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| 1 | Investigation of benzylisoquinoline alkaloid biosynthetic pathway and its transcriptional regulation in lotus显示文摘Lotus predominantly accumulates benzylisoquinoline alkaloids(BIAs),but their biosynthesis and regulation remain unclear.Here,we investigated structural and regulatory genes involved in BIA accumulation in lotus.Two clustered CYP80 genes were identified to be responsible for the biosynthesis of bis-BIAs and aporphine-type BIAs,respectively,and their tissue-specific expression causes divergence in alkaloid component between leaf and embryo.In contrast with the common(S)-reticuline precursor for most BIAs,aporphine alkaloids in lotus leaf may result from the(S)-N-methylcoclaurine precursor.Structural diversity of BIA alkaloids in the leaf is attributed to enzymatic modifications,including intramolecular C–C phenol coupling on ring A and methylation and demethylation at certain positions.Additionally,most BIA biosynthetic pathway genes show higher levels of expression in the leaf of high-BIA cultivar compared with low-BIA cultivar,suggesting transcriptional regulation of BIA accumulation in lotus.Five transcription factors,including three MYBs,one ethylene-responsive factor,and one basic helix–loop–helix(bHLH),were identified to be candidate regulators of BIA biosynthesis in lotus.Our study reveals a BIA biosynthetic pathway and its transcriptional regulation in lotus,which will enable a deeper understanding of BIA biosynthesis in plants. | Xianbao Deng Li Zhao Ting Fang Yaqian Xiong Collins Ogutu Dong Yang Sornkanok Vimolmangkang Yanling Liu Yuepeng Han | 2018 | Horticulture Research2018，5，1： | 8 |
| 2 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 3 | Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats显示文摘 | J. Boateng M. Verghese L. Shackelford L.T. Walker J. Khatiwada S. Ogutu D.S. Williams J. Jones M. Guyton D. Asiamah F. Henderson L. Grant M. DeBruce A. Johnson S. Washington C.B. Chawan | 2006 | Food and Chemical Toxicology2006，，5： | 2 |
| 4 | Pharmacokin- etics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions 显示文摘 | Kokwaro GO Ogutu BR Muchohi SN | 2003 | Br J Clin Pbarmacol2003，56，4： | 1 |
| 5 | Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya显示文摘 | Ogutu BR Apollo OJ Mckinney D | 2009 | PLoS One2009，4，3： | 1 |
| 6 | The impact of ecotourism on livelihood and natural resource management in Eselenkei, Amboseli ecosystem,Kenya 显示文摘 | Ogutu Z A | 2002 | Land Degradation and Development2002，13，3： | 1 |
| 7 | An investigation of the influence of human disturbance on selected soil nutrients in Narok District, Kenya 显示文摘 | OGUTU Z A | 1999 | Environmental Monitoring and Assessment1999，58，1： | 1 |
| 8 | Cerebral malaria:optimizing management显示文摘 | Mturi N Musumba Co Wamoia BM Ogutu BR Newton CR | 2003 | CNS Drugs2003，17，3： | 1 |
| 9 | Mitigating the threat of artemisinin resistance in Africa: improvement of drug-resistance surveillance and response systems 显示文摘 | Talisuna AO Karema C Ogutu B | 2012 | Lancet Infectious Diseases2012，12，11： | 1 |
| 10 | Malaria treatment with atovaquone-proguanil in malaria-immune adults: implications for malaria intervention trials and for pre-exposure prophylaxis of malaria显示文摘 | Polhemus ME Remich S Ogutu B | 2008 | Antimicrob Agents Chemother2008，52，4： | 1 |
| 11 | Non-invasive moisture monitoring within an earth embankment - a precursor to failure显示文摘 | JACKSON P D NORTHMORE K J MELDRUM P I GUNN D A HALLAM J R WAMBURA J WANGUSI B OGUTU G | 2002 | NDT&E International2002，35，： | 1 |
| 12 | a and α-galactosidase activi- ties and oligosaccharidc content in peanuts显示文摘 | Bryant R J Rao D R Ogutu S | 2004 | Plant Foods for Human Nutrition2004，58，： | 1 |
| 13 | Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area显示文摘 | Polhemus ME Remich SA Ogutu BR | 2009 | PLoS One2009，4，7： | 1 |
| 14 | The novel use of intestinal mucosal matrix for vaginal vault dehiscence following laparoscopic radical hys- terectomy for cervical carcinoma 显示文摘 | Ogutu D Das S Mould T | 2010 | European Journal of Obstetrics Gynecology and Reproductive Biology2010，151，2： | 1 |
| 15 | Blood stage malaria vaccine eliciting high antigen specific antibody concentrations con- fers no protection to young children in Western Kenya显示文摘 | Ogutu BR Apollo OJ McKinney D | 2009 | PLoS One2009，4，3： | 1 |
| 16 | Famotidine in the management of gastro-oesophageal reflux显示文摘 | Okoth FA Lule GN Ogutu EO | 1994 | East Afr Med J1994，71，1： | 1 |
| 17 | Mitigating the threat of artemisinin resistance in Africa: improvement of drug-resis- tance surveillance and response systems 显示文摘 | Talisuna AO Karema C Ogutu B | 2012 | Lancet Infect Dis2012，12，11： | 1 |
| 18 | Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions显示文摘 | Muchohi SN Kokwaro GO Ogutu BR | | 0，，04： | 1 |
| 19 | Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups-new classes of PPAR γ/δ and PPAR α/γ/δ agonists显示文摘 | Liang S Ogutu H | 2007 | Bioorg Med Chem Lett2007，17，4： | 1 |
| 20 | The novel use of intestinal mucosal ma-trix for vaginal vault dehiscence following laparoscopic radical hysterec-tomy for cervical carcinoma显示文摘 | Ogutu D Das S Mould rF | 2010 | Eur J Obstet Gynecol Reprod Biol2010，151，2： | 1 |
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