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| 1 | 关于城市蔓延和交通规划的政治与政策显示文摘文章从分析什么是可持续的城市形态入手,探讨了城市住区形态、交通设施和环境影响之间密切的相互作用关系。通过对荷兰、意大利和美国的实例研究,作者关注在西方社会中有关推动规划合理化和民主化过程的城市政策和政治基础;反映了他们为控制城市蔓延,正在寻求多种模式和手段以及多样化的解决方案。 | Federico Oliva Marco Facchinetti Valeria Fedeli 刘川 | 2002 | 国外城市规划2002，17，6： | 17 |
| 2 | 在没有危险因素的情况下,正常的低密度脂蛋白胆固醇水平与亚临床动脉粥样硬化相关显示文摘普遍认为缺乏心血管病危险因素(cardiovascular risk factors,CVRF)人群的动脉粥样硬化发生风险低,然而,无CVRF的个体仍然有心血管事件发生。为了确定无CVRF个体中亚临床动脉粥样硬化的预测因子, | Fernández-Friera L Fuster V López-Melgar B Oliva B García-Ruiz JM Mendiguren J Bueno H Pocock S Ibánez B Fernández-Ortiz A Sanz J 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 17 |
| 3 | Pediatric gastrointestinal bleeding: Perspectives from the Italian Society of Pediatric Gastroenterology显示文摘There are many causes of gastrointestinal bleeding(GIB) in children, and this condition is not rare, having a reported incidence of 6.4%. Causes vary with age, but show considerable overlap; moreover, while many of the causes in the pediatric population are similar to those in adults, some lesions are unique to children. The diagnostic approach for pediatric GIB includes definition of the etiology, localization of the bleeding site and determination of the severity of bleeding; timely and accurate diagnosis is necessary to reduce morbidity and mortality. To assist medical care providers in the evaluation and management of children with GIB, the 'Gastro-Ped Bleed Team' of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition(SIGENP) carried out a systematic search on MEDLINE via Pub Med(http://gffzz16a62c593b5540ceh50pwfuoqpofv6vw5.ffgz.tsg.suse.edu.cn/pubmed/) to identify all articles published in English from January 1990 to 2016; the following key words were used to conduct the electronic search: 'upper GIB' and 'pediatric' [all fields]; 'lower GIB' and 'pediatric' [all fields]; 'obscure GIB' and 'pediatric' [all fields]; 'GIB' and 'endoscopy' [all fields]; 'GIB' and 'therapy' [all fields]. The identified publications included articles describing randomized controlled trials, reviews, case reports, cohort studies, casecontrol studies and observational studies. References from the pertinent articles were also reviewed. This paper expresses a position statement of SIGENP that can have an immediate impact on clinical practice and for which sufficient evidence is not available in literature. The experts participating in this effort were selected according to their expertise and professional qualifications. | Claudio Romano Salvatore Oliva Stefano Martellossi Erasmo Miele Serena Arrigo Maria Giovanna Graziani Sabrina Cardile Federica Gaiani Gian Luigi de'Angelis Filippo Torroni | 2017 | World Journal of Gastroenterology2017，23，8： | 12 |
| 4 | Alcohol,nutrition and liver cancer:Role of Toll-like receptor signaling显示文摘This article reviews the evidence that ties the development of hepatocellular carcinoma (HCC) to the natural immune pro-inflammatory response to chronic liver disease, with a focus on the role of Toll-like receptor (TLR) signaling as the mechanism of liver stem cell/progenitor transformation to HCC. Two exemplary models of this phenomenon are reviewed in detail. One model applies chronic ethanol/lipopolysaccharide feeding to the activated TLR4 signaling pathway. The other applies chronic feeding of a carcinogenic drug, in which TLR2 and 4 signaling pathways are activated. In the drug-induced model, two major methyl donors, S-adenosylmethionine and betaine, prevent the upregulation of the TLR signaling pathways and abrogate the stem cell/progenitor proliferation response when fed with the carcinogenic drug. This observation supports a nutritional approach to liver cancer prevention and treatment. The observation that upregulation of the TLR signaling pathways leads to liver tumor formation gives evidence to the popular concept that the chronic pro-inflammatory response is an important mechanism of liver oncogenesis. It provides a nutritional approach, which could prevent HCC from developing in many chronic liver diseases. | Samuel W French Joan Oliva Barbara A French Fawzia Bardag-Gorce | 2010 | World Journal of Gastroenterology2010，16，11： | 11 |
| 5 | 卵巢原发性子宫内膜间质肉瘤27例临床病理分析:形态学和生物学行为特征类似于子宫低级别子宫内膜间质肉瘤显示文摘原发性子宫外的子宫内膜间质肿瘤非常罕见,作者报道27例卵巢原发性子宫内膜间质肉瘤的临床病理特征。患者年龄38—76岁,平均56岁。20例为单侧卵巢病变,7例累及双侧卵巢。肿瘤直径1—20cm,平均9.5cm。实性区域切面呈典型的黄褐色,6例伴出血和(或)坏死, | Oliva E Egger J F Young R H 康锶鹏 余英豪 | 2014 | 临床与实验病理学杂志2014，30，7： | 11 |
| 6 | 相同基因型而不同表现型的PRKAG2基因突变一家系报道显示文摘目的 位于7号染色体上的腺苷一磷酸激活的蛋白激酶γ^2调节亚单位基因(PRKAG2基因)调节代谢通路。报道一个具有PRKAG2基因突变而临床表现型不同的家系。方法 使用DNA直接测序法,对一个具有多种形式心律失常的患者家系(13例患者)进行PRKAG2外显子及外显子和内含子拼接部位序列筛查寻找基因突变。结果 心电图显示患者家系存在窦性心动过缓、短PR间期、完全性右束支传导阻滞、房室传导阻滞和房性心动过速。其中3例患者在年轻时发生猝死,没有1例有预激综合征(预激)表现,只有1例有心肌肥厚。DNA测序结果显示,该家系所有患者皆有一个PRKAG2错义突变(R302Q)。这个基因突变以前曾描述并与预激和左室肥厚有关。结论 PRKAG2基因突变不仅导致预激而且与多种临床表现型有关。完全性右束支传导阻滞、窦性心动过缓、短PR间期应该高度怀疑有PRKAG2基因突变的可能。 | 洪葵 Antonio Oliva 程晓曙 Pedro Brugada Joseph Brugada Eduardo-back Sternick Ramon Brugada | 2007 | 中华心血管病杂志2007，35，6： | 9 |
| 7 | Italian survey on non-steroidal anti-inflammatory drugsand gastrointestinal bleeding in children显示文摘AIM: To investigate gastrointestinal complications associated with non-steroidal anti-inflammatory drug(NSAIDs) use in children.METHODS: A retrospective, multicenter study was conducted between January 2005 and January 2013, with the participation of 8 Italian pediatric gastroenterology centers. We collected all the cases of patients who refer to emergency room for suspected gastrointestinal bleeding following NSAIDs consumption, and underwent endoscopic evaluation. Previous medical history, associated risk factors, symptoms and signs at presentation, diagnostic procedures, severity of bleeding and management of gastrointestinal bleeding were collected. In addition, data regarding type of drug used, indication, dose, duration of treatment and prescriber(physician or selfmedication) were examined. RESULTS: Fifty-one patients, including 34 males, were enrolled(median age: 7.8 years). Ibuprofen was the most used NSAID [35/51 patients(68.6%)]. Pain was the most frequent indication for NSAIDs use [29/51 patients(56.9%)]. Seven patients had positive family history of Helicobacter pylori(H. pylori) infection or peptic ulcer, and 12 had associated comorbidities. Twenty-four(47%) out of 51 patients used medication inappropriately. Hematemesis was the most frequent symptom(33.3%). Upper gastrointestinal endoscopy revealed gastric lesions in 32/51(62%) patients, duodenal lesions in 17(33%) and esophageal lesions in 8(15%). In 10/51(19.6%) patients, a diagnosis of H. pylori gastritis was made. Forty-eight(94%) patients underwent medical therapy, with spontaneous bleeding resolution, while in 3/51(6%) patients, an endoscopic hemostasis was needed.CONCLUSION: The data collected in this study confirms that adverse events with the involvement of the gastrointestinal tract secondary to NSAID use are also common in | Sabrina Cardile Massimo Martinelli Arrigo Barabino Paolo Gandullia Salvatore Oliva Giovanni Di Nardo Luigi Dall'Oglio Francesca Rea Gian Luigi de'Angelis Barbara Bizzarri Graziella Guariso Enzo Masci Annamaria Staiano Erasmo Miele Claudio Romano | 2016 | World Journal of Gastroenterology2016，22，5： | 7 |
| 8 | A pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release显示文摘Pediatric Menetrier's disease (MD) is an uncommon, acute, self-limited hypertrophic gastropathy characterized by enlarged gastric folds associated with epithelial hyperplasia and usually accompanied by protein losing gastropathy. Gastric cytomegalovirus infection is found in one third of MD children and its treatment is often associated with remission. Diagnosis often requires fullthickness biopsy due to inability to detect typical histological findings with conventional endoscopic biopsy. We report an uncommon case of non self-limited pediatric MD needing endoscopic mucosal resection for diagnosis which was then successfully treated with octreotide long-acting release (LAR). To the best of our knowledge, this is the first pediatric MD case successfully treated with octreotide LAR. Our experience suggests octreotide LAR as treatment for refractory MD before gastrectomy. | Giovanni Di Nardo Salvatore Oliva Marina Aloi Federica Ferrari Simone Frediani Adriana Marcheggiano Salvatore Cucchiara | 2012 | World Journal of Gastroenterology2012，18，21： | 6 |
| 9 | Capsule endoscopy in pediatrics: A 10-years journey显示文摘Video capsule endoscopy(CE) for evaluation the esophagus(ECE), small bowel(SBCE) and the colon(CCE) is particularly useful in pediatrics, because this imaging modality does not require ionizing radiation, deep sedation or general anesthesia. The risk of capsule retention appears to be dependent on indication rather than age and parallels the adult experience by indication, making SBCE a relatively safe procedure with a significant diagnostic yield. The newest indication, assessment of mucosal change, greatly enhances and expands its potential benefit. The diagnostic role of CE extends beyond the SB. The use of ECE also may enhance our knowledge of esophageal disease and assist patient care. Colon CCE is a novel minimally invasive and painless endoscopic technique allowing exploration of the colon without need for sedation, rectal intubation and gas insufflation. The limited data on ECE and CCE in pediatrics does not yet allow the same conclusions regarding efficacy; however, both appear to provide safe methods to assess and monitor mucosal change in their respective areas with little discomfort. Moreover, although experience has been limited, the patency capsule may help lessen the potential of capsule retention; and newly researched protocols for bowel cleaning may further enhance CE's diagnostic yield. However, further research is needed to optimize the use of the various CE procedures in pediatric populations. | Salvatore Oliva Stanley A Cohen Giovanni Di Nardo Gianfranco Gualdi Salvatore Cucchiara Emanuele Casciani | 2014 | World Journal of Gastroenterology2014，20，44： | 6 |
| 10 | Photosynthesis and activity of superoxide dismutase, peroxidase and glutathione reductase in cotton under salt stress显示文摘 | Diego A. Meloni Marco A. Oliva Carlos A. Martinez José Cambraia | 2002 | Environmental and Experimental Botany2002，，1： | 6 |
| 11 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 12 | Chronic epididymitis and Grade III varicocele and their associations with semen characteristics in men consulting for couple infertility显示文摘长期的附睾炎和精索静脉曲张是在在不孕会诊的时候在精液特征上为夫妇不孕,而是他们的影响做咨询的人的经常观察的生殖器的混乱仍然是争论的一件事。我们调查了在阿根廷有他们在 1999 和 2015 之间的第一不孕咨询的夫妇的 652 个男搭挡。有长期的附睾炎的人(n = 253 ) ,等级 III 精索静脉曲张(n = 106 ) ,并且两个条件(n = 125 ) 与一个控制组相比(n = 168 ) 没有这些混乱,人创作了或任何其它认出了男不孕的原因。我们证明介绍了孤立的长期的附睾炎的人是更可能的有低精子活动性和反常精子形态学以及白血房间的一个高数字的高百分比。有孤立的等级 III 精索静脉曲张的人有低精子生产和活动性和反常精子形态学的一个增加的百分比。最后,同时与等级 III 精索静脉曲张介绍了长期的附睾炎的人有低精子活动性并且增加了反常精子形态学的百分比以及白血房间的一个高数字。生殖器的机关的物理检查可以识别普通混乱,病人不孕的潜在地深奥的同样原因的因素。这些混乱与应该在从可得到的治疗学的选择识别最好的治疗帮助的特定的精液的侧面被联系,有效性,安全,并且允许差不多可能的自然概念。 | Alejandro Oliva Luc Multigner | 2018 | Asian Journal of Andrology2018，20，4： | 5 |
| 13 | Proteomics and the genetics of sperm chromatin condensation显示文摘精子发生包含极其显著细胞,基因并且染色质变化导致高度专业化的精子房间的产生。Proteomics 允许填写 spermatogenic 房间和他们的功能的学习的蛋白质的鉴定。在集体 spectrometry (MS ) 的最近的开发显著地增加了产量识别并且学习精子蛋白质。在人、不同的模型种类的几千个睾丸和 spermatozoan 蛋白质的目录正在变得可得到,安装随后的研究的基础,诊断应用程序并且可能特定的处理的未来开发。现在的评论打算在精子发生并且在成熟精子房间的不同阶段总结基因的钥匙和染色质变化并且评论一会儿可得到的 proteomic 研究。 | Rafael Oliva Judit Castillo | 2011 | Asian Journal of Andrology2011，13，1： | 4 |
| 14 | Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronically显示文摘AIM:To examine the effects of ethanol-induced proteasome inhibition,and the effects of proteasome inhibition in the regulation of epigenetic mechanisms. METHODS:Rats were fed ethanol for 1 mo using the Tsukamoto-French model and were compared to rats given the proteasome inhibitor PS-341(Bortezomib, Velcade?)by intraperitoneal injection.Microarray analysis and real time PCR were performed and proteasome activity assays and Western blot analysis were performed using isolated nuclei. RESULTS:Chronic ethanol feeding caused a significant inhibition of the ubiquitin proteasome pathway in the nucleus,which led to changes in the turnover of transcriptional factors,histone-modifying enzymes, and,therefore,affected epigenetic mechanisms. Chronic ethanol feeding was related to an increase in histone acetylation,and it is hypothesized that the proteasome proteolytic activity regulated histone modifications by controlling the stability of histone modifying enzymes,and,therefore,regulated the chromatin structure,allowing easy access to chromatin by RNA polymerase,and,thus,proper gene expression.Proteasome inhibition by PS-341 increased histone acetylation similar to chronic ethanol feeding. In addition,proteasome inhibition caused dramatic changes in hepatic remethylation reactions as there was a significant decrease in the enzymes responsible for the regeneration of S-adenosylmethionine,and, in particular,a significant decrease in the betaine- homocysteine methyltransferase enzyme.This suggested that hypomethylation was associated with proteasome inhibition,as indicated by the decrease in histone methylation. CONCLUSION:The role of proteasome inhibition in regulating epigenetic mechanisms,and its link to liver injury in alcoholic liver disease,is thus a promising approach to study liver injury due to chronic ethanol consumption. | Joan Oliva Jennifer Dedes Samuel W French Fawzia Bardag-Gorce | 2009 | World Journal of Gastroenterology2009，15，6： | 4 |
| 15 | Altered histone retention and epigenetic modifications in the sperm of infertile men显示文摘 | Rafael Oliva Josep Luis Ballesca | 2012 | Asian Journal of Andrology2012，14，2： | 3 |
| 16 | Bortezomib enhances fatty liver preservation in I nstitut G eorge L opez‐1 solution through adenosine monophosphate activated protein kinase and Akt / mTOR pathways显示文摘 | Mohamed Bejaoui Mohamed Amine Zaouali Emma Folch‐Puy Eirini Pantazi Fawzia Bardag‐Gorce Teresa Carbonell Joan Oliva Antoni Rimola Hassen Ben Abdennebi Joan Roselló‐Catafau | 2014 | J Pharm Pharmacol2014，，1： | 3 |
| 17 | Preparation and Characterization of Flexible, Transparent and Thermally Stable Aromatic Co-polyamides显示文摘Two aromatic co-polyamides were synthesized combining two diacid monomers containing bulky pendant groups, 5-(9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboximido)isophthalic acid(DEAIA) and 5-tert-butylisophthalic acid(TERT), with 4,4′-(hexafluoroisopropylidene)dianiline(HFA) or 2,3,5,6-tetramethyl-1,4-phenylenediamine(Durene) by direct polycondensation. The structures of the obtained aromatic co-polyamides were confirmed by FTIR, Raman and 1 H-NMR. The co-copolyamide films, DHTH and DDTD, exhibited rms-roughness values between 0.94 and 1.60 nm, respectively. Moreover, they presented good thermal stability up to300 °C. Young's moduli of the co-polyamide films were between 4.1 and 4.3 GPa. X-ray diffraction results showed that the co-polyamide films were amorphous due to the incorporation of both bulky pendant groups, tert-butyl and dibenzobarrelene. The combination of bulky pendant groups provided intrinsically transparent co-polyamide films with a transmittance higher than 88% in the range of 400-780 nm.Due to these outstanding film and optical properties, they are suggested to be flexible substrates in applications for solar cell and other portable electronic devices. | José Antonio Tec-Sánchez Andrés Iván Oliva Arias Manuel Aguilar-Vega Juan Valerio Cauich-Rodríguez José Luis Santiago-García | 2019 | Chinese Journal of Polymer Science2019，37，2： | 3 |
| 18 | Critical endpoint and inverse magnetic catalysis for finite temperature and density quark matter in a magnetic background显示文摘 | M. Ruggieri L. Oliva P. Castorina R. Gatto V. Greco | 2014 | Physics Letters B2014，，： | 2 |
| 19 | Large gangliocytic paraganglioma of the duodenum:A rare entity显示文摘Gangliocytic paragangliomas are rare tumors that almost exclusively occur within the second portion of the duodenum. Although these tumors generally have a benign clinical course, they have the potential to recur or metastasize to regional lymph nodes. The case report presented here describes a 57-year-old female patient with melena, progressive asthenia, anemia, and a mass in the second-third portion of the duodenum that was treated by local excision. The patient was diagnosed with a friable bleeding tumor. The histologic analysis showed that the tumor was a 4 cm gangliocytic paraganglioma without a malignant cell pattern. In the absence of local invasion or distant metastasis, endoscopic resection represents a feasible, curative therapy. Although endoscopic polypectomy is currently considered the treatment of choice, it is not recommended if the size of the tumor is > 3 cm and/or there is active or recent bleeding. Patients diagnosed with a gangliocytic paraganglioma should be closely followed-up for possible local recurrence. | Alejandra Gordillo Hernández Eduardo Dominguez-Adame Lanuza Auxiliadora Cano Matias Rosario Perez Huertas Katherine Maria Gallardo Rodriguez Purificacion Gallinato Perez Fernando Oliva Mompean | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 20 | On the irreversible photo-bleaching phenomenon in obliquely-evaporated GeS2 glass films 显示文摘 | MARQUEZ E BERNAL- OLIVA A M GONZALEZLEAL J M | 1997 | J NonCryst Solids1997，222，： | 2 |
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