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| 1 | Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome显示文摘AIM: To investigate the effect of rosuvastatin monotherapy on non-alcoholic steatohepatitis(NASH). At present there is no effective treatment for non-alcoholic fatty liver disease or its advanced form NASH.METHODS: This prospective study included 20 biopsy proven patients with NASH, metabolic syndrome(Met S) and dyslipidaemia. Biochemical parameters of the blood of the patients and an ultrasonography of the liver were performed at baseline. Then patients receivedlifestyle advice and were treated for a 12 mo period with rosuvastatin(10 mg/d) monotherapy. Patients were re-evaluated during the study at 3 mo intervals, during which biochemical parameters of the blood were measured including liver enzymes. A repeat biopsy and ultrasonography of the liver were performed at the end of the study in all 20 patients. Changes in liver enzymes, fasting plasma glucose, serum creatinine, serum uric acid(SUA), high sensitivity C reactive protein(hs CRP) and lipid profile were assessed every 3 mo. The primary endpoint was the resolution of NASH and the secondary endpoints were the changes in liver enzyme and lipid values.RESULTS: The repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, while the 20 th, which had no improvement but no deterioration either, developed arterial hypertension and substantial rise in triglyceride levels during the study, probably due to changes in lifestyle including alcohol abuse. Serum alanine transaminase, aspartate transaminase, and γ-glutamyl transpeptidase were normalised by the 3rd treatment month(ANOVA P < 0.001), while alkaline phosphatase activities by the 6th treatment month(ANOVA, P = 0.01). Fasting plasma glucose and glycated haemoglobin were significantly reduced(P < 0.001). Lipid values were normalised by the 3rd treatment month. No patient had Met S by the 9th treatment month. Body mass index and waist circumference remained unchanged during the study. Thus, changes in liver pathology and function should be attributed solely to rosuvastatin treatment. A limitation of the study is the absence of a control group.CONCLUSION: These findings suggest that rosuvastatin monotherapy could ameliorate biopsy proven NASH and resolve Met S within 12 mo. These effects and the reduction of fasting plasma glucose and SUA levels may reduce the risk of vascular and liver morbidity and mortality in NASH patients. These findings need confirmation in larger studies. | Konstantinos Kargiotis Vasilios G Athyros Olga Giouleme Niki Katsiki Evangelia Katsiki Panagiotis Anagnostis Chrysoula Boutari Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，21，25： | 18 |
| 2 | Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms显示文摘The possible relationship between diabetes mellitus (DM) and colorectal cancer (CRC), concerning pathophysiological and molecular mechanisms is highlighted in this review. The most recent and complete articles and developments in this particular field were thoroughly reviewed. Common risk factors, such as obesity, sedentary lifestyle, and Western diet between DM and CRC, led to the theory that DM might be a causal agent for CRC development. Various studies have connected type 2 DM and CRC, either proximal or distal, in both sexes. Additionally, chronic insulin treatment has been linked with increased colorectal tumor risk among type 2 diabetic patients. Interestingly, elevated hemoglobin A1c has been proven to be an independent predictor of aggressive clinical behavior in CRC patients. These mechanisms include the insulin-like growth factor-hyperinsulinemia theory and the participation of oncogenic intracellular signaling pathways. Furthermore, it has been proposed that Cox-2 inhibitors might have a role in decreasing the incidence of CRC. Finally, the use of statins to reduce the risk for colon cancer in patients with diabetes has remained controversial. Diabetic patients over 50 should receive counseling regarding their elevated risk for CRC, and screening colonoscopy should be recommended before initiating insulin therapy. However, there are no current guidelines, and this strategy is not yet applicable to some countries, as the corresponding risk would not allow screening colonoscopy to be adopted. There is strong evidence to indicate that DM is a causal agent for CRC development. This conclusion provides new impetus for re-evaluating CRC screening worldwide. | Olga Giouleme Michael D Diamantidis Marios G Katsaros | 2011 | World Journal of Gastroenterology2011，17，4： | 15 |
| 3 | Beneficiation of the gold bearing ore by gravity and flotation显示文摘Gold concentration usually consists of gravity separation, flotation, cyanidation, or the combination of these processes. The choice among these processes depends on the mineralogical characterization and gold content of the ore. Recently, the recovery of gold using gravity methods has gained attention because of low cost and environmentally friendly operations. In this study, gold pre-concentrates were produced by the stepwise gravity separation and flotation techniques. The Knelson concentrator and conventional flotation were employed for the recovery of gold. Gold bearing ore samples were taken from Gümüshane Region, northern east part of Turkey. As a result of stepwise Knelson concentration experiments, a gold concentrate assaying around 620 g/t is produced with 41.4wt% recovery. On the other hand, a gold concentrate about 82 g/t is obtained with 89.9wt% recovery from a gold ore assaying 6 g/t Au by direct flotation. | Alim Gül Olga Kangal Ayhan A. Sirkeci Güven nal | 2012 | International Journal of Minerals,Metallurgy and Materials2012，19，2： | 10 |
| 4 | 海南地区强磁暴期间强区域扩展F事件研究显示文摘利用2004年海南DPS-4数字测高仪观测到的强区域扩展F(SSF)数据,分析研究了5个强磁暴(Dst<-100 nT)事件期间海南SSF的响应特征.结果发现,在海南地区,5个强磁暴事件中有3个磁暴Dst最小值位于2200—0200 LT之间,在磁暴主相及恢复相初期均出现了SSF现象,这种触发作用可能源于磁层直接渗透电场的作用,而另两个磁暴Dst最小值均发生在白天,一个SSF现象出现在磁暴的恢复相晚间,另一个SSF现象出现在超强磁暴的初相晚间,后者可能由该超强磁暴的急始造成的直接渗透电场所触发;5个强磁暴期间发生的SSF现象或者仅出现在午夜前,或者先出现在午夜前并持续到午夜后;同时,还就这些观测结果与Dabas等人有关磁暴对ESF影响的结论进行对比和讨论. | 王国军 史建魁 王霄 刘振兴 Zherebtsov G Olga P | 2007 | 空间科学学报2007，27，5： | 6 |
| 5 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 6 | Pancreatic adenocarcinoma:Outstanding problems显示文摘Pancreatic adenocarcinoma remains the fourth leading cause of cancer-related death and is one of the most aggressive malignant tumors with an overall 5-year survival rate of less than 4%.Surgical resection remains the only potentially curative treatment but is only possible for 15%-20% of patients with pancreatic adenocarcinoma.About 40% of patients have locally advanced nonresectable disease.In the past,determination of pancreatic cancer resectability was made at surgical exploration.The development of modern imaging techniques has allowed preoperative staging of patients.Institutions disagree about the criteria used to classify patients.Vascular invasion in pancreatic cancers plays a very important role in determining treatment and prognosis.There is no evidence-based consensus on the optimal preoperative imaging assessment of patients with suspected pancreatic cancer and a unified definition ofborderline resectable pancreatic cancer is also lacking.Thus,there is much room for improvement in all aspects of treatment for pancreatic cancer.Multi-detector computed tomography has been widely accepted as the imaging technique of choice for diagnosing and staging pancreatic cancer.With improved surgical techniques and advanced perioperative management,vascular resection and reconstruction are performed more frequently;patients thought once to be unresectable are undergoing radical surgery.However,when attempting heroic surgery,a realistic approach concerning the patient's age and health status,probability of recovery after surgery,perioperative morbidity and mortality and life quality after tumor resection is necessary. | Olga P Zakharova Grigory G Karmazanovsky Viacheslav I Egorov | 2012 | World Journal of Gastrointestinal Surgery2012，4，5： | 4 |
| 7 | The presence of ANP in rat peritoneal mast cells显示文摘Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fraction of mast cells was obtained by separation of rat peritoneal cells on a Percoll density gradient. By Western blotting, two ANP-immunoreactive proteins of molecular masses of 2.5 kDa and 16.9 kDa were detected in lysates from these mast cells. Electron microscope immunogold labeling has revealed the presence of ANP-immunoreactive material in storage, secreting and released granules of mast cells. Our findings indicate the rat peritoneal mast cells to contain both ANP prohormone and ANP. These both peptides are located in mast cell secretory granules and released by mechanism of degranulation. It is discussed that many mast cell functions might be due to production of natriuretic peptides by these cells. | Marina G MARTYNOVA Olga A BYSTROVA Olga M MOISEEVA Anton L EVDONIN Kirill A KONDRATOV Natalja D MEDVEDEVA | 2005 | Cell Research2005，15，10： | 3 |
| 8 | Panax ginseng natural populations: their past, current state and perspectives显示文摘瞄准:人参属人参,遗传和它 Primorye (俄国) 的自然人口的个体发生的结构的交配系统被调查。方法:基因差异用紧密相联的酶和荧光灯地基于的自动化放大碎片长度多型性(AFLP ) 和简单顺序被估计重复(SSR ) 标记。结果:在种类水平的全部的基因差异与紧密相联的酶是低的试金(0.023 ) ,和有 AFLP (0.255 ) 和 SSR (0.259 ) 的高度方法。它根据紧密相联的酶(>99%) 在人口以内被观察, AFLP (>85%) ,和 SSR (>73%) 试金。基因可变性分发的索引指出开拓殖民地在早 Holocene 在温暖的时期期间从南部的避难处由人参的 Sikhote-Alin 种。到异花受粉和自花传粉的人参植物的能力被显示出,人参属人参是容许的单性生殖的植物的假设被证实。人参的繁殖系统拥有授精进程的高粘性和稳定性帮助种类处于压力条件幸存。外部或内部的因素引起的骚乱能由于人参小卵或单性生殖的胚胎开发的形态基因的潜力被减少。因为一些生活阶段是不在的或很少发生,人参人口的生活阶段结构的分析证明所有他们不是完整成分的。结论:在所有 3 张人口,处女和年轻生产个人是占优势的。人口学习了的这个工具是可行的,自然人参人口的再介绍还是可能的。 | Yuri N ZHURAVLEV Olga G KOREN Galina D REUNOVA Tamara I MUZAROK Tatiyana Yu GORPENCHENKO Irina L KATS Yuliya A KHROLENKO | 2008 | Acta Pharmacologica Sinica2008，29，9： | 3 |
| 9 | Regulation of Human Placental Development by Oxygen Tension显示文摘 | Olga G Zhou Y John W L | 1997 | Science1997，277，： | 2 |
| 10 | C - Jun N - terminal kinase is essential for growth of human T98G glioblastoma cells 显示文摘 | Olga P Myriam G Frederic B | 2000 | J Biol Chem2000，275，24： | 1 |
| 11 | Epidemiology of commu- nity-acquired pneumonia in older adults:a population-based study 显示文摘 | Angel VC Olga G Teyesa RB | 2009 | Respir Med2009，103，2： | 1 |
| 12 | Adipokines in breast milk:an update 显示文摘 | Catl G Olga^ Diindar N Diindar BN | 2014 | Journal of clinical research in pediatric en-docrinology2014，6，4： | 1 |
| 13 | Increased blastocyst formation of cloned porcine embryos produced with donor cells pre-treated with Xenopus egg extract and/or digitonin显示文摘 | Ying Liu Olga ?strup Juan Li Gábor Vajta Lin Lin Peter M. Kragh Stig Purup Poul Hyttel Henrik Callesen | 2011 | Zygote2011，，1： | 1 |
| 14 | Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma:a novel target for treatment显示文摘 | OLGA G GIDEON R ARNON N | 2008 | Neoplasia2008，10，： | 1 |
| 15 | Genome-wide association study of systemic sclerosis identifies CD247 as a novel susceptibility locus显示文摘 | Timothy RDJ Radstake Olga G | 2010 | Nat Genet2010，42，5： | 1 |
| 16 | Effect of specific interactions on structure property relationships of thermoplastic IPNs based on polyurethane and styrene-co-acrylic acid ionomers显示文摘 | Olga G Olga S Alexander B | 2007 | Macromolecular Symposia2007，254，1： | 1 |
| 17 | The canditae tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis 显示文摘 | IGORL G SERGEY K OLGA C | 2004 | Nature2004，428，6980： | 1 |
| 18 | Molecular mechanisms of biocatalytic desulfurization of fossil fuels显示文摘 | Kevin A G Olga S P Gregry T M Lei X Daniel J M Charles H S | 1996 | Nature Biotechnology1996，14，12： | 1 |
| 19 | Characterisation of low-fat high-dietary fibre frankfurters显示文摘 | NURIA G M MARIA 1 A A OLGA M B | 1999 | Meat Science1999，52，： | 1 |
| 20 | New genus-specific primers for the PCR identification of members of the genera Pseudonocardia and Saccharopolyspora显示文摘 | RAQUEL M LGNACIO G OLGA G | 1999 | International Journal of Systematic Bacteriology1999，49，： | 1 |
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