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| 1 | 子宫内膜异位症妇女月经期腹膜及子宫内膜生物学相关细胞因子和生长因子的基因表达增加显示文摘Objective: To examine differential messenger RNA(mRNA)-expression of relevant cytokines, metalloproteases, growth and adhesion factors in endometrium and peritoneum from women with endometriosis when compared with women without the disease duringmenstrual and luteal phases of the cycle. Design: Patients with endometriosis were compared with control patients. Setting: University hospital. Patient(s): A total of 35 patients(20 patients during the luteal phase and 15 patients during the menstrual phase)were selected for this study on the basis of cycle phase and presence or absence of endometriosis. Intervention( s): In this study, endometriosis was laparoscopically and histologically confirmed in 24 women with endometriosis of revised American Society for Reproductive Medicine(ASRM) stage I-II(n=12) and revised ASRM stage III-IV(n=12), and the presence of a normal pelvis was documented by laparoscopy in 11 control patients. The macroscopically normal peritoneum tissues were collected from lateral wall left or right, near the colon ascendens or descendens. Main Outcome Measure(s): The expression levels were determined as ratios between the target molecules and β-actin as housekeeping gene. Result(s): In women with endometriosis, peritoneal mRNA levels of matrix metalloproteinase(MMP)-3, transforming growth factor-β, interleukin(IL)-6, and intercellular adhesion molecule-1 and endometrial mRNA levels of MMP-3, tumor necrosis factor(TNF)-α, and IL-8 were significantly higher during the menstrual phase when compared with luteal phase. During the menstrual phase of the cycle, both endometrial expression of TNF-α, IL-8, and MMP-3 mRNA levels and peritoneal expression of transforming growth factor-β, IL-6, and intercellular adhesion molecule-1 mRNA levels were significantly higher in women with endometriosis when compared with controls. Immunohistochemical staining confirmed the presence of TNF-αin peritoneum and endometrium in both women with endometriosis and controls. Conclusion(s): Increased endometrial and peritoneal cytokine mRNA expression during menstruation may contribute to a pelvic inflammatory microenvironment favoring the development of endometriosis. | Kyama C.M. Overbergh L. Debrock S. T.M. D'Hghe 党慧敏 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，10： | 2 |
| 2 | An Overview of Real-Time Quantitative PCR: Applications to Quantify Cytokine Gene Expression显示文摘 | Annapaula Giulietti Lut Overbergh Dirk Valckx Brigitte Decallonne Roger Bouillon Chantal Mathieu | 2001 | Methods2001，，4： | 2 |
| 3 | Monocytes from type 2 diabetic patients have a pro-inflammatory profile显示文摘 | Annapaula Giulietti Evelyne van Etten Lut Overbergh Katinka Stoffels Roger Bouillon Chantal Mathieu | 2006 | Diabetes Research and Clinical Practice2006，，1： | 2 |
| 4 | An overview of real-time quantitative PCR:Applications to quantify cytokine gene expression 显示文摘 | GIULIETTI A OVERBERGH L VALCKX D | 2001 | Methods2001，25，4： | 1 |
| 5 | Treatment ofautoimmune diabetes recurrence in non-obese diabetic mice bymouse interferon-beta in combination with an analogue of lalpha,25-dihydroxyvitamin-D-3显示文摘 | Gysemans C Van Etten E Overbergh L | 2002 | Clin Exp Iinnunol2002，128，2： | 1 |
| 6 | Immune regulation of 25-hydr- oxyvitamin-d(3)-lalpha- hydro- xylase in human monocytes显示文摘 | Stoffels K Overbergh L Giulietti A | 2006 | J Bone Miner Re s2006，21，1： | 1 |
| 7 | Human T lymphocytesare direct targets of 1,25-dihydroxyvitamin D3 in the immunesystem显示文摘 | Baeke F Korf H Overbergh L | 2010 | J Steroid Biochem Mol Biol2010，121，12： | 1 |
| 8 | Treatment of autoimmune dia- betes recurrence in non-obese diab- etic mice by mouse interferon-beta in combination with an analogue of 1 alpha, 25- dihydro- xyvitamin-D-3显示文摘 | Gysemans C Van Etten E Overbergh L | 2002 | Clinl Exp Immunol2002，128，2： | 1 |
| 9 | Unaltered diabetes presentation in NOD mice lacking the vitamin D receptor显示文摘 | Gysemans C van Etten E Overbergh L | 2008 | Diabetes2008，57，1： | 1 |
| 10 | Vitamin D and diabetes: its importance for beta cell and immune function 显示文摘 | Wolden-Kirk H Overbergh L Christen HT | 2011 | Mol Cell Endocrinol2011，347，12： | 1 |
| 11 | An overview of real- time quantitative PCR: applications to quantify cytokine gene expression 显示文摘 | GIULti tti A OVERBERGH L VALCKX D | 2001 | Methods2001，25，4： | 1 |
| 12 | Immune regulation of 25 -hydroxyvitamin-D ( 3 )-1 alpha-hydroxylase in human monocytes显示文摘 | Stoffels K Overbergh L Giulietti A | 2006 | J Bone Miner Res2006，，： | 1 |
| 13 | An overview of real-time quantitative PCR:applications to quantify cytokine gene expression显示文摘 | Giulietti A Overbergh L Valckx D | | 0，，： | 1 |
| 14 | An overview of real-time quantitative PCR:applications to quantify cytokine geneexpression显示文摘 | Giulietti A Overbergh L Valckx D | 2001 | Methods2001，25，4： | 1 |
| 15 | The Use of RealTime Reverse Transcriptase PCR for the Quantification of Cytokine Gene Expression显示文摘 | Overbergh L Giulietti A Valckx D | 2003 | J Biomol Tech2003，14，1： | 1 |
| 16 | An overview of real-time quantitative PCR: applications to quantifycytokine gene expression显示文摘 | Giulietti A Overbergh L Valckx D | 2001 | Methods2001，25，4： | 1 |
| 17 | An overview of real-time quantitative PCR: applications to quantify cytokine gene expression 显示文摘 | Giulietti A Overbergh L Valckx D | 2001 | Methods2001，25，4： | 1 |
| 18 | Endometrial and peritoneal expression of aromatase,cytokines,and adhesion factors in women with endometriosis显示文摘 | Kyama CM Overbergh L Mihalyi A | 2008 | Fertil Steril2008，89，2： | 1 |
| 19 | An overview of real-time quantitative PCR: Applications to quantify cytokine gene expression 显示文摘 | Giulietti A Overbergh L Valckx D | 2001 | Methods2001，25，： | 1 |
| 20 | Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis显示文摘 | KYAMA C M OVERBERGH L DEBROCK S | 2006 | Fertil Steril2006，85，6： | 1 |
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