|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | The role of international trade on environmental efficieney A DEA approach显示文摘 | Fatma T Osman Z | 2001 | Eco- nomic Modeling2001，18，1： | 1 |
| 4 | Catching-up and innovation in high-and low-income countries显示文摘 | FATMA T OSMAN Z | 1997 | Economics Letters1997，54，1： | 1 |
| 5 | Intravenous dexmedetomidine, but not midazolam,prolongs bupivacaine spinal anesthesia 显示文摘 | Fatma NK Belgin Y Gurkan T | 2010 | Can J Anaesth2010，27，1： | 1 |
| 6 | Sea-blue histioeytes in the bone marrow of a boy with sever congenital neutropenia assoiated with G6PC3 mutation显示文摘 | Betul T Mualla T Fatma G | 2014 | Brihaem2014，165，4： | 1 |
| 7 | Polyol pathway-dependent osmotic and oxidative stresses in aldose reductase-mediated apoptosis in human lens epithelial cells:role of AOP2 显示文摘 | Kubo E Urakami T Fatma N | 2004 | Biochem Biophys Res Commun2004，314，4： | 1 |
| 8 | Intravenous dexmedetomidine,but not midazolam,prolongs bupiva-caine spinal anesthesia显示文摘 | Fatma N K Belgin Y Gurkan T | 2010 | Can J Anaesth2010，27，1： | 1 |
| 9 | Chromium (VI) induced oxidative stress in Hapalosiphon fontinalis 显示文摘 | Bano F Zutshi S Fatma T | 2012 | World Journal of Microbiology and Biotechnology2012，28，7： | 1 |
| 10 | Polyol pathway-de- pendent osmotic and oxidative stresses in aldose reduc- tase-mediated apoptosis in human lens epithelial cells: role of AOP2 显示文摘 | Kubo E Urakami T Fatma N | 2004 | Biochem Biophys Res Commun2004，314，4： | 1 |
| 11 | Novel benzimidazole-pyrimidine conjugates as potent antitumor agents显示文摘 | Beba T A ti Fatma A F R Mostafa ti R | 2010 | Eur J tied Chem2010，45，： | 1 |
| 12 | LEDGF, a survival factor, activates stress-related genes 显示文摘 | Shinohara T Singh DE Fatma N | 2002 | Prog Retin Eye Res2002，21，： | 1 |
| 13 | Tumor anti-initiating activity of some novel 3, 4-dihydropyrimidinones显示文摘 | Hanaa A T Fatma B Amira M G | 2009 | Pharmacological Reports2009，61，： | 1 |
| 14 | Dry deposition fluxes and deposition velocities of PAHsat an urban site in Turkey显示文摘 | Yu C T Fatma E | 2007 | Atmospheric Environment2007，41，6： | 1 |
| 15 | Fuzzy portfolio selection using fuzzy analytic hierarchy process显示文摘 | FATMA T BEYZA A | 2009 | Information Sciences2009，179，12： | 1 |
| 16 | Fuzzy portfolio selection using fuzzy analytichierarchy process 显示文摘 | Fatma T Beyza A | 2009 | Information Sciences2009，179，12： | 1 |
| 17 | Dry deposition fluxes and deposition velocities of PAHs at an urban site in Turkey显示文摘 | Yu¨ C T Fatma E | 2007 | Atmospheric Environment2007，41，6： | 1 |
| 18 | Development of antioxidative defense system of wheat seedlings in response to high light显示文摘 | Miskra N P Fatma T Singhal G | 1995 | Physiol Plant1995，95，： | 1 |
| 19 | Polyol pathway-dependent osmotic and oxidative stresses in aldose reductase-mediated apoptosis in human lens epithelial cells: role of AOP'2 显示文摘 | Kubo E Urakami T Fatma N | 2004 | Biochem Biophys Res Commun2004，314，4： | 1 |
| 20 | Development of an- tioxidative defense system of wheat seedlings in re-sponse to high light 显示文摘 | Mishra N P Fatma T Singhal G S | 1995 | Physiol Plant1995，，95： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员