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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation显示文摘血浆膜(下午) 水泡是发生的动态充满肌动朊的房间伸出,例如在胞质分裂期间,似变形虫的房间活动性和房间附件。用对 21 个肌动朊成核因素的一幅指向的 siRNA 屏幕,我们在房间粘附期间在下午 blebbing 识别一篇小说和人的透明 formin DIAPH3 的必要角色。DIAPH3 的抑制禁止了 blebbing 支持快速的房间传播包含 β 1-integrin。DIAPH3 的多重 isoforms 在 mRNA 和 isoforms, 3 和 7 是然而没导致充满肌动朊的伸出的形成的最大、很丰富的 isoforms 的蛋白质水平上被检测。更确切地说,下午 blebbing 明确地包含了低丰富 isoform 7 由透明自动调整的领域的删除引起了 filopodia 的形成的 isoform 的 1 DIAPH3 和激活。Dimerization 和肌动朊集会活动为由 DIAPH3 isoforms 的特定的房间伸出的正式就职是必要的 1 和 7。我们的数据建议包括 GTPase 有约束力的域的 N 终端区域象它在水泡和 filopodia 之间的伸出活动一样决定了 formin 的 subcellular 本地化。我们建议由 DIAPH3 的 isoform 选择的肌动朊汇编施加特定并且调整的差别在房间粘附和活动性期间工作。 | Jana Stastna Xiaoyu Pan Haicui Wang Alina Kollmannsperger Stefan Kutscheidt Volker Lohmann Robert Grosse Oliver T Fackler | 2012 | Cell Research2012，22，4： | 6 |
| 3 | Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin显示文摘瞄准:Microcirculatory 机能障碍和免费的氧激进分子是在严重尖锐胰腺炎的致病的重要因素。另外的氧交货可能每氧化提高类脂化合物,但是可以也改进胰腺的微循环。这研究在严重尖锐胰腺炎的一个啮齿类动物模型在氧激进分子和微循环的形成上估计免费细胞的牛的血红素的效果。方法:在尖锐胰腺炎 Wistar 老鼠的正式就职以后的十五分钟收到了任何一个 0.8 mL 牛的血红素(HBOC-200 ) , hydroxyethyl 淀粉(HES ) 或保证血量正常替换的生理盐水的 2.4 mL。在检查的 6 h 以后,胰每氧化产品 malondialdehyde (MDA ) 为类脂化合物的间接测量被切除并且很快处理了并且在胰腺的织物减少了谷胱甘肽(GSH ) 。结果:HBOC-200 的单个申请改进了胰腺的微循环并且显著地减少了组织病理学说的织物损坏。MDA 的织物集中没在这些组之间不同。另外,在 GSH 层次的差别都没被检测。结论:不过 HBOC-200 和 HES 的单个申请改进胰腺的微循环,在类脂化合物的没有差别每氧化,产品被检测。另外的氧供应(HBOC-200 ) 的有益的效果不每氧化导致提高的类脂化合物。 | Helge Kleinhans Oliver Mann Paulus G Schurr Jussuf T Kaifi Bente Hansen Jakob R Izbicki Tim Strate | 2006 | World Journal of Gastroenterology2006，12，18： | 6 |
| 4 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 5 | Epidemiology of extended-spectrum beta-lactamase-producing Enterobacter isolates in a Spanish hospital during a 12-year period 显示文摘 | Canton R Oliver A Coque T M | 2002 | J Clin Microbiol2002，40，： | 3 |
| 6 | Restrictions to HIV-1 replication in resting CD4+T lymphocytes显示文摘CD4 + T 淋巴细胞代表人的免疫不全病毒(HIV ) 的主要目标房间人口。处于一个激活的状态,居住在淋巴的器官的 CD4 + T 细胞是在感染的个人的进行中的 HIV-1 复制的一座主要水库。相反,放松 CD4 + T 房间对生产 HIV-1 感染高度抵抗,还大规模在疾病前进期间被弄空并且代表为在 vivo 的病毒的一座实质的潜伏的水库。在放松 CD4 + T 房间阻止 HIV-1 的复制的障碍包括外皮的肌动朊的僵硬的层并且,在 HIV-1 入口以后早,限制到来的病毒的 RNA 染色体的反向的抄写的块。定义这些限制的分子的底在 HIV 研究仍然是中央待研究的问题之一。最近的进展解开了 HIV-1 由绕过入口的机制堵住并且建立了主人房间限制因素 SAMHD1, deoxynucleoside triphosphate triphosphohydrolase,到在放松 CD4 + T 房间的 HIV-1 反向的抄写的细胞的限制的一个中央决定因素。这评论总结我们分子的水流和和放松 CD4 + T 淋巴细胞的 HIV-1 的滑稽得多的相互作用的 pathophysiological 理解。 | Xiaoyu Pan Hanna-Mari Baldauf Oliver T Keppler Oliver T Fackler | 2013 | Cell Research2013，23，7： | 2 |
| 7 | Energy and economic evaluation of building-integrated photovohaics 显示文摘 | OLIVER M JACKSON T | 2001 | Energy2001，，26： | 1 |
| 8 | Thrombin-cleaved COOH(-)terminal osteopontin peptide binds with cyclophilin C to CD147 in murine brest cancer cells显示文摘 | MiZ Oliver T Guo H | 2007 | Cancer Res2007，67，： | 1 |
| 9 | Hot Spares for DoS Attacks 显示文摘 | T Darmohray R Oliver | 2000 | The Magazine of USENIX and SAGE2000，25，4： | 1 |
| 10 | Pressure and Velocity Distribution for Air Flow Through Fruits Packed in Shipping Containers Using Porous Media Flow Analysis 显示文摘 | Talbot M T Oliver C C Gaffney P E | 1990 | ASHARE Transactions1990，9，： | 1 |
| 11 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 12 | The legitimacy of strategic alliances: An institutional perspective显示文摘 | Dacin M T Oliver C Roy J P | 2007 | Strategic Management Journal2007，28，2： | 1 |
| 13 | Transient liquid phase diffusion bonding A1-6061 using nano-dispersed Ni coatings 显示文摘 | COOKE K O KHAN T I OLIVER G D | 2011 | Materials and Design2011，33，： | 1 |
| 14 | Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells 显示文摘 | KUBO T HATTON R D OLIVER J | 2004 | J Immunol2004，173，12： | 1 |
| 15 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 16 | A new maximum likelihood joint segmentation technique for multitemporal SAR and multiband optical images显示文摘 | LOMBARDO P OLIVER C J PELLIZZERI T M | 2003 | IEEE Transactions on Geoscience and Remote Sensing2003，41，11： | 1 |
| 17 | Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway显示文摘 | Ohtsuka T Buchsbaum D Oliver P | 2003 | Oncogene2003，22，13： | 1 |
| 18 | Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus显示文摘 | King GL Shiba T Oliver J | 1994 | Annu Rev Med1994，45，： | 1 |
| 19 | An antidia2betic thiazolidinedione is a high affinity ligand for peroxisome proliferator activated receptor gamma 显示文摘 | Lehmann J N Moore L B Smith Oliver T A | 1995 | J Biol Chem1995，270，12： | 1 |
| 20 | Forest management effects on carabid beetle communities in coniferous and broadleaved forests: implications for conservation显示文摘 | Fuller R J Oliver T H Leather H R | 2008 | Insect Conservation and Diversity2008，1，： | 1 |
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