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| 1 | Functional brain imaging of gastrointestinal sensation in health and disease显示文摘It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive- exert an influence on gastrointestinal sensorimotor function. More specifi cally, a link between psychological factors and visceral hypersensitivity has been suggested, mainly based on research in functional gastrointestinal disorder patients. However, until recently, the exact nature of this putative relationship remained unclear, mainly due to a lack of non-invasive methods to study the (neurobiological) mechanisms underlying this relationship in non-sleeping humans. As functional brain imaging, introduced in visceral sensory neuroscience some 10 years ago, does provide a method for in vivo study of brain-gut interactions, insight into the neurobiological mechanisms underlying visceral sensation in general and the influence of psychological factors more particularly, has rapidly grown. In this article, an overview of brain imaging evidence on gastrointestinal sensation will be given, with special emphasis on the brain mechanisms underlying the interaction between affective & cognitive processes and visceral sensation. First, the reciprocal neural pathways between the brain and the gut (brain- gut axis) will be briefky outlined, including brain imaging evidence in healthy volunteers. Second, functional brain imaging studies assessing the influence of psychological factors on brain processing of visceral sensation in healthy humans will be discussed in more detail. Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorderpatients will be highlighted. | Lukas Van Oudenhove Steven J Coen Qasim Aziz | 2007 | World Journal of Gastroenterology2007，13，25： | 9 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Efficacy of Buspirone, a Fundus-Relaxing Drug, in Patients With Functional Dyspepsia显示文摘 | Jan Tack Pieter Janssen Tatsuhiro Masaoka Ricard Farré Lukas Van Oudenhove | 2012 | Clinical Gastroenterology and Hepatology2012，，11： | 2 |
| 4 | GEERAERTS B, et al Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors or somatisation显示文摘 | VAN OUDENHOVE L VANDENBERGHE J | 2008 | Gut2008，57，： | 1 |
| 5 | Influence of experimentally induced anxiety on gastric sensor motor function in humans显示文摘 | Geeraerts B Vandenberghe J Van Oudenhove L | 2005 | Gastroenterology2005，129，5： | 1 |
| 6 | Determinants of symptom severity and weight loss in functional dyspepsia 显示文摘 | Van Oudenhove L Vandenberghe J Brecht G | 2006 | Gastroenterology2006，130，： | 1 |
| 7 | Abuse history, depression, and somatization are associated with gas- tric sensitivity and gastric emptying in functional dyspepsia 显示文摘 | Van Oudenhove L Vandenberghe J Vos R | 2011 | Psychosom Med2011，73，8： | 1 |
| 8 | Influence of experimentally induced anxiety on gastric sensorimotor function in humans显示文摘 | Geeraerts B Vandenberghe J Van Oudenhove | 2005 | Gastroenterology2005，129，： | 1 |
| 9 | Relationship between anxiety and gastric sensorimotor function in functional dyspepsia显示文摘 | Van Oudenhove L Vandenberghe J Geeraerts B | 2007 | Psychosom Med2007，69，5： | 1 |
| 10 | Postprandial symptoms originating from the stomach in functional dyspepsia显示文摘 | H. Vanheel T. Vanuytsel L. Oudenhove R. Farré K. Verbeke J. Tack | 2013 | Neurogastroenterol. Motil2013，，11： | 1 |
| 11 | Depression and somatization are associated with increased postprandial symptoms in patients with irritable bowel syndrome显示文摘 | Van Oudenhove L Trnblom H Strsrud S | 2016 | Gastroenterology2016，150，4： | 1 |
| 12 | Relationshipbetween anxiety and gastric sensorimotor function in functional dyspepsia显示文摘 | Van Oudenhove L Vandenberghe J Geeraers B | 2007 | Psychosom Med2007，69，5： | 1 |
| 13 | Sensitivity testing in irritable bowel syndrome with rectal capsaicin stimulations: role of TRPV1 upregulation and sensitization in visceral hypersensitivity显示文摘 | Van Wanrooij SJ Wouters MM Van Oudenhove L | 2014 | Am J Gastroenterol2014，109，1： | 1 |
| 14 | Influence of experimentally induced anxiety on gastric sensorimotor function in humans显示文摘 | Geeraerts B Vandenberghe J Van Oudenhove L | | 0，，05： | 1 |
| 15 | Immune dys- function in patients with functional gastrointestinal disorders显示文摘 | Kindt S Van Oudenhove L Broekaert D | 2009 | Neurogastroenterol Motil2009，21，4： | 1 |
| 16 | Central nervous system involvement in functional gastrointestinal disorders 显示文摘 | Van Oudenhove L Demyttenaere K Tack J et a1 | 2004 | Best Pract Res Clin Gastroenterol2004，18，4： | 1 |
| 17 | Peripheral and central mechanisms of visceral sensitization in man显示文摘 | P.Anand Q.Aziz R.Willert L.Van Oudenhove | 2007 | Neurogastroenterology & Motility2007，，： | 1 |
| 18 | Determinants of symptom severity and weight loss in functional dyspepsia显示文摘 | Van Oudenhove L Joris V Geeraerts B | 2008 | Gut2008，57，12： | 1 |
| 19 | Central nervous system involvement in functional gastrointestinal disorders显示文摘 | van Oudenhove L Demyttenaere K Tack J | 2004 | Best Pract Res Clin Gastroenterol2004，18，4： | 1 |
| 20 | Regional cerebral blood flow during gastric balloon distention in functionaldyspepsia 显示文摘 | Vandenberghe J Dupont P Van Oudenhove L | 2007 | Gastroenterology2007，132，5： | 1 |
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