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| 1 | Potential role of imaging in assessing harmful effects on spermatogenesis in adult testes with varicocele显示文摘Varicocele is characterized by an abnormal dilatation and retrograde blood flow in the spermatic veins. Varicocele is the leading correctable cause of male infertility. Although it is highly prevalent in infertile men, it is also observed in individuals with normal fertility. Determining which men are negatively affected by varicocele would enable clinicians to better select those men who will benefit from treatment. To assess the functional status of the testes in men with varicocele, color Doppler sonographic parameters were evaluated. Testicular arterial blood flow was significantly reduced in men with varicocele, reflecting an impairment of spermatogenesis. An improvement in the testicular blood supply was found after varicocelectomy on spectral Doppler analysis. Testicular contrast harmonic imaging and elastography might improve our knowledge about the influence of varicocele on intratesticular microcirculation and tissue stiffness, respectively, providing possible information on the early damage of testicular structure by varicocele. Magnetic resonance imaging(MRI), with measurement of apparent diffusion coefficient has been used to assess the degree of testicular dysfunction and to evaluate the effectiveness of varicocele repair. Large prospective studies are needed to validate the possible role of functional sonography and MRI in the assessment of early defects of spermatogenesis in testes with varicocele. | Athina C Tsili Olga N Xiropotamou Anastasios Sylakos Vasilios Maliakas Nikolaos Sofikitis Maria I Argyropoulou | 2017 | World Journal of Radiology2017，9，2： | 4 |
| 2 | Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases显示文摘AIM: To investigate the expression of nucleoporin 88 (Nup88) in hepatitis B virus (HBV) and C virus (HCV)-related liver diseases. METHODS: We generated a new monoclonal Nup88 antibody to investigate the Nup88 protein expression by immunohistochemistry (IHC) in 294 paraffin-embedded liver specimens comprising all stages of hepatocellular carcinogenesis. In addition, in cell culture experiments HBV-positive (HepG2.2.15 and HB611) and HBV-negative (HepG2) hepatoma cell lines were tested for the Nup88 expression by Western-immunoblotting to test data obtained by IHC.RESULTS: Specific Nup88 expression was found in chronic HCV hepatitis and unspecific chronic hepatitis, whereas no or very weak Nup88 expression was detected in normal liver. The Nup88 expression was markedly reduced or missing in mild chronic HBV infection and inversely correlated with HBcAg expression. Irrespective of the HBV- or HCV-status, increasing Nup88 expression was observed in cirrhosis and dysplastic nodules, and Nup88 was highly expressed in hepatocellular carcinomas. The intensity of Nup88 expression significantly increased during carcinogenesis (P < 0.0001) and correlated with dedifferentiation (P < 0.0001). Interestingly, Nup88 protein expression was significantly downregulated in HBV-positive HepG2.2.15 (P < 0.002) and HB611 (P < 0.001) cell lines as compared to HBV-negative HepG2 cells. CONCLUSION: Based on our immunohistochemical data, HBV and HCV are unlikely to influence the expression of Nup88 in cirrhotic and neoplastic liver tissue, but point to an interaction of HBV with the nuclear pore in chronic hepatitis. The expression of Nup88 in nonneoplastic liver tissue might reflect enhanced metabolic activity of the liver tissue. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. | Martina Knoess Anna Kordelia Kurz Olga Goreva Nuran Bektas Kai Breuhahn Magarethe Odenthal Peter Schirmacher Hans Peter Dienes C Thomas Bock Hanswalter Zentgraf Axel zur Hausen | 2006 | World Journal of Gastroenterology2006，12，36： | 4 |
| 3 | Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image显示文摘 | Barbara C Silva William D Leslie Heinrich Resch Olivier Lamy Olga Lesnyak Neil Binkley Eugene V McCloskey John A Kanis John P Bilezikian | 2014 | J Bone Miner Res2014，，3： | 2 |
| 4 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 5 | Impact of ovine whey protein concentrates and clarification by products on the yield and quality of whey cheese显示文摘 | CARLOS D P OLGA D ANGEL C | 2007 | Food Technology Biotechnology2007，4，2： | 1 |
| 6 | Newadvances in extending the shelf - life of fresh - cut fruits : 显示文摘 | Robert C Soliva - Fortuny Olga Martin - Belloso | 2003 | Trends in Food Science and Technology2003，14，3： | 1 |
| 7 | The canditae tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis 显示文摘 | IGORL G SERGEY K OLGA C | 2004 | Nature2004，428，6980： | 1 |
| 8 | Hepsin promotes pros-tate cancer progression andmetastasis显示文摘 | Olga K John C Janni M | | 0，，15： | 1 |
| 9 | New advances in extending the shelf-life of fresh-cut fruits:a review显示文摘 | Robert c soliva-fortuny Olga martin-belloso | 2003 | Trends in Food science and Technology2003，，14： | 1 |
| 10 | Liver protective effect of ursodeoxy-cholic acid includes regulation of ADAM17 activity 显示文摘 | Halka B Karel C Olga Z | 2013 | BMC Gastroenterol2013，13，1： | 1 |
| 11 | The calcium sensing receptor(CaR) is involved in strontium ranelate-induced osteoblast proliferation显示文摘 | Naibedya C Stephen JQ Olga K | 2007 | Bioche Pharmacol2007，74，3： | 1 |
| 12 | Trace elements distribution in soil,pore wa- ter and groundwater in Buenos Aires,Argentina 显示文摘 | olga s H Alicia F c | 2009 | Geoderma2009，149，： | 1 |
| 13 | A natural clouding agent from orange peels obtained using polygalacturonase and cellulase 显示文摘 | Alexandre E B Robert C S F Olga M B | 2005 | Food Chemistry2005，92，1： | 1 |
| 14 | New Advances in Extending the Shelf-life of Fresh-cut Fruits:a Review显示文摘 | SOLIVA-FORTUNY Robert C MARTIlN-BELLOSO Olga | 2003 | Tends in Food Science and Technology2003，14，9： | 1 |
| 15 | Missing Value Estimation Methods for DNA Microarrays显示文摘 | Olga T Michael C Sherlock G Pat B Trevor H Robert T David B Russ B A | 2001 | Bioinformatics2001，17，： | 1 |
| 16 | Ganglioside GD3 sensitizes human hepato -ma cells to cancer therapy显示文摘 | Raquel P Albert M Olga C | 2002 | J Bio Chem2002，277，49： | 1 |
| 17 | Analysis of Antennas on Board Arbitrary Structures Modeled by NURBS Surfaces显示文摘 | Jesus P Juan A S Olga M C | 1997 | IEEE Trans on Antennas Propag1997，45，6： | 1 |
| 18 | Agglomeration econo- mies in manufacturing industries case of spain 显示文摘 | Olga A V Jose-Maria C R Xulia G C | 2004 | Applied Economics2004，36，18： | 1 |
| 19 | The effects of vacuum annealing on the structure and surface chemistry of iron: Nickel alloy nanoparticles显示文摘 | MICHELLE D THOMAS B S RICHARD A C OLGA R ROBERT J B GARETH M H | 2010 | Journal of Nanoparticle Research2010，12，6： | 1 |
| 20 | The canditae tumour suppress or protein ING4 regulates brain turnout growth and angiogenesis显示文摘 | Igorl G Sergey K Olga C | 2004 | Nature2004，428，6980： | 1 |
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