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| 1 | 2型糖尿病患者采用血管紧张素转换酶抑制剂治疗后血清肌酐急性升高及其继续治疗对主要临床结局的影响显示文摘血管紧张素转换酶抑制剂开始治疗后血清肌酐急性升高≥30%时推荐停药。但血清肌酐升高后继续服药或停药对主要临床结局的长期影响仍不明确。在ADVANCE(糖尿病与血管疾病行动:培哚普利-吲达帕胺与达美康缓释片对照评估)试验中,11 140例糖尿病患者在6周活性导入期后随机采用培哚普利-吲达帕胺或安慰剂治疗。 | Ohkuma T Jun M Rodgers A Cooper ME Glasziou P Hamet P Harrap S Mancia G Marre M Neal B Perkovic V Poulter N Williams B Zoungas S Chalmers J Woodward M 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，1： | 6 |
| 2 | Effect of short-tube orifice size on the performance of an air source heatpump during the reverse-cycle defrost显示文摘 | O'Neal D L Pterson K T Anand N K | 1991 | Int J Refrig1991，14，7： | 4 |
| 3 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 4 | Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer显示文摘gonadal 睾丸激素合成的抑制首先代表标准为变形前列腺癌症的治疗的线治疗。在得阉割抵抗的前列腺癌症(CRPC ) 的病人的多数,然而,通过自己在肾上腺或在肿瘤以内生产的雄激素检测雄激素受体(AR ) 的坚持的激活是可能的。Abiraterone 醋酸盐作为 17 α 与活动作为双功能的细胞色素 P450 酶 CYP17 的一个不可逆的禁止者被开发; -hydroxylase 和 17,20-lyase。CYP17 为从胆固醇的 nongonadal 雄激素的生产是必要的。基于与 abiraterone 和泼尼松对泼尼松在全面幸存(OS ) 显示出重要改进的阶段 III 试用,在 2011 的 abiraterone 的规章的赞同代表了指向 AR 为与 CRPC 在人改进结果是必要的原则的证明。 17 α 的抑制;由 abiraterone 的 -hydroxylase 由于垂体的调停皮质醇的抑制的损失导致在上游的 mineralocorticoids 的累积促肾上腺皮质的荷尔蒙( ACTH ),为 17,20-lyase 为 CYP17 禁止者的开发向一个基本原理提供增加的特性( orteronel , galeterone 和 VT-464 )没有外长的 corticosteroids ,那能潜在地被管理。在这篇文章,我们考察 abiraterone 和另外的 CYP17 禁止者的发展;有 abiraterone 的最近的研究在 quality-of-life,反应的潜在的早预言者,并且关于另外的代理人的 abiraterone 的最佳的定序上通知我们的理解象药效果那样的临床的参数;并且提供卓见进抵抗机制给导致临床的试用,药联合设计了延长 abiraterone 利益或恢复 abiraterone 活动的 CYP17 禁止者的翻译研究结果。 | Mark N Stein | 2014 | Asian Journal of Andrology2014，16，3： | 3 |
| 5 | Refrigeration system dynamics during the reverse cycle defrost显示文摘 | O'Neal D L Pterson K T Anand N K | 1989 | ASHRAE Transaction1989，95，2： | 2 |
| 6 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 7 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 8 | Psychological interventions for women with metastatic breast cancer显示文摘 | Edwards AG Hulbert-Williams N Neal RD | 2008 | Cochrane Database Syst Rev2008，3，00： | 1 |
| 9 | Percutaneous vertebroplasty treat ment of steroid-induced osteoporotic compression fractures 显示文摘 | Ohn MM Michelle P Neal N | 1998 | Arthritis and Rheumatism1998，41，1： | 1 |
| 10 | A role for oxida- tive stress in suppressing serum immunoglobulin levels in lead-exposed Fisher 344 rats显示文摘 | Ereal N Neal R Treeratphan P | 2000 | Arch Environ Con- tam Toxicol2000，39，2： | 1 |
| 11 | Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response显示文摘 | PEREIRA E R LIAO N NEALE G A | | 0，，09： | 1 |
| 12 | Seed losses in commercial harvesting of oilseed rape显示文摘 | Price J S Hobson R N Neale M A | 1996 | J Agric Engng Res1996，65，： | 1 |
| 13 | CpG oligodeoxynucleotides are potent enhancers of radio- and chemoresponses of murine tumors显示文摘 | Mason KA Neal R Hunter N | 2006 | Radiother Oncoh2006，80，2： | 1 |
| 14 | Seed losses in commercial harvesting of oilseed rape 显示文摘 | Price J S Hobson R N Neale M A | 1996 | Journal of Agricultural Engineering Research1996，65，3： | 1 |
| 15 | Effect of salt and wter balance on recovery of gastrointestinal function after elective colonic resection: a randomized controlled trial 显示文摘 | Lobo D N Bostock K A Neal K R | 2002 | Lancet2002，359，9320： | 1 |
| 16 | Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle显示文摘 | O'Neal P Alamdari N Smith I | 2009 | J Cell Biochem2009，108，4： | 1 |
| 17 | β-Adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampus 显示文摘 | Jennifer N Gelinas Gustavo Tenorio Neal Lemon | 2008 | Learn Mem2008，15，5： | 1 |
| 18 | 显示文摘 | Zhu K Neale N R Miedaner A | 2007 | Nano Lett2007，7，： | 1 |
| 19 | Thermal interference of adjacent legs in a vertical U-tube heat exchanger for a ground- coupled heat pump 显示文摘 | N K Muraya D L O Neal W M Heffington | 1996 | ASHRAE Transactions1996，102，2： | 1 |
| 20 | Effect of a coadsorbent on the performance of dye-sensitized TiO2 solar cells: Shielding versus band-edge movement 显示文摘 | NEALE N R KOPIDAKIS N GR? LTZEL M | 2005 | Journal of Physical Chemistry B2005，109，23： | 1 |
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