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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Current concepts and newer developme- nts in the treatment of malignant gliomas 显示文摘 | Omay S Vogelbaum M | 2009 | Indian J Cancer2009，46，2： | 1 |
| 3 | Using gas chromatography to characterize a direct coal liquefaction naphtha显示文摘 | Badaoui Omais Marion Courtiade Nadège Charon Christophe Roullet Jérémie Ponthus Didier Thiébaut | 2011 | Journal of Chromatography A2011，，： | 1 |
| 4 | Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart disease显示文摘 | OZBARAN M OMAY S B NALBANTGIL S | 2004 | Eur J Cardiothorac Surg2004，25，： | 1 |
| 5 | Changes in soil microbial and chemical properties under long-tem~ crop rotation and fertilization显示文摘 | Omay A B Rice C W Maddux L D | 1997 | Soil Sci Soc Am J1997，61，： | 1 |
| 6 | Changes in soil microbial and chemical properties under long-term crop rotation and fertilization显示文摘 | Omay A B Rice C W | 1997 | Soil Science Society of America Journal1997，61，6： | 1 |
| 7 | Computational cytometer based on magnetically modulated coherent imaging and deep learning显示文摘Detecting rare cells within blood has numerous applications in disease diagnostics.Existing rare cell detection techniques are typically hindered by their high cost and low throughput.Here,we present a computational cytometer based on magnetically modulated lensless speckle imaging,which introduces oscillatory motion to the magneticbead-conjugated rare cells of interest through a periodic magnetic force and uses lensless time-resolved holographic speckle imaging to rapidly detect the target cells in three dimensions(3D).In addition to using cell-specific antibodies to magnetically label target cells,detection specificity is further enhanced through a deep-learning-based classifier that is based on a densely connected pseudo-3D convolutional neural network(P3D CNN),which automatically detects rare cells of interest based on their spatio-temporal features under a controlled magnetic force.To demonstrate the performance of this technique,we built a high-throughput,compact and cost-effective prototype for detecting MCF7 cancer cells spiked in whole blood samples.Through serial dilution experiments,we quantified the limit of detection(LoD)as 10 cells per millilitre of whole blood,which could be further improved through multiplexing parallel imaging channels within the same instrument.This compact,cost-effective and high-throughput computational cytometer can potentially be used for rare cell detection and quantification in bodily fluids for a variety of biomedical applications. | Yibo Zhang Mengxing Ouyang Aniruddha Ray Tairan Liu Janay Kong Bijie Bai Donghyuk Kim Alexander Guziak Yi Luo Alborz Feizi Katherine Tsai Zhuoran Duan Xuewei Liu Danny Kim Chloe Cheung Sener Yalcin Hatice Ceylan Koydemir Omai B.Garner Dino Di Carlo Aydogan Ozcan | 2019 | Light(Science & Applications)2019，8，1： | 1 |
| 8 | Re-examining the threshold effects in the inflation-growth nexus with cross-sectionally dependent non- linear panel: Evidence from six industrialized economies显示文摘 | Omay T znur Kan E | 2010 | E- conomic Modelling2010，27，5： | 1 |
| 9 | Effect of magnesium,MK-801 and combination of magnesium and MK-801 on blood-brain barrier permeability and brain edema after experimental traumatic diffuse brain injury显示文摘 | Imer M Omay B Uzunkol A | 2009 | Neurol Res2009，31，9： | 1 |
| 10 | Changes in soil microbial and chemical properties under long-term crop rotation and fertilization 显示文摘 | Omay A B Rice C W Maddux L D | 1997 | Soil Science Society of America Journal1997，61，16： | 1 |
| 11 | Abdominal ultrasonography for the diagnosis of strangulation in small bowel obstruction显示文摘 | Ogata M Omai S Hosotani R | 1994 | Br J Surg1994，81，： | 1 |
| 12 | Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart disease显示文摘 | Ozbaran M Omay SB Nalbantgil S | 2004 | Eur J Cardiothorac Surg2004，25，3： | 1 |
| 13 | Current concepts and newer developments in the treatment of malignant gliomas显示文摘 | Omay S Vogelbaum M | 2009 | Indian J Cancer2009，46，2： | 1 |
| 14 | Low-grade gliomas:when and how to treat显示文摘 | Omay SB Piepmeier JM Knisely JP | | 0，，04： | 1 |
| 15 | Lung cancer brain me- tastases显示文摘 | Goldberg SB Contessa JN Omay SB | 2015 | Cancer J2015，21，5： | 1 |
| 16 | Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling显示文摘 | Omai B. Garner Kevin T. Bush Kabir B. Nigam Yu Yamaguchi Ding Xu Jeffrey D. Esko Sanjay K. Nigam | 2011 | Developmental Biology2011，，2： | 1 |
| 17 | Autologous peripherai stem cell transplantation in patients with congestive heart failure due to ischemic heart disease显示文摘 | Ozbaran M Omay SB Nalbantgil S | 2004 | Eur J Cardiothorac Surg2004，25，： | 1 |
| 18 | Re-examining the threshold effects in the inflation-growth nexus with cross-section- ally dependent nonlinear panel: evidence from six in- dustrialized economies 显示文摘 | OMAY T ZNUR KAN E | 2010 | Economic Modeling2010，27，5： | 1 |
| 19 | Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart disease显示文摘 | Ozbaran M Omay SB Nalbantgil S | 2004 | Eur J Cardiothorac Surg2004，25，： | 1 |
| 20 | Division S-3-Soil Biology & Biochemistry显示文摘 | Rice C W Maddux L D | 1997 | Soil Sci Soc Am1997，，61： | 1 |
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