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| 1 | 某浅水湖型水源地土臭素(GSM)和2-甲基异莰醇(2-MIB)的变化规律显示文摘以2016年某水源地水样为研究对象,对该水源水的致臭物质2-甲基异莰醇(2-MIB)、土臭素(GSM)以及藻类含量进行检测。通过环境因素相关性分析,构建水源水季节预警机制。研究表明:2-MIB与GSM的含量在夏秋季比较高,在冬春季相对较低;同时,2-MIB的含量在7月、8月远远高于臭阈值,这两种物质在3月、4月浓度均有所上升,与藻类浓度的变化规律基本一致。 | 张建芳 顾青清 符策竿 张泾凯 牛璐瑶 Kristoffer OOMs 刘洪波 | 2018 | 净水技术2018，37，11： | 5 |
| 2 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 3 | Developmental regulation of RI TL-DNA gene expression in roots, shoots and tubers of transformed potato (Solanum tuberosum cv. Desiree)显示文摘 | Gert Ooms David Twell Margreet E. Bossen J. Harry C. Hoge Michael M. Burrell | 1986 | Plant Molecular Biology1986，，5： | 2 |
| 4 | Relationship between soil chemical factors and grassland diversity显示文摘 | F. Janssens A. Peeters J.R.B. Tallowin J.P. Bakker R.M. Bekker F. Fillat M.J.M. Oomes | 1998 | Plant and Soil1998，，1： | 2 |
| 5 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 6 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 7 | HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome显示文摘 | WESTERHOUT E M OOMS M VINK M | 2005 | Nucleic Acids Res2005，33，2： | 1 |
| 8 | 23Na TQF NMR imaging for the study of spinal disc tissue显示文摘 | Ooms KJ Cannella M Vege AJ | 2008 | J Magn Reson2008，195，1： | 1 |
| 9 | Trabecular bone response to injectable calcium phosphate (Ca-P)cement显示文摘 | Ooms EM Wolke GC | 2002 | J Biomed Mater Res2002，61，： | 1 |
| 10 | Measurements of the horizonal movements of a sprayer boom on the longitudinal spray distribution in field conditions显示文摘 | Ooms D Ruter R Lebeau F | 2002 | Crop Protection2002，22，1： | 1 |
| 11 | Fails in the eld- erly:a prospective study of risk factors and risk profiles 显示文摘 | Graafmans WC Ooms ME Hof stee HMA | 1996 | Am J Epide - miol1996，143，： | 1 |
| 12 | Single amino acid mutations in the capsid switch the neutralisation phenotype of porcine circovirus 2显示文摘 | Saha D Lefebvre D J Ooms K | | 0，，07： | 1 |
| 13 | The Qulity Effect : Does Financial Liberalization Improve the Allocation of Capital显示文摘 | ABIAD A OOMES N UEDA K | 2008 | Journal of Development Economics2008，87，2： | 1 |
| 14 | The Quality Effect: Does Financial Liberalization Improve the Allocation of Capital? 显示文摘 | Abiad Abdul Oomes Nienke and Ueda Kenichi 2004 | 2004 | IMF Working Paper2004，，： | 1 |
| 15 | Detection of anal sphincter defects in female patients with fecal inconti- nence:a comparison of 3-dimensionaltransperineal ultra- sound and 2-dimensional endoanal ultrasound 显示文摘 | Oom DM West RL Schouten WR | 2012 | Dis Colon Rectum2012，55，6： | 1 |
| 16 | Martius flap: an adjunct for repair of complex, low rectovaginal fistula 显示文摘 | Gosselink MP Oom DM Zimmerman DD | 2009 | Am J Surg2009，197，6： | 1 |
| 17 | Generic solid phase extraction-liquid chromatography-tandem mass spectrometry method for fast determination of drugs in bio-logical fluids显示文摘 | Schellen A Ooms B van de Lagemaat D | 2003 | J Chromatogr B2003，788，2： | 1 |
| 18 | Predictors of fractures in elderly women显示文摘 | Tromp AM Ooms ME Popp-Snijders C | 2000 | Osteoporos Int2000，11，： | 1 |
| 19 | The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease 显示文摘 | Ooms LM Horan KA Rahman P | 2009 | The Bio- Chemical Journal2009，419，1： | 1 |
| 20 | Long Memory and Level Shifts: Re-analyzing Inflation Rates 显示文摘 | Bos C S Franses P H Ooms M | 1999 | Empirical Economics1999，24，3： | 1 |
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