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| 1 | Pathological response measured using virtual microscopic slides for gastric cancer patients who underwent neoadjuvant chemotherapy显示文摘BACKGROUND Although pathological response is a common endpoint used to assess the efficacy of neoadjuvant chemotherapy (NAC) for gastric cancer, the problem of a low rate of concordance from evaluations among pathologists remains unresolved. Moreover, there is no globally accepted consensus regarding the optimal evaluation. A previous study based on a clinical trial suggested that pathological response measured using digitally captured virtual microscopic slides predicted patients’ survival well. However, the pathological concordance rate of this approach and its usefulness in clinical practice were unknown. AIM To investigate the prognostic utility of pathological response measured using digital microscopic slides in clinical practice. METHODS We retrospectively evaluated pathological specimens of gastric cancer patients who underwent NAC followed by surgery and achieved R0 resection between March 2009 and May 2015. Residual tumor area and primary tumor beds were measured in one captured image slide, which contained the largest diameter of the resected specimens. We classified patients with < 10% residual tumor relative to the primary tumorous area as responders, and the rest as non-responders;we then compared overall survival (OS) and relapse-free survival (RFS) between these two groups. Next, we compared the prognostic utility of this method using conventional Japanese criteria. RESULTS Fifty-four patients were evaluated. The concordance rate between two evaluators was 96.2%. Median RFS of 25 responders and 29 non-responders was not reached (NR) vs 18.2 mo [hazard ratio (HR)= 0.35, P = 0.023], and median OS was NR vs 40.7 mo (HR = 0.3, P = 0.016), respectively. This prognostic value was statistically significant even after adjustment for age, eastern cooperative oncology group performance status, macroscopic type, reason for NAC, and T- and Nclassification (HR = 0.23, P = 0.018). This result was also observed even in subgroup analyses for different macroscopic types (Borrmann type 4/non-type 4) and histological types (differentiated/undifferentiated). Moreover, the adjusted HR for OS between responders and non-responders was lower in this method than that in the conventional histological evaluation of Japanese Classification of Gastric Carcinoma criteria (0.23 vs 0.39, respectively). CONCLUSION The measurement of pathological response using digitally captured virtual microscopic slides may be useful in clinical practice. | Sadayuki Kawai Tadakazu Shimoda Takashi Nakajima Masanori Terashima Katsuhiro Omae Nozomu Machida Hirofumi Yasui | 2019 | World Journal of Gastroenterology2019，25，35： | 2 |
| 2 | Support and promoter effect of ruthenium catalyst 3显示文摘 | Aika K Kumasaka M Oma T | 1996 | Appl Catal1996，28，： | 2 |
| 3 | Clinical characterization of gastric lesions initially diagnosed as low‐grade adenomas on forceps biopsy显示文摘 | Akiyoshi Kasuga Yorimasa Yamamoto Junko Fujisaki Kazuhisa Okada Masami Omae Akiyoshi Ishiyama Toshiaki Hirasawa Akiko Chino Tomohiro Tsuchida Masahiro Igarashi Etsuo Hoshino Noriko Yamamoto Minoru Kawaguchi Rikiya Fujita | 2012 | Digestive Endoscopy2012，，5： | 2 |
| 4 | Long-term outcomes of endoscopic submucosal dissection for undifferentiated-type early gastric cancer显示文摘 | K. Okada J. Fujisaki T. Yoshida H. Ishikawa T. Suganuma A. Kasuga M. Omae M. Kubota A. Ishiyama T. Hirasawa A. Chino M. Inamori Y. Yamamoto N. Yamamoto T. Tsuchida Y. Tamegai A. Nakajima E. Hoshino M. Igarashi | 2012 | Endoscopy2012，，02： | 2 |
| 5 | OMA为中国电视巨擎CCTV设计新总部大楼显示文摘中央电视台的55.3万平方米的新总部大楼将出现在北京新的中央商务区建造的首批300座高层建筑之中。总建设成本估计约6亿欧元(约48亿人民币)。该工程是为2008年的北京奥运会建设的。 | OMA | 2003 | 时代建筑2003，46，2： | 2 |
| 6 | Application of visante optical coherence tomography tear meniscus height measurement in the diagnosis of dry eye disease显示文摘 | Ibrahim OMA Dogru M Takano Y | 2010 | Ophthalmology2010，117，： | 1 |
| 7 | Organometallic intramolecular- coordination five- membered ring compounds show high reactivity and high selectivity 显示文摘 | OMAE I | 2003 | Chem Rev2003，，103： | 1 |
| 8 | Aggregates from mutant and wild-type α-synclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments显示文摘 | El-agnaf OMA Jakes R Curran MD | 1998 | FEBS Lett1998，440，： | 1 |
| 9 | Morphological Transition of the Regular Structure of Poly(styrene-block--butadiene-block-styrene) at the Interface with Poly(xylenyl) ether)显示文摘 | Mitsuteru Mutsuda Hitomi Omae | 2004 | Macromolecules2004，37，： | 1 |
| 10 | Microsphere-induced embolic stroke:an MRI study显示文摘 | Mayzel-Oreg O Omae T Kazemi M | 2004 | Magn Reson Med2004，51，： | 1 |
| 11 | Determination of vanillin and related flavor compounds in cocoa drink by capillary electrophoresis 显示文摘 | M Ohashi H Omae M Hashida | 2007 | Journal of Chromatography A2007，1138，12： | 1 |
| 12 | Interstitial pulmonary disorders in indium-processing workers显示文摘 | CHONAN T TAGUCHI O OMAE K | | 0，，02： | 1 |
| 13 | Indium lung-case reports and epidemiology显示文摘 | Omae K Nakano M Tanaka A | 2011 | Int Arch Occup Environ Health2011，84，5： | 1 |
| 14 | Exposure to hardly soluble indium compounds in ITO production and recycling plants is a new risk for interstitial lung damage显示文摘 | HAMAGUCHI T OMAE K TAKEBAYASHI T | | 0，，01： | 1 |
| 15 | Causal relationship between indium compound inhalation and effects on the lungs显示文摘 | NAKANO M OMAE K TANAKA A | | 0，，06： | 1 |
| 16 | Exposure to hardly soluble indium compounds in ITO production and recycling plants is a new risk for interstitial lung damage 显示文摘 | Hamaguchi T Omae K Takebayashi T | 2008 | Oceup Environ Med2008，65，10： | 1 |
| 17 | An approach for analysis of urban morphology: methods to deriye morphological properties of city blocks by using an urban landscape model and their interpretations显示文摘 | Yoshida H Omae M | 2005 | Computers Environment and Urban Systems2005，29，： | 1 |
| 18 | Interstitial pulmonary disorders in indium-processing works 显示文摘 | Chonan T Taguchi K Omae | 2007 | European Respiratory Journal2007，29，2： | 1 |
| 19 | placebo 显示文摘 | Sesti F Capozzolo T Pietrop01]i A et aL Recurrence rate of endometri- oma aler lapamscopic cystectomy: a comparative randomized trial be- twecn post-operative hormonal suppression trvatment m' dietary therapy vs | 2009 | Eur J Obstet Gynecel Repmd Biol2009，146，1： | 1 |
| 20 | Cross sectional observation of the effects of carbon disulphide on arteriosclerosis in rayon manufacturing workers 显示文摘 | Omae K Takebayashi T Nomiyama T | 1998 | Occup Environ Med1998，55，7： | 1 |
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