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| 1 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 2 | Cultured meat from muscle stem cells: A review of challenges and prospects显示文摘Growing muscle tissue in culture from animal stem cells to produce meat theoretically eliminates the need to sacrifice animals. So-called 'cultured' or 'synthetic' or 'in vitro' meat could in theory be constructed with different characteristics and be produced faster and more efficiently than traditional meat. The technique to generate cultured muscle tissues from stem cells was described long ago, but has not yet been developed for the commercial production of cultured meat products. The technology is at an early stage and prerequisites of implementation include a reasonably high level of consumer acceptance, and the development of commercially-viable means of large scale production. Recent advancements in tissue culture techniques suggest that production may be economically feasible, provided it has physical properties in terms of colour, flavour, aroma, texture and palatability that are comparable to conventional meat. Although considerable progress has been made during recent years, important issues remain to be resolved, including the characterization of social and ethical constraints, the fine-tuning of culture conditions, and the development of culture media that are cost-effective and free of animal products. Consumer acceptance and confidence in in vitro produced cultured meat might be a significant impediment that hinders the marketing process. | Isam T Kadim Osman Mahgoub Senan Baqir Bernard Faye Roger Purchas | 2015 | Journal of Integrative Agriculture2015，14，2： | 20 |
| 3 | The effects on prognosis of surgical treatment of hypertensive putaminal hematomas through transsylvian transinsular approach显示文摘 | R. Alper Kaya Osman Türkmeno?lu Ibrahim M Ziyal Türker Dalkili? Yüksel ?ahin Yunus Aydin | 2003 | Surgical Neurology2003，，3： | 2 |
| 4 | Neurochemical metabolites in the medial prefrontal cortex in bipolar disorder A proton magnetic resonance spectroscopy study显示文摘The aim of this study was to investigate proton magnetic resonance spectroscopy metabolite values in the medial prefrontal cortex of individuals with euthymic bipolar disorder. The subjects consisted of 15 patients with euthymic bipolar disorder type Ⅰ and 15 healthy controls. We performed proton magnetic resonance spectroscopy of the bilateral medial prefrontal cortex and measured levels of N-acetyl aspartate, choline and creatine. Levels of these three metabolites in the medial prefrontal cortex were found to be lower in patients with bipolar disorder compared with healthy controls. A positive correlation was found between illness duration and choline levels in the right medial prefrontal cortex. Our study suggests that during the euthymic period, there are abnormalities in cellular energy and membrane phospholipid metabolism in the medial prefrontal cortex, and that this may impair neuronal activity and integrity. | Osman zdel Demet Kalayci Gülfizar Szeri-Varma Yilmaz Kiroglu Selim Tümkaya Tuge Toker-Ugurlu | 2012 | Neural Regeneration Research2012，7，36： | 2 |
| 5 | Bending behavior of short steel cylinders under axial force fluctuations显示文摘 | Osman T C Shozo N Kazuo T | 2008 | Engineering Structures2008，30，3： | 1 |
| 6 | Integrating value analysis and quality function deployment for evaluating design alternatives显示文摘 | CARIAGA I ELDIRABY T OSMAN H | 2007 | Journal of Construction Engineering and Man agement2007，133，10： | 1 |
| 7 | The role of international trade on environmental efficieney A DEA approach显示文摘 | Fatma T Osman Z | 2001 | Eco- nomic Modeling2001，18，1： | 1 |
| 8 | Increased levels of vascular endothelial growth factor in the aqueous hu- mor of patients with diabetic retinopathy显示文摘 | Selim KM Sahan D Muhittin T Osman C Mustafa O | 2010 | Indian J Ophthal- mol2010，58，5： | 1 |
| 9 | Catching-up and innovation in high-and low-income countries显示文摘 | FATMA T OSMAN Z | 1997 | Economics Letters1997，54，1： | 1 |
| 10 | Fluorinated deoxyglueose posi- tron emission tomography imaging in progressive metastatic prostate caneer显示文摘 | Morris M J Akhurst T Osman I | 2002 | Urology2002，59，： | 1 |
| 11 | Profiles of proinflammatory cytokines in the serum of rabbits after experimentally induced acute pancreatitis显示文摘 | Osman MO Gesser B Mortensen J T | 2002 | Cytokine2002，17，1： | 1 |
| 12 | Support vector machines显示文摘 | Hearst M A Dumais S T Osman E Platt J Scholkopf B | 1998 | IEEE Journal on Intelligent Systems and their Applications1998，13，4： | 1 |
| 13 | The effects on prognosis of surgical treatment of hypertensive putaminal hematomas through transsylvian transinsular approach显示文摘 | R. Alper Kaya Osman Türkmeno?lu Ibrahim M Ziyal Türker Dalkili? Yüksel ?ahin Yunus Aydin | 2003 | Surgical Neurology2003，，3： | 1 |
| 14 | Suppression of the Sendal virus M protein through a novel short interfering RNA ap- proach inhibits viral particle production but does not affect viral RNA synthesis显示文摘 | MOTTET OSMAN G ISEN1 F PELET T | 2007 | J Virol2007，81，6： | 1 |
| 15 | Low-power holmium: YAG laser urethrotomy for treatment of urethral strictures: func- tional outcome and quality of life 显示文摘 | KAMP S KNOLL T OSMAN MM | 2006 | J Endourol2006，20，1： | 1 |
| 16 | A quantitative,randomized study evaluating three methods of mesenchymal stem cell delivery follow in myocardial infarction显示文摘 | Freyman T Polin G Osman H | | 0，，： | 1 |
| 17 | Insulin resistance differentially affects the PI3-kinase and MAP kinase-mediated signalingin human muscle显示文摘 | Cosi K Maezono K Osman A Pendergrass M Pratipanawatr T DeFronzo RA | 2000 | J Clin Invest2000，105，3： | 1 |
| 18 | A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction 显示文摘 | FREYMAN T POLIN G OSMAN H | 2006 | Eur Heart J2006，27，9： | 1 |
| 19 | A model for the simulation of the interactions between dynamic tooth loads and contact fatigue in spur gears显示文摘 | Osman T Velex Ph | 2012 | Tribol Int2012，46，1： | 1 |
| 20 | Experimental analysis of high-speed air-water jet flow in an abrasive water jet mixing tube显示文摘 | OSMAN A H MABROUKI T THERY B | 2004 | Flow Measurement and Instrumentatiore2004，15，1： | 1 |
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