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| 1 | 年龄相关性黄斑变性的脉络膜厚度评价(英文)显示文摘目的:通过光学相干断层扫描(optical coherence tomography,OCT;RTVue 100-2;V 5.1,Optovue,Fremont,CA,USA)测量比较非新生血管性与新生血管性年龄相关性黄斑变性(age-related macular degeneration,AMD)黄斑中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT),并分析脉络膜厚度(choroidal thickness,CT)对AMD新血管形成的影响。方法:本研究为回顾性、横断面研究。以单侧眼患有新生血管性AMD且对侧眼患有非新生血管性AMD的24例患者(48眼)作为研究组,选取年龄与眼轴长度相匹配的40例健康眼作为对照组。非新生血管性AMD亚组研究对象是黄斑区有玻璃疣和/或色素变化眼,而新生血管性AMD亚组研究对象是由于脉络膜新生血管而致视网膜下或视网膜内有渗出液和/或脂性渗出眼。运用OCT垂直测量外侧高反射线(视网膜色素上皮层)到脉络膜巩膜交界面间的距离。选取7个不同点进行脉络膜厚度测量,测量区域为距黄斑中心凹颞侧和鼻侧1500μm范围,测量间距为500μm。测量结果在亚组间进行统计学对比研究。结果:研究组患者平均年龄为72.4±8.97(60~82)岁,对照组受试者平均年龄为71.2±8.8(58~81)岁。新生血管性AMD组中平均SFCT明显大于非新生血管性AMD组的厚度(P<0.05)。非新生血管性AMD组中,平均SFCT与平均鼻、颞侧脉络膜厚度比较,差异无统计学意义(P>0.05);而新生血管性AMD组中,平均SFCT与平均鼻、颞侧脉络膜厚度比较,差异有统计学意义(P<0.05)。结论:运用OCT对脉络膜厚度进行测量,有助于理解AMD的病理生理机制。然而,仍需要大型前瞻性研究来探求新生血管性AMD中SFCT增厚的原因。 | Erkan Unsal Kadir Eltutar Ozen Ayranci Osmanbasoglu Sibel Zιrtιloglu Osman Kιzιlay Hulya Gungel | 2014 | 国际眼科杂志2014，14，9： | 4 |
| 2 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 3 | The role of international trade on environmental efficieney A DEA approach显示文摘 | Fatma T Osman Z | 2001 | Eco- nomic Modeling2001，18，1： | 1 |
| 4 | Catching-up and innovation in high-and low-income countries显示文摘 | FATMA T OSMAN Z | 1997 | Economics Letters1997，54，1： | 1 |
| 5 | PUF panel adhesives doped with additional urea and reinforced by isocyanates 显示文摘 | OSMAN Z PIZZI A KANTNER W | 2005 | Holz Roh Werkst2005，63，： | 1 |
| 6 | A Regression Analysis of the Effect of Energy Use on Agriculture 显示文摘 | Osman Karkacier Z Gokalp Goktolga Adrian Cicek | 2006 | Energy Policy2006，34，18： | 1 |
| 7 | Anal- ysis of key molecules of the innate immune system in mammary epithelial cells isolated from marker-assis- ted and conventionally selected cattle显示文摘 | GRIESBECK Z B OSMAN M KUHN C | 2009 | J Dairy Res2009，92，9： | 1 |
| 8 | Aflatoxin MI in breast-milk of UAE women 显示文摘 | ABDULRAZZAQ Y M OSMAN N YOUSIF Z M | 2003 | Ann Trop Paediatr2003，23，3： | 1 |
| 9 | Input-Output Analysis of Energy Use in Agriculture显示文摘 | Osman Karkacier Gokalp Goktolga Z | | 0，，46： | 1 |
| 10 | COBRA Framework to Evaluate e-Government Services A Citizen- Centric Perspective显示文摘 | Osman I H Anouze A L Irani Z | 2014 | Government Information Quarterly2014，31，2： | 1 |
| 11 | Conductivity enhancement due to ion dissociation in plasticized chitosan based polymer electrolytes 显示文摘 | Osman Z Ibrahim Z A Arof A K | 2001 | Carbohydrate Polymers2001，44，2： | 1 |
| 12 | Experi?mental assessment of hydrostatic thrust bearing perfor?mance显示文摘 | OSMAN T A DORID M SAFAR Z S | | 0，，03： | 1 |
| 13 | The effects on prognosis of surgical treatment of hypertensive putaminal hema-tomas through transsylvian transinsular approach 显示文摘 | Ralper K Osman T Ibrahim Z | 2003 | Surg Neurol2003，59，： | 1 |
| 14 | Effect of dietary protein level on the reproductive performance of female swordtails Xiphophorus heUeri (Poeciliidae) 显示文摘 | Chong A S C Ishak S D Osman Z | 2004 | Aquaculture2004，234，38： | 1 |
| 15 | Generation of bcr-abl specific cytotoxic T-lymphocytes by using dendritic cells pulsed with bcr-abl (b3a2) peptide: its appticabitity for donor leukocyte transfusions in marrow grafted CML patients显示文摘 | Osman Y Takahashi M Zheng Z | 1999 | Leukemia1999，13，2： | 1 |
| 16 | Underlying causes of recurrent pneumonia in Turkish children 显示文摘 | Osman O Sinan S Arzu B Pelin Z Ulker E | 2010 | Turk J Med Sci2010，40，1： | 1 |
| 17 | Different magnetic models in the design of hydrodynamic journal bearings lubricated with non-Newtonian ferrofluid显示文摘 | OSMAN T A NADA G S SAFAR Z S | 2003 | Tribology Letters2003，14，3： | 1 |
| 18 | Input-output analysis of energy use in agriculture显示文摘 | Osman Karkacier Gokalp Goktolga Z | 2005 | Energy Conversion and Management2005，，46： | 1 |
| 19 | Experimental assessment of hydrostatic thrust bearing performance显示文摘 | OSMAN T A DORID M SAFAR Z S | 1996 | Tribology International1996，29，3： | 1 |
| 20 | Input-output analysis of energy use in agriculture 显示文摘 | OSMAN K GOKALP Z G | 2005 | Energy Conversion and Management2005，46，： | 1 |
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