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| 1 | Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells显示文摘人的 pluripotent 干细胞(hPSC ) 导出 endothelial 系细胞组成有希望的来源因为在这个竞技场的治疗学的 revascularization,而是进步被临床上可伸缩的区别协议和在移植之上与宿主发行量集成的一个功能的容器网络的低效的形成的缺乏妨碍了。在绿的地方,使用一根人的胚胎的干细胞记者房间线荧光灯蛋白质表示被 endothelial 驾驶房间特定的 VE-cadherin (VEC ) 倡导者,我们为 > 屏蔽了;60 bioactive 将支持 endothelial 区别,并且发现 BMP4 和 GSK-3β 的那个政府的小分子;在有 VEGF 的一个早阶段和处理的禁止者 -- 在一个以后的阶段表明小径的槽口的 A 和抑制在六天以内导致了 hPSCs 的有效区别到 endothelial 系。这条顺序的途径产生了 >到 endothelial 房间(EC ) 的 hPSCs 的50%变换,明确地 VEC + CD31 + CD34 + CD14 − KDR 在 endothelial 系房间之中展出了更高的 angiogenic 和 clonogenic 增长潜力的高 endothelial 祖先( EP )。药品的抑制或基因槽口发信号击倒,在有 VEGF 的联合 -- 一个处理,经由 KDR + mesodermal 先锋和对成熟 EC 的 EP 的变换的封锁导致了 EP 的有效形成。当移植了进 immunocompromised 老鼠时,产生 EP 成功地与吻合在 vivo 形成了功能的毛状的容器到主人容器。在我们的协议表明电路的这 VEGF-A-Notch 的操作由 12- 导致导出 hPSC 的 EP 的快速的大规模生产到 20 褶层对当前的方法,它可以与与成熟 EC 相比形成能力的优异容器为再生 vascularization 用作一张吸引人的房间人口。 | Makoto Sahara Emil M Hansson Oliver Wemet Kathy O Lui Daniela Spater Kenneth R Chien | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 3 | 成人直肠脱垂、直肠内套叠、直肠前膨出及阴道肠疝的评估与处理显示文摘直肠脱垂是指直肠全层肠壁突出于肛缘。直肠内脱垂或称直肠内套叠的定义为直肠全层肠壁脱垂但并没有突出于肛门外。直肠脱垂和内套叠常常与直肠前膨出(直肠阴道隔向前方疝人阴道)和阴道肠疝(直肠阴道腹膜形成深疝)同时存在。总地来说,这些问题常统称作“盆底功能障碍”。本综述的重点是后盆腔,即直肠,上述疾病均绕其发生。 | Oliver M Jones Christopher Cunningham Ian Lindsey 苏万春(译) 陈雷(校) | 2011 | 英国医学杂志中文版2011，14，3： | 3 |
| 4 | Epidemiology of extended-spectrum beta-lactamase-producing Enterobacter isolates in a Spanish hospital during a 12-year period 显示文摘 | Canton R Oliver A Coque T M | 2002 | J Clin Microbiol2002，40，： | 3 |
| 5 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 6 | Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice显示文摘Endothelin-1 (ET-1 ) 为哺乳动物的开发和生活是必要的,但是它也在 pathophysiological 条件下面在增加的心血管的风险被含有。这研究的目的是在水管和瘦、肥胖的老鼠的肾的动脉在内皮细胞层依赖者和内皮细胞层无关的回答上决定 prepro-endothelin-1 基因的 endothelial overexpression 的影响。肥胖被 high-fat-diet (HFD ) 导致在有 prepro-endothelin-1 基因的 Tie-1 倡导者驱动的、内皮细胞层特定的 overexpression 的老鼠的消费(TET het ) 并且在里面野类型(WT ) 一个 C57BL/6N 背景上的同窝出生的人。等轴的紧张在戒指被测量(与内皮细胞层) 主动脉(A) ,颈动脉(CA ) 并且肠骨(IA ) 动脉象一样主要(MRA ) 并且部分肾(SRA ) 动脉;所有实验在 L 名字或 COX 禁止者 meclofenamate 的缺席或存在被进行。prostacyclin 和 thromboxane A2 的版本被 ELISA 测量。在 MRA, TET het 本身增加了收缩到 endothelin-1,但是反应响应血清素在 SRA 被减少;面对 L 名字在 SRA 到醋胆素然而并非胰岛素有也改进的松驰。HFD 本身扩充了收缩到 endothelin-1 (MRA ) 并且到 thromboxane prostanoid (TP ) 受体收缩筋 U46619 (CA, MRA ) 象到 isoproterenol (A) 的便于的松驰一样。HFD 和 TET het overexpression 增加了 MRA 和 SRA 的收缩到 vasoconstrictors 然而并非面对 meclofenamate;这联合也在 A 扩充了进一步的松驰到 isoproterenol。到在 IA 的 endothelin-1 的收缩被 endothelin 阻止 -- 受体对手 BQ-123 但是仅仅由 BQ-788 在肥胖的老鼠稀释了。COX-1 禁止者 FR122047 废除了 CA 的收缩到醋胆素。prostacyclin 的版本从肥胖的 TET het 老鼠并且由 FR122047 废除了。这些调查结果建议那 endothelial TET 在瘦动物的 het overexpression 在脉管的应答上有最小的效果。不管多么有肥胖的 comorbid, endothelin-1-modulated,调停 prostanoid 的肾的动脉的机能障碍变得明显。 | Oliver BARETELLA Sookja K CHUNG Aimin XU Paul M VANHOUTFE | 2017 | Acta Pharmacologica Sinica2017，38，4： | 2 |
| 7 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 8 | Aberrant Th2 inflammation drives dysfunction of alveolar macrophages and susceptibility to bacterial pneumonia显示文摘The ubiquitin ligase,Itch,is required to prevent autoinflammatory disease in mice and humans.Itch-deficient mice develop lethal pulmonary inflammation characterized by the production of Th2 cytokines(for example,interleukin-4(IL-4));however,the contribution of Itch to immune defense against respiratory pathogens has not been determined.We found that Itch-deficient mice were highly susceptible to intranasal infection with the respiratory pathogen Klebsiella pneumoniae.Infected Itch-deficient mice exhibited increased immune cell infiltration,cytokine levels and bacterial burden in the respiratory tract compared with control mice.However,numbers of resident alveolar macrophages were reduced in the lungs from Itch-deficient mice both before and after infection.High levels of Th2 cytokines in the respiratory tract correlated with deceased alveolar macrophages,and genetic ablation of IL-4 restored alveolar macrophages and host defense to K.pneumoniae in Itch-deficient mice,suggesting that loss of alveolar macrophages occurred as a consequence of Th2 inflammation.Adoptive transfer of Itch−/−CD4+T cells into Rag−/−mice was sufficient to drive reduction in numbers of Itch-replete alveolar macrophages.Finally,we found that Stat6 signaling downstream of the IL-4 receptor directly reduced fitness of alveolar macrophages when these cells were exposed to the Itch−/−inflamed respiratory tract.These data suggest that Th2 inflammation directly impairs alveolar macrophage fitness in Itch−/−mice,and elucidate a previously unappreciated link between Th2 cells,alveolar macrophages and susceptibility to bacterial infection. | Emily K Moser Natania S Field Paula M Oliver | 2018 | Cellular & Molecular Immunology2018，15，5： | 2 |
| 9 | An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiment显示文摘 | Oliver W C Pharr G M | 1992 | J Mater Res1992，7，6： | 2 |
| 10 | Energy and economic evaluation of building-integrated photovohaics 显示文摘 | OLIVER M JACKSON T | 2001 | Energy2001，，26： | 1 |
| 11 | Compliance and results of treatment for amblyopia in children more than 8 years old显示文摘 | Oliver M Neumann R Chaimoviteh Y Gotesman N Shimshoni M | 1986 | Am J Ophthalmol1986，15，： | 1 |
| 12 | Improved Technique for Determining Hardness and Elastic Modulus Using Load and Displacement Sensing Indentation Experiments 显示文摘 | Oliver W C Pharr G M | 1992 | Journal of Materials Re- search1992，7，6： | 1 |
| 13 | Pressure and Velocity Distribution for Air Flow Through Fruits Packed in Shipping Containers Using Porous Media Flow Analysis 显示文摘 | Talbot M T Oliver C C Gaffney P E | 1990 | ASHARE Transactions1990，9，： | 1 |
| 14 | Arterial hypertension in the adolescent:its possible relation to the salt taste threshold 显示文摘 | del Negro MC Oliver M Arocha I | 1992 | Rev Esp Cardiol1992，45，4： | 1 |
| 15 | Modeling material failure in concrete structures under cyelie aetions显示文摘 | Faria R Oliver J Cervera M | 2004 | Journal of Structural Engineering2004，130，12： | 1 |
| 16 | Impact of sodium and uhrafihration profiling on hemodialysis- related symptoms 显示文摘 | Oliver M J Edwards LJ Churchill DN | 2001 | J Am Soc Nephrol2001，12，1： | 1 |
| 17 | On the Measurement of Stress-strain Curves by Spherical Indentation显示文摘 | E G Herbert G M Pharr W C Oliver B N Lucas J L Hay | 2001 | Thin Solid Films2001，，： | 1 |
| 18 | An improved technique for determining hardness and elastic-modulus using load and displacement sensing indentation experiments显示文摘 | Oliver W C Pharr G M | 1992 | Journal of Materials Research1992，7，： | 1 |
| 19 | An Improved Technique for Determining Hardness and Elastic Modulus Using Load and Displacement Sensing Indentation Experiments显示文摘 | Oliver W C Pharr G M | 1992 | Journal of Materials Research1992，7，6： | 1 |
| 20 | The dynamic relation between stock returns and trading volume:domestic and cross-country evidence显示文摘 | Lee Bong-Soo Rui Oliver M | 2002 | Journal of banking and finance2002，26，： | 1 |
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