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| 1 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 2 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 3 | Runx3 knockouts and stomach cancer显示文摘 | Levanon D Brenner O Otto F | 2003 | EMBO Rep2003，4，6： | 1 |
| 4 | Persistent immune activation in HIV-1 infection is associated with progression to AIDS显示文摘 | Hazenberg M D Otto S A van Benthem B H | 2003 | AIDS2003，17，： | 1 |
| 5 | Persistent immune activation in HIV-1 infection is associated with progression to AIDS显示文摘 | Hazenberg M D Otto S A van Benthem B H | 2003 | AIDS2003，17，： | 1 |
| 6 | Post- traumatic stress disorder symptoms following media exposure to tragic events: Impact of 9/11 on children at risk for anxiety disorders显示文摘 | Otto M W Henin A Hirshfeld- Becker D R | 2007 | Journal of Anxiety Disorders2007，21，7： | 1 |
| 7 | Discovery of recurrent KIF5B-RET fusions and other targetable alterations from clinical NSCLC specimens 显示文摘 | Capelletti M Lipson D Otto G | 2012 | J Clin Oncol2012，30，15： | 1 |
| 8 | A pilot study of functional cognitive behavioral Therapy (fCBT) for schizophrenia 显示文摘 | Cather C Penn D Otto MW | 2005 | Schizophr Res2005，74，23： | 1 |
| 9 | Developmental outcome and psychosocial adjustment in children after surgery for congenital heart disease during infancy 显示文摘 | Katja H Karl - Otto D Herman K | 2007 | SRIP2007，25，2： | 1 |
| 10 | The rhesus macaque as an animal model for pelvic organ peolapse显示文摘 | Otto L N Slayden O D Clark A L | 2002 | Am J Obstet Gynecol2002，186，33： | 1 |
| 11 | Induction of mucosal antibodies by live attenuated and inactivated influenza virus vaccines in the chronically ill elderly显示文摘 | Otto E E Powers D C | 1996 | J Infect Dis1996，173，2： | 1 |
| 12 | Evaluation of a new measure of blood glucose variability in diabetes显示文摘 | Kovatchev BP Otto E Cox D | 2006 | Diabetes Care2006，29，1： | 1 |
| 13 | Evaluation of a new measure of blood glucose variability in diabetes显示文摘 | Kovatchev BP Otto E Cox D | 2006 | Diabetes Care2006，29，11： | 1 |
| 14 | Association of aortic valve sclerosis with cardiovascular mortality and morbidity in the elderly 显示文摘 | OTtO C M LIND B K KITZMAN D W | 1999 | N Engl J Med1999，341，1： | 1 |
| 15 | A method for architecting product platforms显示文摘 | GONZALER-ZUGASTI J P OTTO K N BAKER J D | 2000 | Research in Engineering Deslgn2000，12，2： | 1 |
| 16 | Early T-cell inactivation and apoptosis-critical events for tolerance induction after allogeneic liver transplantation显示文摘 | Meyer D Thorwarth W Otto C | 2001 | Trans- plantation Proc2001，33，12： | 1 |
| 17 | Efficacy and safety of great sa- phenous vein sclerotherapy using standardized polidocanol foam (ES- AF) :a randomised controlled muhicentre clinical trial显示文摘 | Rabe E Otto J Schliephake D | 2008 | Eur J Vasc Endovasc Surg2008，35，2： | 1 |
| 18 | T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation:a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)显示文摘 | Hazenberg M D Stuart J W Otto S A | 2000 | {H}Blood2000，，01： | 1 |
| 19 | Systematic review and classifieation of complications after anterior, posterior, apieal, and total vaginal mesh implantation for prolapse repair显示文摘 | Barski D Otto T Gerullis H | 2014 | Surg Teehnol Int2014，24，： | 1 |
| 20 | Function of Nic- otiana tabacum aquaporins as chloroplast gas pores challenges the concept of membrane COz permeability 显示文摘 | Uehlein N Otto B Hanson D T | 2008 | The Plant Cell Online2008，20，3： | 1 |
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