G Mahdie H | 2000 | Am J Obstet Gynecol2000，182，2： | 1 |
| 7 | 查看详情显示文摘 | Schuch R Garibian A Nygaard P Raymond S Araik G Hans H S Patrick J P Per N | | 0，，： | 1 |
| 8 | Effect of estuarine sediment pH and oxidation-reduction potential on microbial hydrocarbon degradation 显示文摘 | Hambrick G A DeLaune R D Patrick W H | 1980 | Appl Environ Mierobiol1980，40，2： | 1 |
| 9 | Fiber grating sensors 显示文摘 | A D Kersey M A Davis H J Patrick M LeBlanc K P Koo C G Askins M A Putnam E J Friebele | 1997 | Lightwave Technology1997，15，8： | 1 |
| 10 | Adaptive wavelet transform for vibration signal modeling and application in fault diagnosis of water hydraulic motor 显示文摘 | Chen H X Patrick S K Chua G H L | 2006 | Mechanical Systems and Signal Processing2006，，20： | 1 |
| 11 | Fenton-driven chemical regeneration of MTBE-spent GAC显示文摘 | Scott G H Patrick K J Wendell P E | 2005 | Water Research2005，39，10： | 1 |
| 12 | Quality of life of persons with urinary incontinence: Development of a new measure 显示文摘 | Wagner T H Patrick D L Bavendam T G | 1996 | Urology1996，47，： | 1 |
| 13 | The Synthesis and Molecular Structures of the Crystalline 1-aza2-phospha(v)allyllithium Compounds and2 and the Preparation and Characterisation of the New Phosphinimines CH(R^1)(R^2)P(Ph)2=NSiMe3显示文摘 | PETER B HITCHCOCK MICHAEL F LAPPERT PATRICK G H UITERWEERD | 1999 | J Chem Soc Dalton Trans1999，，： | 1 |
| 14 | Multiple independent emer- gences of type 2 vaccine-derived polioviruses during a large outbreak in northern Nigeria显示文摘 | Burns C C Shaw J Jorba J Bukbuk D Adu F Gumede N Pate M A Abanida E A Gasasira A Iber J Chen Q Vincent A Chenoweth P Henderson E Wannemuehler K Naeem A Umarni R N Nishimura Y Shimizu H Baba M Adeniji A Williams A J Kil- patrick D R Oberste M S Wassilak S G Tomori O Pallansch M A Kew O | 2013 | J Virol2013，87，9： | 1 |
| 15 | Clinical indications for noninvasive positive pressure ventilation in chronic respiratory failure due to restrictive lung disease,COPD,and nocturnal hypoventilation -a consensus conference report显示文摘 | Allen G Patrick L Nicholas H | | 0，，2： | 1 |
| 16 | Hybrid fiber Bragg grating/long period fiber grating sensor for strain/temperature discrimination显示文摘 | Patrick H J Williams G M Kersey A D | | 0，，09： | 1 |
| 17 | Genetic characterization of type 2 porcine circovirus(PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential Pck-restriction fragment lenth polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2显示文摘 | Martijn F Patrick G H Mike G | 2000 | J Clin Microbiol2000，38，7： | 1 |
| 18 | Amplitude mask patterned on an excimer laser mirror for high intensity writing of long period fibre gratings显示文摘 | Patrick H J Askins C G McElhanon R W | 1997 | Electronics Letters1997，33，13： | 1 |
| 19 | Fiber grating sensors显示文摘 | KERSEY A D DAVIS M A PATRICK H J LeBLANC M KOO K P ASKINS C G PUTNAM M A FRIEBELE E J | 1997 | Journal Lightwave Technology1997，15，8： | 1 |
| 20 | Hybrid fiber Bragg grating/long period fiber grating sensor for strain/temperature discrimination显示文摘 | Patrick H J Williams G M Kersey A D | 1996 | IEEE Photon Technol Lett1996，8，9： | 1 |
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