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| 1 | An update–tissue engineered nerve grafts for the repair of peripheral nerve injuries显示文摘Peripheral nerve injuries(PNI) are caused by a range of etiologies and result in a broad spectrum of disability. While nerve autografts are the current gold standard for the reconstruction of extensive nerve damage, the limited supply of autologous nerve and complications associated with harvesting nerve from a second surgical site has driven groups from multiple disciplines, including biomedical engineering, neurosurgery, plastic surgery, and orthopedic surgery, to develop a suitable or superior alternative to autografting. Over the last couple of decades, various types of scaffolds, such as acellular nerve grafts(ANGs), nerve guidance conduits, and non-nervous tissues, have been filled with Schwann cells, stem cells, and/or neurotrophic factors to develop tissue engineered nerve grafts(TENGs). Although these have shown promising effects on peripheral nerve regeneration in experimental models, the autograft has remained the gold standard for large nerve gaps. This review provides a discussion of recent advances in the development of TENGs and their efficacy in experimental models. Specifically, TENGs have been enhanced via incorporation of genetically engineered cells, methods to improve stem cell survival and differentiation, optimized delivery of neurotrophic factors via drug delivery systems(DDS), co-administration of platelet-rich plasma(PRP), and pretreatment with chondroitinase ABC(Ch-ABC). Other notable advancements include conduits that have been bioengineered to mimic native nerve structure via cell-derived extracellular matrix(ECM) deposition, and the development of transplantable living nervous tissue constructs from rat and human dorsal root ganglia(DRG) neurons. Grafts composed of non-nervous tissues, such as vein, artery, and muscle, will be briefly discussed. | Nitesh P.Patel Kristopher A.Lyon Jason H.Huang | 2018 | Neural Regeneration Research2018，13，5： | 12 |
| 2 | One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation显示文摘A new series of pyrido[1,2-α]benzimidazole derivatives bearing the aryloxypyrazole nucleus have been synthesized by base-catalyzed cyclocondensation reaction through multi-component reaction(MCR) approach.All the synthesized compounds were investigated against a representative panel of pathogenic strains using broth microdilution minimum inhibitory concentration(MIC) method for their in vitro antimicrobial activity.Reviewing the data,majority of the compounds were found to be active against employed pathogens.SAR study explores that antimicrobial activity is strongly depends on the nature of the substituents at the ether linked aryl ring attached to the pyrazole unit,together with the substituent present on the C_5 of the benzimidazole unit. | Hardik H.Jardosh Chetan B.Sangani Manish P.Patel Ranjan G.Patel | 2013 | Chinese Chemical Letters2013，24，2： | 9 |
| 3 | Microwave assisted synthesis of novel Hantzsch 1,4-dihydropyridines,acridine-1,8-diones and polyhydroquinolines bearing the tetrazolo[1,5-α]quinoline moiety and their antimicrobial activity assess显示文摘Microwave assisted efficient Hantzsch reaction via four-component coupling reactions of tetrazolo[1,5-α]quinoline-4-carbal-dehyde, dimedone/cyclohexane-1,3-dione,ethyl/methyl acetoacetate and ammonium acetate was described as the preparation of tetrazolo[1,5-α]quinoline based 1,4-dihydropyridines,acridine-1,8-diones and polyhydroquinolines.The process presented here is simple,rapid,environmentally welcoming and high yielding.All the derivatives were subjected to an in vitro antimicrobial screening against a representative panel of bacteria and fungi and results worth further investigations. | Niraj K.Ladani Divyesh C.Mungra Manish P.Patel Ranjan G.Patel | 2011 | Chinese Chemical Letters2011，22，12： | 7 |
| 4 | A new fast swelling poly[DAPB-co-DMAAm-co-AASS] superabsorbent hydrogel for removal of anionic dyes from water显示文摘The objective of this research is to utilize a new poly[N,N-diallyl pyrrolidinium bromide-co-N,Ndimethyl acrylamide-co-acrylic acid sodium salt]superabsorbent hydrogel(SAH)for the removal of two anionic dyes,e.g.,Reactive Red 5B(RR5B)and Reactive Orange M2R(ROM2R),from water.The SAH was characterized by swelling in water,FTIR,TGA and SEM.The SAH DDA6showed good swelling property and thermal stability.We have also investigated the parameters affecting dye adsorption such as pH,adsorbent dose,adsorption rate and initial dye concentration.The experimental data were also analyzed by applying the well known Langmuir and Freundlich isotherm models. | Yatin N.Patel Manish P.Patel | 2013 | Chinese Chemical Letters2013，24，11： | 5 |
| 5 | Synthesis of new superabsorbent poly(NIPAAm/AA/N-allylisatin)nanohydrogel for effective removal of As(Ⅴ) and Cd(Ⅱ) toxic metal ions显示文摘The present studies highlight the effective removal of As(V) and Cd(II) from aqueous solutions by superabsorbent poly(NlPAAm/AA/N-allylisatin) nanohydrogel.Batch removal studies were performed as a function of treatment time,initial metal ion concentration,pH,and adsorbent dose.TEM micrographs confirm the particle size distribution in the range between 5 nm and 10 nm.The simple and metal ions adsorbed nanohydrogels were characterized by FT-IR,TGA,and EDX analysis.Finally,the equilibrium removal efficiency of the nanohydrogel was analyzed according to the Langmuir and Freundlich adsorption isotherm models which showed the removal of As(V) and Cd(II) metal ions fitted to Freundlich and Langmuir isotherms,respectively.Removal efficiency order of the metal ions is As(V) > Cd(II). | Viran P.Mahida Manish P.Patel | 2014 | Chinese Chemical Letters2014，25，4： | 5 |
| 6 | Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma显示文摘Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of 'mitochondrial medicine' is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic. | Jenna L.Gollihue Samir P.Patel Alexander G.Rabchevsky | 2018 | Neural Regeneration Research2018，13，2： | 5 |
| 7 | The Soft X-ray Imager(SXI)on the SMILE Mission显示文摘The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission.SMILE is a joint science mission between the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS)and is due for launch in 2025.SXI is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SMILE orbit.SXI is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s exosphere.SWCX provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field lines.The sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SMILE will enable such movements to be tracked for segments lasting many hours.SXI is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States. | S.Sembay A.L.Alme D.Agnolon T.Arnold A.Beardmore A.Belén Balado Margeli C.Bicknell C.Bouldin G.Branduardi-Raymont T.Crawford J.P.Breuer T.Buggey G.Butcher R.Canchal J.A.Carter A.Cheney Y.Collado-Vega H.Connor T.Crawford N.Eaton C.Feldman C.Forsyth T.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gordillo H-P.Gröbelbauer M.Guedel Y.Guo M.Hailey D.Hall R.Hampson J.Hasiba O.Hetherington A.Holland S-Y.Hsieh M.W.J.Hubbard H.Jeszenszky M.Jones T.Kennedy K.Koch-Mehrin S.Kögl S.Krucker K.D.Kuntz C.Lakin G.Laky O.Lylund A.Martindale J.Miguel Mas Hesse R.Nakamura K.Oksavik N.Østgaard H.Ottacher R.Ottensamer C.Pagani S.Parsons P.Patel J.Pearson G.Peikert F.S.Porter T.Pouliantis B.H.Qureshi W.Raab G.Randal A.M.Read N.M.M.Roque M.E.Rostad C.Runciman S.Sachdev A.Samsonov M.Soman D.Sibeck S.Smit J.Søndergaard R.Speight S.Stavland M.Steller TianRan Sun J.Thornhill W.Thomas K.Ullaland B.Walsh D.Walton C.Wang S.Yang | 2024 | Earth and Planetary Physics2024，8，1： | 4 |
| 8 | Synthesis and in vitro antimicrobial screening of new pyrano[4,3-b]pyrane derivatives of 1H-pyrazole显示文摘pyrano 的一个新系列[4,3-b ] pyrane 4al 适用 1H-pyrazole 被一个壶底综合了 1H-pyrazole-4-carbaldehyde 1al 的催化 cyclocondensation 反应, malononitrile 2 并且 4-hydroxy-6-methylpyrone 3。所有综合混合物对六细菌的病原体被屏蔽,也就是 B。subtilis, C。tetani, S。pneumoniae, S。typhi, V。cholerae, E。coli 和抗真菌的活动对,二真菌的病原体,一。fumigatus 和 C。用肉汤 microdilution MIC 方法的 albicans。一些混合物被发现同等或更多的有势力比商业药的,对大多数采用的种类。 | Chetan B.Sangani Divyesh C.Mungra Manish P.Patel Ranjan G.Patel | 2012 | Chinese Chemical Letters2012，23，1： | 4 |
| 9 | Development of a sensitive and rapid method for quantitation of (S)-(-)- and (R)-(+)-metoprolol in human plasma by chiral LC–ESI–MS/MS显示文摘A selective, sensitive and high throughput liquid chromatography-tandem mass spectrometry(LC–ESI–MS/MS) method has been developed for separation and quantification of metoprolol enantiomers on a chiral Lux Amylose-2(250 mm 4.6 mm, 5 mm) column. Solid phase extraction of(S)-()- and(R)-(t)-metoprolol and rac-metoprolol-d6 as an internal standard(IS)was achieved on Lichrosep DVB HL cartridges employing 200 mL human plasma. Both the analytes were chromatographically separated with a resolution factor of 2.24 using 15 mM ammonium acetate in water, pH 5.0 and 0.1%(v/v) diethyl amine in acetonitrile(50:50, v/v) as the mobile phase within 7.0 min. The precursor-product ion transitions for the enantiomers and IS were monitored in the multiple reaction monitoring and positive ionization mode. The method was validated over the concentration range of 0.500–500 ng/mL for both the enantiomers. Matrix effect was assessed by post-column analyte infusion experiment and the mean extraction recovery was greater than 94.0% for both the enantiomers at all quality control levels. The stability of analytes was evaluated in plasma and whole blood under different storage conditions. The method was successfully applied to a clinical study in 14 healthy volunteers after oral administration of200 mg metoprolol tablet under fasting conditions. The assay reproducibility is shown by reanalysis of 68 incurred samples. The suitability of the developed method was assessed in comparison | Primal Sharma Pritesh Contractor Swati Guttikar Daxesh P.Patel Pranav S.Shrivastav | 2014 | Journal of Pharmaceutical Analysis2014，4，1： | 3 |
| 10 | Targeting mitoNEET with pioglitazone for therapeutic neuroprotection after spinal cord injury显示文摘There is mounting evidence that targeting mitochondrial dysfunction following neurotrauma could be key in developing effective therapeutic strategies since mitochondria are known to play a major role in cellular bioenergetics,function,and survival following traumatic spinal cord injury(SCI) | Alexander G.Rabchevsky Samir P.Patel Patrick G.Sullivan | 2017 | Neural Regeneration Research2017，12，11： | 3 |
| 11 | Molecular iodine catalyzed synthesis of tetrazolo[1,5-a]-quinoline based imidazoles as a new class of antimicrobial and antituberculosis agents显示文摘一系列一些新 tetrazolo [1,5-a ] 喹啉基于的 tetrasubstituted 咪唑衍生物 6al 被 tetrazolo 的反应综合了[1,5-a ] quinoline-4-carbaldehyde 3ad, benzil 4,芳香的胺 5ac 和铵醋酸盐面对通过一个壶多部件反应(宏) 的碘来临。所有衍生物为值得进一步的调查的抗菌剂和 antituberculosis 活动和结果被屏蔽。 | Divyesh C.Mungra Harshad G.Kathrotiya Niraj K.Ladani Manish P.Patel Ranjan G.Patel | 2012 | Chinese Chemical Letters2012，23，12： | 3 |
| 12 | An efficient synthesis of 3'-quinolinyl substituted imidazole-5-one derivatives catalyzed by zeolite and their antimicrobial activity显示文摘新喹啉基于的一系列一些 imidazole-5-one 衍生物被 oxazol-5-ones,各种各样的代替 p 的苯胺和沸石的熔化在 pyridine 综合了。所有衍生物受到一在里面对值得进一步的调查的细菌和真菌和结果的一块代表性的面板屏蔽的 vitro 抗菌剂。 | Harshad G.Kathrotiya Nilav A.Patel Ranjan G.Patel Manish P.Patel | 2012 | Chinese Chemical Letters2012，23，3： | 3 |
| 13 | Synthesis and in vitro antimicrobial activity of N-arylquinoline derivatives bearing 2-morpholinoquinoline moiety显示文摘A new series of N-arylquinoline derivatives 5a-x bearing 2-morpholinoquinoline moiety has been synthesized by one pot base catalyzed cyclocondensation reaction of 2-morpholinoquinoline-3-carbaldehydes 2a-c,malononitrile 3 andβ-enaminones 4a-h. All the synthesized compounds were screened for their in vitro antimicrobial activity against six bacterial pathogens,namely Streptococcus pneumoniae,Clostridium tetani,Bacillus subtilis,Salmonella typhi,Vibrio cholerae,Escherichia coli and against two fungal pathogens,Aspergillus fumigatus and Candida albicans using broth microdilution MIC method.Of the compounds studied,majority of the compounds were found to active against C.tetani,B.subtilis and C.albicans as compared to first-line standard drugs. | Jigar A.Makawana Manish P.Patel Ranjan G.Patel | 2012 | Chinese Chemical Letters2012，23，4： | 2 |
| 14 | Determination of lercanidipine in human plasma by an improved UPLC–MS/MS method for a bioequivalence study显示文摘An improved and reliable ultra-performance liquid chromatography/tandem mass spectrometry(UPLC–MS/MS) method has been developed and validated for the determination of lercanidipine in human plasma. Plasma samples with lercanidipine-d3 as an internal standard(IS) were prepared by solid phase extraction on Phenomenex Strata-X cartridges using 100 μL of human plasma. Chromatographic analysis was performed on UPLC BEH C_(18)(50 mm*2.1 mm, 1.7μm) column under isocratic conditions. Linear calibration curves were obtained over a wide dynamic concentration range of 0.010–20.0 ng/mL. Matrix effect was assessed by post-column infusion, post-extraction spiking and standard-line slope methods.The mean extraction recovery was >94% for the analyte and IS. Inter-batch and intra-batch precision(%CV) across five quality controls was <5.8%. Bioequivalence study was performed with 36 healthy subjects after oral administration of 10 mg of lercanidipine and the assay reproducibility was evaluated by reanalysis of 133 incurred samples. | Darshan V.Chaudhary Daxesh P.Patel Priyanka A.Shah Jaivik V.Shah Mallika Sanyal Pranav S.Shrivastav | 2016 | Journal of Pharmaceutical Analysis2016，6，2： | 2 |
| 15 | Synthesis of N-arylquinolone derivatives bearing 2-thiophenoxyquinolines and their antimicrobial evaluation显示文摘A new series of 2-thiophenoxyquinolines based trifluoromethyl substituted N-aryl quinolone derivatives8a–f and 9a–f have been synthesized via a one-pot multicomponent reaction. In vitro antimicrobial activity of the synthesized compounds was investigated against a representative panel of pathogenic strains. Compounds 8c, 9c and 9e exhibited comparable antimicrobial activity to first line drugs. | Mehul B.Kanani Manish P.Patel | 2014 | Chinese Chemical Letters2014，25，7： | 1 |
| 16 | Synthesis,characterization and antimicrobial activity of some new biquinoline derivatives containing a thiazole moiety显示文摘A series of new biquinoline derivatives containing a thiazole moiety were synthesized by a one-pot,base-catalyzed cyclocondensation reaction of 2-chloro-3-formyl quinoline,malononitrile and enaminone.All the synthesized compounds were characterized by elemental analysis,FT-IR,~1H NMR and ^(13)C NMR data.All the synthesized compounds were screened against three bacterial pathogens,namely Bacillus cereus,B.substilis and Escherichia coli and for antifungal activity against three fungal pathogens,Aspergillus niger,Fusarium oxisporum and Rhizopus using the disc diffusion method. | Nirav K.Shah Nimesh M.Shah Manish P.Patel Ranjan G.Patel | 2012 | Chinese Chemical Letters2012，23，4： | 1 |
| 17 | Endoscopic Management of Pediatric Cholesteatoma显示文摘Pediatric cholesteatoma occurs in one of two forms:congenital cholesteatoma,developing from embryonic epidermal cell rests or acquired cholesteatoma,associated with a focal defect in the tympanic membrane.This disease has been traditionally managed with the operating microscope,often requiring mastoidectomy for adequate visualization of and access to the middle ear and mastoid cavities.Recently,advances in endoscopic equipment have enabled otologists to manage most cases of pediatric cholesteatoma via a minimally-invasive,transcanal endoscopic approach.This review discusses the current literature relating to the etiopathogenesis,assessment and endoscopic management of pediatric cholesteatoma.Early outcomes of endoscopic treatment,emerging trends and technologies are also reviewed. | Peter J.Ryan Nirmal P.Patel | 2020 | Journal of Otology2020，15，1： | 1 |
| 18 | Determination of cilostazol and its active metabolite 3,4-dehydro cilostazol from small plasma volume by UPLC-MS/MS显示文摘A simple,rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) method has been developed for the simultaneous determination of cilostazol and its pharmacologically active metabolite 3,4-dehydro cilostazol in human plasma using deuterated analogs as internal standards(ISs).Plasma samples were prepared using solid phase extraction and chromatographic separation was performed on UPLC BEH C_(18)(50 mm × 2.1 mm.1.7 μm) column.The method was established over a concentration range of 0.5-1000 ng/mL for cilostazol and 0.5-500 ng/mL for 3.4-dehydro cilostazol.Intra- and inter-batch precision(%CV) and accuracy for the analytes were found within 0.93-1.88 and 98.8-101.7% for cilostazol and 0.91-2.79 and 98.0-102.7% for the metabolite respectively.The assay recovery was within 95-97% for both the analytes and internal standards.The method was successfully applied to support a bioequivalence study of 100 mg cilostazol in30 healthy subjects. | Nejal M.Bhatt Vijay D.Chavada Daxesh P.Patel Primal Sharma Mallika Sanyal Pranav S.Shrivastav | 2015 | Journal of Pharmaceutical Analysis2015，5，1： | 1 |
| 19 | PS-TBD triggered general protocol for the synthesis of 4H-chromene,pyrano[4,3-b]pyran and pyrano[3,2-c]chromene derivatives of 1H-pyrazole and their biological activities显示文摘A general protocol has been developed for the facile construction of titled derivatives via three component reaction between 3-substituted phenyl-1H-pyrazole-4-carbaldehyde, malononitrile and various Michael donors in presence of 5 mol% polystyrene supported 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene(PS-TBD). PS-TBD was reused for at least five runs with nearly constant catalytic activity. All compounds were screened for antimicrobial and antioxidant activities. | Nileshkumar D.Vala Hardik H.Jardosh Manish P.Patel | 2016 | Chinese Chemical Letters2016，27，1： | 1 |
| 20 | A UK‐based cost–utility analysis of radiofrequency ablation or oesophagectomy for the management of high‐grade dysplasia in Barrett’s oesophagus显示文摘 | P. C.Boger D.Turner P.Roderick P.Patel | 2010 | Alimentary Pharmacology & Therapeutics (鈥?)2010，，11： | 1 |
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