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您的检索式：作者名="Overbergh L."
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| 1 | 子宫内膜异位症妇女月经期腹膜及子宫内膜生物学相关细胞因子和生长因子的基因表达增加显示文摘Objective: To examine differential messenger RNA(mRNA)-expression of relevant cytokines, metalloproteases, growth and adhesion factors in endometrium and peritoneum from women with endometriosis when compared with women without the disease duringmenstrual and luteal phases of the cycle. Design: Patients with endometriosis were compared with control patients. Setting: University hospital. Patient(s): A total of 35 patients(20 patients during the luteal phase and 15 patients during the menstrual phase)were selected for this study on the basis of cycle phase and presence or absence of endometriosis. Intervention( s): In this study, endometriosis was laparoscopically and histologically confirmed in 24 women with endometriosis of revised American Society for Reproductive Medicine(ASRM) stage I-II(n=12) and revised ASRM stage III-IV(n=12), and the presence of a normal pelvis was documented by laparoscopy in 11 control patients. The macroscopically normal peritoneum tissues were collected from lateral wall left or right, near the colon ascendens or descendens. Main Outcome Measure(s): The expression levels were determined as ratios between the target molecules and β-actin as housekeeping gene. Result(s): In women with endometriosis, peritoneal mRNA levels of matrix metalloproteinase(MMP)-3, transforming growth factor-β, interleukin(IL)-6, and intercellular adhesion molecule-1 and endometrial mRNA levels of MMP-3, tumor necrosis factor(TNF)-α, and IL-8 were significantly higher during the menstrual phase when compared with luteal phase. During the menstrual phase of the cycle, both endometrial expression of TNF-α, IL-8, and MMP-3 mRNA levels and peritoneal expression of transforming growth factor-β, IL-6, and intercellular adhesion molecule-1 mRNA levels were significantly higher in women with endometriosis when compared with controls. Immunohistochemical staining confirmed the presence of TNF-αin peritoneum and endometrium in both women with endometriosis and controls. Conclusion(s): Increased endometrial and peritoneal cytokine mRNA expression during menstruation may contribute to a pelvic inflammatory microenvironment favoring the development of endometriosis. | Kyama C.M. Overbergh L. Debrock S. T.M. D'Hghe 党慧敏 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，10： | 2 |
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