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| 1 | Molecular targeting agents associated with transarterial chemoembolization or radiofrequency ablation in hepatocarcinoma treatment显示文摘Hepatocellular carcinoma(HCC)is the fifth most common cause of cancer in the world.According to Barcelona Clinic Liver Cancer modified criteria,patients with early stage disease are candidate to radiofrequency ablation(RFA),while patients with intermediate stage HCC are usually treated by transarterial chemoembolization(TACE).TACE and RFA induce a transient devascularisation effect followed by strong neoangiogenic stimulus.In fact,after these procedures,it has been demonstrated an up-regulation of pro-angiogenic and growth factors such as vascular endothelial growth factor-A,which might contribute to accelerated progression in patients with incomplete response.Several studies have demonstrated that MAP-kinase and AKT pathways,in addition to neo-angiogenesis,have an important role in the development of HCC.In advanced HCC,anti-angiogenic therapy and tyrosine kinases inhibitors showed potential clinical benefit.Actually,a number of clinical studies are ongoing testing these agents in combination with TACE or RFA.In this paper,we have reviewed the most recent preclinical and clinical results of such trials. | Girolamo Ranieri Ilaria Marech Vito Lorusso Veronica Goffredo Angelo Paradiso Domenico Ribatti Cosmo Damiano Gadaleta | 2014 | World Journal of Gastroenterology2014，20，2： | 14 |
| 2 | 胸苷酸合成酶和拓扑异构酶-1及Ki-67对伊立替康联合5-氟脲嘧啶治疗晚期大肠癌的预测价值显示文摘目的探讨胸苷酸合成酶(TS)、拓扑异构酶1(Topo1)和肿瘤增殖指标Ki67对伊立替康(CPT11)联合5氟脲嘧啶(5Fu)治疗晚期大肠癌患者的临床疗效和预后的预测价值。方法采用免疫组化方法检测了CPT11+5Fu一线治疗78例大肠癌患者的TS、Topo1和Ki67的表达,并与化疗疗效和患者的临床预后进行了分析。结果各检测指标的表达水平与临床疗效之间无关,但是临床预后不同。其中,TS低表达患者表现明显长的肿瘤进展时间(TTP,P<0.05)和存活期(OS,P<0.05);Ki67低表达也预示长的OS(P<0.05)。与单个指标相比较,两个指标的联合也不能预测临床疗效,但是对预后的判断作用明显提高。TS低表达、Ki67低表达以及TS和Ki67均低表达患者的中位TTP分别为9,8和17个月(P=0.02);TS低表达、Topo1低表达以及TS和Topo1均低表达患者的中位TTP分别为9,9和13个月(P=0.03);而Topo1低表达、Ki67低表达、Ki67和Topo1均低表达患者的中位TTP分别为8,9和11个月(P=0.05)。其中任何两个指标均低表达肿瘤的TTP和OS均明显长于高表达者(P<0.05)。结论TS、Topo1和Ki67不能预测大肠癌患者CPT11+5Fu的疗效,但对其临床预后有一定的预测作用。其中任何两个指标的联合,比单一指标对患者预后的预测价值明显提高。 | 徐建明 朱步东 Mangia Anita Simone Gianni Montemurro Severino Giuliani Francesco Maiello Evaristo Colucci Giuseppe Paradiso Angelo | 2005 | 中华肿瘤杂志2005，27，5： | 9 |
| 3 | H pylori status and angiogenesis factors in human gastric carcinoma显示文摘AIM: To investigate H pylori expression in gastric cancer patients in relation to primary tumor angiogenic markers, such as microvessel density (MVD), thymidine phospho- rylase (TP), vascular endothelial growth factor receptor-1 (VEGF-R1), p53 and circulating VEGF levels. METHODS: Angiogenic markers were analyzed immu- nohistochemically in 56 primary gastric cancers. H pylori cytotoxin (vacA) and the cytotoxin-associated gene (cagA) amplification were evaluated using PCR assay. Serum H pylori IgG antibodies and serum/plasma circulating VEGF levels were detected in 39 and 38 patients by ELI- SA, respectively. RESULTS: A total of 69% of patients were positive for circulating IgG antibodies against H pylori. cagA-positive H pylori strains were found in 41% of gastric patients. vacA was found in 50% of patients; s1 strains were more highly expressed among vacA-positive patients. The presence of the s1 strain was signifi cantly associ- ated with cagA (P = 0.0001). MVD was signifi cantly cor- related with both tumor VEGF expression (r = 0.361, P = 0.009) and serum VEGF levels (r = -0.347, P = 0.041).Conversely, neither VEGF-R1 expression nor MVD was related to p53 expression. However, H pylori was not related to any angiogenic markers except for the plasma VEGF level (P = 0.026). CONCLUSION: H pylori antigen is related to higher plasma VEGF levels, but not to angiogenic character- istics. It can be hypothesized that the toxic effects of H pylori on angiogenesis occurs in early preclinical dis- ease phase or in long-lasting aggressive infections, but only when high H pylori IgG levels are persistent. | Anita Mangia Annalisa Chiriatti Girolamo Ranieri Ines Abbate Maria Coviello Giovanni Simone Francesco Alfredo Zito Severino Montemurro Antonello Rucci Alfredo Di Leo Stefania Tommasi Pasquale Berloco Jian Ming Xu Angelo Paradiso | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 4 | A Method for the Determination of Turbulence Intensity by Means of a Fast Response Pressure Probe and its Application in a LP Turbine显示文摘This paper describes the measurements and the post-processing procedure adopted for the determination of the turbulence intensity in a low pressure turbine (LPT) by means of a single sensor fast response aerodynamic pressure probe. The rig was designed in cooperation with MTU Aero Engines and considerable efforts were put into the adjustment of all relevant model parameters. Blade count ratio, airfoil aspect ratio, reduced massflow, reduced speed, inlet turbulence intensity and Reynolds numbers were chosen to reproduce the full scale LP turbine. Measurements were performed adopting a phase-locked acquisition technique in order to provide the time resolved flow field downstream of the turbine rotor. The total pressure random fluctuations are obtained by selectively filtering, in the frequency domain, the deterministic unsteadiness due to the rotor blades and coherent structures. The turbulence intensity is derived from the inverse Fourier transform and the correlations between total pressure and velocity fluctuations. The determination of the turbulence intensity allows the discussion of the interaction processes between the stator and rotor for engine-representative operating conditions of the turbine. | Davide Lengani Berardo Paradiso Andreas Marn | 2012 | Journal of Thermal Science2012，21，1： | 3 |
| 5 | Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity显示文摘 | Letizia Porcelli Anna E. Quatrale Paola Mantuano Maria G. Leo Nicola Silvestris Jean F. Rolland Enza Carioggia Marco Lioce Angelo Paradiso Amalia Azzariti | 2013 | Molecular Oncology2013，，3： | 2 |
| 6 | Implantation of AMS 700 LGX penile prosthesis preserves penile length without the need for penile lengthening procedures显示文摘当保守处理失败时,可膨胀的阴茎修复术(IPP ) 的培植是可勃起的机能障碍的一个生长得很好的权威的解决方案。阴茎植入可以弄短阴茎。AMS 700 LGX IPP 在普通使用,但是在它的机械可靠性,中期的 postsurgical 病人满足,和吝啬的阴茎长度上报导保藏正在缺乏。我们在 AMS 700 LGX 的培植以后在 6 和 12 个月调查吝啬的阴茎长度,机械可靠性,和耐心的满足。这未来的研究连续地注册了经历初次的 IPP 的人从 2009 年 2 月植入外科到 2012 年 4 月。拉长的松驰的阴茎长度,在 50% 点的阴茎长度和僵硬(P50 和 P100 ) 和可勃起的功能(IIEF ) 和可勃起的机能障碍的国际索引的 100% 治疗盘点满足(编辑) 分数,在 6 和 12 月 postsurgery 被测量。经历了 AMS 700 LGX 培植的 45 个病人(中部的年龄 61 年) 并且完成了 6 月的后续,(80%) 36 完成了学习。在拉长的松驰的阴茎长度的重要差别在 6 和 12 个月之间被看见(P = 0.033 ) 。P100 显著地也在 6 和 12 个月被增加,与到 12 个月的从基线的 10% 增加的一个平均数(1.3 0.4 厘米) 。在在 6 和 12 个月的吝啬的 IIEF 分数的差别为需要的领域是重要的(P = 0.0001 ) 并且为全面满足(P = 0.002 ) ;然而,平均数在 6 和 12 个月编辑分数显著地没被改进。AMS 700 LGX 是为在经历阴茎修复术培植的人保存阴茎长度的一个强大的工具。 | Carlo Luigi Augusto Negro Matteo Paradiso Alessandro Rocca Franco Bardari | 2016 | Asian Journal of Andrology2016，18，1： | 2 |
| 7 | Hydrogen peroxide, nitric oxide and cytosolic ascorbate peroxidase at the crossroad between defence and cell death 显示文摘 | de Pinto M C Paradiso A Leonetti P | 2006 | Plant Journal2006，48，5： | 1 |
| 8 | Postexposure application of Fas receptor small-interfering RNA to suppress sulfur mustard-induced apoptosis in human airway epithelial cells:implication for a therapeutic approach显示文摘 | Keyser BM Andres DK Nealley E Holmes WW Benton B Paradiso D | 2013 | J Pharmacol Exp Ther2013，344，1： | 1 |
| 9 | Surgical management of the adult tethered cord syndrome: indications, techniques and long term outcomes in a series of 60 patients 显示文摘 | Lee G Paradiso G Tator C | 2006 | Neurosurg Spine2006，4，： | 1 |
| 10 | Energy scavenging with shoe-mounted piezoelectrics 显示文摘 | Shenck N S Paradiso J A | 2001 | IEEE Micro2001，21，3： | 1 |
| 11 | Formation of cross- linked chloroperoxidase aggregates in the pores of mesoce|lular foams: characterization by SANS and catalytic properties 显示文摘 | Jung D Paradiso M Wallacher D | 2009 | ChemSusChem2009，2，2： | 1 |
| 12 | HCC heterogeneity: molecular pathogenesis and clinical implications显示文摘 | Fransvea E Paradiso A Antonaci S | 2009 | Cell Oncol2009，31，： | 1 |
| 13 | Energy scavenging for mobile and wireless electronics显示文摘 | PARADISO J A STARNER T | | 0，，01： | 1 |
| 14 | Infectious process of the parvovirus H-1: correlation of protein content, particle density and viral infectivity 显示文摘 | Paradiso PR | 1981 | J Virol1981，，： | 1 |
| 15 | Desloratadine in combination with montelukast in the treatment of chronic urticaria : a randomized, double-blind, placebo-controlled study显示文摘 | NETTIS E COLANARDI M C PARADISO M T | 2004 | Clin Exp Allergy2004，34，9： | 1 |
| 16 | Survival advantage of combined chemoradiotherapy compared with resection as the initial treatment of patients with regional pancreatic carcinoma显示文摘 | Snady H Bruckner H Cooperman A Paradiso J Kiefer L | | 0，，： | 1 |
| 17 | Energy Scavenging for Mobile and Wireless Electronics 显示文摘 | PARADISO J A STARNER T | 2005 | Pervasive Computing2005，4，1： | 1 |
| 18 | Genetic alterations in hereditary breast cancer 显示文摘 | Cipollini G Tommasi S Paradiso A | 2004 | Ann Oncol2004，15，： | 1 |
| 19 | GnRH receptors in human breast cancer and its contiguous not-involved breast tissue显示文摘 | Paradiso A Pezzetta A Cellamare G | 2000 | J Endocrinol Invest2000，23，2： | 1 |
| 20 | Expression of adhesion molecules and extracellular matrix proteins in glioblastomas: relation to angiogenesis and spread显示文摘 | Vitolo D Paradiso P Uccini S | 1996 | Histopathology1996，28，6： | 1 |
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