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| 1 | Significant decrease in prevalence ofHelicobacter pylori in the Czech Republic显示文摘AIM:To study possible decrease in prevalence of Helicobacter pylori(H.pylori) infection in the Czech Republic within a 10-year period.METHODS:A total of 22 centres entered the study.The catchment areas of these centres covered cities and towns with more than 20 000 inhabitants,smaller towns(≤ 20 000 inhabitants) with surrounding villages and rural areas,and were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1 837 subjects(aged 5-98 years) took part in the study,randomly selected out of 38 147 people from the general population.H.pylori infection was investigated by means of a 13 C-urea breath test.Breath samples in duplicates were analysed using isotope ratio mass spectrometry.The cut-off point was 3.5.Social and demographic characteristics were based on data from self-completed questionnaires.RESULTS:The overall prevalence of H.pylori infection was 23.5%(430/1826),and 4.8%(20/420) in children aged 15 or less.There was no statistically significant difference in prevalence between males(24.3%;208/857) and females(22.9%,222/969,P = 0.494).H.pylori infection was strongly associated with higher age,among subjects aged 55+ years,prevalence of H.pylori infection was 39.8%(252/633,P < 0.001).The highest prevalence of H.pylori infection was found among persons aged 55-64 years(43.9%,97/221) and 75+ years(37.9%,58/153).Among study subjects aged 15+ years,prevalence of H.pylori infection was significantly increased in those with lowest education(odds risk 3.19,95% CI 1.87-5.47).Compared to never married(14.1%),the prevalence of H.pylori infection was statistically significantly higher among married(35.4%,246/694,P < 0.001),divorced(36.8%,49/133,P < 0.001) and widowed study subjects(40.2%,45/112,P < 0.001),both in minimally and fully adjusted analysis.There was no significant difference in the prevalence of H.pylori infection between married and widowed subjects(35.4%,246/694 vs 40.2%,45/112,P = 0.389).There was little variation in smoking prevalence across categories of smoking and there was no evidence of an increased risk ofH.pylori infection among current or past smokers in our data(odds risk 1.04 with 95% CI 0.78-1.40 for current smokers;odds ratio 0.83 with 95% CI 0.60-1.16 for former smokers).The current prevalence of H.pylori in 2011 was significantly lower compared to the prevalence reported from identical geographical areas in 2001(23.5%vs 41.7%,P < 0.001).CONCLUSION:The overall prevalence of H.pylori infection in the general population has fallen substantially in the Czech Republic over the past 10 years. | Jan Bure Marcela Kopáová Ilona Koupil Bohumil Seifert Miluka kodová Fendrichová Jana pirková Viktor Voíek Stanislav Rejchrt TomáDouda Norbert Král Ilja Tachecí | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 3 | Long-term survival of a patient after resection of a gastrointestinal stromal tumor arising from the pancreas显示文摘BACKGROUND:Gastrointestinal stromal tumors (GISTs) may arise in any part of the gastrointestinal tract;extragastrointestinal locations are extremely rare.Only a few cases of extragastrointestinal stromal tumor arising from the pancreas were reported.None of the reports described a long-term follow-up of the patients.METHOD:This report describes an interesting and unusual case of GIST arising from the pancreas.RESULTS:A 74-year-old female presented with a palpable abdominal mass.CT scan showed a large mass 11×8×4 cm originating from the tail of the pancreas.Percutaneous biopsy revealed a GIST predominantly with spindle cells,but some parts also contained epitheloid cells.The patient was treated by distal pancreatic resection with splenectomy.Immunohistochemistry of the tumor showed a staining pattern characteristic of GIST.The patient has achieved a long-term survival of five years and six months without any sign of recurrence of the disease.CONCLUSION:This is the first reported case of an extragastrointestinal stromal tumor arising from the pancreas treated surgically,with a long-term survival. | Filip eka Bohumil Jon Alexander Ferko Zdeněk ubrt Dimitar H Nikolov Věra Tyová | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 3 |
| 4 | Evidence for a Role of Second Pathophysiological Stress in Prevention of Delayed Neuronal Death in the Hippocampal CA1 Region显示文摘 | Jozef Burda Milina Matia?ová Miroslav Gottlieb Viera Danielisová Miroslava Némethová Lidia Garcia Matilde Salinas Rastislav Burda | 2005 | Neurochemical Research2005，，11： | 2 |
| 5 | Super d-antimagic Labelings of Disconnected Plane Graphs显示文摘这份报纸处理以如此的一个方法把一张飞机图的顶点,边和脸标记,一张脸的标签和包围那张脸的顶点和边的标签总和为那张脸的重量的问题,并且所有 站在一起s 的脸的重量组成差别 d 的算术前进,为每 s ,那出现在图。纸检验如此的标记的存在为拆散飞机图的联合。 | Martin BAA Mirka MILLER Oudone PHANALASY Andrea SEMANIOV-FEOVKOV | 2010 | Acta Mathematica Sinica,English Series2010，26，12： | 2 |
| 6 | Neuroprotective agents effective against radiation damage of central nervous system显示文摘Ionizing radiation caused by medical treatments,nuclear events or even space flights can irreversibly damage structure and function of brain cells.That can result in serious brain damage,with memory and behavior disorders,or even fatal oncologic or neurodegenerative illnesses.Currently used treatments and drugs are mostly targeting biochemical processes of cell apoptosis,radiation toxicity,neuroinflammation,and conditions such as cognitive-behavioral disturbances or others that result from the radiation insult.With most drugs,the side effects and potential toxicity are also to be considered.Therefore,many agents have not been approved for clinical use yet.In this review,we focus on the latest and most effective agents that have been used in animal and also in the human research,and clinical treatments.They could have the potential therapeutical use in cases of radiation damage of central nervous system,and also in prevention considering their radioprotecting effect of nervous tissue. | Mária Lalkovičová | 2022 | Neural Regeneration Research2022，17，9： | 2 |
| 7 | The clinical significance of sinus membrane perforation during augmentation of the maxillary sinus 显示文摘 | Ardekian L Oved - Peleg E Mactei E | 2006 | Oral Maxillofac Surg2006，64，2： | 1 |
| 8 | Neurostructural predictors of Alzheimer's disease: a META-analysis of VBM studies显示文摘 | Ferreira LK Diniz BS Forlenza OV | 2011 | Neurobiol Aging2011，32，10： | 1 |
| 9 | Quantification of short term signaling by the epidermal growth factor receptor显示文摘 | Kholodenko BN Demin OV Moehren G | 1999 | J Biol Chem1999，274，30： | 1 |
| 10 | Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage显示文摘 | Libby RT Li Y Savinova OV | 2005 | PLoS Genet2005，1，： | 1 |
| 11 | Inhibition of phospho- lipase A2 reduces neurite outgrowth and neuronalviability显示文摘 | Forlenza OV Mendes CT Marie SK | 2007 | Prostaglandins Leukot Essent Fatty Acids2007，76，1： | 1 |
| 12 | Results of transeulaneous nephrolithotifpsy using the combined lithotrip-ton 2 in 1 Swiss lithoelast master显示文摘 | Teodorovich OV Zabmdina NB Dzhabfe D | 2002 | Urologiia2002，，5： | 1 |
| 13 | Individual characterization of stably expanded T cell clones in ankylosing spondylitis patients显示文摘 | Mamedov IZ Britanova OV Chkalina AV | 2009 | Autoimmunity2009，42，6： | 1 |
| 14 | Preparation of nanosized micro/mesoporous composites via simultaneous synthesis of Beta/MCM-48 phases显示文摘 | P. Proke?ová S. Mintova J. ?ejka T. Bein | 2003 | Microporous and Mesoporous Materials2003，，1： | 1 |
| 15 | The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxiainducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells显示文摘 | Razorenova OV Castellini L Colavitti R | 2014 | Mol Cell Biol2014，34，： | 1 |
| 16 | Mesenchymal stem cells:Sources,phenotype and differentiation potential显示文摘 | Payushina OV Domaratskaya EI Starostin VI | | 0，，02： | 1 |
| 17 | Pigment epithelium-derived factor: a potent inhibitor of angiogenesis 显示文摘 | Awson DW Volpert OV Gillis P | 1999 | Science1999，285，5425： | 1 |
| 18 | Role of Tet proteins in 5mC to 5-11mC conversion, ES-eell self-renewal and inner eell mass specification显示文摘 | Itt S D'Alessin AC Taranova OV | 2010 | Nature2010，466，7310： | 1 |
| 19 | Evaluation of the purity of vitamin a oil-based preparationsby thin-layer chromatography显示文摘 | OV CHECHETA EF SAFONOVA Al SLIVKIN | 2008 | Pharmaceutical ChemistryJournal2008，42，12： | 1 |
| 20 | Endothelial lipase modified high density lipoprotein exhibits diminished ability to mediate SR-BI(scavenger receptor B type I)-dependent free-cholesterol efflux 显示文摘 | Gauster M Oskelkova OV Innerlohinger J | 2004 | Biochem J2004，382，1： | 1 |
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